Phylodynamics of H5N1 Highly Pathogenic Avian Influenza in Europe, 2005-2010: Potential for Molecular Surveillance of New Outbreaks.

Previous Bayesian phylogeographic studies of H5N1 highly pathogenic avian influenza viruses (HPAIVs) explored the origin and spread of the epidemic from China into Russia, indicating that HPAIV circulated in Russia prior to its detection there in 2005. In this study, we extend this research to explore the evolution and spread of HPAIV within Europe during the 2005-2010 epidemic, using all available sequences of the hemagglutinin (HA) and neuraminidase (NA) gene regions that were collected in Europe and Russia during the outbreak. We use discrete-trait phylodynamic models within a Bayesian statistical framework to explore the evolution of HPAIV. Our results indicate that the genetic diversity and effective population size of HPAIV peaked between mid-2005 and early 2006, followed by drastic decline in 2007, which coincides with the end of the epidemic in Europe. Our results also suggest that domestic birds were the most likely source of the spread of the virus from Russia into Europe. Additionally, estimates of viral dispersal routes indicate that Russia, Romania, and Germany were key epicenters of these outbreaks. Our study quantifies the dynamics of a major European HPAIV pandemic and substantiates the ability of phylodynamic models to improve molecular surveillance of novel AIVs

Simplified form of tinnitus retraining therapy in adults: a retrospective study.

BACKGROUND: Since the first description of tinnitus retraining therapy (TRT), clinicians have modified and customised the method of TRT in order to suit their practice and their patients. A simplified form of TRT is used at Ealing Primary Care Trust Audiology Department. Simplified TRT is different from TRT in the type and (shorter) duration of the counseling but is similar to TRT in the application of sound therapy except for patients exhibiting tinnitus with no hearing loss and no decreased sound tolerance (wearable sound generators were not mandatory or recommended here, whereas they are for TRT). The main goal of this retrospective study was to assess the efficacy of simplified TRT. METHODS: Data were collected from a series of 42 consecutive patients who underwent simplified TRT for a period of 3 to 23 months. Perceived tinnitus handicap was measured by the Tinnitus Handicap Inventory (THI) and perceived tinnitus loudness, annoyance and the effect of tinnitus on life were assessed through the Visual Analog Scale (VAS). RESULTS: The mean THI and VAS scores were significantly decreased after 3 to 23 months of treatment. The mean decline of the THI score was 45 (SD = 22) and the difference between pre- and post-treatment scores was statistically significant. The mean decline of the VAS scores was 1.6 (SD = 2.1) for tinnitus loudness, 3.6 (SD = 2.6) for annoyance, and 3.9 (SD = 2.3) for effect on life. The differences between pre- and post-treatment VAS scores were statistically significant for tinnitus loudness, annoyance, and effect on life. The decline of THI scores was not significantly correlated with age and duration of tinnitus. CONCLUSION: The results suggest that benefit may be obtained from a substantially simplified form of TRT.RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are

A practice-led approach to facial animation research

In facial expression research, it is well established that certain emotional expressions are universally recognized. Studies into the observer perception of dynamic expressions have built upon this research by highlighting the importance of particular facial regions, timings, and temporal configurations to perception and interpretation. In many studies, the stimuli for such studies have been generated through posing by non-experts or performances by trained actors. However, skilled character animators are capable of crafting recognizable, believable emotional facial expressions as a part of their professional practice. ‘Emotional Avatars’ was conceived as an interdisciplinary research project which would draw upon the knowledge of animation practice and emotional psychology. The aim of the project was to jointly investigate the artistic generation and observer perception of emotional expression animation to determine whether the nuances of emotional facial expression could be artistically choreographed to enhance audience interpretation

Examining global perspectives of engineering students: Determining educational impact

Globalization is causing higher education to adapt their approaches to student learning, especially those in the engineering disciplines as the nature and impact of their work becomes more cross-cultural and diverse. The efforts of programmatic change have led universities to emphasize new or different student experiences and educational practices to better prepare graduates for this societal change. Given this trend, research on which educational practices have the most impact on preparing engineering graduates to enter a global workforce is needed. Research has shown that international experiences like study abroad have a positive impact on students\u27 global perspectives, especially when they engage in international programs and opportunities throughout college. Unfortunately, engineering students have been underrepresented among study abroad participants (less than 10%) historically, due to a variety of reasons (e.g., lack of preparation, structured curricula, lack of integration). Thus, this thesis examines how global perspectives can develop throughout college separate from study abroad experiences and investigates which educational opportunities (i.e., courses, co-curricular experiences) have the largest impact on the development of these global perspectives, as well as their interest in pursuing international experiences in general. Data was collected from 480 first year and 55 graduating engineering students at Rowan University between the Fall 2018 and Spring 2020 semesters using a nationally normed instrument called the Global Perspective Inventory (GPI), that measures global learning and development. In addition to the GPI, this study surveyed graduating students on their participation in High-Impact Educational Practices (HIEP) (i.e. first-year seminars, common intellectual experiences, learning communities, writing intensive courses, collaborative projects, undergraduate research, global learning, service- or community-based learning, internships, and capstone projects) and its relationship with global perspective development. This research identifies courses, co-curricular activities, and HIEPs that help broaden global perspectives of engineering students (before or during college), as well as provide an understanding of which aspects of global perspectives they influence most. According to these analyses, students experienced broadening of global perspectives from participation in multi-cultural courses, discussions of current events with peers, and the following of an international crisis. This study explored and discusses the main reasons engineering students do not want to participate in an international experience and provides some guidelines as to how engineering educators can promote global perspective development for the critical mass of engineering students (who don\u27t or can\u27t participate in traditional programs). The results of this thesis inform engineering educators and leadership on how global learning can be promoted in and around the classroom, with the intent of preparing the majority of engineering students with the knowledge, skills, and attitudes to compete globally. This thesis also provides insights into how educational practices are developing (or not developing) engineering students in this context, and whether a traditional international experience should be required as part of engineering student\u27s degree plan (and the efficacy of stay at home alternatives to such a requirement)

Representation of Instantaneous and Short-Term Loudness in the Human Cortex.

Acoustic signals pass through numerous transforms in the auditory system before perceptual attributes such as loudness and pitch are derived. However, relatively little is known as to exactly when these transformations happen, and where, cortically or sub-cortically, they occur. In an effort to examine this, we investigated the latencies and locations of cortical entrainment to two transforms predicted by a model of loudness perception for time-varying sounds: the transforms were instantaneous loudness and short-term loudness, where the latter is hypothesized to be derived from the former and therefore should occur later in time. Entrainment of cortical activity was estimated from electro- and magneto-encephalographic (EMEG) activity, recorded while healthy subjects listened to continuous speech. There was entrainment to instantaneous loudness bilaterally at 45, 100, and 165 ms, in Heschl's gyrus, dorsal lateral sulcus, and Heschl's gyrus, respectively. Entrainment to short-term loudness was found in both the dorsal lateral sulcus and superior temporal sulcus at 275 ms. These results suggest that short-term loudness is derived from instantaneous loudness, and that this derivation occurs after processing in sub-cortical structures.This work was supported by an ERC Advanced Grant (230570, ‘Neurolex’) to WMW, and by MRC Cognition and Brain Sciences Unit (CBU) funding to WMW (U.1055.04.002.00001.01). Computing resources were provided by the MRC-CBU.This is the final version of the article. It first appeared from Frontiers via http://dx.doi.org/10.3389/fnins.2016.0018

Front Solutions for Bistable Differential-Difference Equations with Inhomogeneous Diffusion

This is the published version, also available here: http://dx.doi.org/10.1137/100807156.We consider a bistable differential-difference equation with inhomogeneous diffusion. Employing a piecewise linear nonlinearity, often referred to as McKean's caricature of the cubic, we construct front solutions which correspond, in the case of homogeneous diffusion, to monotone traveling front solutions or, in the case of propagation failure, to stationary front solutions. A general form for these fronts is given for essentially arbitrary inhomogeneous discrete diffusion, and conditions are given for the existence of solutions to the original discrete Nagumo equation. The specific case of one defect is considered in depth, giving a complete understanding of propagation failure and a grasp on changes in wave speed. Insight into the dynamic behavior of these front solutions as a function of the magnitude and relative position of the defects is obtained with the assistance of numerical results

Front Solutions for Bistable Differential-Difference Equations with Inhomogeneous Diffusion

We consider a bistable differential-difference equation with inhomogeneous diffusion. Employing a piecewise linear nonlinearity, often referred to as McKean\u27s caricature of the cubic, we construct front solutions which correspond, in the case of homogeneous diffusion, to monotone traveling front solutions or, in the case of propagation failure, to stationary front solutions. A general form for these fronts is given for essentially arbitrary inhomogeneous discrete diffusion, and conditions are given for the existence of solutions to the original discrete Nagumo equation. The specific case of one defect is considered in depth, giving a complete understanding of propagation failure and a grasp on changes in wave speed. Insight into the dynamic behavior of these front solutions as a function of the magnitude and relative position of the defects is obtained with the assistance of numerical results

What's the best treatment for sebaceous cysts?

Punch biopsy excision appears to be superior to traditional wide elliptical excision for the treatment of sebaceous cysts when intervention is necessary (strength of recommendation [SOR]: B, based on 1 small randomized study). No rigorous metho- dological studies have compared punch biopsy excision of sebaceous cysts with the minimal excision technique