Polynomial reconstruction of electric charge distribution on the conductive plate caused by external electric field

The paper proposes an original method of calculating the charge distribution on the surface of the conductive plate introduced into the external electrostatic field. The authors managed to obtain the polynomials which allow to solve the integral equation that establishes the relationship between charge distribution of the conductive plate and the potential distribution of the external field and the potential on the surface of the plate. The proposed algorithms solutions are valid in the presence of axial symmetry of the field and the plate. Examples of calculation of conductor charge distribution in the presence of external field by using a polynomial expansion have been presented. The comparisons of results calculated by the polynomial method and by known analytical solutions have been given

Basis for the model of parameter permeability prediction of productive strata in oil and gas deposits development

Basis for prediction of strata permeability of oil and gas deposits has been presented. The prediction model from the viewpoint of continuum mechanics (the theory of viscosity-elastic body creeping) is justified in terms of estimating deformation gradient, water permeability, piezoconductivity and permeability of hydrocarbon productive strata. To construct the pattern of these parameters the programming complex «Balance-Hydrodynamics» was used. One of the units of this complex allows the construction of predictive permeability patterns to use only the results of well prospecting seismology and hydrodynamic tests. The method was successfully applied at a number of hydrocarbon deposits development in Tomsk region

COLON CAPSULE ENDOSCOPY: POSSIBILITIES OF NON-INVASIVE DIAGNOSTICS OF COLON DISEASES

Purpose. Evaluation of feasibility of colon capsule endoscopy (CCE), as non-invasive method of diagnostics of colon abnormalities.Patients and methods. From 31.01.2014 to 10.01.2017 we successfully performed 100 CCE in 101 (99,0%) patients (m-50, f-48, mean age 44,7 ± 14,8 years, range 22–81), including 2 twins aged 8 years (CCE was performed with pediatrician). The main indication for colonoscopy was colorectal cancer screening (73 (73,0%) pts). The indication for colonoscopy to 2 twins was complicated Peutz Jeghers syndrome in one of them. CCE was performed using the system PillCam (Given Imaging) and capsule PillCam Colon 2. For the bowel preparation we used two-stage regimen; for the evaluation of preparation — J.A. Leighton scale.Results. Preparation was adequate in 88 (88,0%) pts, non-adequate — in 12 (12,0%) pts. Total CCE was performed in 82 (82,0%) patients. The mean colon transit time was 4 hours 43 min ± 3 hours15 min. Total evaluation of the colon was performed in 82 (82,0%) pts. Mucosal lesions were revealed in 75 (75,0%) pts, including epithelial polyps in 52 (69,3%) pts. We also revealed comorbid lesions in 41 (54,6%) pts. Colonoscopy after CCE was recommended to 28 (37,3%) pts because of polyp detection, sized ≥6 mm, and because of inflammatory changes of colon mucosa, but only 11 (39,3%) pts were performed colonoscopy.Conclusion. In this article the experience of colon capsule endoscopy demonstrates the principal possibility of noninvasive evaluation of the colon and detection of colon abnormalities

Blended Educational Technologies in Higher Education: Systematic Review of Domestic Publications

The article presents the results of generalization and systematization of scientific and practical information on the variety of types of blended educational technologies used in Russian higher education institutions. This specific product of digitalization causes the greatest interest of researchers and practitioners in the field of education. This systematic review is based on national scientific publications related to the development and practical implementation of educational technologies in higher education. The authors have analyzed 180 papers published between 2016 and 2021 in peer-reviewed scientific journals approved by the Higher Attestation Commission. Methods of qualitative and quantitative content analysis, systems analysis and contextological analysis, as well as analytical grouping, have been used.Content analysis of publications showed that the main property of blended educational technologies is their variability, which manifests itself through the described system of indicators. However, the structural organization of blended educational technologies models remains the most debatable issue among researches.The authors have identified and described the main directions in the development of the theory and practical application of blended educational technologies, namely: the formation of the structure and boundaries of the conceptual and terminological field; elaboration of the methodological basis of blended education development and definition of theoretical basis for changing traditional learning systems by designing a learning process based on the mechanisms of pedagogical and digital technologies integration.It has been established that the empirical studies with the elements of experimental work focused on defining the most effective combinations of traditional and digital educational technologies dominate in the national scientific community. The most popular methods of such integration include rotation of forms and types of learning activity in traditional and digital learning environments, integration of digital and traditional educational technologies based on the Moodle learning management system, as well as inclusion of separate forms and means of e-learning in the educational process

Supernovae - Optical Precursors of Short Gamma-Ray Bursts

The probability of observing "supernova - gamma-ray burst" (GRB) pair events and recurrent GRBs from one galaxy in a time interval of several years has been estimated. Supernova explosions in binary systems accompanied by the formation of a short-lived pair of compact objects can be the sources of such events. If a short GRB is generated during the collision of a pair, then approximately each of ~300 short GRBs with redshift z must have an optical precursor - a supernova in the observer's time interval <2(1+z)yr. If the supernova explosion has the pattern of a hypernova, then a successive observation of long and short GRBs is possible. The scenario for the generation of multiple GRBs in collapsing galactic nuclei is also discussed.Comment: 12 pages, 1 figure; this paper has the e-precursor arXiv:1101.3298 [astro-ph.HE

Swift J164449.3+573451 event: generation in the collapsing star cluster?

We discuss the multiband energy release in a model of a collapsing galactic nucleus, and we try to interpret the unique super-long cosmic gamma-ray event Swift J164449.3+573451 (GRB 110328A by early classification) in this scenario. Neutron stars and stellar-mass black holes can form evolutionary a compact self-gravitating subsystem in the galactic center. Collisions and merges of these stellar remnants during an avalanche contraction and collapse of the cluster core can produce powerful events in different bands due to several mechanisms. Collisions of neutron stars and stellar-mass black holes can generate gamma-ray bursts (GRBs) similar to the ordinary models of short GRB origin. The bright peaks during the first two days may also be a consequence of multiple matter supply (due to matter release in the collisions) and accretion onto the forming supermassive black hole. Numerous smaller peaks and later quasi-steady radiation can arise from gravitational lensing, late accretion of gas onto the supermassive black hole, and from particle acceleration by shock waves. Even if this model will not reproduce exactly all the Swift J164449.3+573451 properties in future observations, such collapses of galactic nuclei can be available for detection in other events.Comment: 7 pages, replaced by the final versio

Investigation of physico-chemical properties of drugs iron (III) hydroxide polymaltosate and iron protein succinylate

The purpose of the study is to study the physico-chemical properties of M iron (III) hydroxide polymaltosate and iron protein succinylate, such as the ability to dissociate, the hydrogen pH in various aqueous solutions, redox properties.Цель исследования – изучение физико-химических свойств ЛП железа (III) гидроксид полимальтозат и железа протеин сукцинилат, таких как способность к диссоциации, водородного показателя рН в различных водных растворах, окислительно-восстановительных свойств

The role of the KIBRA and APOE genes in developing spatial abilities in humans

In the contemporary high-tech society, spatial abilities predict individual life and professional success, especially in the STEM (Science, Technology, Engineering, and Mathematics) disciplines. According to neurobiological hypotheses, individual differences in cognitive abilities may be attributed to the functioning of genes involved in the regulation of neurogenesis and synaptic plasticity. In addition, genome-wide association studies identified rs17070145 located in the KIBRA gene, which was associated with individual differences in episodic memory. Considering a significant role of genetic and environmental components in cognitive functioning, the present study aimed to estimate the main effect of NGF (rs6330), NRXN1 (rs1045881, rs4971648), KIBRA (rs17070145), NRG1 (rs6994992), BDNF (rs6265), GRIN2B (rs3764030), APOE (rs7412, rs429358), and SNAP25 (rs363050) gene polymorphisms and to assess the effect of gene-environment interactions on individual differences in spatial ability in individuals without cognitive decline aged 18–25 years (N = 1011, 80 % women). Spatial abilities were measured using a battery of cognitive tests including the assessment of “3D shape rotation” (mental rotation). Multiple regression analysis, which was carried out in the total sample controlling for sex, ethnicity and the presence of the “risk” APOE ε4 allele, demonstrated the association of the rs17070145 Т-allele in the KIBRA gene with enhanced spatial ability (β = 1.32; pFDR = 0.037) compared to carriers of the rs17070145 CC-genotype. The analysis of gene-environment interactions revealed that nicotine smoking (β = 3.74; p = 0.010) and urban/rural residency in childhood (β = –6.94; p = 0.0002) modulated the association of KIBRA rs17070145 and АРОЕ (rs7412, rs429358) gene variants with individual differences in mental rotation, respectively. The data obtained confirm the effect of the KIBRA rs17070145 Т-allele on improved cognitive functioning and for the first time evidence the association of the mentioned genetic variant with spatial abilities in humans. A “protective” effect of the APOE ε2 allele on enhanced cognitive functioning is observed only under certain conditions related to childhood rearing

The effectiveness of blended learning technologies in higher education: Assessment methodology

Introduction. The modern system of higher education has undergone a serious digital transformation in recent years. Electronic, blended, mobile learning is being actively introduced. However, the most significant innovative trend in modern education in recent years is blended learning, which is characterised using both traditional and digital learning technologies, which together contribute to the preservation of university traditions and the active use of modern information and communication tools in solving educational problems. The use of new models of blended learning makes higher education more accessible to all categories of not only Russian but also foreign students, stimulating their independence and increasing motivation for education based on the rich experience of their digital communication. In this regard, scientists and practitioners show increasing interest to the problem of the effective use of blended learning technologies, approaches and methods in higher education. Aim. The present research aims to theoretically substantiate the methodology for studying the blended learning technologies effectiveness, to develop and approbate appropriate methodological tools, followed by its verification for reliability and validity. Methodology and research methods. The problem research of the effectiveness of the blended learning technologies applied in higher education provides for the analysis of foreign and Russian science literature; systematisation and generalisation of the applied approaches; the use of modelling methods and mathematical statistics. The studying methodology of blended learning technologies effectiveness is represented by the integration of procedural, activity-based and environmental approaches in the selection and justification of three criteria for evaluation (effective, didactic, resource) and a system of their indicators in higher educational practice, which served as the theoretical basis of the developed methodology and selected methodological tools. Results. In the course of the research, the authors formulated conceptual foundations and developed a methodology to study the effectiveness of blended learning technologies used in modern higher education. Procedural stages were defined, and evaluation tools were described. The methodology was approbated and verified for reliability and validity. Scientific novelty. The concept and methodology of studying the blended learning technologies effectiveness is a component of quality management concept of higher education in the context of its digital transformation and its resource-didactic provision. The authors’ methodology not only reflects current trends in improving the objectivity of pedagogical assessment, but also replenishes its scientific and methodological arsenal with the addition of a multi-level system of goals, criteria and methods for determining the effectiveness of blended learning technologies in higher education. Practical significance. A new methodology to study the blended learning technologies effectiveness in the higher education system is proposed. Based on the obtained valid data and the results of the approbation, it is concluded that the authors’ methodology has functional certainty, providing controllability in the didactic and resource support for the effective use of different models of blended learning. The practical application of the methodology will contribute to improving the quality of blended learning in higher education and the involvement of the main members of higher education (teachers and students) in the process of designing and selecting traditional and digital technologies to ensure its effectiveness.Введение. Современная система высшего образования за последние годы подверглась серьезной цифровой трансформации, активно внедряется электронное, смешанное, мобильное обучение. Наиболее значимым инновационным трендом является смешанное обучение, для которого характерно применение как традиционных, так и цифровых образовательных технологий, что в совокупности способствует сохранению вузовских традиций и активному применению современных информационно-коммуникативных средств в решении образовательных задач. Использование новых моделей смешанного обучения делает вузовское образование более доступным для всех категорий не только российских, но и зарубежных студентов, стимулирующим их самостоятельность и повышающим мотивацию к образованию с опорой на богатый опыт их цифровой коммуникации. В связи с этим усиливается интерес ученых и практиков к проблеме эффективного применения смешанных образовательных технологий (СОТ), подходам и методам ее изучения в вузе. Целью настоящей работы является теоретическое обоснование методики изучения эффективности смешанных образовательных технологий, разработка и апробация соответствующего методического инструментария с последующей его проверкой на надежность и валидность. Методология, методы и методики исследования. Исследование проблемы эффективности смешанных образовательных технологий, применяемых в вузах, предусматривает анализ зарубежной и отечественной литературы; систематизацию и обобщение используемых подходов; применение методов моделирования и математической статистики. Методология изучения эффективности СОТ представлена интеграцией процессуального, деятельностного и средового подходов в отборе и обосновании трех критериев для оценки (результативный, дидактический, ресурсный) и системы их показателей в вузовской образовательной практике, которые выступили теоретической основой разработанной методики и отобранного методического инструментария. Результаты. В процессе исследования были сформулированы концептуальные основы и разработана методика изучения эффективности СОТ, применяемых в современном высшем образовании, определены процедурные этапы и описаны инструменты оценивания, проведены апробация и проверка методики на надежность и валидность. Научная новизна. Концепция и методика изучения эффективности СОТ является составляющей концепции управления качеством высшего образования в условиях его цифровой трансформации и ресурсно-дидактического обеспечения. Авторская методика не только отражает современные тенденции в повышении объективности педагогического оценивания, но и пополняет его научно-методический арсенал с дополнением многоуровневой системы целей, критериев и методов определения эффективности СОТ в вузе. Практическая значимость. Предложена новая методика для изучения эффективности СОТ в системе высшего образования. На основе полученных валидных данных и результатов апробации сделан вывод о том, что авторская методика имеет функциональную определенность, способствуя управляемости в дидактическом и ресурсном обеспечении эффективного применения разных моделей смешанного обучения. Практическое применение этой методики будет способствовать повышению качества смешанного обучения в высшей школе и вовлеченности основных субъектов вузовского образования (преподавателей и студентов) в процесс проектирования и отбора традиционных и цифровых технологий для обеспечения его эффективности.Работа поддержана Российским научным фондом (проект № 22-28-00013).The research was supported by the Russian Science Foundation (project No. 22-28-00013)