A Comparative study for the analysis of outcome in cases of inferior turbinate hypertrophy by various methods of Turbinoplasty

Turbinoplasty is surgery aimed at treating nasal turbinate enlargement. Nasal turbinate hypertrophy (enlargement) is usually caused by nasal allergies and is a major cause of nasal congestion. Usually, this can be treated medically. However, when medical management fails, the turbinates can be surgically reduced in size and repositioned to allow for a larger nasal airway. The term turbinoplasty is used because we try to remove as little tissue as possible in reshaping and repositioning the turbinate. In our study, by using three different methods of turbinate reduction procedures namely Conventional sub mucosal resection of turbinate. Microdebrider assisted submucosal resection, Cryosurgery, 60 patients were operated, and reviewed during first, third, sixth month of post operative period. The outcomes and complication during the post operative period were studied and analyzed. Patients were analyzed by using Diagnostic Nasal Endoscopy and NOSE SCORE methods. In our study Microdebrider assisted sub mucosal resection method of turbinate reduction found to have 100% improvement in relieving the nasal obstruction on six months follow up, when compared with conventional sub mucosal resection and cryosurgery

Detonation driven shock wave interactions with perforated plates

The study of detonations and their interactions is vital for the understanding of the high-speed flow physics involved and the ultimate goal of controlling their detrimental effects. However, producing safe and repeatable detonations within the laboratory can be quite challenging, leading to the use of computational studies which ultimately require experimental data for their validation. The objective of this study is to examine the induced flow field from the interaction of a shock front and accompanying products of combustion, produced from the detonation taking place within a non-electrical tube lined with explosive material, with porous plates with varying porosities, 0.7–9.7%. State of the art high-speed schlieren photography alongside high-resolution pressure measurements is used to visualise the induced flow field and examine the attenuation effects which occur at different porosities. The detonation tube is placed at different distances from the plates' surface, 0–30 mm, and the pressure at the rear of the plate is recorded and compared. The results indicate that depending on the level of porosity and the Mach number of the precursor shock front secondary reflected and transmitted shock waves are formed through the coalescence of compression waves. With reduced porosity, the plates act almost as a solid surface, therefore the shock propagates faster along its surface

STABILITY INDICATING METHOD DEVELOPMENT AND VALIDATION OF METFORMIN AND ERTUGLIFLOZIN BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY WITH PDA DETECTION AND ITS APPLICATION TO TABLET DOSAGE FORM

Objective: A sensitive, rapid, accurate, and precise stability indicating high-performance liquid chromatography method was developed and validated for the simultaneous estimation of metformin (MET) and ertugliflozin (ERT). Methods: The planned chromatographic method was developed using Kromasil C18 column using 0.1 M sodium dihydrogen phosphate methanol (50:50, by volume, pH 4.0) as mobile phase system followed by peak area response measurement at 238 nm. The developed method was validated by means of ICH guidelines about system suitability, linearity, sensitivity, selectivity, accuracy, precision, robustness, and specificity. Results: Calibration curves of MET and ERT are linear from 250 to 750 μg/ml and 3.75 to 11.25 μg/ml, respectively. Relative standard deviation is <2.0% and recovery is ̴ 100%. Successfully, the developed method was applied for the simultaneous determination of MET and ERT in tablets and to study degradation of MET and ERT in acidic, alkaline, oxidation, thermal, and photolytic degradation conditions. No obstructions from additional common excipients of tablets and degradants were observed. Conclusion: The results recommended method suitability for the analysis of MET and ERT in quality control laboratories

Oxidation of some catecholamines by sodium N-chloro-p-toluenesulfonamide in acid medium: A kinetic and mechanistic approach

The kinetics of the oxidation of five catecholamines viz., dopamine (A), L-dopa (B), methyldopa (C), epinephrine (D) and norepinephrine (E) by sodium N-chloro-p-toluenesulfonamide or chloramine-T (CAT) in presence of HClO 4 was studied at 30 ± 0.1 °C. The five reactions followed identical kinetics with a first-order dependence on CAT o, fractional-order in substrate o, and inverse fractional-order in H +. Under comparable experimental conditions, the rate of oxidation of catecholamines increases in the order D > E > A > B > C. The variation of ionic strength of the medium and the addition of p-toluenesulfonamide or halide ions had no significant effect on the reaction rate. The rate increased with decreasing dielectric constant of the medium. The solvent isotope effect was studied using D 2O. A Michaelis-Menten type mechanism has been suggested to explain the results. Equilibrium and decomposition constants for CAT-catecholamine complexes have been evaluated. CH 3C 6H 4SO 2NHCl of the oxidant has been postulated as the reactive oxidizing species and oxidation products were identified. An isokinetic relationship is observed with β = 361 K, indicating that enthalpy factors control the reaction rate. The mechanism proposed and the derived rate law are consistent with the observed kinetics. © Central European Science Journals. All rights reserved

Toxic epidermal necrolysis: a severe cutaneous adverse drug reaction

Toxic epidermal necrolysis (TEN) is a rare but serious is a rare but potentially life-threatening condition. It is primarily a cutaneous reaction to various precipitating agents, characterized by wide spread erythema and detachment of the epidermis from the dermis. Among the various cutaneous adverse drug reactions, TEN occupy a primary place in terms of mortality. In TEN large sheets of skin are lost from the body surface, thereby decreasing the protecting function of the skin, which results in complications. Usually, TEN is self-limited in absence of complications. If complicated by sepsis, there will be increased chances of mortality. The main treatment would be cessation of the causative drug and early admission of the patient for supportive care and minimizing the occurrence of complications. The present articles reviews the etiology, pathophysiology, differential diagnosis and treatment protocol, with a case of TEN occurrence in a child of 4 years age after consuming phenytoin syrup for febrile convulsions

The Provision of Time to the Elderly by Their Children

This paper uses matched data on the elderly and their children to study the provision of time by children to the elderly. It develops a Tobit model as well as a structural model to analyze the determinants of this decision. The main determinants of the amount of time given to parents appear to be the parent's age, reported health, and institutionalization status, and the children's age, health, and sex. Older parents, less healthy parents, and non-institutionalized parents receive more time from their children, while younger children, healthier children, and female children provide more time. In contrast to these demographic determinants, economic variables, such as children's wage rate and income levels, appear to play a rather insignificant role in the provision of time. In addition, the evidence does not support the hypothesis that parents purchase time from their children.

Study of detonation interactions inside a 2-D ejector using detonation transmission tubing

Study of detonation interactions inside a two-dimensional ejector using detonation transmission tubing was reported. The main objective of the ejector assembly in the study is to make the flow-field as close to 2-D as possible. Optical-grade Perspex sheets with a thickness of 10 mm were used on both sides of the nozzle to allow visualization of the flow. Wall pressure measurements were conducted at the locations. The NONEL tube was flush with the entrance of the nozzle. The signal to begin pressure measurements and image acquisition was obtained through a Kulite XT-190 transducer. The detonation was initiate by an electronic blasting machine, DynoStart 2, with a capacitance of 0.2μF and an output voltage of 2500 V. High-speed shadowgraphy was employed to visualize the flow. The results show that the effects of 3-D flow at the initial stage of the detonation affect the incident shock front and the reflected shock wave system at the nozzle entrance

Ruthenium catalyzed oxidative conversion of isatins to anthranilic acids: Mechanistic study

Oxidation of isatins (isatin, 5-methylisatin, 5-bromoisatin, and 5-nitroisatin) to their corresponding anthranilic acids was performed with sodium N-bromo-p-toluenesulfonamide or bromamine-T (BAT) as an oxidant and ruthenium trichloride (Ru(III)) as a catalyst in HCl medium at 30 +/- 0.1 degrees C. The four reactions follow identical kinetics with a first-order dependence each on [BAT](o) and [Ru(III)], zero-order on [Isatin], and inverse fractional-order on [H(+)]. Activation parameters have been deduced for the composite reaction. The rates satisfactorily correlate with the Hammett U relationship and the reaction constant p is -0.36 signifies that the electron donating groups accelerate the reaction while the electron withdrawing groups retard the rate. An isokinetic relationship is observed with beta = 360 K, indicating that enthalpy factors control the reaction rate. Oxidation products of isatins were identified as their corresponding anthranilic acids by GC-MS analysis and the yields were found to be > 90%. Under similar experimental conditions, the kinetics of Ru(III)-catalyzed oxidation of isatins with BAT has been compared with that of uncatalyzed reactions, revealing that the catalyzed reactions are three to fourfold faster. The observed results have been explained by a plausible mechanism and the related rate law has been deduced. The method adopted for the oxidation of isatins to anthranilic acids in the present work offers several advantages and can be scaled up to industrial operation. (c) 2008 American Institute of Chemical Engineers

Ru(III)-catalysed oxidation of some N-heterocycles by chloramine-T in hydrochloric acid medium: A kinetic and mechanistic study

The kinetics of the ruthenium(III) chloride (Ru(III))-catalysed oxidation of five N-heterocycles (S) viz. imidazole (IzlH), benzimidazole (BzlH), 2-hydroxybenzimidazole (2-HyBzlH), 2-aminobenzimidazole (2-AmBzlH) and 2-phenylbenzimidazole (2-PhBzlH) by sodium-N-chloro-p-toluenesulfonamide (chloramine-T; CAT) in the presence of HCl has been studied at 313 K. The oxidation reaction follows the identical kinetics for all the five N-heterocycles and obeys the rate law, rate = k CAT0 S 0 x H+y Ru(III)z, where x, y and z are less than unity. Addition of p-toluenesulfonamide (PTS) retards the reaction rate. Variation of ionic strength of the medium and the addition of halide ions show negligible effect on the rate of the reaction. The rate was found to increase in D2O medium and showed positive dielectric effect. The reaction products are identified. The rates are measured at different temperatures for all substrates and the composite activation parameters have been computed from the Arrhenius plots. From enthalpy-entropy relationships and Exner correlations, the calculated isokinetic temperature (β) of 392 K is much higher than the experimental temperature (313 K), indicating that, the rate has been under enthalpy control. Relative reactivity of these substrates are in the order: 2-HyBzlH > 2-AmBzlH > BzlH > IzlH > 2-PhBzlH. This trend may be attributed to resonance and inductive effects. Further, the kinetics of Ru(III)-catalysed oxidation of these N-heterocycles have been compared with uncatalysed reactions (in the absence of Ru(III) catalyst) and found that the catalysed reactions are 16-20 times faster. The catalytic constant (KC) was also calculated for each substrate at different temperatures. From the plots of log KC versus 1/T, values of activation parameters with respect to the catalyst have been evaluated. H2O+Cl has been postulated as the reactive oxidizing species. The reaction mechanism and the derived rate law are consistent with the observed experimental results. © 2004 Elsevier B.V. All rights reserved