2,276 research outputs found
Keeping Research Data Safe 2: Final Report
The first Keeping Research Data Safe study funded by JISC made a major contribution to understanding of long-term preservation costs for research data by developing a cost model and indentifying cost variables for preserving research data in UK universities (Beagrie et al, 2008). However it was completed over a very constrained timescale of four months with little opportunity to follow up other major issues or sources of preservation cost information it identified. It noted that digital preservation costs are notoriously difficult to address in part because of the absence of good case studies and longitudinal information for digital preservation costs or cost variables. In January 2009 JISC issued an ITT for a study on the identification of long-lived digital datasets for the purposes of cost analysis. The aim of this work was to provide a larger body of material and evidence against which existing and future data preservation cost modelling exercises could be tested and validated. The proposal for the KRDS2 study was submitted in response by a consortium consisting of 4 partners involved in the original Keeping Research Data Safe study (Universities of Cambridge and Southampton, Charles Beagrie Ltd, and OCLC Research) and 4 new partners with significant data collections and interests in preservation costs (Archaeology Data Service, University of London Computer Centre, University of Oxford, and the UK Data Archive). A range of supplementary materials in support of this main report have been made available on the KRDS2 project website at http://www.beagrie.com/jisc.php. That website will be maintained and continuously updated with future work as a resource for KRDS users
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Price behavior in a dynamic oligopsony: Washington processing potatoes - A comment
Chirped-pulse interferometry with finite frequency correlations
Chirped-pulse interferometry is a new interferometric technique encapsulating
the advantages of the quantum Hong-Ou-Mandel interferometer without the
drawbacks of using entangled photons. Both interferometers can exhibit
even-order dispersion cancellation which allows high resolution optical delay
measurements even in thick optical samples. In the present work, we show that
finite frequency correlations in chirped-pulse interferometry and
Hong-Ou-Mandel interferometry limit the degree of dispersion cancellation. Our
results are important considerations in designing practical devices based on
these technologies.Comment: 10 pages, 2 figure
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Recognizing the cooperative and independent mitochondrial functions of Parkin and PINK1
The university of new hampshire magnetometer payload
Rocket measurements of ionospheric current and equatorial electroje
Finite-Dimensional Bicomplex Hilbert Spaces
This paper is a detailed study of finite-dimensional modules defined on
bicomplex numbers. A number of results are proved on bicomplex square matrices,
linear operators, orthogonal bases, self-adjoint operators and Hilbert spaces,
including the spectral decomposition theorem. Applications to concepts relevant
to quantum mechanics, like the evolution operator, are pointed out.Comment: 21 page
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Inhibition of apoptotic Bax translocation to the mitochondria is a central function of parkin
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder, affecting 1–3% of the population over 65. Mutations in the ubiquitin E3 ligase parkin are the most common cause of autosomal recessive PD. The parkin protein possesses potent cell-protective properties and has been mechanistically linked to both the regulation of apoptosis and the turnover of damaged mitochondria. Here, we explored these two functions of parkin and the relative scale of these processes in various cell types. While biochemical analyses and subcellular fractionation were sufficient to observe robust parkin-dependent mitophagy in immortalized cells, higher resolution techniques appear to be required for primary culture systems. These approaches, however, did affirm a critical role for parkin in the regulation of apoptosis in primary cultured neurons and all other cells studied. Our prior work demonstrated that parkin-dependent ubiquitination of endogenous Bax inhibits its mitochondrial translocation and can account for the anti-apoptotic effects of parkin. Having found a central role for parkin in the regulation of apoptosis, we further investigated the parkin-Bax interaction. We observed that the BH3 domain of Bax is critical for its recognition by parkin, and identified two lysines that are crucial for parkin-dependent regulation of Bax translocation. Last, a disease-linked mutation in parkin failed to influence Bax translocation to mitochondria after apoptotic stress. Taken together, our data suggest that regulation of apoptosis by the inhibition of Bax translocation is a prevalent physiological function of parkin regardless of the kind of cell stress, preventing overt cell death and supporting cell viability during mitochondrial injury and repair
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