294 research outputs found
State Casket Sales and Restrictions: A Pointless Undertaking?
We utilize a new micro dataset of prices of funeral goods and services at individual funeral homes, plus data from the Census to examine the effects of state regulations that restrict entry into funeral goods market. In particular, some states have regulations that allow only licensed funeral homes to sell caskets, while others allow unlicensed retailers, such as Costco, to compete with funeral homes in the sale of caskets. However, as caskets and funeral services are complements, generally purchased in one-to-one proportions, it is not a priori clear that casket sale restrictions can expand the rent extraction capabilities of licensed funeral homes. Our results suggest that when courts lift funeral goods sales restrictions the prices of funeral goods fall but the prices of funeral services rise by nearly as much. Overall, our results support the "one monopoly rent" hypothesis; we do not find that overall funeral home revenues decline when funeral goods sales are lifted.
Impaired self awareness after traumatic brain injury: inter-rater reliability and factor structure of the dysexecutive questionnairre (DEX) in patients, significant others and clinicians
Aims: This study sought to address two questions: (1) what is the inter-rater reliability
of the Dysexecutive Questionnaire (DEX) when completed by patients, their significant
others, and clinicians; and (2) does the factor structure of the DEX vary for these three
groups?
Methods: We obtained DEX ratings for 113 patients with an acquired brain injury from
two brain injury services in the UK and two services in Ireland. We gathered data from
two groups of raters—”significant others” (DEX-SO) such as partners and close family
members and “clinicians” (DEX-C), who were psychologists or rehabilitation physicians
working closely with the patient and who were able to provide an opinion about the
patient’s level of everyday executive functioning. Intra-class correlation coefficients and
their 95% confidence intervals were calculated between each of the three groups (self,
significant other, clinician). Principal axis factor (PAF) analyses were also conducted for
each of the three groups.
Results: The factor analysis revealed a consistent one-factor model for each of the
three groups of raters. However, the inter-rater reliability analyses showed a low level of
agreement between the self-ratings and the ratings of the two groups of independent
raters. We also found low agreement between the significant others and the clinicians.
Conclusion: Although there was a consistent finding of a single factor solution for each
of the three groups, the low level of agreement between significant others and clinicians
raises a question about the reliability of the DEX.</p
Impaired self awareness after traumatic brain injury: inter-rater reliability and factor structure of the dysexecutive questionnairre (DEX) in patients, significant others and clinicians
Aims: This study sought to address two questions: (1) what is the inter-rater reliability
of the Dysexecutive Questionnaire (DEX) when completed by patients, their significant
others, and clinicians; and (2) does the factor structure of the DEX vary for these three
groups?
Methods: We obtained DEX ratings for 113 patients with an acquired brain injury from
two brain injury services in the UK and two services in Ireland. We gathered data from
two groups of raters—”significant others” (DEX-SO) such as partners and close family
members and “clinicians” (DEX-C), who were psychologists or rehabilitation physicians
working closely with the patient and who were able to provide an opinion about the
patient’s level of everyday executive functioning. Intra-class correlation coefficients and
their 95% confidence intervals were calculated between each of the three groups (self,
significant other, clinician). Principal axis factor (PAF) analyses were also conducted for
each of the three groups.
Results: The factor analysis revealed a consistent one-factor model for each of the
three groups of raters. However, the inter-rater reliability analyses showed a low level of
agreement between the self-ratings and the ratings of the two groups of independent
raters. We also found low agreement between the significant others and the clinicians.
Conclusion: Although there was a consistent finding of a single factor solution for each
of the three groups, the low level of agreement between significant others and clinicians
raises a question about the reliability of the DEX.</p
Complex cytogenetic rearrangements at the DURS1 locus in syndromic Duane retraction syndrome
Key Clinical Message A patient with syndromic Duane retraction syndrome harbors a chromosome 811.1q13.2 inversion and 8p11.1-q12.3 marker chromosome containing subregions with differing mosaicism and allele frequencies. This case highlights the potential requirement for multiple genetic methods to gain insight into genotype–phenotype correlation, and ultimately into molecular mechanisms that underlie human disease
Diagnostic value of exome and whole genome sequencing in craniosynostosis
Background Craniosynostosis, the premature fusion of one or more cranial sutures, occurs in ~1 in 2250 births, either in isolation or as part of a syndrome. Mutations in at least 57 genes have been associated with craniosynostosis, but only a minority of these are included in routine laboratory genetic testing. Methods We used exome or whole genome sequencing to seek a genetic cause in a cohort of 40 subjects with craniosynostosis, selected by clinical or molecular geneticists as being high-priority cases, and in whom prior clinically driven genetic testing had been negative. Results We identified likely associated mutations in 15 patients (37.5%), involving 14 different genes. All genes were mutated in single families, except for IL11RA (two families). We classified the other positive diagnoses as follows: commonly mutated craniosynostosis genes with atypical presentation (EFNB1, TWIST1); other core craniosynostosis genes (CDC45, MSX2, ZIC1); genes for which mutations are only rarely associated with craniosynostosis (FBN1, HUWE1, KRAS, STAT3); and known disease genes for which a causal relationship with craniosynostosis is currently unknown (AHDC1, NTRK2). In two further families, likely novel disease genes are currently undergoing functional validation. In 5 of the 15 positive cases, the (previously unanticipated) molecular diagnosis had immediate, actionable consequences for either genetic or medical management (mutations in EFNB1, FBN1, KRAS, NTRK2, STAT3). Conclusions This substantial genetic heterogeneity, and the multiple actionable mutations identified, emphasises the benefits of exome/whole genome sequencing to identify causal mutations in craniosynostosis cases for which routine clinical testing has yielded negative results
Effects of protein–carbohydrate supplementation on immunity and resistance training outcomes: a double-blind, randomized, controlled clinical trial
Purpose:
To examine the impact of ingesting hydrolyzed beef protein, whey protein, and carbohydrate on resistance training outcomes, body composition, muscle thickness, blood indices of health and salivary human neutrophil peptides (HNP1-3), as reference of humoral immunity followed an 8-week resistance training program in college athletes.
Methods:
Twenty-seven recreationally physically active males and females (n = 9 per treatment) were randomly assigned to one of the three groups: hydrolyzed beef protein, whey protein, or non-protein isoenergetic carbohydrate. Treatment consisted of ingesting 20 g of supplement, mixed with orange juice, once a day immediately post-workout or before breakfast on non-training days. Measurements were performed pre- and post-intervention on total load (kg) lifted at the first and last workout, body composition (via plethysmography) vastus medialis thickness (mm) (via ultrasonography), and blood indices of health. Salivary HNP1-3 were determined before and after performing the first and last workout.
Results:
Salivary concentration and secretion rates of the HNP1-3 decreased in the beef condition only from pre-first-workout (1.90 ± 0.83 μg/mL; 2.95 ± 2.83 μg/min, respectively) to pre-last-workout (0.92 ± 0.63 μg/mL, p = 0.025, d = 1.03; 0.76 ± 0.74 μg/min, p = 0.049, d = 0.95), and post-last-workout (0.95 ± 0.60 μg/mL, p = 0.032, d = 1.00; 0.59 ± 0.52 μg/min, p = 0.027, d = 1.02). No other significant differences between groups were observed.
Conclusions:
Supplementation with a carbohydrate–protein beverage may support resistance training outcomes in a comparable way as the ingestion of only carbohydrate. Furthermore, the ingestion of 20 g of hydrolyzed beef protein resulted in a decreased level and secretion rates of the HNP1-3 from baseline with no negative effect on blood indices of health
Advances and unmet needs in genetic, basic and clinical science in Alport syndrome::report from the 2015 International Workshop on Alport Syndrome
Alport syndrome (AS) is a genetic disease characterized by haematuric glomerulopathy variably associated with hearing loss and anterior lenticonus. It is caused by mutations in the COL4A3, COL4A4 or COL4A5 genes encoding the α3α4α5(IV) collagen heterotrimer. AS is rare, but it accounts for >1% of patients receiving renal replacement therapy. Angiotensin-converting enzyme inhibition slows, but does not stop, the progression to renal failure; therefore, there is an urgent requirement to expand and intensify research towards discovering new therapeutic targets and new therapies. The 2015 International Workshop on Alport Syndrome targeted unmet needs in basic science, genetics and diagnosis, clinical research and current clinical care. In three intensive days, more than 100 international experts including physicians, geneticists, researchers from academia and industry, and patient representatives from all over the world participated in panel discussions and breakout groups. This report summarizes the most important priority areas including (i) understanding the crucial role of podocyte protection and regeneration, (ii) targeting mutations by new molecular techniques for new animal models and potential gene therapy, (iii) creating optimal interaction between nephrologists and geneticists for early diagnosis, (iv) establishing standards for mutation screening and databases, (v) improving widespread accessibility to current standards of clinical care, (vi) improving collaboration with the pharmaceutical/biotech industry to investigate new therapies, (vii) research in hearing loss as a huge unmet need in Alport patients and (viii) the need to evaluate the risk and benefit of novel (including 'repurposing') therapies on an international basis
The U.S. Environmental Protection Agency Particulate Matter Health Effects Research Centers Program: a midcourse report of status, progress, and plans.
In 1998 Congress mandated expanded U.S. Environmental Protection Agency (U.S. EPA) health effects research on ambient air particulate matter (PM) and a National Research Council (NRC) committee to provide research oversight. The U.S. EPA currently supports intramural and extramural PM research, including five academically based PM centers. The PM centers in their first 2.5 years have initiated research directed at critical issues identified by the NRC committee, including collaborative activities, and sponsored scientific workshops in key research areas. Through these activities, there is a better understanding of PM health effects and scientific uncertainties. Future PM centers research will focus on long-term effects associated with chronic PM exposures. This report provides a synopsis of accomplishments to date, short-term goals (during the next 2.5 years) and longer-term goals. It consists of six sections: biological mechanisms, acute effects, chronic effects, dosimetry, exposure assessment, and the specific attributes of a coordinated PM centers program
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