Long-term outcomes of the global tuberculosis and COVID-19 co-infection cohort

Background: Longitudinal cohort data of patients with tuberculosis (TB) and coronavirus disease 2019 (COVID-19) are lacking. In our global study, we describe long-term outcomes of patients affected by TB and COVID-19. Methods: We collected data from 174 centres in 31 countries on all patients affected by COVID-19 and TB between 1 March 2020 and 30 September 2022. Patients were followed-up until cure, death or end of cohort time. All patients had TB and COVID-19; for analysis purposes, deaths were attributed to TB, COVID-19 or both. Survival analysis was performed using Cox proportional risk-regression models, and the log-rank test was used to compare survival and mortality attributed to TB, COVID-19 or both. Results: Overall, 788 patients with COVID-19 and TB (active or sequelae) were recruited from 31 countries, and 10.8% (n=85) died during the observation period. Survival was significantly lower among patients whose death was attributed to TB and COVID-19 versus those dying because of either TB or COVID-19 alone (p<0.001). Significant adjusted risk factors for TB mortality were higher age (hazard ratio (HR) 1.05, 95% CI 1.03-1.07), HIV infection (HR 2.29, 95% CI 1.02-5.16) and invasive ventilation (HR 4.28, 95% CI 2.34-7.83). For COVID-19 mortality, the adjusted risks were higher age (HR 1.03, 95% CI 1.02-1.04), male sex (HR 2.21, 95% CI 1.24-3.91), oxygen requirement (HR 7.93, 95% CI 3.44-18.26) and invasive ventilation (HR 2.19, 95% CI 1.36-3.53). Conclusions: In our global cohort, death was the outcome in >10% of patients with TB and COVID-19. A range of demographic and clinical predictors are associated with adverse outcomes

Active tuberculosis, sequelae and COVID-19 co-infection: first cohort of 49 cases

46sinonemixedTadolini, Marina; Codecasa, Luigi Ruffo; García-García, José-María; Blanc, François-Xavier; Borisov, Sergey; Alffenaar, Jan-Willem; Andréjak, Claire; Bachez, Pierre; Bart, Pierre-Alexandre; Belilovski, Evgeny; Cardoso-Landivar, José; Centis, Rosella; D'Ambrosio, Lia; Luiza De Souza-Galvão, María-; Dominguez-Castellano, Angel; Dourmane, Samir; Fréchet Jachym, Mathilde; Froissart, Antoine; Giacomet, Vania; Goletti, Delia; Grard, Soazic; Gualano, Gina; Izadifar, Armine; Le Du, Damien; Marín Royo, Margarita; Mazza-Stalder, Jesica; Motta, Ilaria; Ong, Catherine Wei Min; Palmieri, Fabrizio; Rivière, Frédéric; Rodrigo, Teresa; Silva, Denise Rossato; Sánchez-Montalvá, Adrián; Saporiti, Matteo; Scarpellini, Paolo; Schlemmer, Frédéric; Spanevello, Antonio; Sumarokova, Elena; Tabernero, Eva; Tambyah, Paul Anantharajah; Tiberi, Simon; Torre, Alessandro; Visca, Dina; Zabaleta Murguiondo, Miguel; Sotgiu, Giovanni; Migliori, Giovanni BattistaTadolini, Marina; Codecasa, Luigi Ruffo; García-García, José-María; Blanc, François-Xavier; Borisov, Sergey; Alffenaar, Jan-Willem; Andréjak, Claire; Bachez, Pierre; Bart, Pierre-Alexandre; Belilovski, Evgeny; Cardoso-Landivar, José; Centis, Rosella; D'Ambrosio, Lia; Luiza De Souza-Galvão, María-; Dominguez-Castellano, Angel; Dourmane, Samir; Fréchet Jachym, Mathilde; Froissart, Antoine; Giacomet, Vania; Goletti, Delia; Grard, Soazic; Gualano, Gina; Izadifar, Armine; Le Du, Damien; Marín Royo, Margarita; Mazza-Stalder, Jesica; Motta, Ilaria; Ong, Catherine Wei Min; Palmieri, Fabrizio; Rivière, Frédéric; Rodrigo, Teresa; Silva, Denise Rossato; Sánchez-Montalvá, Adrián; Saporiti, Matteo; Scarpellini, Paolo; Schlemmer, Frédéric; Spanevello, Antonio; Sumarokova, Elena; Tabernero, Eva; Tambyah, Paul Anantharajah; Tiberi, Simon; Torre, Alessandro; Visca, Dina; Zabaleta Murguiondo, Miguel; Sotgiu, Giovanni; Migliori, Giovanni Battist