A Case of Subhyaloid Haemorrhage Managed with ND:YAG Laser Hyaloidotomy

Subhyaloid hemorrhage is rarely seen in ophthalmological practice in young males. We managed one such case in our set-up. A youngmale presented with sudden decreased vision. Fundus showed large collection of darkish red colored blood in subhyaloid space of theposterior pole in front of the macula, typical of sub-hyaloid hemorrhage. Treatment includes, amongst others, Nd: YAG laserhyaloidotomy. Prognosis, if treated on appropriate lines, is usually good. This case was being reported for general awareness.Key-words: Nd: Yag laser hyaloidotomy, premacular sub-hyaloid haemorrhag

Use of hydrophilic and hydrophobic polymers for the development of controlled release tizanidine matrix tablets

The aim of the present study was to develop tizanidine controlled release matrix. Formulations were designed using central composite method with the help of design expert version 7.0 software. Avicel pH 101 in the range of 14-50% was used as a filler, while HPMC K4M and K100M in the range of 25-55%, Ethylcellulose 10 ST and 10FP in the range of 15 - 45% and Kollidon SR in the range of 25-60% were used as controlled release agents in designing different formulations. Various physical parameters including powder flow for blends and weight variation, thickness, hardness, friability, disintegration time and in-vitro release were tested for tablets. Assay of tablets were also performed as specified in USP 35 NF 32. Physical parameters of both powder blend and compressed tablets such as compressibility index, angle of repose, weight variation, thickness, hardness, friability, disintegration time and assay were evaluated and found to be satisfactory for formulations K4M2, K4M3, K4M9, K100M2, K100M3, K100M9, E10FP2, E10FP9, KSR2, KSR3 & KSR9. In vitro dissolution study was conducted in 900 ml of 0.1N HCl, phosphate buffer pH 4.5 and 6.8 medium using USP Apparatus II. In vitro release profiles indicated that formulations prepared with Ethocel 10 standard were unable to control the release of drug while formulations K4M2, K100M9, E10FP2 & KSR2 having polymer content ranging from 40-55% showed a controlled drug release pattern in the above mentioned medium. Zero-order drug release kinetics was observed for formulations K4M2, K100M9, E10FP2 & KSR2. Similarity test (f 2) results for K4M2, E10FP2 & KSR2 were found to be comparable with reference formulation K100M9. Response Surface plots were also prepared for evaluating the effect of independent variable on the responses. Stability study was performed as per ICH guidelines and the calculated shelf life was 24-30 months for formulation K4M2, K100M9 and E10FP2.O objetivo do presente estudo foi desenvolver matriz de de tizanidina de liberação controlada. As formulações foram projetadas usando o método do componente, central com a ajuda de software Design expert(r), versão 7.0. Utilizou-se Avicel pH 101, no intervalo de 14-50%, como material de preenchimento, enquanto HPMC K4M e K100M, no intervalo de 25-55%, Etilcelulose 10 ST e 10FP, no intervalo de 15-45% e Kollidon SR, na faixa de 25-60% foram utilizados como agentes de liberação controlada, no planejamento de formulações diferentes. Vários parâmetros físicos, incluindo o fluxo de pó para as misturas e variação de peso, espessura, dureza, friabilidade, tempo de desintegração e liberação in vitro, foram testados para comprimidos. Ensaios dos comprimidos foram, também, realizados, tal como especificado em USP 35 NF 32. Avaliaram-se os parâmetros físicos de ambos, mistura em pó e comprimidos, como índice de compressibilidade, ângulo de repouso, variação de peso, espessura, dureza, friabilidade, tempo de desintegração e de ensaio, considerando-os satisfatórios para as formulações K4M2, K4M3, K4M9, K100M2, K100M3, K100M9, E10FP2, E10FP9, KSR2, KSR3 e KSR9. O estudo de dissolução in vitro foi realizado em 900 mL de HCl 0,1 N, tampão de fosfato pH 4,5 e meio 6,8, usando aparelho USP II. Os perfis de liberação in vitro indicaram que as formulações preparadas com Ethocel 10 padrão não foram capazes de controlar a liberação do fármaco, enquanto as formulações K4M2, K100M9, E10FP2e KSR2, com teor de polímero variando entre 40 e 55% apresentaram padrão de liberação controlada de fármaco no meio anteriormente mencionado. Observou-se cinética de liberação de fármaco de ordem zero para as formulações K4M2 , K100M9, E10FP2 e KSR2. Resultados do teste de similaridade (f 2) para K4M2, E10FP2 e KSR2 foram comparáveis com a formulação de referência K100M9. Gráficos de superfície de resposta também avaliaram o efeito da variável independente sobre as respostas. Estudo de estabilidade foi realizado conforme as diretrizes do ICH e a vida de prateleira calculada foi de 24-30 meses para as formulações K4M2, K100M9 e E10FP2

5-[(E)-(2,6-Dichloro­benzyl­idene)amino]-2-hy­droxy­benzoic acid

There are two geometrically different mol­ecules in the asymmetric unit of the title compound, C14H9Cl2NO3. The 5-amino-2-hy­droxy­benzoic acid units [r.m.s. deviations of 0.0323 and 0.0414 Å] and 2,6-dichloro­benzaldehyde groups [r.m.s. deviations of 0.0285 and 0.0226 Å] are roughly planar and oriented at dihedral angles of 11.69 (13) and 83.12 (6)° in the two mol­ecules. An intra­molecular O—H⋯O hydrogen bond completes an S(6) ring motif in each mol­ecule. The two mol­ecules form dimers with each other through inter­molecular O—H⋯N and C—H⋯O hydrogen bonds, completing an R 2 2(8) ring motif. The dimers are inter­linked via inter­molecular O—H⋯N and C—H⋯O hydrogen bonds, forming polymeric sheets

The Impact of Education on Total Fertility Rate in Pakistan (1981-2008)

Most of the developing countries are facing the problem of high population growth, which is causing numerous social and economic problems. The Total Fertility Rate (TFR) in most of developing countries stands higher than the developed countries (UNPD, 2000). The TFR in Pakistan was 7.0 in 1989.The continuous efforts on part of government of Pakistan bought it to 3.0 in 2008. The present study aimed at finding out the impact of education on Total Fertility Rate (TFR) in Pakistan during the period 1981-2008. Econometric techniques, Multiple Regression Model and Johansen Cointegration have been used to derive results. The results show that mean age at marriage (male), the education of both sexes and the age of women are the most important factors affecting TFR. Women education can be more useful weapon to control TFR, if it is at secondary level. Female age at marriage also negatively affects TFR. In order to achieve the desired level of population growth, the government of Pakistan should focus on Primary as well as secondary education for male as well as female

The Impact of Education on Total Fertility Rate in Pakistan (1981-2008)

Most of the developing countries are facing the problem of high population growth, which is causing numerous social and economic problems. The Total Fertility Rate (TFR) in most of developing countries stands higher than the developed countries (UNPD, 2000). The TFR in Pakistan was 7.0 in 1989.The continuous efforts on part of government of Pakistan bought it to 3.0 in 2008. The present study aimed at finding out the impact of education on Total Fertility Rate (TFR) in Pakistan during the period 1981-2008. Econometric techniques, Multiple Regression Model and Johansen Cointegration have been used to derive results. The results show that mean age at marriage (male), the education of both sexes and the age of women are the most important factors affecting TFR. Women education can be more useful weapon to control TFR, if it is at secondary level. Female age at marriage also negatively affects TFR. In order to achieve the desired level of population growth, the government of Pakistan should focus on Primary as well as secondary education for male as well as female

Integration of Data Driven Technologies in Smart Grids for Resilient and Sustainable Smart Cities: A Comprehensive Review

A modern-day society demands resilient, reliable, and smart urban infrastructure for effective and in telligent operations and deployment. However, unexpected, high-impact, and low-probability events such as earthquakes, tsunamis, tornadoes, and hurricanes make the design of such robust infrastructure more complex. As a result of such events, a power system infrastructure can be severely affected, leading to unprecedented events, such as blackouts. Nevertheless, the integration of smart grids into the existing framework of smart cities adds to their resilience. Therefore, designing a resilient and reliable power system network is an inevitable requirement of modern smart city infras tructure. With the deployment of the Internet of Things (IoT), smart cities infrastructures have taken a transformational turn towards introducing technologies that do not only provide ease and comfort to the citizens but are also feasible in terms of sustainability and dependability. This paper presents a holistic view of a resilient and sustainable smart city architecture that utilizes IoT, big data analytics, unmanned aerial vehicles, and smart grids through intelligent integration of renew able energy resources. In addition, the impact of disasters on the power system infrastructure is investigated and different types of optimization techniques that can be used to sustain the power flow in the network during disturbances are compared and analyzed. Furthermore, a comparative review analysis of different data-driven machine learning techniques for sustainable smart cities is performed along with the discussion on open research issues and challenges

Study of Debris Flow Impact on Bridge Pier

The destructive nature of debris has ability to transport large boulders and wooden material along with the flow whose impact can pose serious safety risks to a bridge. In this study an effort has been made to study the impact of varying debris densities on a bridge pier.  The experimentation was carried out in Hydraulics Laboratory, Civil Engineering Department, University of Engineering and Technology Taxila. Hexagonal wooden pier model was used. Wooden sticks of uniform size and mass were used to act as debris in flow. Respective discharges were determined against different flow velocities. Dial gauge was installed carefully beside the bridge pier in a way that deflections were easily measurable. This debris of masses 189, 253, 316, 379 and 442 grams was floated on water for five trials at discharges of 10.3, 12.8, 16, 23.8 and 28.9 liters per second. Debris hit the pier and caused a deflection in it. These deflections were measured by a dial gauge. The results show that with increasing debris mass and intensity of flow velocity, the impact on the pier bridge in term of deflection increased. A hydraulic structure's health can be monitored using the findings of the current study

Determinants of Household’s Demand for Electricity in District Peshawar

The main purpose of this study is to explore the role of economic and noneconomic factors in the determination of household’s demand for electricity in district Peshawar. Primary data was collected for this purpose from 200 households of City Rural Division during November-December 2009. Multinomial logistic model was used to derive estimates. The study concluded that income, number of rooms, price of electricity, weather and education are important determinants of household demand for electricity in district Peshawar. However, the study suggested that a provincial level study in this regard will be more helpful for government in understanding the real pattern of domestic demand for electricity

The Role of Education in Agricultural Productivity in Khyber Pakhtunkhwa(1975-2008)

Agriculture is considered as the backbone of Pakistan’s economy and a reasonable proportion of population is engaged in it. The present study aims at finding the role of education in productivity of wheat, sugarcane and tobacco crops in Khyber Pakhtunkhwa (KPK) during the period 1975-2008. The econometric techniques Ordinary Least Squares (OLS) and Cointegration have been used for analysis. The estimation results obtained from OLS shows that education, fertilizers and area under cultivation are significant determinants of agricultural productivity in KPK. The results of cointegration confirmed the existence of long run relationship between education and agricultural productivity. It is therefore, suggested to adopt effective measures to increase school enrollment especially in rural areas of the study area. Furthermore, provision of high quality fertilizers and increase in area under cultivation can be helpful in enhancing the productivity of food and cash crops in the study area