29 research outputs found
Dark Energy and Gravity
I review the problem of dark energy focusing on the cosmological constant as
the candidate and discuss its implications for the nature of gravity. Part 1
briefly overviews the currently popular `concordance cosmology' and summarises
the evidence for dark energy. It also provides the observational and
theoretical arguments in favour of the cosmological constant as the candidate
and emphasises why no other approach really solves the conceptual problems
usually attributed to the cosmological constant. Part 2 describes some of the
approaches to understand the nature of the cosmological constant and attempts
to extract the key ingredients which must be present in any viable solution. I
argue that (i)the cosmological constant problem cannot be satisfactorily solved
until gravitational action is made invariant under the shift of the matter
lagrangian by a constant and (ii) this cannot happen if the metric is the
dynamical variable. Hence the cosmological constant problem essentially has to
do with our (mis)understanding of the nature of gravity. Part 3 discusses an
alternative perspective on gravity in which the action is explicitly invariant
under the above transformation. Extremizing this action leads to an equation
determining the background geometry which gives Einstein's theory at the lowest
order with Lanczos-Lovelock type corrections. (Condensed abstract).Comment: Invited Review for a special Gen.Rel.Grav. issue on Dark Energy,
edited by G.F.R.Ellis, R.Maartens and H.Nicolai; revtex; 22 pages; 2 figure
Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel
A major use of the 1000 Genomes Project (1000GP) data is genotype imputation in genome-wide association studies (GWAS). Here we develop a method to estimate haplotypes from low-coverage sequencing data that can take advantage of single-nucleotide polymorphism (SNP) microarray genotypes on the same samples. First the SNP array data are phased to build a backbone (or 'scaffold') of haplotypes across each chromosome. We then phase the sequence data 'onto' this haplotype scaffold. This approach can take advantage of relatedness between sequenced and non-sequenced samples to improve accuracy. We use this method to create a new 1000GP haplotype reference set for use by the human genetic community. Using a set of validation genotypes at SNP and bi-allelic indels we show that these haplotypes have lower genotype discordance and improved imputation performance into downstream GWAS samples, especially at low-frequency variants. © 2014 Macmillan Publishers Limited. All rights reserved
ESTUDO SOBRE A INFLUĂNCIA DO PROCESSO EDUCATIVO NO CONTROLE DA HIPERTENSĂO ARTERIAL
A study was carried out with 23 hypertensive individuals after educational process in order to verify the retention of knowledge and its influence on the hypertension control. After drug treatment it was observed that the level of knowledge was inversely proportional to the blood pressure levels.O estudo foi realizado com 23 pessoas hipertensas em tratamento ambulatorial submetidas a um processo educativo, visando avaliar a retenção de conhecimentos e sua influĂȘncia no controle da pressĂŁo arterial. Os resultados evidenciaram que o nĂvel de conhecimento foi inversamente proporcional aos nĂveis pressĂłricos