295 research outputs found
Expectations in Film Relationships: The Suffocation Model in Motion Pictures
The suffocation model states that marriage expectations in American culture have changed across time (Finkel et al., 2014). To test whether or not the tenets of this model appear in popular media, we examined the representation of love, belonging, esteem, and self-actualization needs in romantic relationships of films from the companionate era (1850-1965) and the self-expressive era (1965-present). Participants (N = 56) rated need fulfillment and expectations within the main romantic relationship in an assigned film. The results suggest that the shift in needs posited by the suffocation model was reflected in high-grossing romance films from the past 100 years. Research limitations and future directions are discussed along with the implications for the bidirectional influence of culture and film
Coupled-channels analysis of the O+Pb fusion barrier distribution
Analyses using simplified coupled-channels models have been unable to
describe the shape of the previously measured fusion barrier distribution for
the doubly magic O+Pb system. This problem was investigated by
re-measuring the fission excitation function for O+Pb with
improved accuracy and performing more exact coupled-channels calculations,
avoiding the constant-coupling and first-order coupling approximations often
used in simplified analyses. Couplings to the single- and 2-phonon states of
Pb, correctly taking into account the excitation energy and the phonon
character of these states, particle transfers, and the effects of varying the
diffuseness of the nuclear potential, were all explored. However, in contrast
to other recent analyses of precise fusion data, no satisfactory simultaneous
description of the shape of the experimental barrier distribution and the
fusion cross-sections for O+Pb was obtained.Comment: RevTex, 29 pages, 7 postscript figures, to appear in PR
Radical nostalgia, progressive patriotism and Labour's 'English problem'
âProgressive patriotsâ have long argued that Englishness can form the basis of a transformative political project, whether based on an historic tradition of resistance to state power or an open and cosmopolitan identity. However, this article suggests that the politics of Englishness present a number of specific dilemmas for Labour. First the historical narrative of a radical tradition in British history is not straightforwardly English and cannot easily be used to support a competitive politics of nationhood, in the way that disaffected English identifiers might desire. Second, the deliberately alternative nature of this âradical nostalgicâ narrative makes it an unlikely basis for a unifying national story. It is also at odds with Labourâs status as a successful party of government, committed to using the power of the British state, rather than opposing it. Finally, while âeveryday Englishnessâ may well align with core Labour values and be less socially conservative, intolerant or racially exclusive than it is often described, its very nature as an everyday practice, rather than a political identity makes it difficult for Labour to co-opt
Identification and Evaluation of Epidemic Prediction and Forecasting Reporting Guidelines: A Systematic Review and a Call for Action
INTRODUCTION: High quality epidemic forecasting and prediction are critical to support response to local, regional and global infectious disease threats. Other fields of biomedical research use consensus reporting guidelines to ensure standardization and quality of research practice among researchers, and to provide a framework for end-users to interpret the validity of study results. The purpose of this study was to determine whether guidelines exist specifically for epidemic forecast and prediction publications.
METHODS: We undertook a formal systematic review to identify and evaluate any published infectious disease epidemic forecasting and prediction reporting guidelines. This review leveraged a team of 18 investigators from US Government and academic sectors.
RESULTS: A literature database search through May 26, 2019, identified 1467 publications (MEDLINE nâŻ=âŻ584, EMBASE nâŻ=âŻ883), and a grey-literature review identified a further 407 publications, yielding a total 1777 unique publications. A paired-reviewer system screened in 25 potentially eligible publications, of which two were ultimately deemed eligible. A qualitative review of these two published reporting guidelines indicated that neither were specific for epidemic forecasting and prediction, although they described reporting items which may be relevant to epidemic forecasting and prediction studies.
CONCLUSIONS: This systematic review confirms that no specific guidelines have been published to standardize the reporting of epidemic forecasting and prediction studies. These findings underscore the need to develop such reporting guidelines in order to improve the transparency, quality and implementation of epidemic forecasting and prediction research in operational public health
Risk, risk factors and surveillance of subsequent malignant neoplasms in childhood cancer survivors: a review
Subsequent malignant neoplasms (SMNs) in childhood cancer survivors cause substantial morbidity and mortality. This review summarizes recent literature on SMN epidemiology, risk factors, surveillance, and interventions. Childhood cancer survivors experience long-term increased SMN risk compared to the general population, with more than 2-fold increased solid tumor risk extending beyond age 40 years. There is a dose-dependent increased risk for solid tumors following radiotherapy, with the highest risks for tumors occurring in or near the treatment field (e.g., >5-fold increased risk for breast, brain, thyroid, skin, bone, and soft-tissue malignancies). Alkylating and anthracycline chemotherapy increase the risk of several solid malignancies in addition to acute leukemia/myelodysplasia and these risks may be modified by other patient characteristics, such as age at exposure and, potentially, inherited genetic susceptibility. Strategies for identifying survivors at risk and initiating long-term surveillance have improved and interventions are underway to improve knowledge about late-treatment effects among survivors and caregivers. Better understanding of treatment-related risk factors and genetic susceptibility holds promise for refining surveillance strategies, and ultimately upfront cancer therapies
Identification and evaluation of epidemic prediction and forecasting reporting guidelines : a systematic review and a call for action
NGR reports funding by NIGMS grant R35GM119582. BMA is supported by Bill and Melinda Gates Foundation through the Global Good Fund. SP and IMB were funded by the Armed Forces Health Surveillance Branch (GEIS: P0116_19_WR_03.11).Introduction: High quality epidemic forecasting and prediction are critical to support response to local, regional and global infectious disease threats. Other fields of biomedical research use consensus reporting guidelines to ensure standardization and quality of research practice among researchers, and to provide a framework for end-users to interpret the validity of study results. The purpose of this study was to determine whether guidelines exist specifically for epidemic forecast and prediction publications. Methods: We undertook a formal systematic review to identify and evaluate any published infectious disease epidemic forecasting and prediction reporting guidelines. This review leveraged a team of 18 investigators from US Government and academic sectors. Results: A literature database search through May 26, 2019, identified 1467 publications (MEDLINE nâŻ=âŻ584, EMBASE nâŻ=âŻ883), and a grey-literature review identified a further 407 publications, yielding a total 1777 unique publications. A paired-reviewer system screened in 25 potentially eligible publications, of which two were ultimately deemed eligible. A qualitative review of these two published reporting guidelines indicated that neither were specific for epidemic forecasting and prediction, although they described reporting items which may be relevant to epidemic forecasting and prediction studies. Conclusions: This systematic review confirms that no specific guidelines have been published to standardize the reporting of epidemic forecasting and prediction studies. These findings underscore the need to develop such reporting guidelines in order to improve the transparency, quality and implementation of epidemic forecasting and prediction research in operational public health.Publisher PDFPeer reviewe
Counter-Insurgency against âkith and kinâ?: the British Army in Northern Ireland, 1970â76
This article argues that state violence in Northern Ireland during the period 1970â1976âwhen violence during the Troubles was at its height and before the re-introduction of the policy of police primacy in 1976âwas on a greatly reduced scale from that seen in British counterinsurgency campaigns in the colonies after the Second World War. When the army attempted to introduce measures used in the coloniesâcurfews, internment without trialâthese proved to be extremely damaging to London's political aims in Northern Ireland, namely the conciliation of the Catholic minority within the United Kingdom and the defeat of the IRA. However, the insistence by William Whitelaw, secretary of state for Northern Ireland (1972â73), on âthrottling back'âthe release of internees and the imposition of unprecedented restrictions on the use of violence by the armyâput a serious strain on civil-military relations in Northern Ireland. The relatively stagnant nature of the conflictâwith units taking casualties in the same small âpatchâ of territory without opportunities for the types of âpositive actionsâ seen in the coloniesâled to some deviancy on the part of small infantry units who sought informal, unsanctioned ways of taking revenge upon the local population. Meanwhile, a disbelieving and defensive attitude at senior levels of command in Northern Ireland meant that informal punitive actions against the local population were often not properly investigated during 1970â72, until more thorough civilian and military investigative procedures were put in place. Finally, a separation of ethnic and cultural identity between the soldiers and the local populationâdespite their being citizens of the same stateâbecame professionally desirable in order for soldiers to carry out difficult, occasionally distasteful work
Author Correction: A consensus-based transparency checklist.
An amendment to this paper has been published and can be accessed via a link at the top of the paper
Quantum Tunneling in Nuclear Fusion
Recent theoretical advances in the study of heavy ion fusion reactions below
the Coulomb barrier are reviewed. Particular emphasis is given to new ways of
analyzing data, such as studying barrier distributions; new approaches to
channel coupling, such as the path integral and Green function formalisms; and
alternative methods to describe nuclear structure effects, such as those using
the Interacting Boson Model. The roles of nucleon transfer, asymmetry effects,
higher-order couplings, and shape-phase transitions are elucidated. The current
status of the fusion of unstable nuclei and very massive systems are briefly
discussed.Comment: To appear in the January 1998 issue of Reviews of Modern Physics. 13
Figures (postscript file for Figure 6 is not available; a hard copy can be
requested from the authors). Full text and figures are also available at
http://nucth.physics.wisc.edu/preprints
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Genomic Profiling of Childhood Tumor Patient-Derived Xenograft Models to Enable Rational Clinical Trial Design.
Accelerating cures for children with cancer remains an immediate challenge as a result of extensive oncogenic heterogeneity between and within histologies, distinct molecular mechanisms evolving between diagnosis and relapsed disease, and limited therapeutic options. To systematically prioritize and rationally test novel agents in preclinical murine models, researchers within the Pediatric Preclinical Testing Consortium are continuously developing patient-derived xenografts (PDXs)-many of which are refractory to current standard-of-care treatments-from high-risk childhood cancers. Here, we genomically characterize 261 PDX models from 37 unique pediatric cancers; demonstrate faithful recapitulation of histologies and subtypes; and refine our understanding of relapsed disease. In addition, we use expression signatures to classify tumors for TP53 and NF1 pathway inactivation. We anticipate that these data will serve as a resource for pediatric oncology drug development and will guide rational clinical trial design for children with cancer
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