Modifiable risk of breast cancer in Northeast Iran: Hope for the future. a case-control study

Background: Breast cancer is the most common cancer in women. Its prevalence is increasing annually by 2. The determination of modifiable risk factors has been the subject of various studies. The aim of this study was to determine risk factors of breast cancer in women in Golestan Province. Patients and Methods: This case-control study was conducted among women with breast cancer recorded in the cancer registry system between 2004 and 2006 (n = 134), and their agematched healthy neighbors (n = 133). Data were statistically analyzed. Results: Age at marriage, menarche and pregnancy, breast feeding, positive family history, marital status, and educational level were not significantly correlated with risk of breast cancer, but age at menopause (< 46.6 years) was significantly correlated (95 confidence interval 1.15-7.37; p = 0.021). Live births, still births, and infant deaths were not significantly different between the 2 groups. For other variables, such as smoking history, no odds ratio was calculated. Conclusion: Results show that there is no significant correlation between variables and risk of breast cancer in our population, except for age at menopause. A large cohort study is recommended. © 2011 S. Karger GmbH, Freiburg

Breast cancer risk factors in women of Golestan Province in Iran: A case-control study

Introduction: Breast cancer is the most common cancer in women (not considering skin cancer). Its prevalence increases about 2% annually and its modifiable risk factors have been determined in various studies. The aim of this study was to evaluate the risk factors of breast cancer in women of Golestan province in Iran. Methods: In this case-control study all breast cancer cases recorded in cancer registry system of Golestan province during years 2004 and 2006 (case group) and their age-matched healthy neighbors (control group) were included (134 cases and 133 controls). Data was collected by interviews based on prepared questionnaire. Data Analysis was done with Chi-square and independent t-test by SPSS 13 software. Results: In cases who married before 19.29 years old, the risk of breast cancer was 0.76 folds, in menarche before 13.37 years old it was 1.3 folds, in women with menopausal age before 46.6 years old, it was 2.91-folds (p=0.021), in who become pregnant before 20.51 years old it was 0.87 folds, in cases who had breast feeding more than 64.35 months it was 0.73 folds, 1.33 folds in singles and in cases who educated under diploma it was 1.2 folds. In patients with a positive family history of breast cancer in grade one and two relatives, it was 0.53 and 0.67 folds, respectively. Conclusion: Results didn't show a significant relationship between variables and risk of breast cancer (except for menopausal age). Some large cohort studies are suggested in this field