19 research outputs found
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Proton - Nucleus Interactions at 200-GeV/c
The investigation of interactions of hadrons with the nucleus in recent time became very important, and there is a hope that it can give the information about the systems produced in this process (lifetime, cross sections etc.) The nuclear photoemulsions are a good detector at the investigation of hadron-nucleus interactions due to a high spatial resolution and a possibility of detection of particles nearly at all energies that enables to study the characteristics of both fast and slow particles. The consistence of emulsion enables to obtain the characteristics of interactions both on light (CNO, <A> = 14) and on heavy(Ag,Br,<A> = 94) nuclei
Comparative analysis of perioperative period in children with different corrections of vesicoureteral reflux
The article presents the analysis of perioperative period of 52 children with different variants of correction of vesicoureteral reflux. It was based on acute-phase proteins amount, cytokines level and adhesion molecules content in blood and urine. the study revealed that if the correction is performed during the latent phase of chronic obstructive pyelonephritis the preference should be given to the endoscopic operations as they do not lead to acute inflammatory process in the urinary trac
ΠΠ΅ΡΠ΅Π½Π½ΡΠ΅ ΡΠ΅Ρ Π½Π΅ΡΠΈΠ΅ΠΌ-99m Π½ΠΈΠ·ΠΊΠΎΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΠ΅ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΡΡ ΠΏΡΠΎΡΡΠ°Ρ-ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Π½ΠΎΠ³ΠΎ Π°Π½ΡΠΈΠ³Π΅Π½Π°
High morbidity and mortality rates of prostate cancer (PCa) determine the requirement of looking for new methods of its early diagnosis. Methods of nuclear medicine have a special place in addressing this problem as they allow functional, metabolic and other processes imaging in body, which occur during the cancer development. This approach supposes the use of radiopharmaceuticals (RP), which are capable of selective binding to a specific biological target, for example, prostate-specific membrane antigen (PSMA), which is known to be overexpressed in PCa. Current development of new radiotracers for PCa imaging is focused on low molecular weight PSMA inhibitors due to their high specific binding to PSMA and rapid urinary excretion. Technetium-99m remains the appropriate radionuclide for diagnostic studies due to its optimal nuclear properties, ease of production and versatile coordination chemistry. Therefore, single-photon emission computed tomography (SPECT) imaging with 99mTc-PSMA radioligands can be a cost effective alternative to PET with 68Ga- or 18F-labeled RP. The aim of this review is to summarize and analyze currently available data on 99mTc-labeled low molecular weight PSMA inhibitors for metastatic PCa imaging.ΠΡΠΎΠ±ΠΎΠ΅ ΠΌΠ΅ΡΡΠΎ Π² ΡΠ°Π½Π½Π΅ΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ΅ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π΅ΠΌΠΎΡΡΠΈ ΡΠ°ΠΊΠΎΠΌ ΠΏΡΠ΅Π΄ΡΡΠ°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ (Π ΠΠ) Π·Π°Π½ΠΈΠΌΠ°ΡΡ ΠΌΠ΅ΡΠΎΠ΄Ρ ΡΠ΄Π΅ΡΠ½ΠΎΠΉ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½Ρ, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡ Π²ΠΈΠ·ΡΠ°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°ΡΡ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΠ΅, ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈ ΠΈΠ½ΡΠ΅ ΠΏΡΠΎΡΠ΅ΡΡΡ Π² ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ΅, Π²ΠΎΠ·Π½ΠΈΠΊΠ°ΡΡΠΈΠ΅ ΠΏΡΠΈ Π½Π°Π»ΠΈΡΠΈΠΈ ΠΎΠ½ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ°. ΠΠ»Π°Π³ΠΎΠ΄Π°ΡΡ Π²ΡΡΠΎΠΊΠΎΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΠΎΠΌΡ ΡΠ²ΡΠ·ΡΠ²Π°Π½ΠΈΡ Ρ ΠΏΡΠΎΡΡΠ°Ρ-ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Π½ΡΠΌ Π°Π½ΡΠΈΠ³Π΅Π½ΠΎΠΌ (ΠΠ‘ΠΠ) ΠΈ Π±ΡΡΡΡΠΎΠΌΡ Π²ΡΠ²Π΅Π΄Π΅Π½ΠΈΡ ΠΈΠ· ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ° Ρ ΠΌΠΎΡΠΎΠΉ ΠΈΠΌΠ΅Π½Π½ΠΎ Π½ΠΈΠ·ΠΊΠΎΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΠ΅ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΡΡ ΠΠ‘ΠΠ Π΄ΠΎΠΌΠΈΠ½ΠΈΡΡΡΡ ΠΏΡΠΈ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ΅ Π½ΠΎΠ²ΡΡ
ΡΠ°Π΄ΠΈΠΎΠΈΠ½Π΄ΠΈΠΊΠ°ΡΠΎΡΠΎΠ² Π΄Π»Ρ Π²ΠΈΠ·ΡΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ Π ΠΠ. Π’Π΅Ρ
Π½Π΅ΡΠΈΠΉ-99m ΠΎΡΡΠ°Π΅ΡΡΡ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ΡΡΠΈΠΌ ΡΠ°Π΄ΠΈΠΎΠ½ΡΠΊΠ»ΠΈΠ΄ΠΎΠΌ Π΄Π»Ρ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π±Π»Π°Π³ΠΎΠ΄Π°ΡΡ ΡΠ²ΠΎΠΈΠΌ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΡΠΌ ΡΠΈΠ·ΠΈΠΊΠΎ-Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠΌ ΡΠ²ΠΎΠΉΡΡΠ²Π°ΠΌ ΠΈ ΡΠ΄ΠΎΠ±ΡΡΠ²Ρ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ. Π ΡΠ²ΡΠ·ΠΈ Ρ ΡΡΠΈΠΌ ΠΎΠ΄Π½ΠΎΡΠΎΡΠΎΠ½Π½Π°Ρ ΡΠΌΠΈΡΡΠΈΠΎΠ½Π½Π°Ρ ΠΊΠΎΠΌΠΏΡΡΡΠ΅ΡΠ½Π°Ρ ΡΠΎΠΌΠΎΠ³ΡΠ°ΡΠΈΡ (ΠΠ€ΠΠΠ’) Ρ ΡΠ°Π΄ΠΈΠΎΠ»ΠΈΠ³Π°Π½Π΄Π°ΠΌΠΈ ΠΊ ΠΠ‘ΠΠ, ΠΌΠ΅ΡΠ΅Π½Π½ΡΠΌΠΈ 99mTc, ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΈ Π²ΡΠ³ΠΎΠ΄Π½ΠΎΠΉ Π°Π»ΡΡΠ΅ΡΠ½Π°ΡΠΈΠ²ΠΎΠΉ ΠΠΠ’ Ρ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ°ΠΌΠΈ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ 68Ga ΠΈΠ»ΠΈ 18F. Π¦Π΅Π»Ρ Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΠΎΠ±Π·ΠΎΡΠ° ΠΎΠ±ΠΎΠ±ΡΠΈΡΡ ΠΈ ΠΏΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°ΡΡ ΠΈΠΌΠ΅ΡΡΠΈΠ΅ΡΡ Π½Π° ΡΠ΅Π³ΠΎΠ΄Π½ΡΡΠ½ΠΈΠΉ Π΄Π΅Π½Ρ Π΄Π°Π½Π½ΡΠ΅ ΠΎ ΠΌΠ΅ΡΠ΅Π½Π½ΡΡ
99mTc Π½ΠΈΠ·ΠΊΠΎΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΡ
ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΡΠ°Ρ
ΠΠ‘ΠΠ, ΠΏΡΠ΅Π΄Π½Π°Π·Π½Π°ΡΠ΅Π½Π½ΡΡ
Π΄Π»Ρ Π²ΠΈΠ·ΡΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΠΌΠ΅ΡΠ°ΡΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π ΠΠ
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Coherent Production of Charged Particles on Nuclei by 400-GeV/c Protons
Topological cross sections {delta}{sub coh}{sup (n)} (n = 1,3,5 and 7) of coherent diffractive dissociation of 400 Gev/c protons on nuclei of photoemulsion elements have been measured. Topological cross sections increase in the energy range from 20 to 400 Gev/c. This growth is the most noticeable for multiprong topologies. The total cross section of diffractive coherent production also increases from 8 to 25 mb/nucleus in this energy range. The increasing of the average multiplicity of charged particles in reaction of coherent proton dissociates is consistent with the logarithmic law <n>{sub coh} = (90.25 {+-} 0.05) inp. + (1.3 {+-} 0.25)
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Multiplicity of Charged Secondaries in Interactions of Protons in an Emulsion at 400-GeV/c
The preliminary results on multiplicities of charged secondaries in proton-nucleus interactions at 400 Gev/c are presented. Multiplicity of produced particles is consistent in the first approximation with the KNO scaling hypothesis for hadron-nucleus interactions. The relations between different moments of multiplicity distribution in proton-nucleons interactions at high energies are discussed too
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The Multiplicity in Fragmentation and Pionisation Regions in p p Interactions at 200-GeV/c
Two BR-2 emulsion stacks 20cm x 10cm x 100 x 0,06 cm in size were irradiated by 200 Gev/c protons at the NAL accelerator in Batavia (US). The scanning along the track was performed. They observed 9339 inelastic interactions on the track length of 3303 m of primary protons