Responsible research and innovation: A manifesto for empirical ethics?

In 2013 the Nuffield Council on Bioethics launched their report Novel Neurotechnologies: Intervening in the Brain. The report, which adopts the European Commission's notion of Responsible Research and Innovation, puts forward a set of priorities to guide ethical research into, and the development of, new therapeutic neurotechnologies. In this paper, we critically engage with these priorities. We argue that the Nuffield Council's priorities, and the Responsible Research and Innovation initiative as a whole, are laudable and should guide research and innovation in all areas of healthcare. However, we argue that operationalising Responsible Research and Innovation requires an in-depth understanding of the research and clinical contexts. Providing such an understanding is an important task for empirical ethics. Drawing on examples from sociology, science and technology studies, and related disciplines, we propose four avenues of social science research which can provide such an understanding. We suggest that these avenues can provide a manifesto for empirical ethics.The paper derives from a project that was funded by Wellcome Trust (Wellcome Trust Biomedical Strategic Award 086034)

Designs on the Web: A case study of online learning for design students

The De Montfort University Electronic Campus initiative started in September 1999. Web‐based learning resources and support have been provided for over 3,000 students via a portfolio of thirty projects ranging across all levels of the university and within every faculty. This paper focuses on one aspect of this initiative: the development of online teaching and learning materials to support first‐year IT modules for students of art and design. An undergraduate module has been converted from traditional, face‐to‐face, delivery to a hybrid combination of Web‐based and studio‐based work in accordance with Laurillard's conversational framework. In the first year of use all the new material has been made available on a pilot basis to a group of 440 students in parallel with conventional lectures and seminars. All the students have had access to the online resources; some students have used them, but some have not. Data on student expectations collected prior to starting on the module are compared with student feedback gathered at the end of the module and student performance data across the two mode's of presentation are compared to establish the relative effectiveness of each approach. In addition the paper reviews the resource implications of developing, delivering and supporting online learning and discusses some of the barriers to implementation that were encountered and overcome

Revised Results for Non-thermal Recombination Flare Hard X-Ray Emission

Brown and Mallik (BM) recently showed that, for hot sources, recombination of non-thermal electrons (NTR) onto highly ionised heavy ions is not negligible compared to non-thermal bremsstrahlung (NTB) as a source of flare hard X-rays (HXRs) and so should be included in modelling non-thermal HXR flare emission. In view of major discrepancies between BM results for the THERMAL continua and those of the Chianti code and of RHESSI solar data, we critically re-examine and correct the BM analysis and modify the conclusions concerning the importance of NTR. Although the analytic Kramers expression used by BM is correct for the purely hydrogenic recombination cross section, the heuristic expressions used by BM to extend the Kramers expression beyond the `bare nucleus' case to which it applies had serious errors. BM results have therefore been recalculated using corrected expressions, which have been validated against the results of detailed calculations. At T ~ 10-30 MK the dominant ions are Fe 22+, 23+, 24+ for which BM erroneously overestimated NTR emission by around an order of magnitude. Contrary to the BM claim, NTR in hot flare plasmas does NOT dominate over NTB, although in some cases it can be comparable and so still very important in inversions of photon spectra to derive electron spectra, especially as NTR includes sharp edge features. The BM claim of dominance of NTR over NTB in deka-keV emission is incorrect due to a serious error in their analysis. However, the NTR contribution can still be large enough to demand inclusion in spectral fitting, the spectral edges having potentially serious effects on inversion of HXR spectra to infer fast electron spectra.Comment: 6 pages, 8 figures, 1 tabl

Human response to vibration in residential environments (NANR209), technical report 2: measurement of response

Based on a review of the literature and the best practice guidance available, a social survey questionnaire was developed to measure residents’ self-reported annoyance and to provide data suitable for establishing exposure-response relationships between levels of annoyance and levels of vibration. The development of the questionnaire was influenced by a number of previous studies such as: the social survey questionnaire developed for the NANR172 Pilot Study of this research (Defra, 2007); best practice guidelines for the development of socio-acoustic surveys issued by ICBEN and presented in the current International Standard (Fields et al., 2001; ISO/TS 15666:2003); the Nordtest Method (2001) for the development of socio-vibration surveys, and a peer review of the social survey questionnaire by international experts in the field. In order to avoid influencing responses and reasons for participation in the research, the survey was introduced as a survey of neighbourhood satisfaction. The questionnaire design, through the use of sections, enables new sections to be added to the questionnaire so that specific vibration sources can be investigated in more depth. In addressing the ‘response’ component in the ‘exposure-response’ relationship, the questionnaire was designed to yield interval-level measurement data suitable for analysis with vibration measurement data via two response scales: the five-point semantic and the eleven-point numerical scales. This decision was largely founded upon the ability of the two scales to meet the criteria established by ICBEN (Fields et al., 2001) for socio-acoustic survey design. Detailed procedures were documented, following the field trial of the questionnaire, in terms of the role of the interviewer, the recording of information and the transfer of the data to the relevant database for subsequent analysis and to inform the vibration team responsible for the ‘exposure’ component of this research project

A new mid-infrared map of the BN/KL region using the Keck telescope

We present a new mid-infrared (12.5micron) map of the BN/KL high-mass star-forming complex in Orion using the LWS instrument at Keck I. Despite poor weather we achieved nearly diffraction-limited images (FWHM = 0.38'') over a roughly 25'' X 25'' region centered on IRc2 down to a flux limit of ~250 mJy. Many of the known infrared (IR) sources in the region break up into smaller sub-components. We have also detected 6 new mid-IR sources. Nearly all of the sources are resolved in our mosaic. The near-IR source ''n'' is slightly elongated in the mid-IR along a NW--SE axis and perfectly bisects the double-peaked radio source ''L''. Source n has been identified as a candidate for powering the large IR luminosity of the BN/KL region (L = 10^5 L_sun). We postulate that the 12 micron emission arises in a circumstellar disk surrounding source n. The morphology of the mid-IR emission and the Orion ''hot core'' (as seen in NH_3 emission), along with the location of water and OH masers, is very suggestive of a bipolar cavity centered on source n and aligned with the rotation axis of the hypothetical circumstellar disk. IRc2, once thought to be the dominant energy source for the BN/KL region, clearly breaks into 4 sub-sources in our mosaic, as seen previously at 3.8 -- 5.0 micron. The anti-correlation of mid-IR emission and NH_3 emission from the nearby hot core indicates that the IRc2 sources are roughly coincident (or behind) the dense hot core. The nature of IRc2 is not clear: neither self-luminous sources (embedded protostars) nor external heating by source I can be definitively ruled out. We also report the discovery of a new arc-like feature SW of the BN object, and some curious morphology surrounding near-IR source ''t".Comment: To appear in The Astronomical Journal, July 2004 (16 pages, 7 figures

Egg quality, triploidy induction and weaning of the Atlantic halibut Hippoglossus hippoglossus

The supply of juvenile Atlantic halibut, Ilippof’lossus hippoglossus, has been sporadic and until recently, has fallen short of expectations, due to difficulties associated with the hatchery phase. This thesis focuses on some specific aspects of intensive hatchery production which needed to be addressed in the areas of egg production and quality, triploidy induction and weaning. A quality assessment technique for halibut eggs, based on observations of morphological anomalies occurring during early blastomere divisions was devised. The degree of abnormality in the appearance of five features was quantified and a strong relationship between these characteristics and hatch rate of eggs incubated in microtitre plates was revealed. It was concluded that this method is of great potential use as an early predictive indicator of egg viability. The effect of temperature on egg production was studied in two broodstock groups held either at ambient or low stable temperature during spawning. High temperatures caused a delay and shortening of the spawning period as well as a reduction in egg quantity and quality. The results indicated that temperature control is a necessary feature of broodstock management at sites where ambient temperature profiles are unsuitable. The efficacy of hydrostatic pressure shocking for the induction of triploidy was tested on newly fertilised eggs. A 5 min pressure shock of 8500 psi, administered around 15 min after fertilisation resulted in high triploidy yields. This treatment had little effect on survival to hatching. However, a preliminary experiment indicated that triploid halibut may be prone to higher mortality through the hatchery cycle. Six weaning experiments were conducted to determine the influence of size, age, and developmental stage of halibut larvae on diet uptake, survival, growth and fry quality. Gradual replacement of Artemia with dry diet, co-feeding, and the use of intermediate diet types, were evaluated. In the absence of live prey, pre-metamorphic larvae (< 100 mg) would accept non-living feed particles but total replacement with a conventional dry diet was unsuccessful. However, following good growth prior to weaning, 700 “day old larvae could be successfully weaned over a nine day period. Improved growth and substantial savings in live feed were among the positive benefits resulting from early weaning