Education management in Ukraine in the context of global economic transformations

The article identifies the features of the management of higher education in Ukraine and in Europe in the context of global economic transformations. In the process of analysis, it was determined that the financing of higher education in European countries is carried out almost equally: at the expense of the State budget and at the expense of individuals. At the same time, the outflow of students from the CIS countries to European countries can be explained by the proposed concepts of providing educational services, the main difference among which consists, firstly, in orientation towards the needs of the state, and secondly, in orientation towards the needs of business structures and various market subjects. It was also determined that the impact of economic factors on the level of education is rather low, and at the same time, this indicator largely depends on the indicator of the social capital. In this regard, the following social trends have been identified that need to be implemented for the successful education management: expanding the population education program, as well as providing lifelong education, ensuring equal access to quality education, strengthening the role of the state in ensuring equity in education, efficient and effective use of education costs, humanization and democratization of education, updating the content, forms, methods and means of training, enhancing the professional competence of teachers, transparency of education systems, the formation of state-public forms of education management.peer-reviewe

Assessing viability of processing ash and slag dumps for energy-efficient ash beneficiation at Magadan CPP

Complex processing of ash and slag waste is a supported directions for the development of environmental friendliness and performance in power engineering. The rational use of this waste in large-scale production processes has now been realized in the construction field. The development of up-to-date beneficiation technologies raises the possibility of extracting various useful components from ash and slag wastes. This study aims to investigate the potential for using energy-efficient ash beneficiation to produce a heavy metal-containing fraction and separate the magnetic fraction. To assess the feasibility of ash beneficiation and its rational use, the technical documentation of ash and slag dumps of PJSC “Magadanenergo” was studied, and semi-quantitative analyses of samples collected from these dumps were carried out. The data on the content of useful components and quantities of ash and slag enabled us to develop complex beneficiation flow sheets, assess their process efficiency, and evaluate their potential financial viability. The estimated volume of metals to be recovered includes 785 tons of Ti (me-1), 183 tons of Sr (me-2), and 4,867 tons of Fe (me-3). The performance indicators of the beneficiation and aggregated values of economic indicators for this project implementation on an industrial scale were calculated. The economic feasibility of the ash processing project showed good values for two out of three models over a ten-year planning horizon. Implementing the project also effectively improves the environmental situation by potentially processing up to 10% of the total volume of ash dumps, fulfilling one-fifth of the Energy Strategy of the Russian Federation’s requirements until 2035. While investigations of ash from the Magadan Cogeneration Power Plant (MCPP) are not new, they were not previously carried out within the framework of studying integrated processing of ash to obtain various useful components

Anti-inflammatory and immunomodulating effects of the bacterial lysate in the <em>in vivo</em> models of aseptic lymphadenitis and pneumococcal pneumonia

Bacterial lysates may produce immunoregulatory effects in the inflammatory diseases that are not directly caused by infectious agents; they may also stimulate the immune response against pathogens which are not a part of the lysate composition. Imudon® is a polyvalent bacterial lysate that is available in orodispersible tablets. However, the influence of this drug product on aseptic inflammation and immune defense against the infectious agents, the antigens of which are not contained in this preparation have not been studied so far. The aim of this study, therefore, was to determine the anti-inflammatory and immunomodulating effects of Imudon® using the models of aseptic lymphadenitis (in Wistar rats) and pneumococcal pneumonia (in Balb/c mice), i.e., the conditions not related to the specific components of the bacterial lysate. Lymphadenitis was induced in rats by administration of λ-carrageenan into a cervical lymph node via an open operative approach. Whereas pneumonia was induced in mice by administering Streptococcus pneumoniae suspension intranasally. The choice of pneumococcus was determined by the absence of pneumococcal antigens in Imudon®, i.e., it cannot be a direct inducer of adaptive immune response against pneumococcal infection. Imudon® was administered intragastrically as a crushed tablet suspension following a therapeutic-preventive regimen (for 14 days daily until the induction of inflammation and for 3 [in the lymphadenitis model] or 5 days [in the model of pneumonia] in three doses thereafter). In the lymphadenitis model, Imudon® demonstrated both local and systemic anti-inflammatory responses manifested in the reduced number of circulating leucocytes and lower TNFα levels and by ameliorated histological features of inflammation in the operated lymph node. In rats, the anti-inflammatory effect was most pronounced when the product was administered at a dose of 2.2 mg/kg (equivalent to a human therapeutic dose) and 6.6 mg/kg. In the model of pneumonia, administration of Imudon® at 4.44 mg/kg (equivalent to a human therapeutic dose) and 13.32 mg/kg demonstrated a trend towards increased survival rate as compared to the control group. On Day 5 after infection Imudon® (4.44 and 13.32 mg/kg) decreased significantly the severity of inflammation and bacterial titer in the lungs. The titer of anti-pneumococcal immunoglobulins A in the bronchoalveolar lavage fluid were found to be higher in the Imudon® treated group (13.32 mg/kg) compared to control group. The results of this study showed high antiinflammatory and immunomodulatory activities of Imudon® and provided an insight into the mechanisms that underlie the clinical effects of this drug in various inflammatory diseases