33 research outputs found
Vitamin D Receptor Gene Polymorphism and the Risk of Colorectal Cancer: A Nested Case-Control Study
<div><p>Epidemiological and experimental evidence suggest that vitamin D is protective against the risk of colorectal cancer. Polymorphisms in the gene encoding vitamin D receptor (VDR), which mediates most of the known cellular effects of vitamin D, have been suggested to alter this association. Here, using a tag SNP approach, we comprehensively evaluated the role of common genetic variants in <i>VDR</i> and their interaction with plasma vitamin D levels in relation to colorectal cancer risk in Japanese populations. A total of 356 colorectal cancer cases and 709 matched control subjects were selected from the participants of the Japan Public Health Center-based Prospective Cohort Study. Among these subjects, 29 <i>VDR</i> single nucleotide polymorphisms (SNPs) were selected and genotyped, and plasma vitamin D concentrations were measured. Conditional logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) of colorectal cancer, with adjustment for potential confounding factors. Among the results, eight <i>VDR</i> SNPs, namely rs2254210, rs1540339, rs2107301, rs11168267, rs11574113, rs731236, rs3847987 and rs11574143, the latter 5 of which were located in the 3′ region, were nominally associated with the risk of colorectal cancer (<i>P</i> = 0.01–0.048). Furthermore, of the above 5 3′ region SNPs, the inverse associations for 3 SNPs (rs11574113, rs3847987 and rs11574143) appeared to be evident only in those with high plasma vitamin D concentration. However, neither of these direct and suggestive interaction analysis associations was significant after multiple testing adjustment. Overall, the findings of this study provide only limited support for an association between common genetic variations in <i>VDR</i> and colorectal cancer risk in the Japanese population.</p></div
Hazard ratios for all-cause and cause-specific mortality according to height category in women.
<p>Hazard ratios for all-cause and cause-specific mortality according to height category in women.</p
<i>VDR</i> and <i>GC</i> gene polymorphisms and colorectal cancer risk.
<p><i>VDR</i> and <i>GC</i> gene polymorphisms and colorectal cancer risk.</p
Baseline characteristics of cases and controls.
<p>Baseline characteristics of cases and controls.</p
Association of <i>VDR</i> and <i>GC</i> gene polymorphisms with colorectal cancer risk according to plasma vitamin D concentration.
<p>Association of <i>VDR</i> and <i>GC</i> gene polymorphisms with colorectal cancer risk according to plasma vitamin D concentration.</p
Baseline characteristics of participants according to height category in men and women.
<p>Baseline characteristics of participants according to height category in men and women.</p
Hazard ratios for all-cause and cause-specific mortality according to height category by birth decade in men.
<p>Hazard ratios for all-cause and cause-specific mortality according to height category by birth decade in men.</p
Additional file 2: of Correlation between global methylation level of peripheral blood leukocytes and serum C reactive protein level modified by MTHFR polymorphism: a cross-sectional study
Table S2. Assessment of association between HP infection and global methylation levels with/without adjustment with life-style factors, folate intake and serum CRP concentration. (DOCX 20 kb
Additional file 1: of Correlation between global methylation level of peripheral blood leukocytes and serum C reactive protein level modified by MTHFR polymorphism: a cross-sectional study
Table S1. Details of the models for the assessment of CRP and global methylation in all subjects. (DOCX 19 kb
Baseline characteristics in women (n = 45,229).
<p>Baseline characteristics in women (n = 45,229).</p