Una herramienta para la medicion de la aversion al riesgo, mediante la caracterizacion de las funciones de utilidad.

129 p.Esta memoria desarrolla una herramienta para la medicion de la adversion al riesgo, basada en la teoria de la utilidad esperada, expuesta por autores tales como Arrow (1965),Machina (1987)Cox y Sadiraj(2001). La idea fue desarrollar un instrumento automatico que genera mediante el analisis de modelos de regresion no lineales un reporte general que determine que forma funcional representa la actitud de las personas bajo condiciones de incertidumbre y por lo tanto refleje el grado de adversion al riesgo de cada Individuo

Intranet corporativa.

126 p.La presente memoria se basara en la presentación de una Metodología para el desarrollo e implementación de una Intranet en la empresa, tomando como referencia y aplicación el trabajo realizado en EMEC S.A. Dicho desarrollo e implementación de una Intranet será lograda a través de la metodología que se propone como parte de este trabajo, la cual será aplicada en una implementación real de una Intranet en la empresa anteriormente citada. La metodología propuesta para el desarrollo de la Intranet, es el complemento con otras metodología de corte informático, de gestión y administración de proyectos, y otras tales como: Modelos relacionales, orientación a objetos, redes, Sistemas operativos, protocolos de comunicación, análisis y determinación de requerimientos organizacionales, etc

Combined therapeutic benefit of mitochondria-targeted antioxidant, MitoQ10, and angiotensin receptor blocker, losartan, on cardiovascular function

<b>Objective:</b><p></p> Mitochondria-derived reactive oxygen species (ROS) play important roles in the development of cardiovascular disease highlighting the need for novel targeted therapies. This study assessed the potential therapeutic benefit of combining the mitochondria-specific antioxidant, MitoQ<sub>10</sub>, with the low-dose angiotensin receptor blocker (ARB), losartan, on attenuation of hypertension and left ventricular hypertrophy. In parallel, we investigated the impact of MitoQ<sub>10</sub> on cardiac hypertrophy in a neonatal cardiomyocyte cell line.<p></p> <b>Methods and results:</b><p></p> Eight-week-old male stroke-prone spontaneously hypertensive rats (SHRSPs, <i>n</i> = 8–11) were treated with low-dose losartan (2.5 mg/kg per day); MitoQ<sub>10</sub> (500 μmol/l); a combination of MitoQ<sub>10</sub> and losartan (M + L); or vehicle for 8 weeks. Systolic pressure and pulse pressure were significantly lower in M + L rats (167.1 ± 2.9 mmHg; 50.2 ± 2.05 mmHg) than in untreated SHRSP (206.6 ± 9 mmHg, P < 0.001; 63.7 ± 2.7 mmHg, P = 0.001) and demonstrated greater improvement than MitoQ10 or low-dose losartan alone, as measured by radiotelemetry. Left ventricular mass index was significantly reduced from 22.8 ± 0.74 to 20.1 ± 0.61 mg/mm in the combination group (P < 0.05). Picrosirius red staining showed significantly reduced cardiac fibrosis in M + L rats (0.82 ± 0.22 A.U.) compared with control (5.94 ± 1.35 A.U., P < 0.01). In H9c2 neonatal rat cardiomyocytes, MitoQ<sub>10</sub> significantly inhibited angiotensin II mediated hypertrophy in a dose-dependent manner (500 nmol/l MitoQ<sub>10</sub> 153.7 ± 3.1 microns vs. angiotensin II 200.1 ± 3.6 microns, P <0.001).<p></p> <b>Conclusion:</b><p></p> Combining MitoQ<sub>10</sub> and low-dose losartan provides additive therapeutic benefit, significantly attenuating development of hypertension and reducing left ventricular hypertrophy. In addition, MitoQ<sub>10</sub> mediates a direct antihypertrophic effect on rat cardiomyocytes <i>in vitro</i>. MitoQ<sub>10</sub> has potential as a novel therapeutic intervention in conjunction with current antihypertensive drugs.<p></p&gt

Tourism policy in the Canary Islands : past experiences, current trends and future plans

The Canary Islands are a well-known brand in Europe, and in 2017 the number of tourist arrivals exceeded 14 million. The heavy tourist inflow in the 1990s prompted the Government of the Canary Islands to adopt a policy to protect the environment by restricting the building of new hotels. This moratorium was abolished in 2018. The paper describes the evolution of Canary Islands tourism policy in recent years and explains how the government, in cooperation with the private sector, is planning transform the Canary archipelago into a destination with distinct features, different from its competitors.peer-reviewe

Effectiveness of a participatory approach for collection of economic data in aquaculture systems at farm level in Brazil.

This paper aims to evaluate the effectiveness of a participatory approach which is currently being applied by the Brazilian Agricultural Research Corporation (Embrapa) and Brazilian Confederation of Agriculture and Livestock (CNA) in aquaculture sector in Brazil

Construir un modelo que represente la problematica de gestion de las listas de espera del area oftalmologica, para el Hospital de referencia de Curico, utilizando la metodologia de dinamica de sistemas.

102 p.La metodología de dinámica de sistemas, es un instrumento no convencional efectivo que permite abordar sistemas complejos como es el caso de las organizaciones de salud donde los factores condicionantes y sus niveles de interacción juegan un rol preponderante al minuto de resolver los problemas de salud que presenta mayoritariamente la población del siglo XXI, con sus cambios epidemiológicos y prioridades sanitarias. Es así como en este proyecto se realiza una adaptación a dicha metodología puesto que la definición del problema no se pudo establecer con precisión sino que sólo una vez que se construyó el modelo, incorporándose en este las variables más significativas que a juicio de los expertos, son los factores de mayor relevancia en el proceso de atención que siguen los pacientes para resolver su problema ocular en la unidad de oftalmología del Hospital de Referencia de Curicó -retinopatía diabética, glaucomas, cataratas, estrabismos y visio refracción. Se aborda entonces, la definición del problema, su conceptualización y formalización con el propósito de modelar y explorar el modelo para inferir los impactos o alteraciones de aquellas variables que permiten reflejar la realidad del sistema y su comportamiento en la gestión de las listas de espera. Las variables que inciden son el factor de crecimiento, la tasa de incidencia, de resolución de la atención primaria, de priorización de los diferentes niveles de tiempo de espera, de atención en las enfermedades correspondientes y los cupos determinados por el hospital de referencia

A quick guide for student-driven community genome annotation

High quality gene models are necessary to expand the molecular and genetic tools available for a target organism, but these are available for only a handful of model organisms that have undergone extensive curation and experimental validation over the course of many years. The majority of gene models present in biological databases today have been identified in draft genome assemblies using automated annotation pipelines that are frequently based on orthologs from distantly related model organisms. Manual curation is time consuming and often requires substantial expertise, but is instrumental in improving gene model structure and identification. Manual annotation may seem to be a daunting and cost-prohibitive task for small research communities but involving undergraduates in community genome annotation consortiums can be mutually beneficial for both education and improved genomic resources. We outline a workflow for efficient manual annotation driven by a team of primarily undergraduate annotators. This model can be scaled to large teams and includes quality control processes through incremental evaluation. Moreover, it gives students an opportunity to increase their understanding of genome biology and to participate in scientific research in collaboration with peers and senior researchers at multiple institutions

Cai custo de produção para tambaqui, pintado e tilápia.

No período de dezembro/2014 a fevereiro/2015, foi observada, de modo geral, redução nos custos de produção nos polos de piscicultura acompanhados pelo Projeto Campo Futuro Aquicultura. Esse decréscimo pode ser verificado com a queda do Custo Operacional Efetivo (COE) estimado no período para produtores de engorda em Palmas (TO), Almas (TO), Cuiabá (MT), Alta Floresta (MT), Sorriso (MT), e na região do Submédio São Francisco, na Bahia e em Pernambuco.bitstream/item/141362/1/CNPASA-2015-aa4.pd

Utilization of sensors and SMS technology to remotely maintain the level of dissolved oxygen, salinity and temperature of fishponds

Due to the occurrence of fish kills in various fish producing areas in our country, millions of pesos and opportunities for the Filipino people had been put into waste. Bataan Peninsula State University (BPSU) collaborated with the Central Luzon Association of Small-scale Aquaculture to devise strategies to address the said problem and prevent further losses. More often than not, a fish kill can be attributed to the low level of dissolved oxygen (DO) in the water, decrease or increase in salinity and sudden increase in temperature, which usually occur after heavy rainfall, flooding or high tide, or high levels of ammonia due to decomposing organic matter and high temperature during summer. For these reasons, BPSU researchers tested the use of radio frequencies and installed sensors in different areas of the fishpond at various depths to remotely monitor the levels of DO, salinity and temperature of the water. Once these reach critical levels, the installed system which comes with a specific program, will send an alarm through radio frequencies via Short Messaging Services (SMS) technology on the cellular/mobile phone of the caretaker or the fishpond operator. Upon receiving the alarm, caretakers were able to adjust the levels of dissolved oxygen, salinity and temperature of the water by remotely switching on the air compressor or the electric water pump using their cellular/ mobile phone, thus preventing losses due to fish kills

A Verilog-A Based Fractional Frequency Synthesizer Model for Fast and Accurate Noise Assessment

This paper presents a new strategy to simulate fractional frequency synthesizer behavioral models with better performance and reduced simulation time. The models are described in Verilog-A with accurate phase noise predictions and they are based on a time jitter to power spectral density transformation of the principal noise sources in a synthesizer. The results of a fractional frequency synthesizer simulation is compared with state of the art Verilog-A descriptions showing a reduction of nearly 20 times. In addition, experimental results of a fractional frequency synthesizer are compared to the simulation results to validate the proposed model