An accurate Rb density measurement method for a plasma wakefield accelerator experiment using a novel Rb reservoir

A method to accurately measure the density of Rb vapor is described. We plan on using this method for the Advanced Wakefield (AWAKE)~\cite{bib:awake} project at CERN , which will be the world's first proton driven plasma wakefield experiment. The method is similar to the hook~\cite{bib:Hook} method and has been described in great detail in the work by W. Tendell Hill et. al.~\cite{bib:densitymeter}. In this method a cosine fit is applied to the interferogram to obtain a relative accuracy on the order of $1\%$ for the vapor density-length product. A single-mode, fiber-based, Mach-Zenhder interferometer will be built and used near the ends of the 10 meter-long AWAKE plasma source to be able to make accurate relative density measurement between these two locations. This can then be used to infer the vapor density gradient along the AWAKE plasma source and also change it to the value desired for the plasma wakefield experiment. Here we describe the plan in detail and show preliminary results obtained using a prototype 8 cm long novel Rb vapor cell.Comment: 5 pages 9 figure

Novel diagnostic for precise measurement of the modulation frequency of Seeded Self-Modulation via Coherent Transition Radiation in AWAKE

We present the set-up and test-measurements of a waveguide-integrated heterodyne diagnostic for coherent transition radiation (CTR) in the AWAKE experiment. The goal of the proof-of-principle experiment AWAKE is to accelerate a witness electron bunch in the plasma wakefield of a long proton bunch that is transformed by Seeded Self-Modulation (SSM) into a train of proton micro-bunches. The CTR pulse of the self-modulated proton bunch is expected to have a frequency in the range of 90-300 GHz and a duration of 300-700 ps. The diagnostic set-up, which is designed to precisely measure the frequency and shape of this CTR-pulse, consists of two waveguide-integrated receivers that are able to measure simultaneously. They cover a significant fraction of the available plasma frequencies: the bandwidth 90-140 GHz as well as the bandwidth 255-270 GHz or 170-260 GHz in an earlier or a latter version of the set-up, respectively. The two mixers convert the CTR into a signal in the range of 5-20 GHz that is measured on a fast oscilloscope, with a high spectral resolution of 1-3 GHz dominated by the pulse length. In this contribution, we will describe the measurement principle, the experimental set-up and a benchmarking of the diagnostic in AWAKE.Comment: Conference proceedings to 3rd European Advanced Accelerator Concepts Worksho

Vitamin D status among male late adolescents living in Southern Switzerland: Role of body composition and lifestyle

BACKGROUND: Poor vitamin D status is a worldwide health problem. Yet, knowledge about vitamin D status among adolescents in Southern Europe is limited. This study investigated concentrations and modulating factors of vitamin D in a healthy population of male late adolescents living in Southern Switzerland. METHODS: All apparently healthy subjects attending for the medical evaluation before the compulsory military service in Southern Switzerland during 2014-2016 were eligible. Dark-skin subjects, subjects on vitamin D supplementation or managed with diseases or drugs involved in vitamin D metabolism were excluded. Anthropometric measurements (body height, weight, fat percentage, mid-upper arm and waist circumference) and blood sampling for total 25-hydroxy-vitamin D, total cholesterol and ferritin concentrations testing, were collected. Participants filled in a structured questionnaire addressing their lifestyle. Characteristics of the subjects with adequate ( 6550 nmol/L- 64250 nmol/L) and insufficient (<50 nmol/L) vitamin D values were compared by Kruskal-Wallis test or \u3c72 test. Odds ratios for 25-hydroxy-vitamin D insufficiency were calculated by univariate and AIC-selected multiple logistic regression models. RESULTS: A total of 1045 subjects volunteered to participate in the study. Insufficient concentrations of vitamin D were detected in 184 (17%). The season of measurement was the most significant factor associated with vitamin D levels and approximately 40% of subjects presented insufficient vitamin D concentrations in winter. After model selection, body fat percentage, frequency and site of recreational physical activity, and the seasonality were significantly associated with the risk of vitamin D insufficiency. CONCLUSIONS: Among healthy male late adolescents in Southern Switzerland, about one every fourth subject presents a poor vitamin D status in non-summer seasons. Body fat percentage, frequent and outdoor recreational physical activity are modulating factors of vitamin D status in this population

Illness tracking in SARS-CoV-2 tested persons using a smartphone app: a non-interventional, prospective, cohort study

There are few data on the range and severity of symptoms of SARS-CoV-2 infection or the impact on life quality in infected, previously healthy, young adults such as Swiss Armed Forces personnel. It is also unclear if an app can be used to remotely monitor symptoms in persons who test positive. Using a smartphone app called ITITP (Illness Tracking in Tested Persons) and weekly pop-up questionnaires, we aimed to evaluate the spectrum, duration, and impact of symptoms reported after a positive SARS-CoV-2 test according to sex, age, location, and comorbidities, and to compare these to responses from persons who tested negative. We followed up 502 participants (57% active participation), including 68 (13.5%) positive tested persons. Hospitalisation was reported by 6% of the positive tested participants. We found that positives reported significantly more symptoms that are typical of COVID-19 compared to negatives. These symptoms with odds ratio (OR > 1) were having difficulty breathing (OR 3.35; 95% CI: 1.16, 9.65; p = 0.03), having a reduced sense of taste (OR 5.45; 95% CI: 1.22, 24.34; p = 0.03) and a reduced sense of smell (OR 18.24; 95% CI: 4.23, 78.69; p < 0.001). Using a random forest model, we showed that tiredness was the single symptom that was rated as having a significant impact on daily activities, whereas the other symptoms, although frequent, had less impact. The study showed that the use of an app was feasible to remotely monitor symptoms in persons infected with SARS-CoV-2 and could be adapted for other settings and new pandemic phases such as the current Omicron wave

Experimental Observation of Energy Modulation in Electron Beams Passing Through Terahertz Dielectric Wakefield Structures

We report observation of a strong wakefield induced energy modulation in an energy-chirped electron bunch passing through a dielectric-lined waveguide. This modulation can be effectively converted into a spatial modulation forming micro-bunches with a periodicity of 0.5 - 1 picosecond, hence capable of driving coherent THz radiation. The experimental results agree well with theoretical predictions.Comment: v3. Reviewers' suggestions incorporated. Accepted by PR

Seasonal variability of the vitamin D effect on physical fitness in adolescents.

Studies investigating the relationship between vitamin D and physical fitness in youth have provided inconsistent findings. Recent evidence indicates that the expression of receptors and vitamin D-modulated genes in young subjects has a seasonal profile. Therefore, we investigated the role of vitamin D on physical fitness across seasons in a total of 977 male adolescents. Anthropometrics, lifestyle, dietary habits, biochemical profiles and physical fitness were studied. Multiple linear regression models, including pairwise interaction terms involving total 25-OH-vitamin D, were fitted. The interacting effect of season and total 25-OH-vitamin D had a significant influence on physical fitness performance (spring and total 25-OH-vitamin D: ß 0.19, SE 0.07, p = 0.007; summer and total 25-OH-vitamin D: ß 0.10, SE 0.06, p = 0.11; autumn and total 25-OH-vitamin D: ß 0.18, SE 0.07, p = 0.01), whereas the main effect of total 25-OH-vitamin D alone was not significant (p = 0.30). Body fat percentage, recreational physical activity level, time spent per day gaming/TV-watching, smoking, and hemoglobin levels were also related to the physical fitness performance score. Future studies should further explore the role of seasonal-dependent effects of vitamin D on health

A proposed demonstration of an experiment of proton-driven plasma wakefield acceleration based on CERN SPS

The proton bunch-driven plasma wakefield acceleration (PWFA) has been proposed as an approach to accelerate an electron beam to the TeV energy regime in a single plasma section. An experimental program has been recently proposed to demonstrate the capability of proton-driven PWFA by using existing proton beams from the European Organization for Nuclear Research (CERN) accelerator complex. At present, a spare Super Proton Synchrotron (SPS) tunnel, having a length of 600 m, could be used for this purpose. The layout of the experiment is introduced. Particle-in-cell simulation results based on realistic SPS beam parameters are presented. Simulations show that working in a self-modulation regime, the wakefield driven by an SPS beam can accelerate an externally injected ~10 MeV electrons to ~2 GeV in a 10-m plasma, with a plasma density of 7 × 1014 cm−

Comparison of office, home and ambulatory blood pressure measurements in hypertensive and suspected hypertensive SWICOS participants.

PURPOSE Hypertension should be confirmed with the use of home BP measurement (HBPM) or 24h ambulatory BP measurement (ABPM). The aim of our study was to compare measurements obtained by OBPM, HBPM and ABPM in individuals with elevated OBPM participating in the population-based Swiss Longitudinal Cohort Study (SWICOS). MATERIAL AND METHODS Participants with OBPM ≥140/90 mmHg assessed their BP using HBPM and ABPM. The cut-off for hypertension was ≥135/85 mmHg for HBPM, ≥130/80 mmHg for ABPM. White-coat hypertension (WCH) was defined as normal HPBM and ABPM in participants not taking antihypertensive drugs. Uncontrolled hypertension was defined as hypertension in HBPM or ABPM despite antihypertensive treatment. RESULTS Of 72 hypertensive subjects with office BP ≥140/90 mmHg and valid measurements of HBPM and ABPM, 39 were males (aged 62.8 ± 11.8y), 33 were females (aged 57.4 ± 14.2y). Hypertension was confirmed with HBPM and ABPM in 17 participants (24%), with ABPM only in 24 further participants (33%), and with HBPM only in 2 further participants (3%). Participants who had hypertension according to ABPM but not HBPM were younger (59 ± 11 y versus 67 ± 16 y; p < 0.001) and more frequently still working (83% versus 23%; p < 0.001). The prevalence of WCH was 28%. Among the 32 subjects taking antihypertensive drugs, uncontrolled hypertension was found in 49%. CONCLUSION This population-based study found a high prevalence of WCH and potential uncontrolled hypertension among individuals with elevated OBPM. This study, therefore, supports the ESH recommendations of complementing OBPM by ABPM or HBPM. The use of HBPM instead of ABPM for the confirmation of hypertension in individuals with elevated OBPM might lead to underdiagnosis and uncontrolled hypertension, in particular in the younger working population. In these individuals, this study suggests using ABPM instead of HBPM