PReS-FINAL-2161: Safety and effectiveness of adalimumab in children with polyarticular juvenile idiopathic arthritis aged 2 to <4 years or >=4 years weighing <15 kg

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Effect of Flow on Caloric Curve for Finite Nuclei

In a finite temperature Thomas-Fermi theory, we construct caloric curves for finite nuclei enclosed in a freeze-out volume few times the normal nuclear volume, with and without inclusion of flow. Without flow, the caloric curve indicates a smooth liquid-gas phase transition whereas with flow, the transition may be very sharp. We discuss these results in the context of two recent experiments, one for heavy symmetric system (Au + Au at 600A MeV) and the other for highly asymmetric system (Au + C at 1A GeV) where different behaviours in the caloric curves are seen.Comment: 11 pages revtex; 4 figs; version to appear in Phys. Rev. Let

Caloric curve in Au + Au collisions

Realistic caloric curves are obtained for $^{197}Au + ^{197}Au$ reaction with incident energy ranging from 35 to 130 MeV/nucleon in the dynamic statistical multifragmentation model. It is shown that for excitation energy 3 to 8 MeV/nucleon, the temperature remains constant in the range 5 to 6 MeV, which is close to experiment. The mechanism of energy deposition through the tripartition of colliding system envisaged in this model together with inter-fragment nuclear interaction are found to play important role. A possible signature of liquid-gas phase transition is seen in the specific heat distribution calculated from these caloric curves, and the critical temperature is found to be $\sim$ 6 to 6.5 MeV.Comment: Revtex, 10 pages, 4 postscipt figures, To appear in Phys. Rev. C (Rapid Communications

The radial arrangement of the human chromosome 7 in the lymphocyte cell nucleus is associated with chromosomal band gene density

This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ Springer-Verlag 2008.In the nuclei of human lymphocytes, chromosome territories are distributed according to the average gene density of each chromosome. However, chromosomes are very heterogeneous in size and base composition, and can contain both very gene-dense and very gene-poor regions. Thus, a precise analysis of chromosome organisation in the nuclei should consider also the distribution of DNA belonging to the chromosomal bands in each chromosome. To improve our understanding of the chromatin organisation, we localised chromosome 7 DNA regions, endowed with different gene densities, in the nuclei of human lymphocytes. Our results showed that this chromosome in cell nuclei is arranged radially with the gene-dense/GC-richest regions exposed towards the nuclear interior and the gene-poorest/GC-poorest ones located at the nuclear periphery. Moreover, we found that chromatin fibres from the 7p22.3 and the 7q22.1 bands are not confined to the territory of the bulk of this chromosome, protruding towards the inner part of the nucleus. Overall, our work demonstrates the radial arrangement of the territory of chromosome 7 in the lymphocyte nucleus and confirms that human genes occupy specific radial positions, presumably to enhance intra- and inter-chromosomal interaction among loci displaying a similar expression pattern, and/or similar replication timing

Isotope thermometery in nuclear multifragmentation

A systematic study of the effect of fragment$-$fragment interaction, quantum statistics, $\gamma$-feeding and collective flow is made in the extraction of the nuclear temperature from the double ratio of the isotopic yields in the statistical model of one-step (Prompt) multifragmentation. Temperature is also extracted from the isotope yield ratios generated in the sequential binary-decay model. Comparison of the thermodynamic temperature with the extracted temperatures for different isotope ratios show some anomaly in both models which is discussed in the context of experimentally measured caloric curves.Comment: uuencoded gzipped file containing 20 pages of text in REVTEX format and 12 figures (Postscript files). Physical Review C (in press