矩形板の幾何学的非線形挙動解析

本論文は､矩形版の幾何学的非線形問過のための-離散化数値解析法について述べものである｡有限変形を考慮した矩形板の変位-ひずみ関係により､矩形板の非線形挙動を支配する増分形の基礎微分方程式を導き､その基礎微分方程式に基づく､直接的で半解析的な､矩形板の非線形問題の一解析法を韻示した.本法により､任意の荷重条件および境界条件の下での､矩形板の幾何学的非線形曲げ問題､後座屈問題を解析した

異方性直角三角形板の自由振動問題の一解析法

An approximate method is used for analyzing the free vibration problem of isotropic and anisotropic right triangular plates with various aspect-ratios and variable thickness.In this paper, a right triangular plate is considered as a kind of equivalent rectangular plate with point supports. Therefore, the free vibration characteristics of any triangular plate can be obtained by analyzing the equivalent rectangular plate. The differential equations of the equivalent rectangular plate with point supports are established based on the first-order shear deformation theory. By transforming the differential equations into integral equations and using numerical integration, the solutions of the partial differential equation can be obtained in discrete form. The Green function, which is the discrete solution for the deflection, is introduced to obtain the characteristic equation of the free vibration. Frequencies and mode shapes are shown for some triangular plates with various aspect-ratio and variable thickness. The effects of boundary conditions and the fibre orientation on the frequency parameters are considered. The efficiency and accuracy of the numerical solutions by the present method are investigated

An analysis of bending problem of laminated rectangular and triangular plates

An approximate method is proposed for analyzing the bending problem of laminated rectangular and triangular plates. An equivalent rectangular plate is used to analyze the bending problem of triangular plates. Based on the first-order shear-deformation theory, the partial differential equations have been established. By making use of numerical integration, the solutions for these equations can be obtained in discrete forms. Numerical results are obtained for some laminated rectangular and triangular plates. The efficiency and accuracy of the numerical solutions by the proposed method are investigated

Free vibration analysis of cross-ply symmetrically laminated right cantilever triangular plates

An approximate method is proposed for analyzing the free vibration problem of cross-ply symmetrically laminated cantilever triangular plates. By adding an extremely thin part, a right triangular plate is translated into an equivalent rectangular plate with non-uniform thickness. Discrete solutions for the deflection of the equivalent plate are obtained and used as Green function. By using the Green function, the characteristic equation of the free vibration can be derived. Frequencies and mode shapes are shown for some laminated cantilever right triangular plates with various aspect-ratios. The efficiency and accuracy of the numerical solutions by the proposed method are investigated

認知症高齢者グループホームにおけるサブ共用空間の計画に関する研究

Residents in the "group homes" for the elderly people with dementia spend a lot of time in the common activity areas. It is well recognized that these common spaces are playing important roles in the group home life. Besides the legally required common areas such as dining rooms and living rooms, some group homes have additional sub-common activity areas. At three group homes in Hokkaido, we have conducted the time study on daily activities of the residents (where and what the residents are doing), employing the behavior observation method as well as the interviews with the care staff. Purpose of this study is to clarify the influences on the life style of the residents coming from the different kinds of physical environments. Based on the findings, we are to establish a basic guideline for the planning of the sub-common spaces in the future group homes. On the survey day, behavior maps were drawn every 10 minutes from 7 a.m. to 8 p.m. Some of the results obtained from this study are shown below. Unexpectedly, the sub-common spaces were not so well utilized by the residents. Therefore, it is quite difficult to determine if these sub-common spaces are giving influence on the life style of the residents or not. With the better and more active utilization of such sub-common spaces by the group home managements, these spaces could play more important roles for the residents. Due attention should also be paid to the physical environments when such sub-common areas be included in the space planning of the group homes

Relation between psychosocial variables and the glycemic control of patients with type 2 diabetes: A cross-sectional and prospective study

<p>Abstract</p> <p>Background</p> <p>This cross-sectional and prospective study used a variety of psychological inventories to evaluate the relationship between psychosocial factors and the glycemic control of patients with type 2 diabetes.</p> <p>Methods</p> <p>Participants were 304 patients with type 2 diabetes who were treated as outpatients at diabetes clinics. All participants were assessed for HbA_1cand completed the following self-report psychological inventories: 1) Diabetes Treatment Satisfaction Questionnaire (DTSQ), 2) Problem Areas in Diabetes Survey (PAID), 3) Well-being Questionnaire 12 (W-BQ12), 4) Self-Esteem Scale (SES), 5) Social Support Scale, and 6) Self-Efficacy Scale. HbA_1cwas again measured one year later. The relationships between the psychosocial variables obtained by analysis of the psychological inventories and baseline or one-year follow-up HbA_1cwere determined.</p> <p>Results</p> <p>Baseline HbA_1cwas significantly correlated with age, diet treatment regimen, number of microvascular complication of diabetes, and the total scores of DTSQ, W-BQ12, PAID, SES and the Self-Efficacy Scale. Hierarchical stepwise multiple regression revealed that significant predictors of baseline HbA_1cwere total DTSQ and PAID scores, along with age, diet treatment regimen, and number of microvascular complication of diabetes after adjustment for demographic, clinical and other psychosocial variables. Two hundred and ninety patients (95.4% of 304) were followed and assessed one year after baseline. Hierarchical stepwise multiple regression analysis showed the significant predictors of follow-up HbA_1cto be total DTSQ and PAID scores, along with age and diet treatment regimen. However, the correlation between baseline and follow-up HbA_1cwas so high that the only other variable to retain significance was diet treatment regimen once baseline HbA_1cwas included in the regression of follow-up HbA_1c.</p> <p>Conclusion</p> <p>The DTSQ and the PAID predicted both current and future HbA_1cto a similar and significant degree in patients with type 2 diabetes.</p

Acetophenone Monomers from Acronychia trifoliolata

Seven new [acronyculatins I-O (1-7)] and four known acetophenone monomers were isolated from a CH 3 OH/CH 2 Cl 2 (1:1) extract (N089419) of Acronychia trifoliolata provided by the U.S. National Cancer Institute (NCI, Frederick, MD, USA). Their structures were characterized by using various NMR and HRMS techniques. Among the known compounds, the structure of acronyculatin B (8) was revised. Some of the isolated compounds were evaluated for antiproliferative activity against human cancer cell lines. While most of the tested compounds were not cytotoxic, acronyculatins I (1) and J (2) showed moderate antiproliferative activity

Alstiphyllanines E–H, picraline and ajmaline-type alkaloids from Alstonia macrophylla inhibiting sodium glucose cotransporter

Three new picraline-type alkaloids, alstiphyllanines E–G (1–3) and a new ajmaline-type alkaloid, alstiphyllanine H (4) were isolated from the leaves of Alstonia macrophylla together with 16 related alkaloids (5–20). Structures and stereochemistry of 1–4 were fully elucidated and characterized by 2D NMR analysis. Alstiphyllanines E and F (1 and 2) showed moderate Na+-glucose cotransporter (SGLT1 and SGLT2) inhibitory activity. A series of a hydroxy substituted derivatives 21–28 at C-17 of the picraline-type alkaloids have been derived as having potent SGLT inhibitory activity. 10-Methoxy-N(1)-methylburnamine-17-O-veratrate (6) exhibited potent inhibitory activity, suggesting that the presence of an ester side chain at C-17 may be important to show SGLT inhibitory activity. Structure activity relationship of alstiphyllanines on inhibitory activity of SGLT was discussed

Development of quantitative atomic modeling for tungsten transport study using LHD plasma with tungsten pellet injection

Quantitative tungsten study with reliable atomic modeling is important for successful achievement of ITER and fusion reactors. We have developed tungsten atomic modeling for understanding the tungsten behavior in fusion plasmas. The modeling is applied to the analysis of tungsten spectra observed from plasmas of the large helical device (LHD) with tungsten pellet injection. We found that extreme ultraviolet (EUV) emission of W24+ to W33+ ions at 1.5–3.5 nm are sensitive to electron temperature and useful to examine the tungsten behavior in edge plasmas. We can reproduce measured EUV spectra at 1.5–3.5 nm by calculated spectra with the tungsten atomic model and obtain charge state distributions of tungsten ions in LHD plasmas at different temperatures around 1 keV. Our model is applied to calculate the unresolved transition array (UTA) seen at 4.5–7 nm tungsten spectra. We analyze the effect of configuration interaction on population kinetics related to the UTA structure in detail and find the importance of two-electron-one-photon transitions between 4p54dn+1– 4p64dn−14f. Radiation power rate of tungsten due to line emissions is also estimated with the model and is consistent with other models within factor 2

CDK4/6 signaling attenuates the effect of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in EGFR-mutant non-small cell lung cancer

Background: Epidermal growth factor receptor (EGFR) mutations, such as exon 19 deletion and exon 21 L858R, are driver oncogenes of non-small cell lung cancer (NSCLC), with EGFR tyrosine kinase inhibitors (TKIs) being effective against EGFR-mutant NSCLC. However, the efficacy of EGFR-TKIs is transient and eventually leads to acquired resistance. Herein, we focused on the significance of cell cycle factors as a mechanism to attenuate the effect of EGFR-TKIs in EGFR-mutant NSCLC before the emergence of acquired resistance. Methods: Using several EGFR-mutant cell lines, we investigated the significance of cell cycle factors to attenuate the effect of EGFR-TKIs in EGFR-mutant NSCLC. Results: In several EGFR-mutant cell lines, certain cancer cells continued to proliferate without EGFR signaling, and the cell cycle regulator retinoblastoma protein (RB) was not completely dephosphorylated. Further inhibition of phosphorylated RB with cyclin-dependent kinase (CDK) 4/6 inhibitors, combined with the EGFR-TKI osimertinib, enhanced G0/G1 cell cycle accumulation and growth inhibition of the EGFR-mutant NSCLC in both in vitro and in vivo models. Furthermore, residual RB phosphorylation without EGFR signaling was maintained by extracellular signal-regulated kinase (ERK) signaling, and the ERK inhibition pathway showed further RB dephosphorylation. Conclusions: Our study demonstrated that the CDK4/6-RB signal axis, maintained by the MAPK pathway, attenuates the efficacy of EGFR-TKIs in EGFR-mutant NSCLC, and targeting CDK4/6 enhances this efficacy. Thus, combining CDK4/6 inhibitors and EGFR-TKI could be a novel treatment strategy for TKI-naïve EGFR-mutant NSCLC