Transition metals-substituted cobalt ferrite nanoparticles for biomedical applications

Transition metals of copper, zinc, chromium and nickel were substituted into cobalt ferrite nanoparticles via a sol-gel route using citric acid as a chelating agent. The microstructure and elemental composition were characterized using scanning electron microscopy combined with energy-dispersive X-ray spectroscopy. Phase analysis of transition metal-substituted cobalt ferrite nanoparticles was performed via X-ray diffraction. Surface wettability was measured using the water contact angle technique. The surface roughness of all nanoparticles was measured using profilometry. Moreover, thermogravimetric analysis and differential scanning calorimetry were performed to determine the temperature at which the decomposition and oxidation of the chelating agents took place. Results indicated that the substitution of transition metals influences strongly the microstructure, crystal structure and antibacterial property of the cobalt ferrite nanoparticles

Biocompatibility of transition metal-substituted cobalt ferrite nanoparticles

Transition metals of copper, zinc, manganese, and nickel were substituted into cobalt ferrite nanoparticles via a sol-gel route using citric acid as a chelating agent. The microstructure and elemental compositions of the nanoparticles were characterized using scanning electron microscopy combined with energy dispersive X-ray spectroscopy. The particle size of the nanoparticles was investigated using particle size analyzer, and the zeta potentials were measured using zeta potential analyzer. The phase components of the synthesized transition metal-substituted cobalt ferrite nanoparticles were studied using Raman spectroscopy. The biocompatibility of the nanoparticles was assessed using osteoblast-like cells. Results indicated that the substitution of transition metals strongly influences the physical, chemical properties, and biocompatibility of the cobalt ferrite nanoparticles

New approaches to the study of spinel ferrite nanoparticles for biomedical applications

This chapter is prepared into six different sections. The first part will provide a brief introduction of spinel ferrite nanoparticles synthesis, the use of chelating agents in the sol-gel method, and applications of spinel ferrite nanoparticles in biomedical fields. The second part will cover an overview of the structure and magnetism of spinel ferrites. The third part will present a summary of different types of chelating agents. The fourth part will provide information of the sol-gel synthesis for ceramic nanoparticles. The fifth part will focus on the preparation of cobalt ferrite nanoparticles by sol-gel methods using polyvinyl alcohol (PVA) and citric acid (CA) as chelating agents. The influence of chelating agents on the physical properties and antibacterial property of cobalt ferrite nanoparticles will be highlighted in the last part. A discussion on chelating agent-metal ion formation and the antibacterial mechanisms of spinel ferrite nanoparticles will be presented