1,617 research outputs found
Recycling of carbon fibre composites
A clear case for carbon fibre recovery and reuse exists on environmental grounds due to the high cost and energy use of virgin fibre production. On a specific energy basis, carbon fibres can be recovered at around 10% of the energy required to manufacture virgin fibres but the scale of the recovery process can make a large difference to overall cost effectiveness. This study will describe the technical and economic challenges associated with the recycling of carbon fibres, the state of the art in recycling technologies and the re-use of fibres in high performance composites
Involution of the mouse mammary gland is associated with an immune cascade and an acute-phase response, involving LBP, CD14 and STAT3
INTRODUCTION:
Involution of the mammary gland is a complex process of controlled apoptosis and tissue remodelling. The aim of the project was to identify genes that are specifically involved in this process.
METHODS:
We used Affymetrix oligonucleotide microarrays to perform a detailed transcript analysis on the mechanism of controlled involution after withdrawal of the pups at day seven of lactation. Some of the results were confirmed by semi-quantitative reverse transcriptase polymerase chain reaction, Western blotting or immunohistochemistry.
RESULTS:
We identified 145 genes that were specifically upregulated during the first 4 days of involution; of these, 49 encoded immunoglobulin genes. A further 12 genes, including those encoding the signal transducer and activator of transcription 3 (STAT3), the lipopolysaccharide receptor (CD14) and lipopolysaccharide-binding protein (LBP), were involved in the acute-phase response, demonstrating that the expression of acute-phase response genes can occur in the mammary gland itself and not only in the liver. Expression of LBP and CD14 was upregulated, at both the RNA and protein level, immediately after pup withdrawal; CD14 was strongly expressed in the luminal epithelial cells. Other genes identified suggested neutrophil activation early in involution, followed by macrophage activation late in the process. Immunohistochemistry and histological staining confirmed the infiltration of the involuting mammary tissue with neutrophils, plasma cells, macrophages and eosinophils.
CONCLUSION:
Oligonucleotide microarrays are a useful tool for identifying genes that are involved in the complex developmental process of mammary gland involution. The genes identified are consistent with an immune cascade, with an early acute-phase response that occurs in the mammary gland itself and resembles a wound healing process
Quantum Monte Carlo Calculations of Pion Scattering from Li
We show that the neutron and proton transition densities predicted by recent
quantum Monte Carlo calculations for A=6,7 nuclei are consistent with pion
scattering from 6Li and 7Li at energies near the Delta resonance. This has
provided a microscopic understanding of the enhancement factors for quadrople
excitations, which were needed to describe pion inelastic scattering within the
nuclear shell model of Cohen and Kurath.Comment: 10 pages, REVTeX, 3 postscript figures; added calculation of elastic
and inelastic pion scattering from 6Li at multiple energie
Randomised controlled trial and economic evaluation of a chest pain observation unit compared with routine care
Objectives To measure the effectiveness and cost effectiveness
of providing care in a chest pain observation unit compared
with routine care for patients with acute, undifferentiated chest
pain.
Design Cluster randomised controlled trial, with 442 days
randomised to the chest pain observation unit or routine care,
and cost effectiveness analysis from a health service costing
perspective.
Setting The emergency department at the Northern General
Hospital, Sheffield, United Kingdom.
Participants 972 patients with acute, undifferentiated chest
pain (479 attending on days when care was delivered in the
chest pain observation unit, 493 on days of routine care)
followed up until six months after initial attendance.
Main outcome measures The proportion of participants
admitted to hospital, the proportion with acute coronary
syndrome sent home inappropriately, major adverse cardiac
events over six months, health utility, hospital reattendance and
readmission, and costs per patient to the health service.
Results Use of a chest pain observation unit reduced the
proportion of patients admitted from 54% to 37% (difference
17%, odds ratio 0.50, 95% confidence interval 0.39 to 0.65,
P < 0.001) and the proportion discharged with acute coronary
syndrome from 14% to 6% (8%, –7% to 23%, P = 0.264). Rates
of cardiac event were unchanged. Care in the chest pain
observation unit was associated with improved health utility
during follow up (0.0137 quality adjusted life years gained, 95%
confidence interval 0.0030 to 0.0254, P = 0.022) and a saving of
£78 per patient (–£56 to £210, P = 0.252).
Conclusions Care in a chest pain observation unit can improve
outcomes and may reduce costs to the health service. It seems
to be more effective and more cost effective than routine care
Complex functional surface design for additive manufacturing
This paper presents a new methodology for the creation of advanced surfaces which can be produced by Additive Manufacturing (AM) methods. Since there is no cost for enhanced complexity, AM allows for new capabilities in surface design. Micro-scale surface features with varying size, shape and pitch can be manufactured by Two-Photon Polymerisation (2PP). Computer-Aided Design (CAD) tools allowing for this variation to be incorporated into the surface design are only just emerging. With the presented methodology, surfaces are created from a single feature design. Variation is applied to the surface features through algorithmic design tools, allowing for arrays of hundreds of unique features can be created by non-CAD experts. The translation of these algorithmic expressions from CAD to a physical surface is investigated. Using the proposed methodology, 2PP is used to create quasi stochastic surfaces for the purpose of enhancing the biointegration of medical implants against current state-of-the-art
Lubricant base stock-surface interaction
Superior performance is by far the most desirable aspect of any Spark Ignition (SI) engine that is designed for competition use. This is closely followed by a predictable life expectancy of the unit. A major aspect that can seriously affect both performance and longevity of the unit are the frictional losses and wear of the reciprocating components within the engine. One of the major areas where frictional losses and excessive wear that can reduce performance at an alarming rate is the first compression ring/cylinder liner interface. This investigation uses lateral force microscopy to determine the congruity of matching individual base stock components to liner material/substrate combinations
Ecosystem Controls on C & N Sequestration Following Afforestation of Agricultural Lands
In our project, we proposed to continue analysis of our available soil samples and data, and to develop new studies to answer the following objectives: Objective 1) Broaden field based studies of ecosystem C and N compartments to enhance current understanding of C and N sequestration and dynamics. Objective 2) Improve our understanding of mechanism controlling C and N stabilization and dynamics. Objective 3) Investigate the interrelated role of soil temperature and organism type and activity as controlling mechanism in SOC dynamics and sequestration
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Ecosystem Controls on C & N Sequestration Following Afforestation of Agricultural Lands
In our project, we proposed to continue analysis of our available soil samples and data, and to develop new studies to answer the following objectives: Objective 1) Broaden field based studies of ecosystem C and N compartments to enhance current understanding of C and N sequestration and dynamics. Objective 2) Improve our understanding of mechanism controlling C and N stabilization and dynamics. Objective 3) Investigate the interrelated role of soil temperature and organism type and activity as controlling mechanism in SOC dynamics and sequestration
Proximal magnetometry of monolayers of magnetic moments
We present a method to measure the magnetic properties of monolayers and
ultra-thin films of magnetic material. The method is based on low energy muon
spin rotation and -detected nuclear magnetic resonance measurements. A
spin probe is used as a "proximal" magnetometer by implanting it in the
substrate, just below the magnetic material. We calculate the expected magnetic
field distribution sensed by the probe and discuss its temperature and
implantation depth dependencies. This method is highly suitable for measuring
the magnetic properties of monolayers of single molecule magnets, but can also
be extended to ultra-thin magnetic films.Comment: To be published in the proceedings of 12th International Conference
on Muon Spin Rotation, Relaxation and Resonanc
A single model of traversable wormholes supported by generalized phantom energy or Chaplygin gas
This paper discusses a new variable equation of state parameter leading to
exact solutions of the Einstein field equations describing traversable
wormholes. In addition to generalizing the notion of phantom energy, the
equation of state generates a mathematical model that combines the generalized
phantom energy and the generalized Chaplygin gas models.Comment: 6 pages, no figure
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