糖尿病性腎症におけるアルブミンの全ネフロン濾過量および再吸収量の増加に関する研究

京都大学0048新制・課程博士博士(医学)甲第20263号医博第4222号新制||医||1020(附属図書館)京都大学大学院医学研究科医学専攻(主査)教授 長船 健二, 教授 小川 修, 教授 福原 俊一学位規則第4条第1項該当Doctor of Medical ScienceKyoto UniversityDFA

Topology optimization of nonlinear optical waveguide devices considering output signal phase

A signal output of optical devices with multi-input ports, such as a logic gate, depends on the phase difference between input ports. In order to cascade optical devices, it is essential to design such devices considering not only desired output power but also desired output signal phase. We propose a topology optimization method for optical devices considering the output signal phase. In our approach, the beam propagation method (BPM) is employed as a numerical simulation method and the adjoint variable method (AVM) is used to calculate the sensitivity of output power and signal phase to design parameters. The validity and the effectiveness of our approach are verified through design examples of a three-branching waveguide with linear media and an all-optical logic gate utilizing nonlinear media

Development and Performance of Kyoto's X-ray Astronomical SOI pixel (SOIPIX) sensor

We have been developing monolithic active pixel sensors, known as Kyoto's X-ray SOIPIXs, based on the CMOS SOI (silicon-on-insulator) technology for next-generation X-ray astronomy satellites. The event trigger output function implemented in each pixel offers microsecond time resolution and enables reduction of the non-X-ray background that dominates the high X-ray energy band above 5--10 keV. A fully depleted SOI with a thick depletion layer and back illumination offers wide band coverage of 0.3--40 keV. Here, we report recent progress in the X-ray SOIPIX development. In this study, we achieved an energy resolution of 300~eV (FWHM) at 6~keV and a read-out noise of 33~e- (rms) in the frame readout mode, which allows us to clearly resolve Mn-K$\alpha$ and K$\beta$. Moreover, we produced a fully depleted layer with a thickness of $500~{\rm \mu m}$. The event-driven readout mode has already been successfully demonstrated.Comment: 7pages, 12figures, SPIE Astronomical Telescopes and Instrumentation 2014, Montreal, Quebec, Canada. appears as Proc. SPIE 9147, Space Telescopes and Instrumentation 2014: Ultraviolet to Gamma Ra

Minimalist Design of Wireframe DNA Nanotubes: Tunable Geometry, Size, Chirality, and Dynamics

DNA nanotubes (NTs) have attracted extensive interest as artificial cytoskeletons for biomedical, synthetic biology, and materials applications. Here, we report the modular design and assembly of a minimalist yet robust DNA wireframe nanotube with tunable cross-sectional geometry, cavity size, chirality, and length, while using only four DNA strands. We introduce an h-motif structure incorporating double-crossover (DX) tile-like DNA edges to achieve structural rigidity and provide efficient self-assembly of h-motif-based DNA nanotube (H-NT) units, thus producing programmable, micrometer-long nanotubes. We demonstrate control of the H-NT nanotube length via short DNA modulators. Finally, we use an enzyme, RNase H, to take these structures out of equilibrium and trigger nanotube assembly at a physiologically relevant temperature, underlining future cellular applications. The minimalist H-NTs can assemble at near-physiological salt conditions and will serve as an easily synthesized, DNA-economical modular template for biosensors, plasmonics, or other functional materials and as cost-efficient drug-delivery vehicles for biomedical applications.A minimalist design of robust DNA nanotubes from only 4 DNA strands, with tunable geometry, chirality, length, and assembly dynamics is reported. The method leads to robust nanotubes under physiologically relevant conditions, as cost-efficient nanomaterial templates or drug-delivery vehicles.+imag

Molecular diagnosis of an infant with TSC2/PKD1 contiguous gene syndrome

A 1-month-old Japanese infant with cardiac rhabdomyoma was diagnosed with TSC2/PKD1 contiguous gene syndrome by targeted panel sequencing with subsequent quantitative polymerase chain reaction that revealed gross monoallelic deletion, including parts of two genes: exons 19–42 of TSC2 and exons 2–46 of PKD1. Early molecular diagnosis can help to detect bilateral renal cyst formation and multidisciplinary follow-up of this multisystem disease