Successful treatment with azithromycin and rifampicin of penicillin and cephalosporin insensitive pneumococcal osteomyelitis in a child with HIV infection: a case report

Pneumococcal infection is common in children with HIV infection, but osteomyelits is unusual. The best treatment for bone and joint infection due to antibiotic resistant pneumococci is not known, especially in immunocompromised children

Совершенствование реагентного режима обогащения полигалитовых руд флотационным методом

The effect of foaming agents of different chemical nature (amyl alcohol, glycolic ether, pine oil) on the flotation of halite from polyhalite ores using alkylmorpholine as a collector was investigated. It was established that the combined adding of amyl alcohol with alkylmorpholine and glycolic ether with alkylmorpholine in the process of sodium chloride flotation allows achieving high technological performance and reduces the consumption of expensive alkylmorpholine by 2 times. The use of pine oil as a foaming agent in a mixture with alkylmorpholine has been established to reduce the collector consumption by 2.2 times. Исследовано влияние пенообразователей различной химической природы (амиловый спирт, гликолевый эфир, сосновое масло) на флотацию галита из полигалитовых руд используя алкилморфолин в качестве собирателя. Установлено, что совместное введение как амилового спирта, так и гликолевого эфира с алкилморфолином в процесс флотации хлорида натрия позволяет достичь высоких технологических показателей и снизить расход дорогостоящего алкилморфолина в 2 раза. Установлено, что применение соснового масла в качестве пенообразователя в смеси с алкилморфолином позволяет снизить расход собирателя в 2,2 раза

Implementation of 14 bits floating point numbers of calculating units for neural network hardware development

An important aspect of modern automation is machine learning. Specifically, neural networks are used for environment analysis and decision making based on available data. This article covers the most frequently performed operations on floating-point numbers in artificial neural networks. Also, a selection of the optimum value of the bit to 14-bit floating-point numbers for implementation on FPGAs was submitted based on the modern architecture of integrated circuits. The description of the floating-point multiplication (multiplier) algorithm was presented. In addition, features of the addition (adder) and subtraction (subtractor) operations were described in the article. Furthermore, operations for such variety of neural networks as a convolution network - mathematical comparison of a floating point ('less than' and 'greater than or equal') were presented. In conclusion, the comparison with calculating units of Atlera was made

Обогащение полигалитовых руд с высоким содержанием галита флотационным методом

Studies on the flotation enrichment of polyhalite-halite ore have been carried out. It was determined that the maximum degree of disclosure of polyhalite-halite ore to the components during grinding falls on the fraction (–0.5 mm). It was established that the enrichment of polyhalite-halite ore is possible by the method of reverse flotation using alkylmorpholine as a collector. It was established that high levels of enrichment of polyhalite-halite ore (recovery of halite 95.41 %) are achieved at high dosage of the collector (1600 g/t).Проведены исследования по флотационному обогащению полигалит-галитовой руды. Определено, что максимальная степень раскрываемости полигалит-галитовой руды на компоненты при измельчении приходится на фракцию (–0,5 мм). Установлено, что обогащение полигалит-галитовой руды возможно методом обратной флотации с использованием в качестве собирателя алкилморфолинов. Установлено, что высокие показатели обогащения полигалит-галитовой руды (извлечение галита 95,41 %) достигаются при значительных расходах собирателя (1600 г/т)

Оптимизация условий очистки полигалитовой руды от галита

A study of treatment of polyhalite ore was conducted by the method of washing halite using water as a washing liquid. The optimal conditions for washing halite from polyhalite ore (water consumption and temperature, contact time of the solid and liquid phases, ore grinding degree) were determined, providing the production of pure polyhalite and filtrate close to saturation with sodium chloride at low polyhalite losses.Проведены исследования обогащения полигалитовой руды методом отмывки галита с использованием воды в качестве промывочной жидкости. Определены оптимальные условия отмывки галита из полигалитовой руды (расход и температура воды, время контактирования твердой и жидкой фаз, степень измельчения руды), обеспечивающие получение чистого полигалита и фильтрата, близкого к насыщению по хлориду натрия при низких потерях полигалита

Global Wheat Head Detection (GWHD) dataset: a large and diverse dataset of high resolution RGB labelled images to develop and benchmark wheat head detection methods

Detection of wheat heads is an important task allowing to estimate pertinent traits including head population density and head characteristics such as sanitary state, size, maturity stage and the presence of awns. Several studies developed methods for wheat head detection from high-resolution RGB imagery. They are based on computer vision and machine learning and are generally calibrated and validated on limited datasets. However, variability in observational conditions, genotypic differences, development stages, head orientation represents a challenge in computer vision. Further, possible blurring due to motion or wind and overlap between heads for dense populations make this task even more complex. Through a joint international collaborative effort, we have built a large, diverse and well-labelled dataset, the Global Wheat Head detection (GWHD) dataset. It contains 4,700 high-resolution RGB images and 190,000 labelled wheat heads collected from several countries around the world at different growth stages with a wide range of genotypes. Guidelines for image acquisition, associating minimum metadata to respect FAIR principles and consistent head labelling methods are proposed when developing new head detection datasets. The GWHD is publicly available at http://www.global-wheat.com/ and aimed at developing and benchmarking methods for wheat head detection.Comment: 16 pages, 7 figures, Dataset pape

Hall Normalization Constants for the Bures Volumes of the n-State Quantum Systems

We report the results of certain integrations of quantum-theoretic interest, relying, in this regard, upon recently developed parameterizations of Boya et al of the n x n density matrices, in terms of squared components of the unit (n-1)-sphere and the n x n unitary matrices. Firstly, we express the normalized volume elements of the Bures (minimal monotone) metric for n = 2 and 3, obtaining thereby "Bures prior probability distributions" over the two- and three-state systems. Then, as an essential first step in extending these results to n > 3, we determine that the "Hall normalization constant" (C_{n}) for the marginal Bures prior probability distribution over the (n-1)-dimensional simplex of the n eigenvalues of the n x n density matrices is, for n = 4, equal to 71680/pi^2. Since we also find that C_{3} = 35/pi, it follows that C_{4} is simply equal to 2^{11} C_{3}/pi. (C_{2} itself is known to equal 2/pi.) The constant C_{5} is also found. It too is associated with a remarkably simple decompositon, involving the product of the eight consecutive prime numbers from 2 to 23. We also preliminarily investigate several cases, n > 5, with the use of quasi-Monte Carlo integration. We hope that the various analyses reported will prove useful in deriving a general formula (which evidence suggests will involve the Bernoulli numbers) for the Hall normalization constant for arbitrary n. This would have diverse applications, including quantum inference and universal quantum coding.Comment: 14 pages, LaTeX, 6 postscript figures. Revised version to appear in J. Phys. A. We make a few slight changes from the previous version, but also add a subsection (III G) in which several variations of the basic problem are newly studied. Rather strong evidence is adduced that the Hall constants are related to partial sums of denominators of the even-indexed Bernoulli numbers, although a general formula is still lackin

Новые липофильные конъюгаты флуоресцирующего NBD-пиперазина: синтез, in silico взаимодействие с липидным бислоем и цитохромами P450

Two new fluorescent NBD-piperazine derivatives with lipophilic substituents of formylcholesterol and hexanoic acid (compounds 2 and 3, respectively) were synthesized. Using in silico calculations, their abilities to permeate through lipid bilayer and to be bound affinely with some cytochromes P450 of human (2 with lanosterol 14α-demethylase CYP51, 3 with drug-metabolizing CYP1A1, CYP2D6, CYP3A4; energy of binding Ebind from –14.4 to –10 kcal/mol) and of mycobacteria (2 with sterol 27-hydroxylase CYP125, 3 with “orphan” CYP164; Ebind from –13.3 to –9.1 kcal/mol) were demonstrated. The synthesized compounds and calculated computational data will contribute to prioritization of in vitro investigations aiming to revealing properties of the proteins.Синтезированы два новых флуоресцирующих производных NBD-пиперазина с липофильными остатками формилхолестерола и гексановой кислоты (соединения 2 и 3 соответственно). Расчетно-теоретическими методами показана их возможность проникать через липидный бислой, а также аффинно связываться с некоторыми цитохромами P450 человека (2 с ланостерол 14α-деметилазой CYP51, 3 c лекарство-превращающими CYP1A1, CYP2D6, CYP3A4; энергия связывания Ebind в диапазоне –14,4…–10 ккал/моль) и микобактерий (2 со стерол-27 гидроксилазой CYP125, 3 с «орфанным» CYP164; Ebind в диапазоне –13,3…–9,1 ккал/моль). Полученные вещества и соответствующие расчетно-теоретические данные будут способствовать приоритезации исследований in vitro для целей исследования функций этих белков

Performance of the CMS Cathode Strip Chambers with Cosmic Rays

The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device in the CMS endcaps. Their performance has been evaluated using data taken during a cosmic ray run in fall 2008. Measured noise levels are low, with the number of noisy channels well below 1%. Coordinate resolution was measured for all types of chambers, and fall in the range 47 microns to 243 microns. The efficiencies for local charged track triggers, for hit and for segments reconstruction were measured, and are above 99%. The timing resolution per layer is approximately 5 ns

Prioritising the most needed paediatric antiretroviral formulations: the PADO4 list

Despite considerable progress in paediatric HIV treatment and timely revision of global policies recommending the use of more effective and tolerable antiretroviral regimens, optimal antiretroviral formulations for infants, children, and adolescents remain limited. The Paediatric Antiretroviral Drug Optimization group reviews medium-term and long-term priorities for antiretroviral drug development to guide industry and other stakeholders on formulations most needed for low-income and middle-income countries. The group convened in December, 2018, to assess progress since the previous meeting and update the list of priority formulations. Issues relating to drug optimisation for neonatal prophylaxis and paediatric treatment, and those relating to the investigation of novel antiretrovirals in adolescents and pregnant and lactating women were also discussed. Continued focus on identifying, prioritising, and providing access to optimal antiretroviral formulations suitable for infants, children, and adolescents is key to ensuring that global HIV treatment targets can be met