Mobility Management in beyond 3G-Environments

Beyond 3G-environments are typically defined as environments that integrate different wireless and fixed access network technologies. In this paper, we address IP based Mobility Management (MM) in beyond 3G-environments with a focus on wireless access networks, motivated by the current trend of WiFi, GPRS, and UMTS networks. The GPRS and UMTS networks provide countrywide network access, while the WiFi networks provide network access in local areas such as city centres and airports. As a result, mobile end-users can be always on-line and connected to their preferred network(s), these network preferences are typically stored in a user profile. For example, an end-user who wishes to be connected with highest bandwidth could be connected to a WiFi network when available and fall back to GPRS when moving outside the hotspot area.\ud In this paper, we consider a combination of MM for legacy services (like web browsing, telnet, etc.) using Mobile IP and multimedia services using SIP. We assume that the end-user makes use of multi-interface terminals with the capability of selecting one or more types of access networks\ud based on preferences. For multimedia sessions, like VoIP or streaming video, we distinguish between changes in network access when the end-user is in a session or not in a session. If the end-user is not in a session, he or she needs to be able to start new sessions and receive invitations for new sessions. If the end-user is in a session, the session needs to be handed over to the new access network as seamless as possible from the perspective of the end-user. We propose an integrated but flexible solution to these problems that facilitates MM with a customizable transparency to applications and end-users

Reducing handover latency in future IP-based wireless networks:Fast Proxy Mobile IPv6

Current IP-level mobility protocols have difficulties meeting the stringent handover delay requirements of future wireless networks. At the same time they do not give sufficient control to the network to control the handover process. This paper presents an extension to Proxy Mobile IP, which is the favorite IP level mobility protocol for the 3GPP System Architecture Evolution / Long Term Evolution (SAE/LTE). The extension, Fast Proxy Mobile IPv6 (FPMIPv6), aims at solving or reducing the control and handover problem. An elementary analysis shows that FPMIPv6 can significantly reduce the handover latency and the loss of packets during handover, especially if handovers can be predicted a few tens of milliseconds before they occur

Negative Correlation Between Economic Structure of Rentier State and Non-Democratization (Case Study: Saudi Arabia)

The Saudi Arabia having patrimonial government politically system and unique nature of power structure that all political affairs set in Ale Saudi dynasty. Government system is traditional and dependent to person and persons of dynasty are absolute rulers and away from criticism and ruler willing prefer to law. Despite of authoritarian and monarchy system and non-democracy development in Saudi Arabia special now that kind of government system isn’t acceptable side of dominant discourse of global community, this country could rely on oil produce regarding to rentier state features have active representation in international communities and too in home sue achievement to legitimacy and vindication. the interests of state-building and to reinforce its legitimacy, which is hardly the act of a state free of interests. Saudi Arabia is also an archetypal example of a state that still faces influence from actors within the state and elite structures, i.e. princes, senior officials, and clerics, among others. In this article analysis rentier state effect on non-democracy development in case study of the Saudi Arabia and research claim is that in nature of relations between rentier state and non-democracy development exist negative correlation. Namely whatever government income dependent to oil export and state economic nature has been independent from peoples, will be decrease from democratic charge in political dimension. This country by oil produce and effect to world powers economies cause that be complex government structure under monarchy system and use endowment of oil rent. Now observe modern dictatorship that despite of economic and social reforms side if internal, regional and international pressures in general dimension of society, will be non-democratic politically structure

Multiorgan failure after sickle cell vaso occlusive attack: integrated clinical and biological emergency

We describe the case of a 30-year-old patient, suffering from composite S/beta + sickle cell disease. He was hospitalized following a vaso-occlusive attack with acute bone pains. Despite an analgesic treatment and transfusion of three units of red blood cells, a non-regenerative anemia appeared within 24 hours. One day later an acute chest syndrome with atelectasis of the left lung and desaturation and multi-organ failure occurred and necessitated the patient\u27s intubation and required him to be placed in an artificial coma. A bronchoalveolar lavage was performed, which eliminated pneumonia but proved, after staining with oil red O, many neutral fatty acid microvacuoles in more than 80% of macrophages, suggesting a pulmonary fat embolism. The hypothesis of a bone marrow necrosis causing a pulmonary fat embolism was discussed and confirmed the next day by the characteristic appearance of the bone marrow. A therapeutic protocol associating iteratively bleeding and red blood cells transfusion was administered on the second day with the objective of maintaining haemoglobin S at less than 20% rate. Successive haemoglobin S assay was applied using a high performance liquid chromatography (HPLC) technique with a quick response within one hour after transfusion or bleeding. This protocol resulted in an improvement in the patient\u27s condition, with a gradual normalization of vital signs and extubation twelve days later and discharge without sequelae twenty-five days later. The succession of rare but serious sickle cell complications anaemia which occurred in this patient could be controlled by adapting the laboratory for the clinical emergency

Comparative study between breast conservative surgery and modified radical mastectomy in early stage of breast carcinoma in a tertiary care hospital

Background: Breast cancer is the most prevalent cancer in women globally, with two million new cases and more than half a million deaths each year. Surgery is the key component of treating breast cancer and there are two primary types of breast surgery available: breast conservative surgery and modified radical mastectomy. The aim of this study was to compare BCS and MRM in the treatment of early-stage breast carcinoma. Methods: This was a prospective observational study that involved 74 patients and was carried out in the Department of Surgery at Shaheed Suhrawardy Medical College & Hospital and Enam Medical College & Hospital with an 18-months minimum follow-up. The time frame for inclusion was from July 2018 through July 2020. There were two patient groups, 37 patients in Group A who underwent breast conservative surgery and Group B was made up of 37 individuals who had MRM for early-stage breast carcinoma. Results: With a mean age of 47.65 years in the BCS group and 48.19 years in the MRM group, the operative time for BCS was 1.04±0.25 hours, whereas 3.20±0.48 hours for MRM. Statistically significant higher amount of post-operative drainage volume in MRM group compared to BCS group (p value=0.000). With an excellent aesthetic outcome rate in BCS group (p value<0.0001) as well as better quality of life than MRM group. Conclusions: Breast conservative surgery and modified radical mastectomy are both oncologically safe treatments for early-stage breast cancer with multidisciplinary approach. BCS offers less trauma, infection and hospital stay; better aesthetic outcome and quality of life than MRM, making it more deserving of being promoted clinically in the treatment of early-stage breast cancer

Structured illumination with thermal imaging (SI-TI): A dynamically reconfigurable metrology for parallelized thermal transport characterization

The recent push for the "materials by design"paradigm requires synergistic integration of scalable computation, synthesis, and characterization. Among these, techniques for efficient measurement of thermal transport can be a bottleneck limiting the experimental database size, especially for diverse materials with a range of roughness, porosity, and anisotropy. Traditional contact thermal measurements have challenges with throughput and the lack of spatially resolvable property mapping, while non-contact pump-probe laser methods generally need mirror smooth sample surfaces and also require serial raster scanning to achieve property mapping. Here, we present structured illumination with thermal imaging (SI-TI), a new thermal characterization tool based on parallelized all-optical heating and thermometry. Experiments on representative dense and porous bulk materials as well as a 3D printed thermoelectric thick film (∼50 μm) demonstrate that SI-TI (1) enables paralleled measurement of multiple regions and samples without raster scanning; (2) can dynamically adjust the heating pattern purely in software, to optimize the measurement sensitivity in different directions for anisotropic materials; and (3) can tolerate rough (∼3 μm) and scratched sample surfaces. This work highlights a new avenue in adaptivity and throughput for thermal characterization of diverse materials

Gonad maturation and spawning of cobra, Rachycentron canadum (Linnaeus, 1766) off the Dungun coast, Malaysia

The reproductive biology of cobia, Rachycentron canadum, from the coastal waters of Dungun, Malaysia was studied from June 2014 to May 2015. From commercial trawls, a total of 201 samples (combined sexes) were collected (fork lengths [FL] 37.5–124.0 cm; body weights 0.5–20.4 g). The overall sex ratio of females to males was 1:0.9, which was not significantly different (χ2 = 2.12, df = 1; p < .05). Estimations of length at 50% maturity (L50) showed that both sexes matured at approximately 75 cm FL; estimated spawning frequency was 6 days. Mean batch fecundity (BF) ranged from 0.55 to 4.32 million eggs. The average number of eggs per gram of ovary was from 2,100 to 5,400 eggs, and relative fecundity 147 eggs/g. There was a weak positive correlation (r2 = .48) between BF and female FL as well as BF with an ovary‐free body weight (r2 = .56), possibly due to females being in a continuous spawning condition and some possibly half‐spent, based on the histological examination of the female gonads. Despite cobia being asynchronous spawners, the gonadosomatic index in both males and females showed peaks in June, November, and particularly March. Based on histological examination, spawning‐capable males were encountered throughout the study period, whereas spawning‐capable females in the late developing subphase were found mostly in March and April. This is the first study on the reproductive aspects of cobia in Malaysian waters

Potentially harmful effects of inspiratory synchronization during pressure preset ventilation

Purpose: Pressure preset ventilation (PPV) modes with set inspiratory time can be classified according to their ability to synchronize pressure delivery with patient's inspiratory efforts (i-synchronization). Non-i-synchronized (like airway pressure release ventilation, APRV), partially i-synchronized (like biphasic airway pressure), and fully i-synchronized modes (like assist-pressure control) can be distinguished. Under identical ventilatory settings across PPV modes, the degree of i-synchronization may affect tidal volume (V T), transpulmonary pressure (P TP), and their variability. We performed bench and clinical studies. Methods: In the bench study, all the PPV modes of five ventilators were tested with an active lung simulator. Spontaneous efforts of −10cmH2O at rates of 20 and 30breaths/min were simulated. Ventilator settings were high pressure 30cmH2O, positive end-expiratory pressure (PEEP) 15cmH2O, frequency 15breaths/min, and inspiratory to expiratory ratios (I:E) 1:3 and 3:1. In the clinical studies, data from eight intubated patients suffering from acute respiratory distress syndrome (ARDS) and ventilated with APRV were compared to the bench tests. In four additional ARDS patients, each of the PPV modes was compared. Results: As the degree of i-synchronization among the different PPV modes increased, mean V T and P TP swings markedly increased while breathing variability decreased. This was consistent with clinical comparison in four ARDS patients. Observational results in eight ARDS patients show low V T and a high variability with APRV. Conclusion: Despite identical ventilator settings, the different PPV modes lead to substantial differences in V T, P TP, and breathing variability in the presence spontaneous efforts. Clinicians should be aware of the possible harmful effects of i-synchronization especially when high V T is undesirabl

Detrimental hemodynamic and inflammatory effects of microparticles originating from septic rats

Objective: Microparticles (MPs) are membrane vesicles with procoagulant and proinflammatory properties released during cell activation and might be potentially involved in the pathophysiology of septic shock. This study was designed to assess the effects of MPs from septic origin on the systemic hemodynamics as well as on the inflammatory, oxidative, and nitrosative stresses.Design: A prospective, randomized, controlled experimental study with repeated measurements. Setting: Investigational animal laboratory. Subjects: Forty healthy rats were randomly allocated to three groups: 10 animals inoculated with MPs isolated from control rats (cMPs), 15 animals inoculated with MPs isolated from sham rats (shMPs), and 15 animals inoculated with MPs isolated from rats with peritonitis (sMPs). Interventions: Rats were anesthetized, mechanically ventilated, and infused with the same amount of cMPs, shMPs, or sMPs. We measured the heart rate, mean arterial pressure, carotid artery, and portal vein blood flows. Hemodynamic parameters were recorded during 7 hours, and then animals were killed. Aorta and heart were harvested for further in vitro tissue analyses. Measurements and Main Results: 1) The cellular origin (phenotype) but not the circulating concentration of MPs was different in septic rats, characterized by a significant increase in leukocyte-derived MPs. 2) sMPs but not cMPs or shMPs decreased mean arterial pressure without any effect on carotid artery and portal vein blood flows. 3) Rats inoculated with sMPs exhibited an increase in superoxide ion production and nuclear factor kappa B activity, overexpression of inducible nitric oxide synthase with subsequent nitric oxide overproduction and decrease in endothelial nitric oxide synthase activation. Conclusions: Rats with sepsis induced by peritonitis exhibited a specific phenotype of MPs. Inoculation of sMPs in healthy rats reproduced hemodynamic, septic inflammatory patterns, associated with oxidative and nitrosative stresses