Identification system for SPIRAL

International audienceFollowing a presentation of the role of numbers and measures in the evaluation of scientific journals, adequate statistical and mathematical indicators are described for some traditional "paper" journals in information science and in communication science. These indicators can be used to improve the impact and the audience of these journals. With new electronic journals, it is easier to determine these indicators. The results of the first statistical study dealing with information science electronic journals is presented

Identification system for SPIRAL

International audienceFollowing a presentation of the role of numbers and measures in the evaluation of scientific journals, adequate statistical and mathematical indicators are described for some traditional "paper" journals in information science and in communication science. These indicators can be used to improve the impact and the audience of these journals. With new electronic journals, it is easier to determine these indicators. The results of the first statistical study dealing with information science electronic journals is presented

Sequential Induction Chemotherapy With Vincristine, Daunorubicin, Cyclophosphamide, and Prednisone in Adult Acute Lymphoblastic-leukemia

Sequential chemotherapy with vincristine, daunorubicin, cyclophosphamide, and prednisone doses was administered to 57 adult patients with acute lymphoblastic leukemia (ALL). Complete remission (CR) was achieved in 51 (89%, 95% confidence intervals, [CI] 78-96%). Among patients achieving CR, 62% were in CR after one sequence of chemotherapy, 23% after two sequences, and 5% after three sequences. Six patients (11%) had resistant disease. All patients experienced profound myelosuppression. Median time to recovery of neutrophils >0.5 x 10(9)/l was 22 days (range: 5-89 days), and of platelets >100 x 10(9)/l 21 days (range: 0-45 days). Nonhematologic WHO grade 3 or more side effects consisted predominantly of hyperbilirubinemia (7%), mucositis (5%), nausea and vomiting (2%), and cutaneous toxicity (1%). Severe infectious complications occurred in only 14% of cases. One patient (2%, 95% CI 0-9%) died of therapy-related toxicity while in early CR. We concluded that sequential use of prednisone seemed at least as effective as continuous administration at the expense of a few adverse side effects

Integrative and comparative genomic analyses identify clinically relevant pulmonary carcinoid groups and unveil the supra-carcinoids

The worldwide incidence of pulmonary carcinoids is increasing, but little is known about their molecular characteristics. Through machine learning and multi-omics factor analysis, we compare and contrast the genomic profiles of 116 pulmonary carcinoids (including 35 atypical), 75 large-cell neuroendocrine carcinomas (LCNEC), and 66 small-cell lung cancers. Here we report that the integrative analyses on 257 lung neuroendocrine neoplasms stratify atypical carcinoids into two prognostic groups with a 10-year overall survival of 88% and 27%, respectively. We identify therapeutically relevant molecular groups of pulmonary carcinoids, suggesting DLL3 and the immune system as candidate therapeutic targets; we confirm the value of OTP expression levels for the prognosis and diagnosis of these diseases, and we unveil the group of supra-carcinoids. This group comprises samples with carcinoid-like morphology yet the molecular and clinical features of the deadly LCNEC, further supporting the previously proposed molecular link between the low- and high-grade lung neuroendocrine neoplasms

Additional file 1: of Statistical method to compare massive parallel sequencing pipelines

R code example. This R code allows reproducing the findings presented in the article regarding comparison results between two pipelines (BWA-GATK and TMAP-NextGen) without taking into account a Gold Standard (here, Sanger sequencing). When Gold Standard results are available, some data preparation steps should be added before modelling. All the details about these steps are given in the R file. (R 16 KB) (R 15 kb