Cis-regulatory basis of sister cell type divergence in the vertebrate retina

Multicellular organisms evolved via repeated functional divergence of transcriptionally related sister cell types, but the mechanisms underlying sister cell type divergence are not well understood. Here, we study a canonical pair of sister cell types, retinal photoreceptors and bipolar cells, to identify the ke

Disk Properties and Density Structure of the Star-Forming Dense Core B335

We present subarcsecond resolution dust continuum observations of the protostellar collapse candidate B335 made with the IRAM Plateau de Bure Interferometer at wavelengths of 1.2 and 3.0 mm. These observations probe to < 100 AU size scales and reveal a compact source component that we identify with a circumstellar disk. We analyze these data in concert with previous lower resolution interferometer observations and find a best fit density structure for B335 that consists of a power law envelope with index p=1.55 +/- 0.04 (r < 5000 AU) together with a disk (r < 100 AU) of flux F_{1.2 mm}=21 +/-2 mJy. We estimate a systematic uncertainty in the power law index delta(p) < 0.15, where the largest error comes from the assumed form of the dust temperature falloff with radius. This determination of the inner density structure of B335 has a precision unique amongst protostellar cores, and it is consistent with the r^{-1.5} profile of gravitational free-fall, in accord with basic expectations for the formation of a star. The flux (and implied mass) of the compact component in B335 is typical of the disks around T Tauri stars.Comment: 16 pages, 2 figures. Accepted to the Astrophysical Journal, sched v596 (2003 Oct 10

Political Deliberation, Interest Conflict, and the Common Knowledge Effect

Deliberation depends on the ability of deliberators to learn from each other through the exchange of information. However, the Common Knowledge Effect (CKE) finding, a well-established phenomenon affecting small-group discussion, shows that when people talk in groups they tend to ignore novel information and instead discuss commonly known information; things that everyone knew before discussion started. Some theorists have worried that the CKE makes small group discussion - one of the most common features of recent democratic innovations - a poor tool for making deliberative democracy a reality. However, most research on the CKE is limited to situations where group members share a common goal or interest, while political deliberation generally happens in situations where citizens have at least some conflicting interests. This paper looks for evidence of the CKE in two group-discussion experiments where subjects had partially conflicting interests, ultimately finding find no evidence of this effect. Scholars of deliberation frequently view conflicting interests as an obstacle to the success of deliberation; this result suggests that conflicting interests may, in fact, enhance deliberation by reducing the overreliance on commonly-known information

An optical coherence microscope for 3-dimensional imaging in developmental biology

An optical coherence microscope (OCM) has been designed and constructed to acquire 3-dimensional images of highly scattering biological tissue. Volume-rendering software is used to enhance 3-D visualization of the data sets. Lateral resolution of the OCM is 5 mm (FWHM), and the depth resolution is 10 mm (FWHM) in tissue. The design trade-offs for a 3-D OCM are discussed, and the fundamental photon noise limitation is measured and compared with theory. A rotating 3-D image of a frog embryo is presented to illustrate the capabilities of the instrument

Limits on Radio Continuum Emission from a Sample of Candidate Contracting Starless Cores

We used the NRAO Very Large Array to search for 3.6 cm continuum emission from embedded protostars in a sample of 8 nearby ``starless'' cores that show spectroscopic evidence for infalling motions in molecular emission lines. We detect a total of 13 compact sources in the eight observed fields to 5 sigma limiting flux levels of typically 0.09 mJy. None of these sources lie within 1' of the central positions of the cores, and they are all likely background objects. Based on an extrapolation of the empirical correlation between the bolometric luminosity and 3.6 cm luminosity for the youngest protostars, these null-detections place upper limits of ~0.1 L_sun (d/140pc)^2 on the luminosities of protostellar sources embedded within these cores. These limits, together with the extended nature of the inward motions inferred from molecular line mapping (Lee et al. 2001), are inconsistent with the inside-out collapse model of singular isothermal spheres and suggest a less centrally condensed phase of core evolution during the earliest stages of star formation.Comment: Accepted to the Astronomical Journal; 12 pages, 1 figur

Envelope Structure of Starless Core L694-2 Derived from a Near-Infrared Extinction Map

We present a near-infrared extinction study of the dark globule L694-2, a starless core that shows strong evidence for inward motions in molecular line profiles. The J,H, and K band data were taken using the European Southern Observatory New Technology Telescope. The best fit simple spherical power law model has index p=2.6 +/- 0.2, over the 0.036--0.1 pc range in radius sampled in extinction. This power law slope is steeper than the value of p=2 for a singular isothermal sphere, the initial condition of the inside-out model for protostellar collapse. Including an additional extinction component along the line of sight further steepens the inferred profile. Fitting a Bonnor-Ebert sphere results in a super-critical value of the dimensionless radius xi_max=25 +/- 3. The unstable configuration of material may be related to the observed inward motions. The Bonnor-Ebert model matches the shape of the observed profile, but significantly underestimates the amount of extinction (by a factor of ~4). This discrepancy in normalization has also been found for the nearby protostellar core B335 (Harvey et al. 2001). A cylindrical density model with scale height H=0.0164+/- 0.002 pc viewed at a small inclination to the cylinder axis provides an equally good radial profile as a power law model, and reproduces the asymmetry of the core remarkably well. In addition, this model provides a basis for understanding the discrepancy in the normalization of the Bonnor-Ebert model, namely that L694-2 has prolate structure, with the full extent (mass) of the core being missed by assuming symmetry between the profiles in the plane of the sky and along the line-of-sight. If the core is sufficiently magnetized then fragmentation may be avoided, and later evolution might produce a protostar similar to B335.Comment: 38 pages, 7 figures, accepted to Astrophysical Journa

Inner Structure of Protostellar Collapse Candidate B335 Derived from Millimeter-Wave Interferometry

We present a study of the density structure of the protostellar collapse candidate B335 using continuum observations from the IRAM Plateau de Bure Interferometer made at wavelengths of 1.2mm and 3.0mm. We analyze these data, which probe spatial scales from 5000 AU to 500 AU, directly in the visibility domain by comparison to synthetic observations constructed from models that assume different physical conditions. This approach allows for much more stringent constraints to be derived from the data than from analysis of images. A single radial power law in density provides a good description of the data, with best fit power law index p=1.65+/-0.05. Through simulations, we quantify the sensitivity of this result to various model uncertainties, including assumptions of temperature distribution, outer boundary, dust opacity spectral index, and an unresolved central component. The largest uncertainty comes from the unknown presence of a centralized point source. A point source with 1.2mm flux of F=12+/-7 mJy reduces the density index to p=1.47+/-0.07. The remaining sources of systematic uncertainty, the most important of which is the temperature distribution, likely contribute a total uncertainty of < 0.2. We therefore find strong evidence that the power law index of the density distribution within 5000 AU is significantly less than the value at larger radii, close to 2.0 from previous studies of dust emission and extinction. These results conform well to the generic paradigm of isolated, low-mass star formation which predicts a power law density index close to p=1.5 for an inner region of gravitational free fall onto the protostar.Comment: Accepted to the Astrophysical Journal; 27 pages, 3 figure

First Measurement of the Clustering Evolution of Photometrically-Classified Quasars

We present new measurements of the quasar autocorrelation from a sample of \~80,000 photometrically-classified quasars taken from SDSS DR1. We find a best-fit model of $\omega(\theta) = (0.066\pm^{0.026}_{0.024})\theta^{-(0.98\pm0.15)}$ for the angular autocorrelation, consistent with estimates from spectroscopic quasar surveys. We show that only models with little or no evolution in the clustering of quasars in comoving coordinates since z~1.4 can recover a scale-length consistent with local galaxies and Active Galactic Nuclei (AGNs). A model with little evolution of quasar clustering in comoving coordinates is best explained in the current cosmological paradigm by rapid evolution in quasar bias. We show that quasar biasing must have changed from b_Q~3 at a (photometric) redshift of z=2.2 to b_Q~1.2-1.3 by z=0.75. Such a rapid increase with redshift in biasing implies that quasars at z~2 cannot be the progenitors of modern L* objects, rather they must now reside in dense environments, such as clusters. Similarly, the duration of the UVX quasar phase must be short enough to explain why local UVX quasars reside in essentially unbiased structures. Our estimates of b_Q are in good agreement with recent spectroscopic results, which demonstrate the implied evolution in b_Q is consistent with quasars inhabiting halos of similar mass at every redshift. Treating quasar clustering as a function of both redshift and luminosity, we find no evidence for luminosity dependence in quasar clustering, and that redshift evolution thus affects quasar clustering more than changes in quasars' luminosity. We provide a new method for quantifying stellar contamination in photometrically-classified quasar catalogs via the correlation function.Comment: 34 pages, 10 figures, 1 table, Accepted to ApJ after: (i) Minor textual changes; (ii) extra points added to Fig.