Nonlinear Trajectory Tracking Control for Marine Vessels with Additive Uncertainties

The paper presents a nonlinear control law for a marine vessel to track a reference trajectory. In the wake of theresults obtained in [19], an integrative approach is incorporated in the linear algebra methodology in order toreduce the effect of the uncertainty in the tracking error. This new approach does not increase the complexityof the design methodology. In addition, the zero convergence of tracking error under polynomial uncertaintiesis demonstrated. Simulation results under environmental disturbance and model mismatches are presentedand discussed.Fil: Serrano, Mario Emanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Ingeniería Química; ArgentinaFil: Godoy Bordes, Sebastian Alejandro. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Ingeniería Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Instituto de Automática. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Automática; ArgentinaFil: Gandolfo, Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Instituto de Automática. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Automática; ArgentinaFil: Mut, Vicente Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Instituto de Automática. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Automática; ArgentinaFil: Scaglia, Gustavo Juan Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Ingeniería Química; Argentin

Defining a standard Set of health outcomes for patients with squamous cell carcinoma of the head and neck in Spain

Purpose: A systematic, standardized collection of health outcomes during patient treatment and follow-up, relevant from the perspective of all stakeholders, is a crucial step toward effective and efficient disease management. This project aimed to define a standard set of health outcomes for patients with squamous cell carcinoma of the head and neck (SCCHN). Methods: The project was led and coordinated by a scientific committee (SC). It comprised: (1) a literature review (to identify variables used during SCCHN management); (2) 1st-SC meeting (to select the variables for presentation during nominal groups-NG); (3) five NG (n=42 experts) and four interviews with patients (to reach consensus on the variables for inclusion); and (4) final-SC meeting (to review the results of NG ensuring consensus on the variables where consensus was not reached). Results: Experts agreed to include the following variables in the standard set: treatment-related (treatment intent and type, response to treatment, treatment toxicity/complication, treatment completion), degree of health (performance status, patient-reported health status, pain, dysphonia, feeding and speech limitations, body image alteration, tracheotomy), survival (overall and progression-free survival, cause of death), nutritional (weight, nutritional intervention), other variables (smoking status, alcohol consumption, patient satisfaction with aftermath care, employment status), and case-mix variables (demographic, tumor-related, clinical and nutritional factors). Conclusions: This project may pave the way to standardizing the collection of health outcomes in SCCHN and promote the incorporation of patients’ perspective in its management. The information provided through the systematic compilation of this standard set may define strategies to achieve high-quality, patient-centered care

Quality of life of patients with metastatic pancreatic adenocarcinoma initiating first-line chemotherapy in routine practice

Background: Despite advances in surgery, radiotherapy, and chemotherapy, pancreatic adenocarcinoma often progresses rapidly and causes death. The physical decline of these patients is expected to impact their quality of life (QoL). Therefore, in addition to objective measures of effectiveness, the evaluation of health-related QoL should be considered a matter of major concern when assessing therapy outcomes. Methods: Observational, prospective, multicenter study including patients with metastatic pancreatic adenocarcinoma who started first-line chemotherapy in 12 Spanish centers. Treatment and clinical characteristics were recorded at baseline. Patients' health-related quality of life, ECOG, and Karnofsky index were measured at baseline, at Days 15 and 30, and every four weeks up to 6months of chemotherapy. Health-related quality of life was measured using the EORTC-QLQ-C30 and EQ-5D questionnaires. Other endpoints included overall survival and progression-free survival. Results: The study sample included 116 patients (median age of 65years). Mean (SD) scores for the QLQ-C30 global health status scale showed a significant increasing trend throughout the treatment (p=0.005). Patients with either a Karnofsky index of 70-80 or ECOG 2 showed greater improvement in the QLQ-C30 global health status score than the corresponding groups with better performance status (p 50 at baseline had significantly greater overall survival and progression-free survival (p=0.005 and p=0.021, respectively). No significant associations were observed regarding the EQ-5D score. Conclusions: Most metastatic pancreatic adenocarcinoma patients receiving first-line chemotherapy showed an increase in health-related quality of life scores throughout the treatment. Patients with lower performance status and health-related quality of life at baseline tended to greater improvement. The EORTC QLQ-C30 scale allowed us to measure the health-related quality of life of metastatic pancreatic adenocarcinoma patients receiving first-line chemotherapy

BOXIAL: La solución IBV para el escaneado 3D de espumas fenólicas y pies en descarga

[EN] El Instituto de Biomecánica (IBV) ha desarrollado BOXIAL, un sistema de escaneado 3D para la digitalización de espumas fenólicas y pies en descarga, basado en un iPad y un sensor de profundidad. Esta herramienta permite obtener, en pocos segundos, superficies 3D de alta calidad compatibles con el principal software de diseño CAD de ortesis plantares. El diseño de BOXIAL orientado al usuario, muy intuitivo y fácil de usar, contribuirá a mejorar la eficiencia operativa y a automatizar la comunicación entre clínicas podológicas y la central de fabricación, reduciendo tasas de errores, costes y tiemposAl IVACE y Fondos FEDER por el apoyo del proyecto dentro del programa de Ayudas para proyectos de I+D del IVACE (código de proyecto IMDEEA/2019/18)Piqueras Fiszman, P.; Soriano-López, LF.; Alemany Mut, MS.; Garrido Jaen, JD.; Montero Vilela, J.; Silva García, J.; Gamón Sanz, A.... (2020). BOXIAL: La solución IBV para el escaneado 3D de espumas fenólicas y pies en descarga. Revista de Biomecánica (Online). (67):1-6. http://hdl.handle.net/10251/171692S166

A computational model for prediction of clot platelet content in flow-diverted intracranial aneurysms

Treatment of intracranial aneurysms with flow-diverting stents is a safe and minimally invasive technique. The goal is stable embolisation that facilitates stent endothelialisation, and elimination of the aneurysm. However, it is not fully understood why some aneurysms fail to develop a stable clot even with sufficient levels of flow reduction. Computational prediction of thrombus formation dynamics can help predict the post-operative response in such challenging cases. In this work, we propose a new model of thrombus formation and platelet dynamics inside intracranial aneurysms. Our novel contribution combines platelet activation and transport with fibrin generation, which is key to characterising stable and unstable thrombus. The model is based on two types of thrombus inside aneurysms: red thrombus (fibrin- and erythrocyte-rich) can be found in unstable clots, while white thrombus (fibrin- and platelet-rich) can be found in stable clots. The thrombus generation model is coupled to a CFD model and the flow-induced platelet index (FiPi) is defined as a quantitative measure of clot stability. Our model is validated against an in vitro phantom study of two flow-diverting stents with different sizing. We demonstrate that our model accurately predicts the lower thrombus stability in the oversized stent scenario. This opens possibilities for using computational simulations to improve endovascular treatment planning and reduce adverse events, such as delayed haemorrhage of flow-diverted aneurysms

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Interespacios, centro intergeneracional

[ES] Se plantea un Centro Intergeneracional al norte de la ciudad de Valencia, en el limite del Barrio de Torrefiel y la huerta, intentado difuminarlo y potenciando la interacción entre la población del barrio. Se proyecta el edificio con una estructura claramente marcada con el fin de liberar al máximo los espacios resultantes, permitiendo una conexión libre entre huerta y ciudad, además de generar espacios flexibles que sirvan para mejorar la relación entre diferentes generaciones, entre ancianos y jóvenes. Se prevé que en las plantas inferiores se ubiquen las zonas taller, relación con la huerta e interacción entre generaciones y en planta superior la zona de formación y mayor privacidad. En definitiva, el edificio se proyecta con la intención de que se convierta en una transición entre huerta y ciudad, creando y articulando espacios de oportunidad e interacción entre diferentes generaciones.[EN] It is an Intergenerational Center north of the city of Valencia, on the edge of the neighborhood of Torrefiel and the land, trying to blur it and enhance the interaction between the people of the neighborhood. The building is projected with a clearly marked structure in order to liberate the resulting spaces as much as possible, the free connection between the land and the city, in addition to generating flexible spaces that serve to improve the relationship between different generations, between the elderly and the young people. It¿s expected that in the ground floor the workshop areas will be located, as well as the relationship between the garden and interaction between generations, and in the upper floor the training area and greater privacy. In short, the building is designed with the intention that it becomes a transition between garden and city, creating and articulating spaces of opportunity and interaction between different generations.Mut Noguera, A. (2019). Interespacios, centro intergeneracional. http://hdl.handle.net/10251/135499TFG

Bioaerosol Concentration in a Cattle Feedlot in Neuquén, Argentina

There is a global trend toward intensive livestock breeding, which tends to increase the microbial load in the environment as well as the presence of volatile compounds and dust that can cause health issues. Cattle is the major producer of Escherichiacoli (E. coli), a group of foodborne bacteria associated with severe human diseases, and Neuquén province in Argentina has one of the highest rates of uremic hemolytic syndrome incidence in the world. This paper presents the results of two sampling events of E. coli bacteria at 39 sites in La Paisana ranch (LPR), in Añelo (Neuquén), considering locations inside the pens, upwind, and downwind of the feedlot with different time steps, using a Microflow α equipment. The ranch has approximately 600 heads and clean and controlled installations. The field experiment included sampling airborne aerosol deposition and concentration using passive and active methods. Concentrations were also estimated using an atmospheric dispersion model. During the field experiment, counts of up to 2970 CFU/m3 were obtained in the cattle stockyards and up to 111 CFU/m3 at a distance of 100 m

Bioaerosol Concentration in a Cattle Feedlot in Neuqu&eacute;n, Argentina

There is a global trend toward intensive livestock breeding, which tends to increase the microbial load in the environment as well as the presence of volatile compounds and dust that can cause health issues. Cattle is the major producer of Escherichiacoli (E. coli), a group of foodborne bacteria associated with severe human diseases, and Neuqu&eacute;n province in Argentina has one of the highest rates of uremic hemolytic syndrome incidence in the world. This paper presents the results of two sampling events of E. coli bacteria at 39 sites in La Paisana ranch (LPR), in A&ntilde;elo (Neuqu&eacute;n), considering locations inside the pens, upwind, and downwind of the feedlot with different time steps, using a Microflow &alpha; equipment. The ranch has approximately 600 heads and clean and controlled installations. The field experiment included sampling airborne aerosol deposition and concentration using passive and active methods. Concentrations were also estimated using an atmospheric dispersion model. During the field experiment, counts of up to 2970 CFU/m3 were obtained in the cattle stockyards and up to 111 CFU/m3 at a distance of 100 m