275 research outputs found
Use of laboratory-developed assays in global HIV-1 treatment-monitoring and research
There has been a surge in the emergence of HIV-1 drug resistance in Low and Middle-Income Countries (LMICs) due to poor drug-adherence and limited access to viral load testing, the current standard for treatment-monitoring. It is estimated that only 75% of people living with HIV (PLWH) worldwide have access to viral load testing. In LMICs, this figure is below 50%. In a recent WHO survey in mostly LMICs, 21 out of 30 countries surveyed found HIV-1 first-line pre-treatment drug resistance in over 10% of study participants. In the worst-affected regions, up to 68% of infants born to HIV-1 positive mothers were found to harbour first-line HIV-1 treatment resistance. This is a huge public health concern. Greater access to treatment-monitoring is required in LMICs if the UNAIDS "third 95" targets are to be achieved by 2030. Here, we review the current challenges of viral load testing and present the case for greater utilization of Laboratory-based assays that quantify intracellular HIV-1 RNA and/or DNA to provide broader worldwide access to HIV-1 surveillance, drug-resistance monitoring, and cure-research
Mapping the strand-specific transcriptome of fission yeast
Pervasive genome-wide transcription is widespread in eukaryotic cells, but key features of the transcriptome have yet to be fully characterized. a new study using antibody-based detection of RNA-DNA duplexes on tiling arrays now reveals a complex, strand-specific transcriptional world in fission yeast
Author Correction: Development of a sensitive, quantitative assay with broad subtype specificity for detection of total HIV-1 nucleic acids in plasma and PBMC
Correction to: Scientific Reports https://doi.org/10.1038/s41598-021-03016-1, published online 28 January 202
Nucleonic resonance excitations with linearly polarized photon in
In this work, an improved quark model approach to the meson
photo-production with an effective Lagrangian is presented. The {\it t}-channel
{\it natural}-parity exchange is taken into account through the Pomeron
exchange, while the {\it unnatural}-parity exchange is described by the
exchange. With a very limited number of parameters, the available experimental
data in the low energy regime can be consistently accounted for. We find that
the beam polarization observables show sensitivities to some {\it s}-channel
individual resonances in the quark model symmetry limit.
Especially, the two resonances and , which belong
to the representation , have dominant contributions
over other excited states. Concerning the essential motivation of searching for
"missing resonances" in meson photo-production, this approach provides a
feasible framework, on which systematic investigations can be done.Comment: 16 pages, Revtex, 9 eps figures, to appear in PR
УСТРОЙСТВО ДЛЯ ОПРЕДЕЛЕНИЯ ФИЗИКО-МЕХАНИЧЕСКИХ СВОЙСТВ ЭЛАСТОМЕРНЫХ МАТЕРИАЛОВ
Developed the device for determining the physical and mechanical properties of elastomeric materials. In contrast to the well-known device that operates on the method of Shore, used to measure only the hardness of elastomeric materials, developed the device can measure not only hardness, but also the relative deformation of the samples made of elastomeric materials, as well as the ability of these materials to restore the original dimensions after deformation. The device has a simple design includes coaxial with the direction of the force transducer strain into an electrical signal that provides a sensitivity of at least 3 mV/μm.Разработано устройство для определения физико-механических свойств эластомерных материалов. В отличие от известного прибора, работающего по методу Шора, применяемого для измерения только твердости эластомерных материалов, разработанное устройство позволяет измерять не только твердость, но и относительные деформации образцов из эластомерных материалов, а также способность этих материалов к восстановлению первоначальных размеров после деформации. Устройство имеет простую конструкцию, содержит соосный с направлением приложения силы преобразователь деформации в электрический сигнал, что обеспечивает чувствительность не менее 3 мВ/мкм
Observation of Pseudoscalar and Axial Vector Resonances in pi- p -> K+ K- pi0 n at 18 GeV
A new measurement of the reaction pi- p -> K+ K- pi0 n has been made at a
beam energy of 18 GeV. A partial wave analysis of the K+ K- pi0 system shows
evidence for three pseudoscalar resonances, eta(1295), eta(1416), and
eta(1485), as well as two axial vectors, f1(1285), and f1(1420). Their observed
masses, widths and decay properties are reported. No signal was observed for
C(1480), an IG J{PC} = 1+ 1{--} state previously reported in phi pi0 decay.Comment: 7 pages, 6 figs, to be submitted to Phys. Let
Observation of exotic meson production in the reaction at 18 GeV/c
An amplitude analysis of an exclusive sample of 5765 events from the reaction
at 18 GeV/c is described. The
production is dominated by natural parity exchange and by
three partial waves: those with and . A
mass-dependent analysis of the partial-wave amplitudes indicates the production
of the meson as well as the meson, observed for the
first time decaying to . The dominant, exotic
(non- partial wave is shown to be resonant with a mass of
GeV/c^2 and a width of GeV/c^2 . This exotic state, the , is produced with a
dependence which is different from that of the meson, indicating
differences between the production mechanisms for the two states.Comment: 5 pages with 4 figure
Confirmation of a pi_1^0 Exotic Meson in the \eta \pi^0 System
The exclusive reaction , at 18 GeV has been studied with a partial wave analysis on a sample
of 23~492 events from BNL experiment E852. A mass-dependent fit
is consistent with a resonant hypothesis for the wave, thus providing
evidence for a neutral exotic meson with , a mass of MeV, and a width of MeV. New
interpretations of the meson exotics in neutral system observed in
E852 and Crystal Barrel experiments are discussed.Comment: p3, rewording the paragraph (at the bottom) about the phase
variations. p4, rewording paragrath "The second method ..." . p4, at the
bottom of paragrath "The third method ..." added consistent with the results
of methods 1 and 2
Partial-wave analysis of the eta pi+ pi- system produced in the reaction pi-p --> eta pi+ pi- n at 18 GeV/c
A partial-wave analysis of 9082 eta pi+ pi- n events produced in the reaction
pi- p --> eta pi+ pi- n at 18.3 GeV/c has been carried out using data from
experiment 852 at Brookhaven National Laboratory. The data are dominated by
J^{PC} = 0^{-+} partial waves consistent with observation of the eta(1295) and
the eta(1440). The mass and width of the eta(1295) were determined to be 1282
+- 5 MeV and 66 +- 13 Mev respectively while the eta(1440) was observed with a
mass of 1404 +- 6 MeV and width of 80 +- 21 MeV. Other partial waves of
importance include the 1++ and the 1+- waves. Results of the partial wave
analysis are combined with results of other experiments to estimate f1(1285)
branching fractions. These values are considerably different from current
values determined without the aid of amplitude analyses.Comment: 22 pages, 8 figure
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