Transmedia Pedagogical Narrative: Stages, Contexts and Dimensions for its Inclusion in the Classroom

En el artículo nos propusimos analizar la inclusión de la Narrativas transmedia pedagógicas y caracterizarlas a partir del estudio de dos experiencias en escuelas secundarias en Argentina en 2017 y 2018. Para el análisis adoptamos una metodología de investigación de tipo cualitativa, basada en técnicas de recolección y producción de datos: entrevistas, observación de las prácticas áulicas, análisis de documentos y revisión de bibliografía. El hallazgo principal del trabajo fue partir de las experiencias en las escuelas para abordar tres contextos (institucional, áulico y de la comunidad), y las dimensiones principales en las que debería reflexionar un docente para implementar la narrativa transmedia como estrategia de enseñanza y aprendizaje. En las conclusiones problematizamos el propósito de crear narrativas transmedia, poniendo en discusión la idea de que la inclusión de las Tecnologías de la Información y la Comunicación (TIC) implica necesariamente una mejora en el proceso educativo, sin reflexionar en profundidad sobre el potencial que tienen estas narrativas para favorecer: el aprendizaje significativo; el desarrollo de habilidades de la cultura digital y el alfabetismo transmedia; y el recupero de aprendizajes informales de los estudiantes y las intervenciones en la comunidad, a partir de la formulación de problemas de la realidad y la afirmación del rol político de la educación.In this article we set out to analyze the inclusion of “Transmedia pedagogical narratives” and characterize them from the study of two experiences in secondary schools in Argentina in 2017 and 2018. For this analysis we adopted a qualitative research methodology, based on collection and production techniques of data: interviews, observation of classroom practices, analysis of documents and review of bibliography. The main finding of this work was to start from the experiences in schools to address three contexts (institutional, classroom and community), and the main dimensions in which a teacher should reflect to implement the transmedia narrative as a teaching and learning strategy. In the conclusions we problematize the purpose of creating transmedia narratives, putting into discussion the idea that the inclusion of ICT necessarily implies an improvement in the educational process, without reflecting in depth on the potential of these narratives to favor meaningful learning; the development of digital culture skills and transmedia literacy; the recovery of informal learning of students and interventions in the community, from the formulation of problems of reality and the affirmation of the political role of education.Fil: Alonso, Exequiel. Universidad Nacional del Centro de la Provincia de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil; ArgentinaFil: Murgia, Viviana. Universidad Nacional del Centro de la Provincia de Buenos Aires; Argentin

Bioadhesive Matrix Tablets Loaded with Lipophilic Nanoparticles as Vehicles for Drugs for Periodontitis Treatment: Development and Characterization

Periodontitis treatment is usually focused on the reduction or eradication of periodontal pathogens using antibiotics against anaerobic bacteria, such as metronidazole (MTR). Moreover, recently the correlation between periodontal diseases and overexpression of reactive oxygen species (ROS) led to the introduction of antioxidant biomolecules in therapy. In this work, bioadhesive buccal tablets, consisting of a hydrophilic matrix loaded with metronidazole and lipophilic nanoparticles as a vehicle of curcumin, were developed. Curcumin (CUR)-loaded nanostructured lipid carriers (NLC) were prepared using glycyrrhetic acid, hexadecanol, isopropyl palmitate and Tween®80 as a surfactant. As method, homogenization followed by high-frequency sonication was used. After dialysis, CUR-NLC dispersion was evaluated in terms of drug loading (DL, 2.2% w/w) and drug recovery (DR, 88% w/w). NLC, characterized by dynamic light scattering and scanning electron microscopy (SEM), exhibited a spherical shape, an average particle size of 121.6 nm and PDI and PZ values considered optimal for a colloidal nanoparticle dispersion indicating good stability of the system. Subsequently, a hydrophilic sponge was obtained by lyophilization of a gel based on trehalose, Natrosol and PVP-K90, loaded with CUR-NLC and MTR. By compression of the sponge, matrix tablets were obtained and characterized in term of porosity, swelling index, mucoadhesion and drugs release. The ability of the matrix tablets to release CUR and MTR when applied on buccal mucosa and the aptitude of actives to penetrate and/or permeate the tissue were evaluated. The data demonstrate the ability of NLC to promote the penetration of CUR into the lipophilic domains of the mucosal membrane, while MTR can penetrate and permeate the mucosal tissue, where it can perform a loco-regional antibacterial activity. These results strongly support the possibility of using this novel matrix tablet for delivering MTR together with CUR for topical treatment of periodontal diseases

Advance on Resveratrol Application in Bone Regeneration: Progress and Perspectives for Use in Oral and Maxillofacial Surgery

The natural polyphenol Resveratrol (RSV) claims numerous positive effects on health due to the well documented biological effects demonstrating its potential as a disease-preventing agent and as adjuvant for treatment of a wide variety of chronic diseases. Since several studies, both in vitro and in vivo, have highlighted the protective bone aptitude of RSV both as promoter of osteoblasts’ proliferation and antagonist of osteoclasts’ differentiation, they could be interesting in view of applications in the field of dentistry and maxillofacial surgery. This review has brought together experimental findings on the use of RSV in the regeneration of bone tissue comprising also its application associated with scaffolds and non-transfusional hemocomponents

Quercetin-Based Nanocomposites as a Tool to Improve Dental Disease Management

The restoration and prosthetic rehabilitation of missing teeth are commonly performed using dental implants, which are extremely effective and long-lasting techniques due to their osteointegration ability with the preimplant tissues. Quercetin is a phytoestrogen-like flavonoid well known for its several positive effects on human health, mostly linked to the anti-inflammatory, antioxidant, and antibacterial activities against both Gram-positive and Gram-negative bacteria. Moreover, many studies in dentistry and the maxillofacial fields have highlighted the positive effects of quercetin on osteogenesis, acting on osteoblast activity and angiogenetic process, and promoting soft and hard tissue regeneration. This review focuses on the role of quercetin on the healing and restoration of bony defects, considering the experimental findings of its application both in vitro and in vivo as a mere compound or in association with scaffolds and dental implants having functionalized surfaces

Antibacterial PEGylated Solid Lipid Microparticles for Cosmeceutical Purpose: Formulation, Characterization, and Efficacy Evaluation

The development of efficacious means of delivering antioxidant polyphenols from natural sources for the treatment of skin diseases is of great interest for many cosmetic and pharmaceutical companies. Resveratrol (RSV) and Limonene (LIM) have been shown to possess good anti-inflammatory and antibacterial properties against Staphylococcus aureus infections responsible for many skin disorders, such as acne vulgaris. In this study, solid lipid microparticles are designed as composite vehicles capable of encapsulating a high amount of trans-RSV and enhancing its absorption through the stratum corneum. A microparticulate system based on mixture of PEGylate lipids, long-chain alcohols and LIM is able to entrap RSV in an amorphous state, increasing its half-life and avoiding inactivation due to isomerization phenomena, which represents the main drawback in topical formulations. Particles have been characterized in term of shape, size distribution and drug loading. Antimicrobial tests against S. aureus have highlighted that empty microspheres possess per se antimicrobial activity, which is enhanced by the presence of LIM, demonstrating that they can represent an interesting bactericide vehicle for RSV administration on the skin

Development of a Multifunctional Bioerodible Nanocomposite Containing Metronidazole and Curcumin to Apply on L-PRF Clot to Promote Tissue Regeneration in Dentistry

Teeth extractions are often followed by alveolar bone reabsorption, although an adequate level of bone is required for reliable rehabilitations by dental implants. Leukocyte and platelet-rich fibrin (L-PRF) has been widely applied in regenerative procedures and with antibiotic and antioxidant agents could play an essential role in hard and soft tissue healing. In this work, a nanocomposite (Sponge-C-MTR) consisting of a hyaluronate-based sponge loaded with metronidazole (MTR) and nanostructured lipid carriers containing curcumin (CUR-NLC) was designed to be wrapped in the L-PRF™ membrane in the post-extraction sockets and characterized. CUR-NLCs, obtained by homogenization followed by high-frequency sonication of the lipid mixture, showed loading capacity (5% w/w), drug recovery (95% w/w), spherical shape with an average particle size of 112.0 nm, and Zeta potential of -24 mV. Sponge-C-MTR was obtained by entrapping CUR-NLC in a hydrophilic matrix by a freeze-drying process, and physico-chemical and cytocompatibility properties were evaluated. Moreover, the aptitude of CUR and MTR to the penetrate and/or permeate both L-PRF™ and porcine buccal tissue was assessed, highlighting MTR penetration and CUR accumulation promoted by the system. The results positively support the action of nanocomposite in dental tissues regeneration when applied together with the L-PRF™

Sol-gel synthesis of V2O5-SiO2 catalyst in the oxidative dehydrogenation of n-butane

The sol-gel method was used to prepare V-SiO2 catalyst by hydrolysis of vanadium acetylacetonate and silicon alkoxide. Structural changes in the vanadium species upon heat treatment at various temperatures were studied by means of XRD, XPS; DRS UV-vis, FTIR and FTIR of absorbed pyridine. From characterization studies, it was possible to conclude that during the synthesis process, vanadium acetylacetonate, is adsorbed on the external surface of silica particles formed by tetraethoxysilane hydrolysis. A catalyst prepared by wet impregnation of commercial SiO2, with identical V/Si surface ratio was used for comparative purposes. The catalytic behaviour of the solids was studied for the oxidative dehydrogenation of n-butane. The results indicate that vanadium silicate gel calcined at 500 °C is the most active solid. It was found that this preparation procedure leads to the formation of a solid with a high surface area which allows a better dispersion of active species. A direct correlation between catalytic activity and Brönsted acidity was also observed. © 2006 Elsevier B.V. All rights reserved.Fil: Murgia, Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones para la Industria Química. Universidad Nacional de Salta. Facultad de Ingeniería. Instituto de Investigaciones para la Industria Química; Argentina. Universidad Nacional de Cuyo. Facultad de Ingeniería; ArgentinaFil: Farfan Torres, Elsa Monica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones para la Industria Química. Universidad Nacional de Salta. Facultad de Ingeniería. Instituto de Investigaciones para la Industria Química; Argentina. Universidad Nacional de Salta. Facultad de Ciencias Exactas; ArgentinaFil: Gottifredi, Juan Carlos Agustin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones para la Industria Química. Universidad Nacional de Salta. Facultad de Ingeniería. Instituto de Investigaciones para la Industria Química; Argentina. Universidad Nacional de Cuyo. Facultad de Ingeniería; ArgentinaFil: Sham, Edgardo Ling. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones para la Industria Química. Universidad Nacional de Salta. Facultad de Ingeniería. Instituto de Investigaciones para la Industria Química; Argentina. Universidad Nacional de Cuyo. Facultad de Ingeniería; Argentin

Oxidative dehydrogenation of propane and n-butane over alumina supported vanadium catalysts

Structural properties of vanadium dispersed species on γ-A1203 are investigated with the scope to detect changes related with V loading in the oxidative dehydrogenation (ODH) of propane and nbutane. XPS, FTIR, and FTIR of absorbed pyridine were used to study the nature of vanadium supported species. Tetrahedral V5+ and probably V4+ species were detected. For vanadium loadings higher than 4.3 % wt octahedral species were also observed. In the n-butane ODH reaction, the selectivity to ODH products decreases when vanadium content increases. However, for propane ODH, the selectivity seems to be independent of vanadium loadings. Low oxygen/alkane feeding ratios favor selectivity to olefins. It is also shown that low V loading catalysts reach selectivities as good as best reported V-Mg-O catalyst.Fil: Murgia, Viviana. Universidad Nacional de Salta. Facultad de Ingeniería; ArgentinaFil: Sham, Edgardo Ling. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones para la Industria Química. Universidad Nacional de Salta. Facultad de Ingeniería. Instituto de Investigaciones para la Industria Química; ArgentinaFil: Gottifredi, Juan Carlos Agustin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones para la Industria Química. Universidad Nacional de Salta. Facultad de Ingeniería. Instituto de Investigaciones para la Industria Química; ArgentinaFil: Farfan Torres, Elsa Monica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones para la Industria Química. Universidad Nacional de Salta. Facultad de Ingeniería. Instituto de Investigaciones para la Industria Química; Argentin

Influence of concentration and order of aggregation of the active phases in V-Mo-O catalysts in the oxidative dehydrogenation of propane

The activation of alkanes by oxidative route is an alternative way to obtain products with greater added value. The mixed catalysts obtained by impregnation of Mo and V on different supports conform a potentially attractive system to achieve dehydrogenation of propane. The activity and selectivity depend on the Mo/V ratio used. In this work, we have studied the effect of the concentration and the order of incorporation of the active phases on the catalytic behavior and the nature of the acid sites on the catalyst surface for this reaction. Catalysts with weight contents of 1.4 and 2.8% of vanadium and/or 4 and 8% of molybdenum were prepared. The results show that for solids with low vanadium load the order of aggregation of the active phases does not modify the catalytic behavior. When vanadium load increases, greater conversion is observed when molybdenum is incorporated in the first place. This behavior can be related to the formation of Mo-V-O species. The catalytic properties are also influenced by the nature and strength of the acid sites on the surface. © 2008.Fil: Murgia, Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones para la Industria Química. Universidad Nacional de Salta. Facultad de Ingeniería. Instituto de Investigaciones para la Industria Química; Argentina. Universidad Nacional de Salta. Facultad de Ingenieria; ArgentinaFil: Farfan Torres, Elsa Monica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones para la Industria Química. Universidad Nacional de Salta. Facultad de Ingeniería. Instituto de Investigaciones para la Industria Química; Argentina. Universidad Nacional de Salta. Facultad de Ciencias Exactas; ArgentinaFil: Gottifredi, Juan Carlos Agustin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones para la Industria Química. Universidad Nacional de Salta. Facultad de Ingeniería. Instituto de Investigaciones para la Industria Química; Argentina. Universidad Nacional de Salta. Facultad de Ingenieria; ArgentinaFil: Sham, Edgardo Ling. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Investigaciones para la Industria Química. Universidad Nacional de Salta. Facultad de Ingeniería. Instituto de Investigaciones para la Industria Química; Argentina. Universidad Nacional de Salta. Facultad de Ingenieria; Argentin

Leucocyte- and Platelet-Rich Fibrin Block: Its Use for the Treatment of a Large Cyst with Implant-Based Rehabilitation

The management of critical-size bone defects is still demanding. Recently, autologous platelet concentrates in combination with bone substitute have been applied and reported in a few studies. Our aim is to report the healing of a critical-size alveolar bone defect treated with a new bone regeneration technique by means of L-PRF and L-PRF blocks. A 45-year-old woman presented a large cystic lesion; the extraction of three teeth, a cyst removal procedure, and bone regeneration procedures with L-PRF and L-PRF blocks were planned. The L-PRF block was prepared by mixing a bone substitute with a piece of L-PRF membrane and liquid fibrinogen. Additionally, after bone healing an implant-based rehabilitation was optimally performed. On the basis of the positive results, in terms of bone healing and tissue regeneration in a large bone defect, the application of L-PRF and L-PRF blocks, in agreement with the scarce literature, is suggested as a feasible procedure in selected cases