78 research outputs found
Origin, criterion, and mechanism of vortex-core reversals in soft magnetic nanodisks under perpendicular bias fields
We studied dynamics of vortex-core reversals driven by circular rotating fields along with static perpendicular magnetic fields of different direction and strength. We found that the application of perpendicular fields H p modifies the starting ground state of vortex magnetizations, thereby instigating the development of a magnetization dip mz,dip in the vicinity of the original core up to its threshold value, m z,dip cri ???-p, which is necessary for vortex-core reversals, where p is the initial core polarization. We found the relationship of the dynamic evolutions of the mz,dip and the out-of-plane gyrofields hz, which was induced, in this case, by vortex-core motion of velocity ??, thereby their critical value relation ??crihz cri. The simulation results indicated that the variation of the critical core velocity ??cri with Hp can be expressed explicitly as ??cri / ?? cri 0 = (??/ ??0) | -p- m z,dip g |, with the core size ?? and the starting ground-state magnetization dip m z,dip g variable with H p, and for the values of ?? cri 0 and ??0 at H p =0. This work offers deeper and/or new insights into the origin, criterion and mechanism of vortex-core reversals under application of static perpendicular bias fields.open7
Criterion for transformation of transverse domain wall to vortex or antivortex wall in soft magnetic thin-film nanostripes
We report on the criterion for the dynamic transformation of the internal
structure of moving domain walls (DWs) in soft magnetic thin-film nanostripes
above the Walker threshold field, Hw. In order for the process of
transformation from transverse wall (TW) to vortex wall (VW) or antivortex wall
(AVW) occurs, the edge-soliton core of the TW-type DW should grow sufficiently
to the full width at half maximum of the out-of-plane magnetizations of the
core area of the stabilized vortex (or antivortex) by moving inward along the
transverse (width) direction. Upon completion of the nucleation of the vortex
(antivortex) core, the VW (AVW) is stabilized, and then its core accompanies
the gyrotropic motion in a potential well (hill) of a given nanostripe. Field
strengths exceeding the Hw, which is the onset field of DW velocity breakdown,
are not sufficient but necessary conditions for dynamic DW transformation
Perpendicular-bias-field-dependent vortex-gyration eigenfrequency
We found that the angular frequency ??0 of vortex-core gyrations is controllable by the application of static perpendicular bias fields Hp as studied by micromagnetic simulations and Thiele's-approach- based quantitative interpretation. The observed linear dependence of ??0 on Hp could be explained in terms of the dynamic variables of the vortex, the gyrovector constant G, and the potential stiffness constant , for cases of negligible damping. Here we calculated the values of G and ?? as a function of Hp directly from the simulation numerical data using Thiele's equivalent force equations, providing a more correct understanding of the remarkable change of ??0 with Hp. This micromagnetic-simulation-based quantitative analysis is a straightforward, accurate, and effective means of understanding vortex dynamics in nanoscale magnetic elements.open7
Out-of-plane current controlled switching of the fourfold degenerate state of a magnetic vortex in soft magnetic nanodots
We report on an observation of transitions of the fourfold degenerate state of a magnetic vortex in soft magnetic nanodots by micromagnetic numerical calculations. The quaternary vortex states in patterned magnetic dots were found to be controllable by changing the density of out-of-plane dc or pulse currents applied to the dots. Each vortex state can be switched to any of the other states by applying different sequence combinations of individual single-step pulse currents. Each step pulse has a characteristic threshold current density and direction. This work offers a promising way for manipulating both the polarization and chirality of magnetic vortices.open161
Edge-Soliton-Mediated Vortex-Core Reversal Dynamics
We report a new reversal mechanism of magnetic vortex cores in nanodot
elements driven by out-of-plane currents, occurring through two coupled
edge-solitons via dynamic transformations between magnetic solitons of
different topological charges. This mechanism differs completely from the well
known switching process mediated by the creation and annihilation of
vortex-antivortex pairs in terms of the associated topological solitons,
energies, and spin-wave emissions. Strongly localized out-of-plane gyrotropic
fields induced by the fast motion of the two coupled edge-solitons enable a
magnetization dip that plays a crucial role in the formation of the reversed
core magnetization. This work provides a new physical insight into the dynamic
transformations of magnetic solitons in nanoelements.Comment: 16 pages, 4 figure
Overcoming the electroluminescence efficiency limitations of perovskite light-emitting diodes.
Organic-inorganic hybrid perovskites are emerging low-cost emitters with very high color purity, but their low luminescent efficiency is a critical drawback. We boosted the current efficiency (CE) of perovskite light-emitting diodes with a simple bilayer structure to 42.9 candela per ampere, similar to the CE of phosphorescent organic light-emitting diodes, with two modifications: We prevented the formation of metallic lead (Pb) atoms that cause strong exciton quenching through a small increase in methylammonium bromide (MABr) molar proportion, and we spatially confined the exciton in uniform MAPbBr3 nanograins (average diameter = 99.7 nanometers) formed by a nanocrystal pinning process and concomitant reduction of exciton diffusion length to 67 nanometers. These changes caused substantial increases in steady-state photoluminescence intensity and efficiency of MAPbBr3 nanograin layers.This work was partially supported by Samsung Research Funding Center of Samsung Electronics under Project Number SRFC-MA-1402-07. A.S. was partially supported by the Engineering and Physical Sciences Research Council (UK).This is the author accepted manuscript. It is currently under an indefinite embargo pending publication by the American Association for the Advancement of Science
Polarization-selective vortex-core switching by orthogonal Gaussian-pulse currents
We experimentally demonstrate low-power-consumption vortex-core switching in
magnetic nanodisks using tailored rotating magnetic fields that are produced
with orthogonal and unipolar Gaussian-pulse currents. Optimal width of the
orthogonal pulses and their time delay are found to be determined only by the
angular eigenfrequency {\omega}_D for a given vortex-state disk of its
polarization p, such that {\sigma} = 1/{\omega}_D and {\Delta}t =
{\pi}p/2{\omega}_D, as studied from analytical and micromagnetic numerical
calculations. The estimated optimal pulse parameters are in good agreements
with the experimentally found results. This work provides a foundation for
energy-efficient information recording in vortex-core cross-point architecture.Comment: 32 pages, 10 figure
Intralymphatic immunotherapy with tyrosine-adsorbed allergens: a double-blind, placebo-controlled trial
Background
Most previous studies used aluminum hydroxide-absorbed allergen extracts in evaluating the potential therapeutic roles of intralymphatic allergen-specific immunotherapy (ILAIT). In this study, we evaluated the therapeutic efficacy and safety of ILAIT with L-tyrosine-adsorbed allergen extracts of Dermatophagoides farinae, D. pteronyssinus, cat, dog, or mixtures thereof, in patients with allergic rhinitis induced by these allergens.
Methods
In this randomized, double-blind, placebo-controlled trial, study subjects received three intralymphatic injections of L-tyrosine-adsorbed allergen extracts (active group) or saline (placebo group) at 4-week intervals.
Results
Although ILAIT reduced daily medication use and skin reactivity to HDM and cat allergens at 4 months after treatment, overall symptom score on a visual analog scale (VAS), sinonasal outcome test-20 (SNOT-20), rhinoconjunctivitis quality of life questionnaire (RQLQ), daily symptom score (dSS), daily medication score (dMS), daily symptom medication score (dSMS), nasal reactivity to HDM allergen, and basophil activity to HDM, cat, and dog allergens at 4 months and 1 year after treatment were similar between the treatment and control groups. Intralymphatic injection was more painful than a venous puncture, and pain at the injection site was the most frequent local adverse event (12.8%); dyspnea and wheezing were the most common systemic adverse events (5.3%).
Conclusions
ILAIT with L-tyrosine-adsorbed allergen extracts does not exhibit profound therapeutic efficacy in allergic rhinitis and can provoke moderate-to-severe systemic reactions and cause pain at the injection site.
Trial registration: clinicaltrials.gov: NCT02665754; date of registration: 28 January 2016This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (NRF-2015R1D1A1A02061943). The funders had no role in the design of the study and collection, analysis, and interpreta‑tion of data and in writing the manuscript. The authors have no other fnancial
relationships relevant to this article to disclose
A Nuclear Localization of the Infectious Haematopoietic Necrosis Virus NV Protein Is Necessary for Optimal Viral Growth
The nonvirion (NV) protein of infectious hematopoietic necrosis virus (IHNV) has been previously reported to be essential for efficient growth and pathogenicity of IHNV. However, little is known about the mechanism by which the NV supports the viral growth. In this study, cellular localization of NV and its role in IHNV growth in host cells was investigated. Through transient transfection in RTG-2 cells of NV fused to green fluorescent protein (GFP), a nuclear localization of NV was demonstrated. Deletion analyses showed that the 32EGDL35 residues were essential for nuclear localization of NV protein, and fusion of these 4 amino acids to GFP directed its transport to the nucleus. We generated a recombinant IHNV, rIHNV-NV-ΔEGDL in which the 32EGDL35 was deleted from the NV. rIHNVs with wild-type NV (rIHNV-NV) or with the NV gene replaced with GFP (rIHNV-ΔNV-GFP) were used as controls. RTG-2 cells infected with rIHNV-ΔNV-GFP and rIHNV-NV-ΔEGDL yielded 12- and 5-fold less infectious virion, respectively, than wild type rIHNV-infected cells at 48 h post-infection (p.i.). While treatment with poly I∶C at 24 h p.i. did not inhibit replication of wild-type rIHNVs, replication rates of rIHNV-ΔNV-GFP and rIHNV-NV-ΔEGDL were inhibited by poly I∶C. In addition, both rIHNV-ΔNV and rIHNV-NV-ΔEGDL induced higher levels of expressions of both IFN1 and Mx1 than wild-type rIHNV. These data suggest that the IHNV NV may support the growth of IHNV through inhibition of the INF system and the amino acid residues of 32EGDL35 responsible for nuclear localization are important for the inhibitory activity of NV
New Era of Air Quality Monitoring from Space: Geostationary Environment Monitoring Spectrometer (GEMS)
GEMS will monitor air quality over Asia at unprecedented spatial and temporal resolution from GEO for the first time, providing column measurements of aerosol, ozone and their precursors (nitrogen dioxide, sulfur dioxide and formaldehyde).
Geostationary Environment Monitoring Spectrometer (GEMS) is scheduled for launch in late 2019 - early 2020 to monitor Air Quality (AQ) at an unprecedented spatial and temporal resolution from a Geostationary Earth Orbit (GEO) for the first time. With the development of UV-visible spectrometers at sub-nm spectral resolution and sophisticated retrieval algorithms, estimates of the column amounts of atmospheric pollutants (O3, NO2, SO2, HCHO, CHOCHO and aerosols) can be obtained. To date, all the UV-visible satellite missions monitoring air quality have been in Low Earth orbit (LEO), allowing one to two observations per day. With UV-visible instruments on GEO platforms, the diurnal variations of these pollutants can now be determined. Details of the GEMS mission are presented, including instrumentation, scientific algorithms, predicted performance, and applications for air quality forecasts through data assimilation. GEMS will be onboard the GEO-KOMPSAT-2 satellite series, which also hosts the Advanced Meteorological Imager (AMI) and Geostationary Ocean Color Imager (GOCI)-2. These three instruments will provide synergistic science products to better understand air quality, meteorology, the long-range transport of air pollutants, emission source distributions, and chemical processes. Faster sampling rates at higher spatial resolution will increase the probability of finding cloud-free pixels, leading to more observations of aerosols and trace gases than is possible from LEO. GEMS will be joined by NASA's TEMPO and ESA's Sentinel-4 to form a GEO AQ satellite constellation in early 2020s, coordinated by the Committee on Earth Observation Satellites (CEOS)
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