19 research outputs found
Resurgence of a Nationâs Radiation Science Driven by Its Nuclear Industry Needs
From MDPI via Jisc Publications RouterHistory: accepted 2021-10-26, pub-electronic 2021-11-23Publication status: PublishedThis article describes the radiation facilities and associated sample preparation, management, and analysis equipment currently in place at the Dalton Cumbrian Facility, a facility which opened in 2011 to support the UKâs nuclear industry. Examples of measurements performed using these facilities are presented to illustrate their versatility and the breadth of research they make possible. Results are presented from research which furthers our understanding of radiation damage to polymeric materials, radiolytic yield of gaseous products in situations relevant to nuclear materials, radiation chemistry in light water reactor cooling systems, material chemistry relevant to immobilization of nuclear waste, and radiation-induced corrosion of fuel cladding elements. Applications of radiation chemistry relevant to health care are also described. Research concerning the mechanisms of radioprotection by dietary carotenoids is reported. An ongoing open-labware project to develop a suite of modular sample handling components suited to radiation research is described, as is the development of a new neutron source able to provide directional beams of neutrons
AI is a viable alternative to high throughput screening: a 318-target study
: High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNetÂź convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNetÂź model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery
Comparison of direct digital and conventional imaging with Ekta Speed Plus and INSIGHT films for the detection of approximal caries
Purpose: To evaluate the accuracy of approximal caries detection comparing enhanced and unenhanced Sidexis CCD-based digital image with Ektaspeed Plus and INSIGHT films. Methods: Fifty-two extracted premolars were imaged under identical standardized geometric and exposure conditions. Four observers, using five points confidence scale, rated 104 approximal surfaces for the presence or absence of carious lesions by means of four image modalities: (1) observer enhanced; (2) unenhanced Sidexis displays; (3) E speed films and (4) F speed film. Histologic sections served as validating criterion for the presence and depth of carious lesions. Diagnostic accuracy was measured as the area beneath the ROC curve. Results: Mean ROC (receiver operating characteristic) curve areas for approximal surfaces were 0.865 (E speed), 0.856 (F speed), 0.816 (unenhanced Sidexis) and 0.776 (observer enhanced). There were no significant differences between unenhanced digital Sidexis and films. Observer enhanced Sidexis images exhibited a statistically significant lower diagnostic accuracy than the film images for two of the observers
The Evidence of the Rugoscopy Effectiveness as a Human Identification Method in Patients Submitted to Rapid Palatal Expansion
The objective of this study was to demonstrate the effectiveness of rugoscopy as a human identification method, even when the patient is submitted to rapid palatal expansion, which in theory would introduce doubt. With this intent, the Rugoscopic Identity was obtained for each subject using the classification formula proposed by Santos based on the intra-oral casts made before and after treatment from patients who were subjected to palatal expansion. The casts were labeled with the patients' initials and randomly arranged for studying. The palatine rugae kept the same patterns in every case studied. The technical error of the intra-evaluator measurement provided a confidence interval of 95%, making rugoscopy a reliable identification method for patients who were submitted to rapid palatal expansion, because even in the presence of intra-oral changes owing to the use of palatal expanders, the palatine rugae retained the biological and technical requirements for the human identification process.581SIS235S23
Dental age in patients with Down syndrome Idade dentĂĄria em pacientes com sĂndrome de Down
The aim of this research was to evaluate dental age in 102 patients with Down Syndrome, using panoramic radiographs. A software program developed by the Discipline of Radiology, School of Dentistry of SĂŁo JosĂ© dos Campos, SĂŁo Paulo State University (UNESP), was used. A table of mineralization chronology of permanent teeth among Brazilians conceived by Nicodemo, Moraes and Medici Filho was used within the software. Statistical analysis of the results showed that 70.91% of the males and 61.21% of the females presented advanced dental age. Only 32.09% of the males and 38.79% of the females presented delayed dental age. Regarding the differences between the dental and chronological ages, two thirds of the males and females presented dental age with differences of up to 12 months, which means that they can be considered to be within normal standards, whereas only 18.87% of the males and 10.21% of the females presented dental age outside normal standards, with differences of over 24 months. In conclusion, the majority of the patients with Down Syndrome were considered to be within the normal standards of mineralization chronology.<br>O objetivo desta pesquisa foi avaliar a idade dentĂĄria em 102 indivĂduos com sĂndrome de Down, por meio de radiografias panorĂąmicas. Foi usado um "software" desenvolvido pela disciplina de Radiologia da Faculdade de Odontologia de SĂŁo JosĂ© dos Campos (UNESP). Neste "software", foi utilizada a tabela de cronologia de mineralização dos dentes permanentes entre brasileiros, de Nicodemo, Moraes e Medici Filho. A anĂĄlise estatĂstica dos resultados mostrou que 70,91% dos indivĂduos do sexo masculino e 61,21% do sexo feminino apresentaram idade dentĂĄria adiantada. Apenas 32,09% dos indivĂduos do sexo masculino e 38,79% dos indivĂduos do sexo feminino apresentaram idade dentĂĄria atrasada. Com relação Ă s diferenças entre idade dentĂĄria e idade cronolĂłgica, dois terços dos indivĂduos dos sexos masculino e feminino apresentaram idades dentĂĄrias com atĂ© 12 meses de diferença, o que significa que estĂŁo dentro do padrĂŁo de normalidade; enquanto 18,87% dos indivĂduos do sexo masculino e 10,21% dos indivĂduos do sexo feminino apresentaram idades dentĂĄrias fora do padrĂŁo de normalidade com diferenças acima de 24 meses. Concluiu-se que a maioria dos pacientes com sĂndrome de Down estava dentro do padrĂŁo de normalidade de desenvolvimento dentĂĄrio
Avaliação da incidĂȘncia de cĂĄrie em pacientes com sĂndrome de Down apĂłs sua inserção em um programa preventivo Evaluation of the incidence of dental caries in patients with Down syndrome after their insertion in a preventive program
O objetivo deste trabalho foi verificar a incidĂȘncia de cĂĄrie dentĂĄria por meio dos Ăndices CPO-D, CPO-S, ceo-d e ceo-s em indivĂduos com sĂndrome de Down regularmente matriculados em um programa preventivo. Foram examinados 24 indivĂduos com sĂndrome de Down de ambos os sexos, com idade entre um e 48 anos. A prevalĂȘncia (situação experimental inicial) e a incidĂȘncia (situação experimental final) de cĂĄrie dentĂĄria foram verificadas utilizando-se os Ăndices CPO-D, CPO-S, ceo-d e ceo-s iniciais e finais dos participantes. Dos 24 indivĂduos examinados, dez (42,0%) eram livres de cĂĄrie. A prevalĂȘncia de cĂĄrie dentĂĄria mostrou valores de CPO-D= 2,33; CPO-S= 3,60; ceo-d= 1,75 e ceo-s= 2,80; enquanto a incidĂȘncia de cĂĄrie apresentou valores de 2,33; 3,80; 1,10 e 1,90, respectivamente. Os indivĂduos com sĂndrome de Down avaliados neste estudo apresentaram baixos Ăndices de cĂĄrie e pequena incidĂȘncia de novas lesĂ”es, enfatizando a importĂąncia da manutenção desses pacientes em programas preventivos.<br>The objective of this work was to verify the incidence of dental caries by means of the CPO-D, CPO-S, ceo-d and ceo-s indexes in patients with Down syndrome regularly enrolled in a preventive program. Twenty four Down syndrome patients of both sexes age range of one to 48 years were examined. The prevalence (initial experimental situation) and incidence (final experimental situation) of dental caries were verified using of the initial and final CPO-D, CPO-S, ceo-d and ceo-s indexes of the participants. From 24 individual examined, 10 (42.0%) were free of caries. The prevalence of dental caries showed values of CPO-D= 2.33; CPO-S= 3.60; ceo-d= 1.75 e ceo-s= 2.80; while the incidence of caries showed values of 2.33; 3.80; 1.10 e 1.90, respectively. Down syndrome individuals evaluated in this study presented low level of caries and small incidence of new lesions, emphasizing the importance of the maintenance of these patients at preventive programs
Organization of professional practices against intrafamily violence against children and adolescents in the institutional context
Objective: to analyze based on the practitioners\u27 discourse, the way they organize their practices confronting situations of intra-family violence against children and adolescents. Method: qualitative research carried out with 15 professionals who work in social and health services located in the southernmost of Brazil. Data were collected through semi-structured interviews, performed at the participants\u27 workplace. We used a theoretical matrix to analyze the data, based on Institutional Ethnography and the technique of discursive textual analysis. Results: the practitioners\u27 practices developed in situations of intra-family violence against children and adolescents are organized on the basis of: power relations that take place in services that respond to violence situations; routines instituted to meet the demands of care in services; and the interplay between the conception of violence as a public health problem and the conception of violence as a social problem. Conclusion: the way these practices are organized is reflected in actions that are not protective against situations of intra-family violence against children and adolescents.Objetivo: analisar, com base no discurso dos profissionais, como ocorre a organização de suas prĂĄticas frente Ă s situaçÔes de violĂȘncia intrafamiliar contra crianças e adolescentes. MĂ©todo: pesquisa qualitativa, realizada com 15 profissionais que atuam em serviços sociais e de saĂșde localizados no extremo sul do Brasil. Os dados foram coletados por meio de entrevistas semiestruturadas, realizadas no prĂłprio local de trabalho dos participantes. Para a anĂĄlise dos dados foi construĂda uma matriz teĂłrica com base na Etnografia Institucional e utilizada a tĂ©cnica de anĂĄlise textual discursiva. Resultados: as prĂĄticas profissionais desenvolvidas nas situaçÔes de violĂȘncia intrafamiliar contra crianças e adolescentes se organizam a partir de: relaçÔes de poder que se desenrolam nos serviços que atendem Ă s situaçÔes de violĂȘncia; rotinas instituĂdas para suprir as demandas de atendimento nos serviços e o inter-jogo entre a concepção de violĂȘncia como um problema de saĂșde pĂșblica e a de violĂȘncia como um problema social. ConclusĂŁo: a maneira como essas prĂĄticas estĂŁo organizadas se reflete em açÔes pouco protetivas frente Ă s situaçÔes de violĂȘncia intrafamiliar contra crianças e adolescentes.Objetivo: analizar, basado en el discurso profesional, como ocurre la organizaciĂłn de sus prĂĄcticas frente a las situaciones de violencia domĂ©stica intrafamiliar contra niños y adolescentes. MĂ©todo: investigaciĂłn cualitativa realizada con 15 profesionales que trabajan en salud y servicios sociales en el sur de Brasil. Los datos fueron recolectados a travĂ©s de entrevistas semiestructuradas realizadas en el lugar de trabajo de los participantes. Para el anĂĄlisis de los datos se construyĂł una matriz teĂłrica basada en la Etnografia Institucional y utilizada la tĂ©cnica de anĂĄlisis textual del discurso. Resultados: las prĂĄcticas profesionales desarrolladas en situaciones de violencia intrafamiliar contra los niños y adolescentes se organizan a partir de: las relaciones de poder que tienen lugar en los servicios que responden a las situaciones de violencia; las rutinas puestas en practica para satisfacer las demandas de servicios de atenciĂłn y el inter-juego entre la concepciĂłn de la violencia como un problema de salud pĂșblica y la violencia como un problema social. ConclusiĂłn: la forma en que estas prĂĄcticas se organizan se refleja en acciones de poca protecciĂłn en el enfrentamiento de las situaciones de violencia intrafamiliar contra niños y adolescentes