Lentiform "Fork Sign" and Parkinsonism After Acute Myocardial Infarction and Cardiac Failure

Univ Fed Sao Paulo, Dept Neurol, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Dept Neurol, Sao Paulo, SP, BrazilWeb of Scienc

Glomeruloid hemangioma as late manifestation of POEMS syndrome

Glomeruloid hemangiomas were first described by Chan in 1990 as a cutaneous marker of POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal proteinemia, and Skin changes). POEMS syndrome is a multisystem disease with a significant cutaneous involvement. Among its manifestations, hemangiomas are common, observed in up to one third of the patients, and, although specific, the glomeruloid subtype is very rare. The vascular endothelium growth factor (VEGF) is an angiogenic stimulation factor, which also induces increased systemic vascular permeability. Thus, a scenario of overexpression of VEGF can credibly lead to the assumption of an association between cutaneous hemangiomas and systemic manifestations, implying prognostic and therapeutic considerations and reinforcing the importance of dermatological periodical consultations for these patients. We report the case of a patient in whom glomeruloid hemangiomas marked the recurrence of POEMS syndrome, occurring before the systemic symptoms. </p

Effects of consumption of galactooligosaccharides obtained through whey enzymatically modified on the faecal flora and nutritional parameters of hamsters

The aim of this research was to evaluate the influence of wheyenzymatically modified rich in galactooligosaccharides in thenutritional characteristics and effects in the microflora of cecumcontents by the study with Golden Syrian hamsters (Mesocricetusauratus) for 28 days (controlled conditions). Three isoproteic dietswere prepared (20% w/w): C (casein), W (whey) and G (wheymodified). The groups studied differed positively from the C regardingfeed and protein efficiency ratio. The relationships (w/w) oforgan/body were found proportional in all diets. The counts ofprobiotics from the cecum contents the groups showed no difference.The pHs of studied groups were lower than C, this acidity can atimpairs the ability of pathogens to grow in the intestine. Resultssuggest that using whey enzymatically modified rich ingalactooligosaccharides could replace the standard diet withnutritional efficiency and possible inhibit the microorganismspathogenic without induce damage in health.Fil: Dos Santos Da Fonseca, Renata Aline. Universidade Federal Do Rio Grande; Brasil. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; ArgentinaFil: Rodrigues Machado, Adriana. Universidade Federal Do Rio Grande; BrasilFil: Muniz Moreira, Lidiane. Universidade Federal Do Rio Grande; BrasilFil: Rodrigues, Rosane S.. Universidade Federal de Pelotas; BrasilFil: Machado, Mirian. Universidade Federal de Pelotas; BrasilFil: Souza Soares, Leonor A.. Universidade Federal Do Rio Grande; BrasilFil: Burkert, Carlos André V.. Universidade Federal Do Rio Grande; BrasilFil: Burkert, Janaína Fernandes de Medeiros. Universidade Federal Do Rio Grande; Brasi

IMPLICAÇÕES SOCIAIS E DE SAÚDE QUE ACOMETEM PESSOAS ENLUTADAS PELA MORTE DE FAMILIARES POR COVID-19

Objetivo: conhecer as implicações sociais e para a saúde que acometem pessoas enlutadas pela morte de familiares vítimas da COVID-19. Método: trata-se de revisão narrativa realizada na plataforma PubCovid-19. Resultados: foi desenvolvido um quadro apresentando as características das dez publicações segundo título, tutoria, ano de publicação, país e periódico. Conclusão: as implicações sociais e de saúde que acometem pessoas enlutadas pela morte de familiares por COVID-19 decorrem do distanciamento social que gera a impossibilidade da realização de rituais de despedida prejudicando a vivência normal do luto, levando ao luto complicado e ao possível adoecimento psíquico.Descritores: Morte. Luto. Covid-19. Saúde Mental. Isolamento

Staphylococcus saprophyticus Recovered from Humans, Food, and Recreational Waters in Rio de Janeiro, Brazil.

Staphylococcus saprophyticus is an important agent of urinary tract infection (UTI) in young women, but information about this pathogen in human microbiota and in common environment is lacking. The aim of this study was to characterize S. saprophyticus isolates from genitoanal microbiota of 621 pregnant women, 10 minas cheese packs, and five beaches in Rio de Janeiro city and compare PFGE profiles of these isolates with five UTI PFGE clusters described in this city. We investigated 65 S. saprophyticus isolates from microbiota, 13 from minas cheese, and 30 from beaches and 32 UTI isolates. Antimicrobial resistance was determined by disk diffusion, MIC by agar dilution, and PCR. Erythromycin-resistance genes erm(C), msr(A), msr(B), mph(C), and lin(A) were found in 93% of isolates. Trimethoprim-sulfamethoxazole resistance correlated with dfrG or dfrA genes. Three cefoxitin-resistant isolates carried the mecA gene. All isolates obtained from cheese were susceptible to all antimicrobial agents. Six of 10 pregnant women with &gt;1 isolate had monoclonal colonization. Isolates from pregnant women shared 100% similarity with UTI PFGE cluster types A and E obtained almost 10 years previously, suggesting temporal persistence of S. saprophyticus. Antimicrobial resistance of beach isolates reflected the profiles of human isolates. Taken together, results indicate a shared source for human and environmental isolates

Long-term short implants performance: Systematic review and meta - Analysisofthe essential assessment parameters

Lack of standard criteria in the outcome assessment makes it difficult to draw conclusions on the clinical performance of short implants and, under these circumstances, determine the reasons for implant failure. This study evaluated, through a systematic review of the literature and meta-analysis, the essential parameters required to assess the long-term clinical performance of short and extra-short implants. Electronic databases (Pubmed- MEDLINE, Cochrane Library Database, Embase, and Lilacs) were searched by two independent reviewers, without language limitation, to identify eligible papers. References from the selected articles were also reviewed. The review included clinical trials involving short dental implants placed in humans, published between January 2000 and March 2014, which described the parameters applied for outcome\u2019s measurements and provided data on survival rates. Thirteen methodologically acceptable studies were selected and 24 parameters were identified. The most frequent parameters assessed were the marginal bone loss and the cumulative implant survival rate, followed by implant failure rate and biological complications such as bleeding on probing and probing pocket depths. Only cumulative implant survival rate data allows meta-analysis revealing a positive effect size (from 0.052 (fixed) to 0.042 (random)), which means that short implant appears to be a successful treatment option. Mechanical complications and crown-to-implant (C/I) ratio measurement were also commonly described, however, considering the available evidence; no strong conclusions could be drawn since different methods were used to assess each parameter. By means of this literature review, a standard evaluation scheme is proposed, being helpful to regiment further investigations and comparisons on future studies

Dr. Jekyll e Mr. Hyde nos trópicos: governança disruptiva e justiça ambiental face à Covid-19

The reference in the title of this article anticipates the dark face and the crooked paths of how public authorities managed Covid-19 in Brazil. Dr. Jekyll and Mr. Hyde, the doctor and monster in the tropics, symbolize scientific denial, the politicization of the virus, and its treatments. This article seeks to collaborate with ongoing researchers, with mixed methods and an approach that unites critical social theory, justice, and environmental racism for the specific Brazilian debate. It has as an illustrative case of inequalities in the territory the city of São Paulo. The starting point is the understanding that the option for a disruptive governance from the government has a method and affects the most disadvantaged classes more intensely.La referencia en el título de este artículo anticipa la cara oscura y los caminos tortuosos de cómo las autoridades públicas gestionaron la Covid-19 en Brasil. El Dr. Jekyll y el Sr. Hyde, el médico y monstruo de los trópicos, simbolizan la negación científica, la politización del virus y sus tratamientos. Este artículo busca colaborar con investigaciones en curso, con métodos mixtos y un enfoque que une la teoría social crítica, la justicia y el racismo ambiental para el debate brasileño. Tiene como caso ilustrativo las desigualdades en el territorio de la ciudad de São Paulo y el punto de partida es el entendimiento de que la opción de gobernanza disruptiva por parte del gobierno tiene un método y afecta más intensamente a las clases más desfavorecidas.La référence dans le titre de cet article anticipe le visage sombre et les chemins tortueux de la façon dont les autorités publiques ont géré la Covid-19 au Brésil. Le Dr Jekyll et M. Hyde, le docteur et monstre sous les tropiques, symbolisent le déni scientifique, la politisation du virus et ses traitements. Cet article cherche à collaborer avec des recherches en cours, avec des méthodes mixtes et une approche qui unit la théorie sociale critique, la justice et le racisme environnemental pour le débat brésilien. Et a comme cas illustratif des inégalités sur le territoire de la ville de São Paulo. Le point de départ est de comprendre que l'option d'une gouvernance disruptive de la part du gouvernement a une méthode et touche plus intensément les classes les plus défavorisées.A referência do título deste artigo antecipa a face sombria e os caminhos tortuosos da forma em que a Covid-19 foi gerida pelas autoridades públicas no Brasil. O Dr. Jekyll e Mr. Hyde, o médico e o monstro nos trópicos, simbolizam o negacionismo científico, a politização do vírus e de seus tratamentos. O presente artigo busca colaborar com pesquisas em formação, com métodos mistos e abordagem que une teoria social crítica, justiça e racismo ambiental, para o debate específico brasileiro, e tem como caso ilustrativo das desigualdades o território da cidade de São Paulo. O ponto de partida é o entendimento de que a opção por uma governança disruptiva por parte do poder público tem método e atinge de forma prejudicial com mais intensidade as classes mais despossuídas

PERFIL CLÍNICO E ENDOSCÓPICO DE PACIENTES COM DOENÇA INFLAMATÓRIA INTESTINAL PROCEDENTES DE UMA POPULAÇÃO MISCIGENADA

Doença inflamatória intestinal (DII), doença de Crohn (DC) e retocolite ulcerativa (RCU) são doenças crônicas, potencialmente incapacitantes e progressivas. Atingem adultos em fase produtiva e podem evoluir com sequelas de grande impacto. Estudos sobre a epidemiologia são de grande relevância, pois, proporcionam esclarecimentos sobre a interferência de múltiplos fatores e facilitam a identificação das áreas de maior prevalência para o investimento adequado em saúde. O objetivo é traçar o perfil clínico e endoscópico dos pacientes com doença inflamatória intestinal (retocolite ulcerativa e doença de Crohn) acompanhados em ambulatório de referência de doença inflamatória intestinal do estado da Bahia. Trata-se de estudo do tipo transversal, com pacientes acompanhados ambulatorialmente em serviço de referência no estado da Bahia. Análise retrospectiva do prontuário para obtenção de dados sócio-demográficos, história da doença atual e pregressa e coleta de informações referentes aos exames laboratoriais e endoscópicos. Classificados conforme critérios de localização e atividade através de índices específicos. Análise exploratória e descritiva dos dados. 105 pacientes fazem parte desta análise. Dentre eles, 38 do sexo masculino e 67 do sexo feminino. O diagnóstico de RCU foi observado em 60 pacientes, com maioria feminina (66,7%), e 45 com diagnóstico de DC, com maioria feminina em 60,0% (p=0,482). A média de idade na DII foi de 39,6, variando entre 18 e 88 anos. A autoclassificação de “raça” revelou 38 negros, 50 mulatos e 17 brancos. Existe predomínio do diagnóstico de RCU em relação a DC, predominam pacientes de uma faixa etária de adultos jovens, maioria do sexo feminino seja na Doença de Crohn ou na Retocolite Ulcerativa, autoclassificados como mulatos. O comportamento dominante na DC foi o não estenosante e não penetrante, com a maioria dos pacientes em remissão. No grupo com RCU, a localização mais comum foi a colite esquerda e a maior parte apresentou hiperemia/enantema/edema e atividade, tendo a atividade clinica leve predominado entre os pacientes. Através do IBDQ notou-se que quanto melhor a atividade clinica maior a pontuação nesse score

Neurokinin-1 receptor, a new modulator of lymphangiogenesis in obese-asthma phenotype

Aims Obesity and asthma are widely prevalent and associated disorders. Recent studies of our group revealed that Substance P (SP) is involved in pathophysiology of obese-asthma phenotype in mice through its selective NK1 receptor (NK1-R). Lymphangiogenesis is impaired in asthma and obesity, and SP activates contractile and inflammatory pathways in lymphatics. Our aim was to study whether NK1-R expression was involved in lymphangiogenesis on visceral (VAT) and subcutaneous (SAT) adipose tissues and in the lungs, in obese-allergen sensitized mice. Main methods Diet-induced obese and ovalbumin (OVA)-sensitized Balb/c mice were treated with a selective NK1-R antagonist (CJ 12,255, Pfizer Inc., USA) or placebo. Lymphatic structures (LYVE-1 +) and NK1-R expression were analyzed by immunohistochemistry. A semi-quantitative score methodology was used for NK1-R expression. Key findings Obesity and allergen-sensitization together increased the number of LYVE-1 + lymphatics in VAT and decreased it in SAT and lungs. NK1-R was mainly expressed on adipocyte membranes of VAT, blood vessel areas of SAT, and in lung epithelium. Obesity and allergen-sensitization combined increased the expression of NK1-R in VAT, SAT and lungs. NK1-R antagonist treatment reversed the effects observed in lymphangiogenesis in those tissues. Significance The obese-asthma phenotype in mice is accompanied by increased expression of NK1-R on adipose tissues and lung epithelium, reflecting that SP released during inflammation may act directly on these tissues. Blocking NK1-R affects lymphangiogenesis, implying a role of SP, with opposite physiological consequences in VAT, and in SAT and lungs. Our results provide a clue for a novel SP role in the obese-asthma phenotype