Spatial Clustering of High Redshift Lyman Break Galaxies

We present a physically motivated semi-analytic model to understand the clustering of high redshift LBGs. We show that the model parameters constrained by the observed luminosity function, can be used to predict large scale (\theta > 80 arcsec) bias and angular correlation function of galaxies. These predictions are shown to reproduce the observations remarkably well. We then adopt these model parameters to calculate the halo occupation distribution (HOD) using the conditional mass function. The halo model using this HOD is shown to provide a reasonably good fit to the observed clustering of LBGs at both large (\theta>80") and small (\theta < 10") angular scales for z=3-5 and several limiting magnitudes. However, our models underpredict the clustering amplitude at intermediate angular scales, where quasi-linear effects are important. The average mass of halos contributing to the observed clustering is found to be 6.2 x 10^{11} M_\odot and the characteristic mass of a parent halo hosting satellite galaxies is 1.2 \times 10^{12} M_\odot for a limiting absolute magnitude of -20.5 at z=4. For a given threshold luminosity these masses decrease with increasing z and at any given z these are found to increase with increasing value of threshold luminosity. We find that approximately 40 % of the halos above a minimum mass M_{min}, can host detectable central galaxies and about 5-10 % of these halos are likely to also host a detectable satellite. The satellites form typically a dynamical timescale prior to the formation of the parent halo. The small angular scale clustering is due to central-satellite pairs and is quite sensitive to changes in the duration of star formation in a halo. The present data favor star formation in a halo lasting typically for a few dynamical time-scales. Our models also reproduce different known trends between parameters related to star formation.Comment: Accepted for publication in MNRA

Risk of Myocardial Infarction among People Living With HIV: An Updated Systematic Review and Meta-Analysis

Objective Cardiovascular disease (CVD) is one of the leading non-AIDS-defining causes of death among HIV-positive (HIV+) individuals. However, the evidence surrounding specific components of CVD risk remains inconclusive. We conducted a systematic review and meta-analysis to synthesise the available evidence and establish the risk of myocardial infarction (MI) among HIV+ compared with uninfected individuals. We also examined MI risk within subgroups of HIV+ individuals according to exposure to combination antiretroviral therapy (ART), ART class/regimen, CD4 cell count and plasma viral load (pVL) levels. Design Systematic review and meta-analysis. Data sources We searched MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials and Cochrane Database of Systematic Reviews until 18 July 2018. Furthermore, we scanned recent HIV conference abstracts (CROI, IAS/AIDS) and bibliographies of relevant articles. Eligibility criteria Original studies published after December 1999 and reporting comparative data relating to the rate of MI among HIV+ individuals were included. Data extraction and synthesis Two reviewers working in duplicate, independently extracted data. Data were pooled using random-effects meta-analysis and reported as relative risk (RR) with 95% CI. Results Thirty-two of the 8130 identified records were included in the review. The pooled RR suggests that HIV+ individuals have a greater risk of MI compared with uninfected individuals (RR: 1.73; 95%&thinsp;CI 1.44 to 2.08). Depending on risk stratification, there was moderate variation according to ART uptake (RR, ART-treated=1.80; 95%&thinsp;CI 1.17 to 2.77; ART-untreated HIV+ individuals: 1.25; 95%&thinsp;CI 0.93 to 1.67, both relative to uninfected individuals). We found low CD4 count, high pVL and certain ART characteristics including cumulative ART exposure, any/cumulative use of protease inhibitors as a class, and exposure to specific ART drugs (eg, abacavir) to be importantly associated with a greater MI risk. Conclusions Our results indicate that HIV infection, low CD4, high pVL, cumulative ART use in general including certain exposure to specific ART class/regimen are associated with increased risk of MI. The association with cumulative ART may be an index of the duration of HIV infection with its attendant inflammation, and not entirely the effect of cumulative exposure to ART per se. &nbsp

Seasonality of Overseas Tourism Demand in Scotland: A Regional Analysis

This paper examines patterns of seasonality in international tourism to the regions of Scotland. Quarterly numbers of overnight stays are disaggregated by trip purpose. Seasonality in vacation tourism to Scotland is shown to be defined by more than a simple rural–urban division. Overseas visiting friends and relatives (VFR) tourism is largely an urban phenomenon and is consequently less seasonal than vacation tourism. Lower seasonal concentration of VFR tourism is not uniform across the regions. Although levels of seasonal intensity of business tourism to the three principal cities of Scotland are approximately the same, there are noticeable variations over time

The Lost Library of Anne Conway

The philosopher Anne Conway (1631-1679) owned a large library, and her reading and book ownership shaped her intellectual life in distinctive ways. Until now, however, almost nothing has been known about the details of her reading or her book collection. Current scholarship assumes that her library, like that of her husband, the third Viscount Conway (c. 1623–1683), was lost or dispersed after her death. This article presents previously unrecognised evidence of Conway’s book ownership, and identifies, for the first time, the only books currently known to survive from her personal library. It traces their path to their current location in the Old Library of Jesus College, Cambridge, through the library of the soldier, book collector, and Cambridge Fellow Francis Sterling (c. 1652-1692). The article demonstrates that the newly identified books reveal previously unknown patterns of intellectual exchange amongst Conway’s family, and argues that they have significant implications for our understanding of her early intellectual development

Substructure in the lens HE 0435-1223

We investigate the properties of dark matter substructure in the gravitational lens HE 0435-1223 (z_l=0.455) via its effects on the positions and flux ratios of the quadruply-imaged background quasar (z_s=1.689). We start with a smooth mass model, add individual, truncated isothermal clumps near the lensed images, and use the Bayesian evidence to compare the quality of different models. Compared with smooth models, models with at least one clump near image A are strongly favored. The mass of this clump within its Einstein radius is log(Mein/Msun) = 7.65 +0.87/-0.84. The Bayesian evidence provides weaker support for a second clump near image B, with log(Mein/Msun) = 6.55 +1.01/-1.51. We also examine models with a full population of substructure, and find the mass fraction in substructure at the Einstein radius to be f_sub > 0.00077, assuming the total clump masses follow a mass function dN/dM proportional to M^(-1.9) over the range M = 10^7-10^10 Msun. Few-clump and population models produce similar Bayesian evidence values, so neither type of model is objectively favored.Comment: 18 pages, 12 figures, 4 tables. MNRAS accepte

Cross-cutting principles for planetary health education

Since the 2015 launch of the Rockefeller Foundation Lancet Commission on planetary health,1 an enormous groundswell of interest in planetary health education has emerged across many disciplines, institutions, and geographical regions. Advancing these global efforts in planetary health education will equip the next generation of scholars to address crucial questions in this emerging field and support the development of a community of practice. To provide a foundation for the growing interest and efforts in this field, the Planetary Health Alliance has facilitated the first attempt to create a set of principles for planetary health education that intersect education at all levels, across all scales, and in all regions of the world—ie, a set of cross-cutting principles

May Measurement Month 2018: a pragmatic global screening campaign to raise awareness of blood pressure by the International Society of Hypertension

Aims Raised blood pressure (BP) is the biggest contributor to mortality and disease burden worldwide and fewer than half of those with hypertension are aware of it. May Measurement Month (MMM) is a global campaign set up in 2017, to raise awareness of high BP and as a pragmatic solution to a lack of formal screening worldwide. The 2018 campaign was expanded, aiming to include more participants and countries. Methods and results Eighty-nine countries participated in MMM 2018. Volunteers (≥18 years) were recruited through opportunistic sampling at a variety of screening sites. Each participant had three BP measurements and completed a questionnaire on demographic, lifestyle, and environmental factors. Hypertension was defined as a systolic BP ≥140 mmHg or diastolic BP ≥90 mmHg, or taking antihypertensive medication. In total, 74.9% of screenees provided three BP readings. Multiple imputation using chained equations was used to impute missing readings. 1 504 963 individuals (mean age 45.3 years; 52.4% female) were screened. After multiple imputation, 502 079 (33.4%) individuals had hypertension, of whom 59.5% were aware of their diagnosis and 55.3% were taking antihypertensive medication. Of those on medication, 60.0% were controlled and of all hypertensives, 33.2% were controlled. We detected 224 285 individuals with untreated hypertension and 111 214 individuals with inadequately treated (systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg) hypertension. Conclusion May Measurement Month expanded significantly compared with 2017, including more participants in more countries. The campaign identified over 335 000 adults with untreated or inadequately treated hypertension. In the absence of systematic screening programmes, MMM was effective at raising awareness at least among these individuals at risk