74 research outputs found
Male Ă Female Interaction for a Pre-Copulatory Trait, but Not a Post-Copulatory Trait, among Cosmopolitan Populations of Drosophila melanogaster
- Author
- A Pischedda
- AG Clark
- Alison Pischedda
- Andrew D. Stewart
- BC Sheldon
- CI Wu
- CT Ting
- D Scott
- DJ Begun
- DJ Hosken
- DW Fulker
- G Arnqvist
- GA Parker
- GA Parker
- H Hollocher
- JA Alipaz
- JA Andrés
- JC Billeter
- JF Ferveur
- K Connolly
- K Iliadi
- L Rowe
- LL Knowles
- Monica K. Little
- NR Henderson
- P Casares
- P Welbergen
- S Gavrilets
- S Pitnick
- T Nilsson
- T Nilsson
- TAF Long
- TAF Long
- TFC Mackay
- TM Panhuis
- William J. Etges
- WJ Swanson
- WR Rice
- WR Rice
- Publication venue
- Public Library of Science
- Publication date
- 14/03/2012
- Field of study
Sexual coevolution occurs when changes in the phenotype of one sex select for changes in the other sex. We can identify the âfootprintâ of this coevolution by mating males and females from different populations and testing for a male-female genotype interaction for a trait associated with male (or female) performance. Here we mated male Drosophila melanogaster from five different continents with females from their own and different continents to test for a male-female interaction for mating speed, a pre-copulatory trait, and female reproductive investment, a post-copulatory trait. We found a strong male-female interaction for mating speed, consistent with previous studies using different populations, suggesting that the potential for sexual coevolution for this trait is present in this species. In contrast, we did not detect a male-female interaction for female reproductive investment. Although a male-female interaction for mating speed is compatible with the hypothesis of ongoing sexual coevolution, the nature of our experimental design is unable to exclude alternate explanations. Thus, the evolutionary mechanisms promoting male-female genotype interactions for pre-copulatory mating traits in D. melanogaster warrant further investigation
Evaluating the impact of Minimum Unit Pricing in Scotland on people who are drinking at harmful levels.
- Author
- Publication venue
- Public Health Scotland
- Publication date
- 01/06/2022
- Field of study
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar M. S.
- Abdel-Aziz M.
- Abdelrazik M.
- Abdollahi H.
- Abdullah T.
- Abecasis G. R.
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- Abel L.
- Abernathy C.
- Abraheem A.
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- Woodyatt W.
- Woolley A. E.
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- Wren L.
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- Wright J.
- Wright M.
- Wrobel N.
- Wu Y.
- Wulandari R.
- Wyllie D. H.
- Wynter I.
- Xavier K.
- Xue X.
- Yadav A.
- Yang J.
- Yassen A. M.
- Yates B.
- Ye C.
- Yun N.
- Zainy T.
- Zak A.
- Zaki A.
- Zamikula J.
- Zanella I.
- Zborowski A. C.
- Zeberg H.
- Zechner M.
- Zguro K.
- Zhang M.
- Zhao J. H.
- Zheng C.
- Zhou W.
- Zitter L.
- Zlatopolsky M.
- Zollner S.
- Zongo O.
- Zucchi P.
- Zyndorf M.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2â4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genesâincluding reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)âin critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
Genetic mechanisms of critical illness in COVID-19.
- Author
- A A Roger Thompson
- A Abraheem
- A Agasou
- A Ahmed
- A Ali
- A Allan
- A Altabaibeh
- A Alvaro
- A Aspinwall
- A Ayers
- A Bamford
- A Barron
- A Bashyal
- A Bellini
- A Bociek
- A Botello
- A Bowes
- A Brady
- A Brayne
- A Brown
- A Brown
- A Butler
- A Campbell
- A Carter
- A Collins
- A Cowley
- A Cowton
- A Cowton
- A Cox
- A Crew
- A Dance
- A Daniel
- A Daniels
- A Dela Rosa
- A Drummond
- A Durie
- A E Heron
- A Easthope
- A Easthope
- A Evans
- A Fofano
- A Gales
- A Ganesan
- A Gardner
- A Garg
- A Gherman
- A Gordon
- A Gratrix
- A Gulati
- A Gupta
- A Haigh
- A Haldeos
- A Harrison
- A Harvey
- A Hayes
- A Higham
- A Higham
- A Hilldrith
- A Holden
- A Hormis
- A Hutcheon
- A Javaid
- A Joseph
- A Kaliappan
- A Katary
- A Kay
- A Kayani
- A Kent
- A Kirkby
- A Knight
- A Kubisz-Pudelko
- A Kuravi
- A Lewis
- A Loveridge
- A Lyle
- A Mayer
- A McAlpine
- A McCarthy
- A McGregor
- A McGregor
- A Meikle
- A Mitchell
- A Mitra
- A Morris
- A Morrison
- A Naranjo
- A Nicholson
- A Nicholson
- A Nilsson
- A Noakes
- A Patel
- A Pickard
- A Poole
- A Price
- A Puxty
- A Quinn
- A Quinn
- A Raithatha
- A Rattray
- A Reddy
- A Reed
- A Reyes
- A Rose
- A Rose
- A Rostron
- A Roy
- A Roynon-Reed
- A S Raj
- A Salberg
- A Sanderson
- A Serrano-Ruiz
- A Solesbury
- A Sukha
- A Swain
- A Tariq
- A Thomas
- A Thomas
- A Todd
- A Tomas
- A Tridente
- A Tucci
- A Turnbull
- A Uriel
- A Ustianowski
- A Vochin
- A Vuylsteke
- A Waite
- A Walden
- A Whileman
- A Wilkinson
- A Williams
- A Williams
- A Wilson
- A Zak
- A Zaki
- Achille Iolascon
- Adam Auton
- Adam Brown
- Agnese Verzuri
- Agostino Ognibene
- Agostino Riva
- Ailsa Golightly
- Alan Maclean
- Alessandra
- Alessandra Stella
- Alessandra Vergori
- Alessia Giorli
- Alexander J Mentzer
- Alice Donati
- Alison M Meynert
- Alistair Nichol
- Ana da Silva Filipe
- Andrea Antinori
- Andrea Cossarizza
- Andrea Ganna
- Andrea Tommasi
- Andrew Rambaut
- Andrew Stenhouse
- Andy Law
- Anjali J Shastri
- Anna Canaccini
- Anna Maria Pinto
- Annarita Giliberti
- Annemarie B Docherty
- Antonella D'Arminio Monforte
- Antonia Ying Wai Ho
- Antonio Di Biagio
- Antony Symons
- Arianna Emiliozzi
- Arianna Gabrieli
- Audrey Coutts
- B Anwar
- B Attwood
- B Baines
- B Blackledge
- B Borislavova
- B Chandler
- B Charles
- B Creagh-Brown
- B David
- B Deacon
- B Deacon
- B Digby
- B Faulkner
- B Fuller
- B Gumbrill
- B Gurung
- B Hadebe
- B Hairsine
- B Hopkins
- B Johnston
- B Lenagh
- B Masunda
- B Ogg
- B Patel
- B Player
- B Purewal
- B Scholefield
- B Shelley
- B Sloan
- B Thomas
- B Wadams
- B Welsh
- B Wilkinson
- B Winter-Goodwin
- B Yates
- Baillie J Kenneth
- Barbara Rossetti
- Beale Rupert
- Beatrice Alex
- Benjamin Bach
- Bretherick Andrew D
- Bruno Frediani
- C Adams
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- C Almaden-Boyle
- C Ashbrook-Raby
- C Basikolo
- C Battle
- C Beazley
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- C Castro Delgado
- C Clark
- C Clulow
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- C Demetriou
- C Dennis
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- C Dunmore
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- C Gorman
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- C Jardine
- C Jennings
- C Jones
- C Kaye
- C Lynch
- C Lyons
- C McCulloch
- C McParland
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- C Murphy
- C Parmar
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- C Pothecary
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- C Prendergast
- C Price
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- C Sell
- C Shovelton
- C Sicat
- C Stuart
- C Summers
- C Swan
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- C Vigurs
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- C Whitton
- C Whyte
- C Wrey Brown
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- Carmen Marciano
- Caroline Abernathy
- Carrol Gamble
- Caterina Lo Rizzo
- Catherine A Shaw
- Catherine H Weldon
- Caulfield Mark
- Ceilia Boz
- Cesira Nencioni
- Chelsea Ye
- Chiara Fallerini
- Chiara Gabbi
- Chiara Spertilli
- Chloe Donohue
- Chris Ponting
- Christoper A Green
- Cinthia E Jannes
- Clare Jackson
- Clohisey Sara
- Cristina Mussini
- D Antcliffe
- D Bakthavatsalam
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- D Baptista
- D Bell
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- D Brealey
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- D Butcher
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- D Collier
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- D Cristiano
- D Dawson
- D Donaldson
- D Duffin
- D Fottrell-Gould
- D Golden
- D Griffin
- D Hamilton
- D Hawcutt
- D Hope
- D Horner
- D Kallon
- D Kaye
- D Kelly
- D Loader
- D Lomas
- D Martin
- D McGlynn
- D McLaughlanv
- D Melia
- D Menzies
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- D Pogson
- D Potla
- D Potoczna
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- D Salutous
- D Scaletta
- D Shaw
- D Skinner
- D Smyth
- D Strachan
- D Tetla
- D Thornton
- D Trodd
- D Vedage
- D Walker
- D Warren
- D Williams
- D Wood
- D Wright
- Daniela Francisci
- Daniella Coker
- Danilo Tacconi
- David A van Heel
- David Bennet
- David L Robertson
- David Stuart
- Dawn Law
- Debby Bogaert
- Derek Murphy
- Domenico A Coviello
- E Abaleke
- E Allan
- E Anastasescu
- E Andrews
- E Apetri
- E B Jude
- E Beech
- E Beranova
- E Bevan
- E Black
- E Brinkworth
- E Collins
- E Combes
- E Davies
- E Dobson
- E Dooks
- E Fisher
- E Gendall
- E Goff
- E Goodwin
- E Gordon
- E Heeney
- E Horsley
- E Hughes
- E Johnson
- E Knights
- E Lee
- E London
- E Maccacari
- E Massey
- E McKenna
- E Meadows
- E Moncur
- E Morino
- E Mwaura
- E Peasgood
- E Perkins
- E Radford
- E Raith
- E Raith
- E Salciute
- E Smith
- E Smithson
- E Stoddard
- E Stones
- E Thomas
- E Tilney
- E Timlick
- E Treus Gude
- E Virgilio
- E Watson
- E Wilby
- Edoardo Conticini
- Egle Saviciute
- Elena Bargagli
- Elena Desanctis
- Elisa Benetti
- Elisa Frullanti
- Elisabetta Menatti
- Elisabetta Schiaroli
- Ellie Mcmaster
- Emma C Thomson
- Emmanuelle Marques
- Enrico Martinelli
- Esther Duncan
- Esther Merlini
- Ewen M Harrison
- F Anderson
- F Auld
- F Bibi
- F Davies
- F Farquhar
- F Fisher
- F Hurford
- F Kibutu
- F McNeela
- F Moore
- F Nasir
- F Trim
- F Wakinshaw
- F Williams
- Fabio Lena
- Fawkes Angie
- Federico Anedda
- Federico Franchi
- Ferdinando Giannattasio
- Filip Taneski
- Filippo Aucella
- Filippo Biscarini
- Floriana Valentino
- Fourman Max Head
- Francesca Andretta
- Francesca Fava
- Francesca Gatti
- Francesca Mari
- Francesca Montagnani
- Francesco Castelli
- Francesco Raimondi
- Furniss James
- G Andrew
- G Arbane
- G Bell
- G Bercades
- G Croston
- G Debreceni
- G Durrant
- G Hambrook
- G Hobden
- G Houston
- G Hughes
- G Jones
- G Lubimbi
- G Maloney
- G Martir
- G Millen
- G Mills
- G O'Connor
- G Padden
- G Randell
- G Sadera
- G Seddon
- G Sera Howe
- G Sloane
- G Subramanian
- G Tsinaslanidis
- G Turner
- G Watson
- G Wray
- Gabriella Coiro
- Gabriella Doddato
- Gail Carson
- Gardar Sveinbjornsson
- Gary Leeming
- Genni Spargi
- Georgios Pollakis
- Giacomo Zanelli
- Gian Piero Caldarelli
- Giancarlo Bosio
- Giuseppe Fiorentino
- Giuseppe Merla
- Gountouna Elvina
- Graham S Cooke
- Griffiths Fiona
- Grimes Graeme
- H Bancroft
- H Bates
- H Belfield
- H Blackman
- H Blakemore
- H Brooke
- H Button
- H Coles
- H Curgenven
- H Filipe
- H Fox
- H Golding
- H Hill
- H Holcombe
- H Houlden
- H Jeffrey
- H Kent
- H Langton
- H McGuinness
- H Meghari
- H Millward
- H Moore
- H Parker
- H Pearson
- H Prady
- H Quinn
- H Rangarajan
- H Rehman
- H Reschreiter
- H Riley
- H Sainsbury
- H Savill
- H Sturgeon
- H T-Michael
- H Tench
- H Tiveran
- H Turner
- H Whittle
- H Willis
- H Wood
- Haley Chris
- Hanning Mal
- Harrison David
- Hayley Hardwick
- Hayward Caroline
- Helen Szoor-McElhinney
- Hinds Charles
- Ho Antonia
- Horby Peter
- I Ali Mohamed Ali
- I Balagosa
- I Birkinshaw
- I Burn
- I Chadbourn
- I D Clement
- I Edmond
- I Frost
- I Hass
- I Hussain
- I Lancoma-Malcolm
- I Leadbitter
- I Nagra
- I Otahal
- I Otahal
- I Turner-Bone
- I Welters
- I White
- I Wynter
- Ilaria Meloni
- Immacolata Andolfo
- Isabella Zanella
- J Allan
- J Barker
- J Bewley
- J Biddle
- J Birch
- J Birch
- J Bradley-Potts
- J Brown
- J Bryant
- J Butler
- J Camsooksai
- J Carter
- J Caterson
- J Cebrian Suarez
- J Cockerill-Taylor
- J Cole
- J Colley
- J Cooper
- J Cupitt
- J Cuttler
- J Daglish
- J Dasgin
- J Dawson
- J Dearden
- J Deery
- J Donnachie
- J Dykes
- J Easton
- J Egan
- J Fernandez Roman
- J Finn
- J Fletcher
- J Frankham
- J Gaylard
- J Gill
- J Godden
- J Goodsell
- J Gregory
- J Greig
- J Gurasashvili
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- J Harris
- J Hatton
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- J Highgate
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- J Hulme
- J Hunt
- J Hutter
- J Ingham
- J Jones
- J Jones
- J K Baillie
- J Kassam
- J Kenneth Baillie
- J Kenneth Baillie
- J Keshet-Price
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- J Little
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- J Martin
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- Keating Sean
- Kenneth A Mclean
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- L Abel
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- L Allen
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- Lia Crotti
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- Lorenzo Salerni
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- Luca Cantarini
- Luca Guidelli
- Luca Masucci
- Luisa Tavecchia
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- M Smith
- M Spivey
- M T Hijazi
- M Taylor
- M Taylor
- M Taylor
- M Taylor
- M Taylor
- M Templeton
- M Thankachen
- M Thirumaran
- M Thomas
- M Tolson
- M Usher
- M Varghese
- M Verlander
- M Vertue
- M Watters
- M White
- M Wiles
- M Williams
- M Wills
- M Woodruff
- M Young
- Maaike Swets
- Mahdad Noursadeghi
- Manu Shankar-Hari
- Marco Castori
- Marco Feri
- Marco Gori
- Marco MandalĂ
- Marco Sita
- Margherita Baldassarri
- Mari E K Niemi
- Mari Ward
- Maria Antonietta Mazzei
- Maria Antonietta Mencarelli
- Maria Bandini
- Maria Eugenia Quiros-Roldan
- Maria Palmieri
- Maria Zambon
- Marie Connor
- Mario Capasso
- Mario U Mondelli
- Marta Corridi
- Maslove David
- Massimiliano Fabbiani
- Massimo Carella
- Massimo Girardis
- Massimo Palmarini
- Massimo Vaghi
- Matteo Bassetti
- Matteo Della Monica
- Matteo Siano
- Mattia Cordioli
- Maurizio Sanarico
- Maurizio Sanguinetti
- Maurizio Spagnesi
- McAuley Danny
- Meera Chand
- Meynert Alison
- Michelle Girvan
- Millar Jonathan
- Mirella Bruttini
- Miriana D'Alessandro
- Montgomery Hugh
- Moore Shona C
- Moutsianas Loukas
- Murphy Lee
- Murray Wham
- N Ahmad
- N Bandla
- N Baxter
- N Boyle
- N Capps
- N Clarke
- N Crisp
- N Davidson
- N Dormand
- N Grau
- N Harris
- N Jacques
- N Keenan
- N Lancaster
- N Love
- N MacCallum
- N Michalak-Glinska
- N Motherwell
- N Muchenje
- N Nikitas
- N Pathan
- N Pattison
- N Proudfoot
- N Rea
- N Richardson
- N Rodden
- N Roe
- N Rogers
- N Runciman
- N Schumacher
- N Schunki
- N Slawson
- N Staines
- N Thomson
- N Truman
- N White
- Nichol Alistair
- Nicholas Parkinson
- Nicholas Price
- Nicky Day
- Nicola Picchiotti
- O Adanini
- O Akinkugbe
- O Ezeobu
- O Jones
- O Kelsall
- O Mercer
- O Mitchelmore
- O Olufuwa
- O Prysyazhna
- O Zongo
- Oosthuyzen Wilna
- Openshaw Peter J M
- P Alexander
- P Anderson
- P Bamford
- P Barry
- P Boyle
- P Clark
- P Coghlan
- P Doble
- P Donnison
- P Ebano
- P Gondo
- P Grant
- P Harding
- P Henderson
- P Hutton
- P Jackson
- P MacGoey
- P May
- P McConnell
- P Mercer
- P O'Brien
- P O'Neil
- P Parkinson
- P Parsons
- P Paul
- P Polgarova
- P Ranga
- P Rice
- P Rogers
- P Saunderson
- P Shanmugasundaram
- P Springle
- P Szedlak
- P Turner
- P Williams
- Pairo-Castineira Erola
- Pamela Raggi
- Paola Magro
- Paolo Cameli
- Paolo Piacentini
- Parkinson Nick
- Pasko Dorota
- Patrick Sulem
- Patrizia Zucchi
- Paul Finernan
- Paul Klenerman
- Pereira Alexandre C
- Peter W Horby
- Pier Giorgio Scotton
- Pierpaolo Parravicini
- Pietro Pinoli
- Ponting Chris P
- Porteous David J
- R Astin-Chamberlain
- R Barber
- R Baruah
- R Bi
- R Bolton
- R Bowles
- R Boyle
- R Bradley
- R Campbell
- R Campbell
- R Chan
- R Charlesworth
- R Clark
- R Crawley
- R Crowe
- R Cusack
- R Davies
- R Doonan
- R Flanagan
- R Gascoyne
- R Girach
- R Gomez
- R Griffiths
- R Hall
- R Hamill
- R Haq
- R Harford
- R Harper
- R Herdman-Grant
- R Howle
- R Jacob
- R Jha
- R Johnson
- R Jones
- R Joy
- R Kanu
- R Kapoor
- R Kausar
- R Khade
- R Kitson
- R Kumar
- R Lean
- R Lim
- R Loosley
- R Lorusso
- R M Genetu
- R Marshall
- R O'Leary
- R Paramsothy
- R Parker
- R Partridge
- R Penn
- R Pepermans Saluzzio
- R Pollard
- R Price
- R Prout
- R Pugh
- R Raobaikady
- R Reece-Anthony
- R Rikunenko
- R Rojo
- R Saha
- R Sandhu
- R Shaw
- R Shokkar
- R Simms
- R Stead
- R Stewart
- R Sundaram
- R Tully
- R Tutton
- R Vincent
- R Walker
- R Wilcox
- R Wolf-Roberts
- R Worner
- R Wulandari
- Rachel Law
- Raffaele Scala
- Rawlik Konrad
- Renieri
- Renzo Scaggiante
- Richard Clark
- Richard S Tedder
- Richmond Anne
- Riinu Pius
- Rita Perna
- Roberta Russo
- Ross Hendry
- Rossella Tita
- Rowan Kathy
- Russell Clark D
- Ruth Armstrong
- Ruth Lyons
- Ryan S Thwaites
- S Agrawal
- S Allen
- S Allibone
- S Anderson
- S Archer
- S Bano
- S Bean
- S Beavis
- S Bell
- S Bennett
- S Benyon
- S Bird
- S Blowes
- S Board
- S Bonner
- S Brett
- S Buckley
- S Campos
- S Cathcart
- S Chapman
- S Charlton
- S Cherian
- S Chukkambotla
- S Clamp
- S Clark
- S Clements
- S Coetzee
- S Cole
- S Cornell
- S Cutler
- S Dale
- S Donlon
- S Farnell-Ward
- S Fowler
- S Garrioch
- S Gibson
- S Gopal
- S Greer
- S Gurung Rai
- S Henderson
- S Hierons
- S Hope
- S Humphreys
- S Hussain
- S Jenkins
- S Jhanji
- S Jones
- S Jose
- S Joseph
- S Kaul
- S Keenan
- S Keith
- S Kennedy-Hay
- S Kimber
- S Kumar
- S Laha
- S Latham
- S Leaver
- S Lee
- S Leggett
- S MacFadyen
- S Manna
- S Marriott
- S Masuko
- S McIvor
- S McKechnie
- S Melling
- S Mellor
- S Mepham
- S Metherell
- S Mitchard
- S Mohamed Ally
- S Monnery
- S Moore
- S Morrison
- S Moultrie
- S Mtuwa
- S Mulla
- S Munt
- S Murdoch
- S O'Sullivan
- S Packham
- S Patch
- S Pearson
- S Pitts
- S Preston
- S Purvis
- S Quaid
- S Ray
- S Roche
- S Rose
- S Rundell
- S Salmi
- S Sathe
- S Selvanayagam
- S Shelton
- S Shepardson
- S Siddiqui
- S Smuts
- S Sousa Arias
- S Spencer
- S Srikaran
- S Stone
- S Swann
- S Tilbey
- S Turki
- S Turney
- S Twiss
- S Wadd
- S Whiteley
- S Williams
- S Wood
- S Yussuf
- Sabino Scolletta
- Samreen Ijaz
- Sandro Mancarella
- Sandro Panese
- Sara Amitrano
- Sara McDonald
- Sarah Law
- Sarah McCafferty
- Saverio Giuseppe Parisi
- Saye Khoo
- Scott Richard
- Semple Malcolm G
- Serafina Valente
- Serena Ludovisi
- Sergio Daga
- SeĂĄn Keating
- Shankar-Hari Manu
- Shen Xia
- Shih Barbara
- Shiranee Sriskandan
- Shona C Moore
- Silvia Cappelli
- Simona Marcantonio
- Simone Furini
- Sophie Halpin
- Sophie Venturelli
- Stefania Mantovani
- Stefano Baratti
- Stefano Ceri
- Stefano Rusconi
- Stella Aslibekyan
- Stephanie Roberts
- Stephen R Knight
- Summers Charlotte
- Susanna Croci
- Susanna Guerrini
- T Anderson
- T Arden
- T Baird
- T Behan
- T Bemand
- T Cosier
- T Coventry
- T Duncan
- T Felton
- T Geary
- T Hazleton
- T Joefield
- T Kannan
- T Lawton
- T Marsden
- T Martin
- T McHugh
- T Newman
- T Nortcliffe
- T O Jones
- T Pogreban
- T Rees
- T Samakomva
- T Smith
- T Smith
- T Szakmany
- T Varghes
- T Williams
- T Wood
- Tammy Gilchrist
- Tenesa Albert
- Teresa Filshtein-Sonmez
- Thomas M Drake
- Thushan de Silva
- Tim Walsh
- Tom Fletcher
- Tom Solomon
- Tony Wackett
- Trevor Paterson
- Tullio Trotta
- Turtle Lance
- U Poultney
- V Amin
- V Anumakonda
- V Bastion
- V Cannons
- V Crickmore
- V Gopal
- V Irvine
- V Kasipandian
- V Krishnamurthy
- V Lake
- V Linnett
- V Martinson
- V Nagarajan
- V Page
- V Parris
- V Parris
- V Pristopan
- V Ratnam
- V Rivers
- V Sarathy
- V Thomas
- V Thwaites
- V Tuckey
- V Turner
- V Wagstaff
- V Waugh
- Valentina Anemoli
- Vanessa Sancho-Shimizu
- Victoria Shaw
- Vitart Veronique
- W Harrison
- W Khaliq
- W Khaliq
- W McCormick
- W Woodyatt
- Walker Susan
- Walsh Timothy
- Wang Bo
- Wei Shen Lim
- Wendy S Barclay
- William A Paxton
- William Greenhalf
- Wilson James F
- Wrobel Nicola
- Wu Yang
- X Qiu
- Y Baird
- Y Choudhury
- Y Hussain
- Y Jackson
- Y Thirlwall
- Yang Jian
- Yang Zhijian
- Z Alldis
- Z Belagodu
- Z Bradshaw
- Z Coton
- Z Daly
- Z Farzad
- Z Fernandez
- Z Garland
- Z Maqsood
- Z Omar
- Z Prime
- Z Scott
- Zechner Marie
- Zhai Ranran
- Zheng Chenqing
- Publication venue
- Nature
- Publication date
- 01/01/2020
- Field of study
Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, PÂ =Â 1.65Â ĂÂ 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, PÂ =Â 2.3Â ĂÂ 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, PÂ =Â 3.98Â ĂÂ Â 10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, PÂ =Â 4.99Â ĂÂ 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice
2011 SOSORT guidelines: Orthopaedic and Rehabilitation treatment of idiopathic scoliosis during growth
- Author
- A Giordano
- A Helfenstein
- A Howard
- A Morton
- A Nachemson
- A Negrini
- A Negrini
- AA Fernandez
- AG Aulisa
- AG Aulisa
- AG Aulisa
- AG Veldhuizen
- AJ Danielsson
- AJ Danielsson
- AJ Danielsson
- AL Nachemson
- Alin B Circo
- Angelo G Aulisa
- AO Berg
- AP Sangole
- AR Shands Jr
- B Buyse
- B Stone
- B Xiong
- BP Yawn
- BS Richards
- C Barrios
- C Botens-Helmus
- C Coillard
- C Coillard
- C Coillard
- C Ferraro
- C Fusco
- C Fusco
- C Grosso
- C Lehnert-Schroth
- C Lewis
- C Lisboa
- C Meyer
- C Meyer
- CD Naylor
- CH Rivard
- Charles H Rivard
- CJ Goldberg
- CV DiRaimondo
- D Carman
- D Gignac
- D Malfair
- D Nauffal
- D Parsch
- D Perie
- D Perie
- D Perie
- DB Piazzini
- DD Aspegren
- DE Katz
- DE Katz
- DE Katz
- DE Rowe
- DG Little
- Dimitris Papadopoulos
- DJ Sucato
- DL Carman
- DL Sackett
- DR Gore
- E Kenanidis
- E Lou
- E Lou
- E Lou
- E Vasiliadis
- E Vasiliadis
- E Vasiliadis
- EJ Rogala
- EM Bunge
- ER Kafer
- ES Vasiliadis
- F D'Osualdo
- F D'Osualdo
- F Landauer
- F Montgomery
- F Zaina
- F Zaina
- F Zaina
- F Zaina
- FA Focarile
- Fabio Zaina
- FP Castro Jr
- G Mener
- G Mollon
- GP Nicholson
- H Brooks
- H King
- H Neugebauer
- H Omeroglu
- H Stoboy
- H Weiss
- H Weiss
- H Weiss
- H Weiss
- H Weiss
- H Weiss
- H-R Weiss
- HA King
- Hans-Rudolf Weiss
- HE Refsum
- HK Wong
- HR Weiss
- HR Weiss
- HR Weiss
- HR Weiss
- HR Weiss
- HR Weiss
- HR Weiss
- HR Weiss
- HR Weiss
- HR Weiss
- HR Weiss
- HR Weiss
- HR Weiss
- HR Weiss
- HR Weiss
- HR Weiss
- HR Weiss
- HR Weiss
- HR Weiss
- HR Weiss
- I Koukourakis
- IA Stokes
- IV Ponseti
- J Bago
- J Bago
- J Cheneau
- J Cheneau
- J Clin
- J de Mauroy
- J Dubousset
- J Durmala
- J Martinez-Llorens
- J Risser
- J Seifert
- JA Janicki
- JA Sevastikoglou
- Jacek Durmala
- James H Wynne
- JB Emans
- JC de Mauroy
- JC de Mauroy
- JC de Mauroy
- JC Leong
- JD Kennedy
- JE Lonstein
- JE Lonstein
- JE Lonstein
- JE Pruijs
- Jean Claude de Mauroy
- JH Wynne
- JI James
- JI Kessler
- JM Shneerson
- JM Shneerson
- JO Sanders
- JO Sanders
- Joseph P O'Brien
- JR Schiller
- JR Smith
- JW Ogilvie
- JW Ogilvie
- K Bagnall
- K Fallstrom
- K McIntire
- K Pehrsson
- K Pehrsson
- K Ward
- K Zaborowska-Sapeta
- KC Chen
- KJ Noonan
- KL White
- KM Bagnall
- KM Bagnall
- L Aulisa
- L De Wilde
- L Duong
- L Rivett
- L Wan
- LA Dolan
- LE Peterson
- LG Lenke
- LG Lenke
- LG Lenke
- LH Pin
- Lorenzo Aulisa
- M Aebi
- M Asher
- M Asher
- M Asher
- M Asher
- M Beauchamp
- M Beausejour
- M Bergoin
- M Estenne
- M Lindeman
- M Marks
- M Nissinen
- M Rigo
- M Rigo
- M Rigo
- M Rigo
- M Rigo
- M Rigo
- M Rigo
- M Romano
- M Takemitsu
- M Vercauteren
- M Ylikoski
- MA Asher
- Manuel Rigo
- MC Hawes
- MC Hawes
- MC Hawes
- MC Hawes
- MC Hawes
- MC Hawes
- MC Hawes
- MD Rigo
- MD Rigo
- ME Potoupnis
- MG Zmurko
- MH Mehta
- MH Mehta
- Michele Romano
- MJ McMaster
- MJ McMaster
- MJ Spoonamore
- ML Lenssinck
- Monica Villagrasa
- MP Warren
- MS Goldberg
- MS Goldberg
- MS Wong
- MS Wong
- MS Wong
- MS Wong
- MW Morningstar
- N Birbaumer
- N Shuren
- N Smania
- NE Mayo
- NH Miller
- NJ Allington
- P Cote
- P Klisic
- P Korovessis
- P Poncet
- P Poncet
- P Sibilla
- P Sibilla
- P Soucacos
- P Stagnara
- P Stagnara
- P Stagnara
- Patrick Knott
- PB Fowler
- PD Sponseller
- PI Tanchev
- PJ DiRocco
- PN Soucacos
- PT Rubery
- R Havey
- R Perdriolle
- R Winter
- RA Dickson
- RA Dickson
- RA Miyasaki
- RE Mannherz
- RG Burwell
- RG Burwell
- RG Burwell
- RG Burwell
- RJ McAlindon
- RJ Smyth
- RT Morrissy
- S Agostini
- S Athanasopoulos
- S Fuschillo
- S Hoppenfeld
- S Kesten
- S Mammano
- S Negrini
- S Negrini
- S Negrini
- S Negrini
- S Negrini
- S Negrini
- S Negrini
- S Negrini
- S Negrini
- S Negrini
- S Negrini
- S Negrini
- S Negrini
- S Negrini
- S Negrini
- S Negrini
- S Negrini
- S Negrini
- S Negrini
- S Negrini
- S Negrini
- S Negrini
- S Negrini
- S Negrini
- S Negrini
- S Negrini
- S Negrini
- S Negrini
- S Negrini
- S Otman
- S Padua
- S Parent
- S Pineda
- S Takahashi
- S Vandal
- S Weinstein
- S Willner
- SC Huang
- Silvia Minozzi
- SJ Jones
- SL Weinstein
- SL Weinstein
- SL Weinstein
- SR Gammon
- SS Upadhyay
- Stefano Negrini
- T Biel
- T Kotani
- T Kotani
- T Kotwicki
- T Kotwicki
- T Kotwicki
- T Kotwicki
- T Kotwicki
- T Kotwicki
- T Laulund
- T Mamyama
- T Maruyama
- T Maruyama
- T Morais
- T Rahman
- T Yrjonen
- TB Grivas
- TB Grivas
- TB Grivas
- TB Grivas
- TB Grivas
- TB Grivas
- TB Grivas
- TB Grivas
- TB Grivas
- TB Grivas
- TB Grivas
- TB Grivas
- TB Grivas
- TB Grivas
- Theodoros B Grivas
- TJ Becker
- Tomasz Kotwicki
- Toru Maruyama
- UM Figueiredo
- V Margonato
- V Mooney
- VT Tolo
- W Blount
- WA den Boer
- WC Horton
- WE MacLean Jr
- WN Sankar
- WP Blount
- WP Bunnell
- WP Bunnell
- WP Bunnell
- WP Bunnell
- WP Bunnell
- Publication venue
- BioMed Central
- Publication date
- 01/01/2012
- Field of study
<p>Abstract</p> <p>Background</p> <p>The International Scientific Society on Scoliosis Orthopaedic and Rehabilitation Treatment (SOSORT), that produced its first Guidelines in 2005, felt the need to revise them and increase their scientific quality. The aim is to offer to all professionals and their patients an evidence-based updated review of the actual evidence on conservative treatment of idiopathic scoliosis (CTIS).</p> <p>Methods</p> <p>All types of professionals (specialty physicians, and allied health professionals) engaged in CTIS have been involved together with a methodologist and a patient representative. A review of all the relevant literature and of the existing Guidelines have been performed. Documents, recommendations, and practical approach flow charts have been developed according to a Delphi procedure. A methodological and practical review has been made, and a final Consensus Session was held during the 2011 Barcelona SOSORT Meeting.</p> <p>Results</p> <p>The contents of the document are: methodology; generalities on idiopathic scoliosis; approach to CTIS in different patients, with practical flow-charts; literature review and recommendations on assessment, bracing, physiotherapy, Physiotherapeutic Specific Exercises (PSE) and other CTIS. Sixty-five recommendations have been given, divided in the following topics: Bracing (20 recommendations), PSE to prevent scoliosis progression during growth (8), PSE during brace treatment and surgical therapy (5), Other conservative treatments (3), Respiratory function and exercises (3), Sports activities (6), Assessment (20). No recommendations reached a Strength of Evidence level I; 2 were level II; 7 level III; and 20 level IV; through the Consensus procedure 26 reached level V and 10 level VI. The Strength of Recommendations was Grade A for 13, B for 49 and C for 3; none had grade D.</p> <p>Conclusion</p> <p>These Guidelines have been a big effort of SOSORT to paint the actual situation of CTIS, starting from the evidence, and filling all the gray areas using a scientific method. According to results, it is possible to understand the lack of research in general on CTIS. SOSORT invites researchers to join, and clinicians to develop good research strategies to allow in the future to support or refute these recommendations according to new and stronger evidence.</p
Basic science232.âCertolizumab pegol prevents pro-inflammatory alterations in endothelial cell function
- Author
- Abdulkader Rita
- Abozaid Hanan S.
- Adab Peymané
- Adizie Tochukwu
- Adshead Rebecca
- Ahmad Yasmeen
- Ahmed Azeem A.
- Akil Mohammed
- Alavi Azita
- Alcorn Desmond
- Alexander Yvonne
- Alexander Yvonne
- Alexander Yvonne
- Allen Maggie
- Amarasena Roshan
- Amarasena Roshan I.
- Ambler Nick
- Amft Nicole
- Amft Nicole
- Amissah-Arthur Maame
- Amos Nicholson
- Anderson David
- Andres Mariano
- Andrews Jacqueline
- Arthur Catherine
- Ashton Simon
- Axford John
- Ayalew Yezenash
- Baburaj Krishnan
- Bacon Paul A.
- Baguley Elaine
- Ball Elisabeth
- Banik Snehashish
- Bari Syed F.
- Barone Francesca
- Barone Francesca
- Barton Anne
- Barton Anne
- Basu Neil
- Bateman James
- Bavakunji Riaz
- Bayley Rachel
- Beasley Marcus
- Bell Aubrey
- Bell Aubrey L.
- Birnbaum Julius
- Bombardieri M.
- Bombardieri Michele
- Bombardieri Michele
- Bombardieri Michele
- Bond Christine
- Bond Ursula
- Borg Frances
- Borg Frances A.
- Bosworth Ailsa
- Boulton John
- Bowman Simon
- Bowness Paul
- Bowness Paul
- Bowness Paul
- Braude Simon
- Brooksby Alan
- Brophy Sinead
- Brown Deborah
- Brown Nina
- Brown Sue J.
- Bruce Ian
- Bruce Ian
- Bruce Ian
- Bruce Ian
- Bruce Ian
- Buckley Chris
- Buckley Chris
- Buckley Chris
- Buckley Chris D.
- Bukhari Marwan
- Bukhari Marwan
- Bukhari Marwan
- Bullock Craig
- Bunn Diane
- Bunn Diane
- Bunning Rowena
- Bunning Rowena A. D.
- Bunning Rowena D.
- Calnan Michael
- Cardy Caroline M.
- Casey Matthew
- Caswell Richard
- Ceeraz Sabrina
- Chan Antoni
- Chana Jasroop K.
- Chapman Victoria
- Chen Liye
- Cheng K. K.
- Chitale Sarang
- Chitale Sarang
- Chiverton Neil
- Chiverton Neil
- Choy Ernest
- Choy Ernest H.
- Christidis Dimitrios
- Cloake Tom
- Cloake Tom
- Clunie Gavin
- Coady David
- Coady David
- Coady David
- Colaco Bernard
- Cole Zoe A.
- Coles Mark
- Collins Fraser
- Cooksey Roxanne
- Cooper Annie
- Cooper Cyrus
- Cooper Cyrus
- Cooper Nicola
- Cope Andrew
- Cordingley Lis
- Corrigall Valerie
- Coward Lucy
- Crawford Aileen
- Crilly Anne
- Cross Alison
- Cross Alison K.
- Crouch Carina
- Crozier Sarah R.
- Cumming Jo
- Curtis Elizabeth M.
- D'Cruz David
- Danda Debashish
- Daniel Priya
- Daniels Jodie
- Darroch James
- Dasgupta Bhaskar
- Dasgupta Bhaskar
- Dasgupta Bhaskar
- Davies Charlotte
- Davies David
- Davies Rebecca
- Davies Ursula M.
- Dent Caroline
- Devanny Ian
- Dey Ida D.
- Dhanjal Mandish
- Dhillon Veena
- DiCicco Maria
- Dixey Josh
- Dixey Josh
- Doherty Teresa
- Donnelly Simon P.
- Driscoll Paul C.
- Duncan G.
- Duncan Rosie
- Dunn Sara
- Dures Emma
- Edgar Suzanne
- Edmonds Sally
- Edwards Christopher J.
- Edwards Christopher J.
- Edwards Steven W.
- Ellis Benjamin
- Ellis Corrinne
- Else Sara
- Emery Paul
- Ennis H.
- Estrach Cristina
- Estrach Cristina
- Evans Bronwen
- Evans Hayley G.
- Evans Laura
- Eyre Tracey
- Fang Hong
- Farrow Luke
- Fattah Zozik
- Ferrell William R.
- Field Max
- Finlay Ron
- Fisher Roman
- Fleming S.
- Fletcher Debbie
- Fluess Elisa
- Foggo Heather
- Fortune F.
- Fu Bo
- Gainsborough Nicola
- Galloway James
- Galloway James
- Garner Rozeena
- Garza-Garcia Acely
- Gathany Tim
- Gayed Mary
- Gayed Mary
- Georgia Ntani
- Giles Ian
- Giles Ian
- Giles Ian
- Giles Joanna L.
- Godfrey Keith M.
- Goff Iain
- Golor G.
- Goodson Nicola J.
- Goodson Nicola J.
- Goodson Nicola J.
- Gordon Caroline
- Gordon Caroline
- Gordon Caroline
- Gorman Claire L.
- Greenbank Cathi
- Griffiths Bridget
- Griffiths Bridget
- Gullick Nicola J.
- Gullick Nicola J.
- Gupta Monica
- Haddock Gail
- Haddock Gail
- Hakim Alan J.
- Halsey John
- Han Chenglong
- Hands Rebecca
- Harper Lorraine
- Harris Claire L.
- Harta N.
- Harvey Nicholas C.
- Hashmi Tahir M.
- Hassan Ahmed I.
- Hassell Andrew
- Hayes Fiona
- Hayes Fiona
- Heaney Jonathan
- Heathfield Sarah
- Heron Louise
- Herrick Ariane
- Hewlett Sarah
- Hewlett Sarah
- Hickling M.
- Horan Michael
- Hsia Elizabeth
- Hughes Michael
- Hui Michelle
- Hull Richard
- Hull Richard G.
- Humby Frances
- Humphreys Jennifer
- Hunter John
- Hunter John
- Husain Muhammad J.
- Hutchinson David
- Hyrich Kimme
- Hyrich Kimme
- Ibrahim Ibrahim
- Inskip Hazel M.
- Ioannou John
- Ioannou Yiannis
- Iqbal Itrat
- Irvine Elizabeth
- Isaacs John
- Isenberg David
- Isenberg David
- Isenberg David
- Isenberg David
- Isenberg David
- Ismajli Mediola
- Jani Meghna
- Jani Meghna
- Jayaraj David M.
- Jayne David
- Jenkins Jessica
- Jennens Hannah
- Jiang C. Q.
- John Elizabeth
- Johnson Phil
- Jones Gareth T.
- Jones Gareth T.
- Jones Simon A.
- Jullion A.
- Kallankara Sathish
- Kate I.
- Kay Lesley
- Keeley Philip
- Keidel Sarah
- Kelly Sara
- Kelly Stephen
- Kendall David
- Kenu Ernest
- Kessler Benedikt M.
- Khamashta Munther
- Khattak Fazlihakim
- Kiely Patrick D.
- Kindness Kathy
- Kollnberger Simon
- Kollnberger Simon
- Kollnberger Simon
- Kretsos K.
- Kumar Kanta
- Kumar Namita
- Kuvikova Inna
- Lam T. H.
- Lane Peter
- Lanyon Peter
- Lanyon Peter
- Lanyon Peter
- Lawton Sally
- Le Maitre Christine
- Le Maitre Christine L.
- Le Maitre Christine L.
- Ledingham Jo
- Lendrem Dennis
- Leung Jansen
- Lewis Cathryn M.
- Lim Ken
- Ling Stephanie
- Lip Stefanie
- Little Jayne
- Littlewood Alison
- Lockhart John
- Loke Yoon
- Lovell Karina
- Low Audrey
- Lunt Mark
- Lunt Mark
- Lutalo Pamela M.
- Macfarlane Gary J.
- Macfarlane Gary J.
- Macfarlane Gary J.
- Macfarlane Matthew V.
- MacGregor Alex
- MacGregor Alex
- MacGregor Alex
- Mackie Sarah L.
- Macphie Elizabeth
- Mahadik Younis
- Mahendranath K. M.
- Main Wong Way
- Malaviya Anshuman P.
- Marks Jonathan
- Marroquin Osiris
- Mason Justin
- Mc Laughlin Maeve
- McBeth John
- McBeth John
- McBurney H.
- McHugh Kirsty
- McHugh Kirsty
- McHugh Neil
- McHugh Neil
- McHugh Neil
- McInnes Iain
- McInnes Ian
- McKenna Frank
- McKeogh John
- Mckew Jennifer R.
- McLaren John
- McLoughlin Yokemei
- Mehta Puja
- Mehta Puja
- Meldrum Gillian
- Mercer Louise
- Middleton Jim
- Millar Auleen M.
- Misra Ramnath
- Mitchell Adam
- Mitchell Sheryl
- Mobasheri Ali
- Moots Robert J.
- Moots Robert J.
- Moots Robert J.
- Morgan Anne
- Morgan Matthew
- Morris Marianne
- Mugford Miranda
- Mulvey Matthew
- Mulvey Matthew R.
- Murfitt Lucy
- Murphy Helen
- Murray-Brown William
- MĂ©rida Angeles Acosta
- Nayar Saba
- Nayar Saba
- Nazeer Moideen Abdul
- Nelson-Piercy Catherine
- Newman W.
- Ng Nora
- Ng Wan-Fai
- Nicholl Karl
- Nikiphorou Elena
- Nikiphorou Elena
- Nowell Mari A.
- O'Connor Mortimer B.
- O'Neill Terence
- Ogunbambi Olabambo
- Oldroyd Alexander G.
- Oomatia Amin
- Oreffo Richard O.
- Osei-Bordom Daniel-Clement
- Osgood Louise
- Ostor Andrew J.
- Owens Martina
- Palmer Helen
- Parker Ben
- Parker Ben
- Parker Ben
- Patel Dipti
- Patel Yusuf
- Patil Pravin
- Paudyal Priya
- Paul Morgan B.
- Pauling John D.
- Payeli Sravan
- Pearce Fiona
- Pease Colin T.
- Pease Colin T.
- Pendleton Neil
- Pericleous Charis
- Pericleous Charis
- Perry Liz
- Petri Michelle
- Phelan Mark J.
- Phillips Ceri J.
- Phillips E.
- Phillips Kate L. E.
- Picarelli G.
- Pierangeli Silvia
- Pierangeli Silvia S.
- Pilling Claire
- Pitzalis C.
- Pitzalis Costantino
- Pitzalis Costantino
- Pitzalis Costantino
- Plant Darren
- Plant Darren
- Platt Philip N.
- Plevin Robin
- Pope Denise
- Popham Maria
- Price Elizabeth
- Price Elizabeth
- Price-Forbes Alec
- Priori R.
- Pushpakom S.
- Rahman Anisur
- Rahman Anisur
- Rahman Anisur
- Rankin Elizabeth
- Rao Chandini
- Ray David W.
- Raza Karim
- Rees Frances
- Regan Marian
- Regan Marian
- Reid David M.
- Renner Christoph
- Reynolds John A.
- Reynolds Piero
- Rhys-Dillon Brian
- Ridley Anna
- Robertson Calum
- Robinson Frances
- Robinson Sandra
- Robinson SiĂąn M.
- Rooke Royston
- Rooney Madeleine
- Roskell S.
- Roussou Thalia
- Roussou Thalia
- Rump-Goodrich Lisa
- Russell M.
- Rutherford Michelle
- Ryan Sarah
- Rysnik Oliwia J.
- Sanderson Tessa
- Sayer Avan A.
- Scott David L.
- Scott Ian C.
- Segeda Iuliia
- Selvan Shilpa
- Semenova Olga
- Sensky T.
- Seoudi N.
- Severn Andrew
- Shah Preeti
- Sharp Charlotte A.
- Shastri Nilabh
- Shaw Jackie
- Shaw Jacqueline
- Shaw S.
- Sheldon Jo
- Shevchuk Sergii
- Siebert Stefan
- Siebert Stefan
- Simpson John
- Sivakumar Rajappa
- Skeoch Sarah
- Sofat Nidhi
- Solymossy Csilla
- Spandley A.
- Spector Tim
- Spencer Jo
- Srikanth Asha
- Steer Sophia
- Stewart Kirsty
- Stockton Marie
- Stone Michael
- Strand V.
- Sutcliffe Nurhan
- Sutton Emily J.
- Swan Joan
- Symmons Deborah
- Symmons Deborah
- Symmons Deborah
- Symmons Deborah
- Symmons Deborah
- Taams Leonie S.
- Tahir Hasan
- Tan Shaun
- Tandon Neeta
- Tappuni T.
- Tarelli Edward
- Taylor P.
- Taylor Peter
- Taylor Peter
- Teh Lee-Suan
- Thapper Muryum
- Thapper Muryum
- Thomas Huw B.
- Thompson Helen
- Timoshanko J.
- Tugnet Nicola
- Tysoe Carolyn
- Vadivelu Saravanan
- Valesini G.
- Vartoukian S.
- Varughese Sneha
- Venning Michael
- Verstappen Suzanne M.
- Viatte Sebastien
- Vincent Tonia
- Walker David
- Walker-Bone Karen
- Walker-Bone Karen
- Walsh David A.
- Wang Edward
- Watson Kath
- Watson Kath D.
- Watts Richard
- Weaver Dan
- West Louise
- West Lucy
- Wilkinson Mark
- Williams Anwen S.
- Williams Anwen S.
- Williams Emma L.
- Williams Frances M.
- Williams Mark
- Williams Mark R.
- Wilson Anthony
- Wilson Gillian
- Wilson Jo
- Win Maw Win
- Woby Steve
- Wong-Baeza Isabel
- Wood Elizabeth F.
- Worthington J.
- Worthington Jane
- Wright Helen L.
- Wright Stephen A.
- Yates Max
- Yee Chee-Seng
- Young Adam
- Young Adam
- Young Stephen
- Young Stephen P.
- Zaki Awal
- Zeef Leo
- Zoma Asad
- Publication venue
- Publication date
- 02/08/2017
- Field of study
Background: Cardiovascular disease is a major comorbidity of rheumatoid arthritis (RA) and a leading cause of death. Chronic systemic inflammation involving tumour necrosis factor alpha (TNF) could contribute to endothelial activation and atherogenesis. A number of anti-TNF therapies are in current use for the treatment of RA, including certolizumab pegol (CZP), (Cimzia Âź; UCB, Belgium). Anti-TNF therapy has been associated with reduced clinical cardiovascular disease risk and ameliorated vascular function in RA patients. However, the specific effects of TNF inhibitors on endothelial cell function are largely unknown. Our aim was to investigate the mechanisms underpinning CZP effects on TNF-activated human endothelial cells. Methods: Human aortic endothelial cells (HAoECs) were cultured in vitro and exposed to a) TNF alone, b) TNF plus CZP, or c) neither agent. Microarray analysis was used to examine the transcriptional profile of cells treated for 6 hrs and quantitative polymerase chain reaction (qPCR) analysed gene expression at 1, 3, 6 and 24 hrs. NF-ÎșB localization and IÎșB degradation were investigated using immunocytochemistry, high content analysis and western blotting. Flow cytometry was conducted to detect microparticle release from HAoECs. Results: Transcriptional profiling revealed that while TNF alone had strong effects on endothelial gene expression, TNF and CZP in combination produced a global gene expression pattern similar to untreated control. The two most highly up-regulated genes in response to TNF treatment were adhesion molecules E-selectin and VCAM-1 (q 0.2 compared to control; p > 0.05 compared to TNF alone). The NF-ÎșB pathway was confirmed as a downstream target of TNF-induced HAoEC activation, via nuclear translocation of NF-ÎșB and degradation of IÎșB, effects which were abolished by treatment with CZP. In addition, flow cytometry detected an increased production of endothelial microparticles in TNF-activated HAoECs, which was prevented by treatment with CZP. Conclusions: We have found at a cellular level that a clinically available TNF inhibitor, CZP reduces the expression of adhesion molecule expression, and prevents TNF-induced activation of the NF-ÎșB pathway. Furthermore, CZP prevents the production of microparticles by activated endothelial cells. This could be central to the prevention of inflammatory environments underlying these conditions and measurement of microparticles has potential as a novel prognostic marker for future cardiovascular events in this patient group. Disclosure statement: Y.A. received a research grant from UCB. I.B. received a research grant from UCB. S.H. received a research grant from UCB. All other authors have declared no conflicts of interes
Dolutegravir twice-daily dosing in children with HIV-associated tuberculosis: a pharmacokinetic and safety study within the open-label, multicentre, randomised, non-inferiority ODYSSEY trial
- Author
- Abraham Pattamukkil
- Abrams Elaine
- Acero Judith
- Agaba Gerald Muzorah
- Ahimbisibwe Grace
- Ahimbisibwe Grace Miriam
- Ainebyoona Barbara
- Akhalwaya Yasmeen
- Akobye Winnie
- Akoojee Nazim
- Ali Shabinah
- Ali Shabinah S
- Amuge Pauline
- Amuge Pauline
- Andrea Catherine
- Ankunda Rogers
- Anugulruengkitt Suvaporn
- Apollo Tsitsi
- Archary Moherndran
- Archary Moherndran
- Arendze Ronelle
- Ategeka Juliet
- Atim Eunice
- Atwine Lorna
- Babiker Abdel
- Babirye Sarah
- Babu Enock
- Baddokwaya Joanita Nankya
- Bagirigomwa Edward
- Baita Angella
- Balamusani David
- Baliram Patsy
- Baliruno David
- Ball Colin
- Balwa Henry
- Bamford Alasdair
- Bandi Srini
- Barker Dominique
- Barlow-Mosha Linda
- Bbuye Dickson
- Begum Shazia
- Behuhuma Osee
- Bernays Sarah
- Besigye Rogers
- Bester Maria
- Bhiri Joyline
- Bilardi Davide
- Bird Kristien
- Bollen Pauline
- Bollen Pauline DJ
- Borg Chiara
- Borges Da Silva Anne-Marie
- Brown Jackie
- Bruno Elena
- Bunupuradah Torsak
- Burger David
- Burger David M
- Buthelezi Nomzamo
- Bwakura-Dangarembizi Mutsa
- Bwakura-Dangarembizi Mutsa F
- Byaruhanga Africanus
- Calvert Joanna
- Casey Petronelle
- Cassim Haseena
- Cebekhulu Sphiwee
- Chailert Sanuphong
- Chalermpantmetagul Suwalai
- Chamjamrat Wanna
- Chan Man
- Chan Man K
- Chandiwana Precious
- Chankun Thannapat
- Chanthaburanun Sararut
- Chanto Nuttawut
- Chidziva Ennie
- Chikowore Minenhle
- Chimanzi Joy
- Chinwong Dujrudee
- Chitongo Stuart
- Chitsamatanga Moses
- Choga Joshua
- Chutima Duangrat
- Clark Basiimwa Roy
- Clayden Polly
- Coelho Alexandra
- Colbers Angela
- Colbers Angela
- Compagnucci Alexandra
- Constança Mendes Ana
- Conway Magda
- Cotton Mark F
- Cotton Mark F
- Crawley Jane
- Cressey Tim R
- Crisp Jacky
- Dadan Sumaya
- Daglish Jacqui
- Danaviah Siva
- Daniel Tseleng
- De Rossi Anita
- Denjanta Sukanda
- Dobbels Els
- Dowie Maria
- Dube Benedictor
- Dube Prosper
- Dudakia Nimisha
- Elwana Alice
- Epalza Cristina
- Eram David
- Erasmus Juan
- Erim Peter
- Escosa Garcia Luis
- Essack Zaakirah
- Estepa Carolina
- Etima Monica
- Fernandes Alexandre
- Fernandez Maite
- Ferrand Rashida A
- Fitzgerald Felicity
- Flynn Jacquie
- Ford Deborah
- Ford Deborah
- Fortuny Guasch Claudia
- Foster Caroline
- Fourie George
- Fourie Yolandie
- Foxall Sophie
- Frank Derusha
- Gandhi Kate
- Garcia India
- Gartner Kathleen
- Gasa Gugu
- Gasa Joshua
- Giaquinto Carlo
- Gibb Diana M
- Gibb Diana M
- Gomez Rico Coral
- Gomez-Pena Daniel
- Gondo Secrecy
- Goodman Anna
- Gorreti Nakalema Maria
- Gozhora Winnie
- Greetanukroh Pisut
- Gregorio Maranon Biobanco
- Grossele Tiziana
- Gwande Shamiso
- Gwaze Tapiwa
- Gwenzi Tsitsi
- Hakim James
- Hakiza Emmanuel
- Harley Ashley
- Isaacs Mornay
- Isabirye Richard
- Ishemunyoro Wilber
- Jacobs Tom
- Jafta Lungile
- Jamil Nasir
- Janse van Rensburg Anita Janse
- Jeaven Vinesh
- Jimenez Jose Luis
- Jourdain Gonzague
- Juliet Katabalwa
- Jumpimai Thidarat
- Junkaew Raungwit
- Jupimai Thidarat
- Kaahwa Winfred
- Kabasonga Mildred
- Kaboggoza Olivia
- Kadhuba Rose Jacqueline
- Kaewbundit Ampika
- Kaewmamueng Kanyanee
- Kafufu Bosco
- Kaka Abdul Hamid
- Kakayi Brenda
- Kamboua Phakamas
- Kanjanavanit Suparat
- Kasangaki Gladys
- Kasipong Naruporn
- Kasozi Miriam
- Kataike Hajira
- Katemba Chrispus
- Kaudha Elizabeth
- Kekane Nkata
- Kekitiinwa Adeodata R
- Kekitiinwa Adeodata R
- Keminyeto Edridah
- Khamduang Woottichai
- Khamjakkaew Warunee
- Khamkon Jiraporn
- Khannak Sasipass
- Khatngam Orapin
- Khayanchoomnoom Tassawan
- Khumalo Busi
- Khunene Mirriam
- Khusuwan Suwimon
- Kibalama Phionah
- Kibenge Robinah
- Kirabira Anthony
- Kityo Cissy M
- Kityo Cissy M
- Kiyimba Lameck
- Klein Nigel
- Klinprung Soraya
- Kobbe Robin
- Kobusingye Olivia
- Kobusungye Josephine
- Kongponoi Areerat
- Koole Olivier
- Kouakam Christelle
- Krueduangkam Nitinart
- Kruenual Namthip
- Kunjaroenrut Nuananong
- Kyambadde Raymonds
- Kyobutungi Priscilla
- Kyomuhendo Flavia
- Kyomukama Erinah
- Königs Christoph
- Lakha Reshma
- Langa Cleopatra
- Laomanit Laddawan
- Lebotsa Emily
- Leenasirimakul Prattana
- Lekku Lawrence
- Lensen Sarah
- Leroy Valériane
- Li Jin
- Liberty Afaaf
- Limplertjareanwanich Juthamas
- Little Emma
- Lugemwa Abbas
- Lugemwa Abbas
- Lutalo Ezra
- Lyall Hermione
- MacDonald Candice
- Machache Gladness
- Madlala Penelope
- Madonsela Tryphina
- Maduna Nomfundo
- Maena Joel
- Mahanontharit Apicha
- Makanga Collin
- Makola Candice
- Makumbi Shafic
- Malgraaf Lucille
- Mamiane Angelous
- Mantkowski Felicia
- Mapfumo Wendy
- Marques Laura
- Maseko Lindiwe
- Masienyane Tshepiso
- Mathiba Ruth
- Matimba Farai
- Matos Ana Cristina
- Mawlana Sajeeda
- Mayanja Emmanuel
- Mayat Fatima
- Mbabazi Ritah
- Mbadaliga Nokuthula
- Mbasani Faith
- McClaughlin Kathleen
- McIlleron Helen
- Meethaisong Watchara
- Mehar (nee Abdulla) Amina Farhana
- Mellado Peña Maria José
- Mendez Garcia Patricia
- Miranda Carlota
- Miwanda Annet
- Mkhize Siphiwe
- Mmolawa Kgosimang
- Mngqibisa Rosie
- Mohamed Fatima
- Moloantoa Tumelo
- Monametsi Maletsatsi
- Montero Samuel
- Moore Cecilia L
- Mosia Rejoice
- Moyo Columbus
- Mthethwa Mumsy
- Mudzingwa Shepherd
- Mudzviti Tawona
- Mugagga Agnes Mary
- Mujuru Hilda
- Mujyambere Emmanuel
- Mukanganiki Trust
- Mukisa Williams Cynthia
- Mulder Mark
- Mulima Disan
- Mulindwa Alice
- Mumbiro Vivian
- Mumbiro Vivian
- Mupambireyi Zivai
- Murciano Cabeza Alba
- Murungi Herbert
- Murungu Dorothy
- Musarurwa Sandra
- Musiime Alex V
- Musiime Victor
- Musisi Maria
- Musoke Nakirya Barbara
- Musoke Philippa
- Musoro Godfrey
- Mustafa Sobia
- Musumba Sharif
- Mutsai Shirley
- Muñoz Fernandez Maria Angeles
- Mwesigwa Rubondo Phyllis
- Na-Rajsima Sathaporn
- Naabalamba Mariam
- Nagawa Immaculate
- Naidoo Allemah
- Nakabuye Sarah
- Nakabuye Shamim
- Nakalanzi Sarah
- Nakawungu Zaam Zinda
- Nalubwama Justine
- Nalugo Annet
- Nalusiba Stella
- Namajja Clementine
- Namanda Sylvia
- Namayanja Paula
- Nambi Esther
- Namuddu Rachael Kikabi
- Namukwaya Stella
- Namuli Florence
- Namusanje Josephine
- Namwanje Rosemary
- Nanan-kanjee Anusha
- Nanduudu Annet
- Nankunda Charity
- Nannungi Maria
- Nansamba Winnie
- Nanthapisal Kesdao
- Nanyonjo Juliet
- Nasaazi Claire
- Nascimento Helena
- Nastouli Eleni
- Nathoo Kusum
- Natuhurira Ian
- Nazzinda Rashidah
- Ncgaba Thabisa
- Ndigendawani Milly
- Ndlovu Makhosonke
- Nentsa Georgina
- Ngampiyaskul Chaiwat
- Ngcobo Ntombenhle
- Ngo Giang Huong Nicole
- Ngwaru Pia
- Nhema Ruth
- Ninsiima Emily
- Ninsiima Gloria
- Nkalo Phiri Misheck
- Noguera Julian Antoni
- Nolan Monica
- Noppakaorattanamanee Thornthun
- Nsibuka Kisekka Muzamil
- Nsirim Eniola
- Nundlal Rashina
- Nunes Rosita
- Nyantsa Lungile
- Nyati Mandisa
- O'Riordan Sean
- Ocitti Labeja Paul
- Odoch Denis
- Oguntimehin Rachel
- Ojok Martin
- Onen Geoffrey
- Orange Wilma
- Ouma Benson
- Ounchanum Pradthana
- Padrao Andreia
- Pako Deborah
- Parker Anna
- Pasko-Szcech Malgorzata
- Patel Reena
- Peongjakta Rukchanok
- Petpranee Turian
- Phillips Tasmin
- Philps Jackie
- Picault Laura
- Pieterse Sonja
- Pinheiro Helena
- Pongprapass Supawadee
- Pozniak Anton
- Prendergast Andrew
- Prieto Tato Luis
- Puangmalai Patcharee
- Puthanakit Thanyawee
- Rakgokong Modiehi
- Ramos Helena
- Ramsagar Nastassja
- Rau Cornelius
- Riault Yoann
- Rojo Conejo Pablo
- Rubanga Eddie
- Rubinga Baker
- Ruklao Chutima
- Runarassamee Pattira
- Rutebarika Diana Antonia
- Rutebarika Diana Antonia
- Saenjum Chalermpong
- Saewtrakool Chayakorn
- Saidi Yacine
- Sainz Costa Talia
- Saisaengjan Chutima
- Sakwa Rebecca
- Sarfati Tatiana
- Sbisi Noshalaza
- Scheppers Dihedile
- Schultze-Strasser Stephan
- Schulze-Sturm Ulf
- Scott Karen
- Seeley Janet
- Serunjogi Robert
- Sewnarain Leora
- Shakeshaft Clare
- Shibemba Mercy
- Shingadia Delane
- Sidhoo Subashinie
- Singh Sheleika
- Sirirungsi Wasna
- Sithebe Sibongile
- Smit Theresa
- Smith Kurt
- Smuts Marlize
- Songtaweesin Wipaporn Natalie
- Spyer Moira
- Sripaoraya Worathip
- Srirompotong Ussanee
- Srirompotong Ussanee
- Srisuk Warunee
- Ssenyonga Mark
- Sudsaard Patamawadee
- Sukrakanchana Praornsuda
- Tearsansern Pathanee
- Teixeira Carla
- Than-in-at Kanchana
- Thapwai Thitiwat
- Thaweesombat Yupawan
- Thewsoongnoen Jutarat
- Thiébaut Rodolphe
- Thomason Margaret
- Thrasyvoulou Laura
- Thungkham Khanungnit
- Tikabibamu Judith
- Tinago Gloria
- Trairat Ketmookda
- Tudor-Williams Gareth
- Tukamushaba Mercy
- Tukwasibwe Deogratiuos
- Tumusiime Julius
- Tuna Joana
- Turkova Anna
- Turkova Anna
- Turner Rebecca
- Udomvised Arttasid
- Vadee Aasia
- Van Huyssteen Hesti
- Van Looy Nadine
- Variava Ebrahim
- Variava Ebrahim
- Vaughan-Gordon Yvonne
- Vecchia Giulio
- Violari Avy
- Violari Avy
- Vowden Richard
- Waalewijn Hylke
- Waalewijn Hylke
- Wampamba Rebecca
- Welch Steve
- Weller Ian
- Weza Sibusisiwe
- White Ellen
- White Ian
- Widuch Kaja
- Wilkes Helen
- Wimonklang Sookpanee
- Wynne Ben
- Yingyong Pacharaporn
- Zuidewind Peter
- Zuidewind Peter
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/07/2022
- Field of study
Background:
Children with HIV-associated tuberculosis (TB) have few antiretroviral therapy (ART) options. We aimed to evaluate the safety and pharmacokinetics of dolutegravir twice-daily dosing in children receiving rifampicin for HIV-associated TB.
Methods:
We nested a two-period, fixed-order pharmacokinetic substudy within the open-label, multicentre, randomised, controlled, non-inferiority ODYSSEY trial at research centres in South Africa, Uganda, and Zimbabwe. Children (aged 4 weeks to <18 years) with HIV-associated TB who were receiving rifampicin and twice-daily dolutegravir were eligible for inclusion. We did a 12-h pharmacokinetic profile on rifampicin and twice-daily dolutegravir and a 24-h profile on once-daily dolutegravir. Geometric mean ratios for trough plasma concentration (Ctrough), area under the plasma concentration time curve from 0 h to 24 h after dosing (AUC0â24 h), and maximum plasma concentration (Cmax) were used to compare dolutegravir concentrations between substudy days. We assessed rifampicin Cmax on the first substudy day. All children within ODYSSEY with HIV-associated TB who received rifampicin and twice-daily dolutegravir were included in the safety analysis. We described adverse events reported from starting twice-daily dolutegravir to 30 days after returning to once-daily dolutegravir. This trial is registered with ClinicalTrials.gov (NCT02259127), EudraCT (2014â002632-14), and the ISRCTN registry (ISRCTN91737921).
Findings:
Between Sept 20, 2016, and June 28, 2021, 37 children with HIV-associated TB (median age 11·9 years [range 0·4â17·6], 19 [51%] were female and 18 [49%] were male, 36 [97%] in Africa and one [3%] in Thailand) received rifampicin with twice-daily dolutegravir and were included in the safety analysis. 20 (54%) of 37 children enrolled in the pharmacokinetic substudy, 14 of whom contributed at least one evaluable pharmacokinetic curve for dolutegravir, including 12 who had within-participant comparisons. Geometric mean ratios for rifampicin and twice-daily dolutegravir versus once-daily dolutegravir were 1·51 (90% CI 1·08â2·11) for Ctrough, 1·23 (0·99â1·53) for AUC0â24 h, and 0·94 (0·76â1·16) for Cmax. Individual dolutegravir Ctrough concentrations were higher than the 90% effective concentration (ie, 0·32 mg/L) in all children receiving rifampicin and twice-daily dolutegravir. Of 18 children with evaluable rifampicin concentrations, 15 (83%) had a Cmax of less than the optimal target concentration of 8 mg/L. Rifampicin geometric mean Cmax was 5·1 mg/L (coefficient of variation 71%). During a median follow-up of 31 weeks (IQR 30â40), 15 grade 3 or higher adverse events occurred among 11 (30%) of 37 children, ten serious adverse events occurred among eight (22%) children, including two deaths (one tuberculosis-related death, one death due to traumatic injury); no adverse events, including deaths, were considered related to dolutegravir.
Interpretation:
Twice-daily dolutegravir was shown to be safe and sufficient to overcome the rifampicin enzyme-inducing effect in children, and could provide a practical ART option for children with HIV-associated TB
Finishing the euchromatic sequence of the human genome
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- Jia Nan
- Jia Xingchang
- Jiang Lu
- Jiang Yanrui
- Jiang Ziyou
- Jimenez Alberto
- Jin Jian
- Jin Yetao
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- Jones Micheil
- Jones Myrna D.
- Jones Steven
- Jong Pieter De
- Jordan Yun
- Joseph Shirin
- Joy Ann
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- Jubb Mark
- Jung Eugine
- JĂ€rke Doris
- Kadner Kristen
- Kagan Ryan
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- Kaida Kaoru
- Kale Pat
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- Kamal Michael
- Kamat Asha
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- Keenan Stephen
- Kegelmeyer Laura
- Kegg Lisa
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- Kelly Shayna P.
- Kelly Susan H.
- Kershaw Joanna
- Kettleborough Ross
- Keys David
- Khan Arsi
- Khan Umer F.
- Khan Ziad Mohid
- Khine Susu
- Khurama Divya
- Kidd Cathy
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- Kong Yi
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- Kosiura Anna
- Kou Zhaohui
- Kovar Christie L.
- Krawczyk Marie-Claude
- Kremitzki Colin
- Kremmidiotis Gabriel
- Krogh Anders
- Kronmiller Brent
- Kruchowski Scott S.
- Kube Michael
- Kubischta Duane
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- Laird Gavin
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- Lamar Betty
- Lambart Christine
- Lamble Ralph
- Lamerdin Jane E.
- Lander Eric S.
- Landers Tom
- Langford Cordelia
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- Lewis Doreen
- Lewis Ernest K.
- Lewis Keith
- Lewis Lakeshia C.
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- Lewis Tammy
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- Li Changfeng
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- Lightning Julia
- Lim Meng K.
- Lindblad-Toh Kerstin
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- Liu Yu
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- Liyanage Dhammika
- Llewellyn-Silva Crystal
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- Lloyd David
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- Longden Ian
- Longmire Johnathan L.
- Lopez Frederick
- Lopez John
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- Lopez Lora
- Loraine Howard
- Lord Rachel
- Lorensuhewa Lorna M.
- Lou Yunian
- Loulseged Hermela
- Loveland Jane
- Lovell Jamie
- Lovett Demetria A.
- Lowenstein Michael G.
- Lowry Stephen
- Lozado Ryan J.
- Lu Lingfeng
- Lu Tao
- Lu Xiuhua
- Lu Yongxiang
- Lu Yontao T.
- Lu Yue
- Lucas Robert
- Lucas Susan
- Lucier Alice
- Lucier Raymond L.
- Ludeman Thom
- Lui Annie
- Lundgren Lyndsey
- Luo Chunqing
- Luo Chunqing
- Lv Gang
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- Löhnert Tschong-Hun
- Ma Cheng
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- Ma Peter
- Ma Qingmei
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- Mabbitt Richard
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- Machrus Migdad
- Macht Madison
- Macken Catherine A.
- MacLean Christine
- Madabhushi Ramki
- Madu Renita C.
- Maeda Hideto
- Maglott Donna
- Maheshwari Manjula
- Mahindartne Mathew
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- Mahnke Ryan
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- Major John
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- Malloy Kevin
- Maltbie Mary I.
- Mangum Brian
- Manning Jonathan
- Manohar Chitra
- Mapua Patricia
- Marabella Dick
- Mardis Elaine R.
- Mareth David
- Mariano Marisa
- Marinelli Lisa
- Mark Graham A.
- Marquis-Homeyer Catherine
- Marr Thomas G.
- Marra Marco
- Marriott Neil
- Marrone Anne
- Marroquin Christian
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- Martin Joel
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- Martin Matthew
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- Martinez Diego
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- Maru Kebede
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- Matsumoto Shuko
- Matsushita Yoshitaka
- Matthews Charles D.
- Matthews Lucy
- Matthews Nick
- Matthews Paul
- Matthews Sterling D.
- Mauceli Evan
- Maunes Cynthia
- Maupin Rachel
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- McLean James
- McLellan Michael D.
- McLeod Michael P.
- McMurdo John
- McMurray Amanda
- McMurray Des
- McMurray Kimberly
- McMurray Kimberly L.
- McNinch Jenny
- McPherson John
- McPherson John D.
- McVicker Graham
- McWilliams Natalie
- Mead Kelly
- Meador Michael G.
- Medina Catherine
- Mehta Nalini
- Meidi Patrick
- Meier Elke
- Meincke Linda J.
- Mejima Mio
- Meldrim James
- Melsopp Craig
- Mendez Sylvia
- Meneus Louis
- Meng Shanshan
- Menuge Noel
- Mercado Christian
- Mercado George
- Mercado Iracema C.
- Mercer Simon
- Merritt Christina E.
- Mesirov Jill P.
- Metzker Michael Lee
- Meyer Rekha
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- Michaelis Evelyn
- Micklem Gos
- Mieczkowski Carl
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- Mihalkanin Danielle
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- Mileur Mason W.
- Miller Christie
- Miller Donald
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- Milne Sarah
- Miner George R.
- Miner Sheri
- Miner Tracie
- Minja Emmanuel
- Minoshima Shinsei
- Minx Patrick J.
- Misra Monica
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- Morgan Jenna
- Morgan Margaret B.
- Morita Hiroko
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- Moyzis Robert K.
- Mu Feng
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- Mullenger Ian
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- Mulrain Leon
- Munday Brian
- Munday Elaine
- Mundt Mark O.
- Mungall Andy
- Munidasa Mala
- Munk A. Christine
- Munk Christie A.
- Munson Glen
- Murakami Katsuhiko
- Murayama Yuji
- Murnane Clare
- Murphy Matthew B.
- Murphy Michael
- Murray Christine
- Murray Debra Dianne
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- Myers Alison
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- MĂŒller Ines
- Nagamine Kentaro
- Nagao Syunsuke
- Nagaraja R.
- Nair Latha
- Nair Seema R.
- Naka Maho
- Nakagawa Masayo
- Nakagawa Saori
- Nakamura Etsuko
- Nakato Eriko
- Nanavati Amit N.
- Nandkeshwar Richard
- Nankervis Colin E.
- Naranjo Cleo M.
- Nash William
- Naylor Jerome
- Nazareth Lynne V.
- Neal Dearl D.
- Negus David
- Nelson Catherine
- Nelson David O.
- Nelson Deborah A.
- Nelson Joanne
- Nelson Kathryn
- Nelson Ward
- Nesbitt Ryan
- Neunkirch Jennifer
- Newes Christian
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- Ng Bee
- Ng Terrance
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- Nguyen Minh
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- Nguyen Natalie M.
- Nguyen Ngoc Bich
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- Ni Lin
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- Nickerson Tim
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- Ning Zemin
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- Nivens Amber
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- Nolan Matt
- Norbu Chou Dolma
- Norbu Nyima
- Nordsiek Gabriele
- Norris Sarah Louise
- Novik Karen
- Nowlin Larry
- Nusbaum Chad
- Nwaokelemeh Ogechi O.
- Nwokenkwo Stanley
- O\u27Donnell Paula
- O\u27Donovan Daniel
- O\u27Leary Sinead
- O\u27Loughlin Jennifer
- O\u27Neill Keith
- Obayashi Izumi
- Obregon Melissa
- Oddone Paola
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- Ogbighele Francess
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- Ohno Saho
- Ohta Nao
- Ohtsubo Masafumi
- Oinn Tom
- Okoawo Ose
- Okui Michiyo
- Okumura Reina
- Okwuonu Geoffrey O.
- Okwuonu Kenneth C.
- Olarnpunsagoon Alisa
- Olivas Jason
- Oliver Hayley
- Oliver Karen
- Olsen Anne S.
- Olson Maynard V.
- Omotosho Bamidele
- Onoda Junko
- Oomori Nobuhiro
- Ooshima Kenshiro
- Oragunye Njideka
- Orantes Jerry
- Orbell Helena
- Osada Misuzu
- Osborn Anthony
- Osborne Joan
- Osman Sahal
- Ovcharenko Ivan
- Overton-Larty Emma
- Oviedo Rodolfo J.
- Ow David
- Ozawa Ritsuko
- Ozersky Philip
- Pace Araceli C.
- Pack Elizabeth
- Padki Anuradha
- Pahlavan Shane
- Palaniappan Krishnaveni
- Palazzolo Michael
- Palmeiri Anthony
- Palmer Sophie
- Pan Jiaofeng
- Pan Sisu
- Panasenko Vladimir
- Pandian Richard
- Parker Adrian
- Parker David Neil
- Parker Stephen
- Parkin Christopher
- Parkin Kim
- Parks Kenya L.
- Parry-Brown Ginny
- Parson-Quintana Beverly
- Pasternak Shiran
- Patel Bella Mayurkumar
- Patel Dina
- Patel Jalpa N.
- Patel Ritesh
- Patel Shripa
- Patel Vishal V.
- Patrick James
- Paul Heidie A.
- Paul Shelia
- Paulson Edward
- Payton Brett A.
- Pearce Alexandra
- Pearman Charlene
- Pearson Danita
- Pecherer Robert M.
- Peck Anna
- Peck Richard
- Pedan John
- Pelan Sarah
- Pelletier Eric
- Peng Vivian
- Peng Vivian
- Peng Yi
- Peng Yi
- Peng Ze
- Peng Ze
- Pennacchio Len A.
- Pennacchio Len A.
- Percy Chantel
- Perez Agapito
- Perez Lesette M.
- Perito Andrew
- Perrault Isabelle
- Perrier Rene
- Perrier Rene
- Perrin William
- Pesavento Brad
- Peters Anna
- Peters Leonard G.
- Peterson Jane
- Peterson Karl
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- Pettett Roger
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- Polman Jos
- Ponting Chris P.
- Porter Aaron
- Porter Keith
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- Potter Christopher
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- Poundstone Pat
- Pourrajabi Nima M.
- Powell Don
- Powell Jason
- Prado Daisy
- Prange Christa
- Prathalingham Radhika
- Predki Paul
- Prigmore Elena
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- Qiang Boqin
- Qiang Boqin
- Qiao Zhenyong
- Qin Xiang
- Quail Michael
- Quan Glenda
- Quarrie Hannah
- Quiles Miyo M.
- Quince Chris
- Quiroz Juana B.
- Qureshi Matloob
- Rabata Dina
- Rachlin Eric K.
- Rachupka Anthony
- Radionenko Maxim
- Rajagopal Mohan
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- Ray Aditya
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- Read Daniel
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- Reily Amy D.
- Reinhardt Astrid
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- Reiter Charlie
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- Richardson Paul
- Richardson Susan
- Ricke Darryl O.
- Ridler Kerry
- Riethman Harold
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- Riley B.E
- Rise Cecil
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- Rives Catharine M.
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- Roberts Simon
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- Robinson Dezere
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- Robinson Donna L.
- Robinson Melanie
- Rochford Rebecca
- Rock Susan M.
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- Rong Li
- Rong Li
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- Roskin Krishna M.
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- Sasaki Takashi
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- Saurin William
- Savery Glenford G.
- Sawada Nori
- Sawhill William W.
- Saxman Eric
- Scarpelli Claude
- Scharfe Maren
- Schatzkamer Kyriena L.
- Scherer Steven Edward
- Schilhabel Markus
- Schlessinger David
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- Siddiqui Roman
- Siepel Adam C.
- Silk Richard
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- Solovyev Victor
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- Sonaike Titilola
- Song Liping
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- Song Xing-Zhi
- Sonnhammer Erik
- Sonnhammer Erik
- Sorelle Richard P.
- Sotheran Elizabeth
- Sougnez Carrie
- Spainhower Corey
- Sparks Anastasia L.
- Spencer Brian
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- Spooner William
- Spraggon Lee
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- Squares Janet
- Stabenau Arne
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- Stalker James
- Stalker John
- Stallings Raymond I.
- Stalvey Malinda
- Stamford Steve
- Stammers Melanie
- Standring Lisa
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- Stege Justin T.
- Steingruber Helen
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- Su Xiaohu
- Subramanian Sandhya
- Subramanian Sandhya
- Sudbrak Ralf
- Sugnet Charles W.
- Sulston John
- Summers Leslie J.
- Sun Hui
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- Sun Jiu Qin
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- Sun Wei
- Sun Yongqiao
- Sun Yu
- Sun Yue
- Sutherland Grant R.
- Sutherland Robert D.
- Sutton Angelica E.
- Svatek Amanda F.
- Svetz Jessica
- Svetz Leah Anne
- Swainson Chris
- Swann Mark
- Swarbreck David
- Swearengen-Shahid Sharhonda
- Sycamore Neil
- SĂ©gurens BĂ©atrice
- Tabor Paul E.
- Tacey Kristina
- Tagett Beckie
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- Takaoka Tori
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- Tatsuyama Miho
- Tatum Owatha I.
- Taudien Stefan
- Taylor Amy
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- Taylor Tineace R.
- Taylor Todd Duane
- Tchuinga Pierre
- Tee Louise
- Telford Ethan Brett
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- Tesfaye Senait
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- Thayer Nina
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- Thomas Daniel
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- Thomas Karen
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- Thommai Roselin
- Thompson Linda S.
- Thorne Rachel Diane
- Thorpe Andrea
- Thorpe Karen
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- Zhan Guoping
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- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers âŒ99% of the euchromatic genome and is accurate to an error rate of âŒ1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
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- Abdelrazik M.
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- Wulandari R.
- Wyllie D.H.
- Wynter I.
- Xavier K.
- Xue X.
- Yadav A.
- Yang J.
- Yassen A.M.
- Yates B.
- Ye C.
- Yun N.
- Zainy T.
- Zak A.
- Zaki A.
- Zamikula J.
- Zanella I.
- Zborowski A.C.
- Zeberg H.
- Zechner M.
- Zechner M.
- Zguro K.
- Zhang M.
- Zhao J.H.
- Zheng C.
- Zhou W.
- Zitter L.
- Zlatopolsky M.
- Zongo O.
- Zucchi P.
- Zyndorf M.
- Zöllner S.
- Ă svold B.O.
- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 07/07/2022
- Field of study
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genesâincluding reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)âin critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
Correction to: Cluster identification, selection, and description in Cluster randomized crossover trials: the PREP-IT trials
- Author
- Acerboni-Flores Francesc
- Achor Timothy S.
- Adams John D.
- Al-Asiri Jamal
- Alavedra-Massana Anna
- Altman Kyle M.
- Anglada-Torres Neus
- Apostle Kelly L.
- Baele Joseph R.
- Bailey Daniel
- Bartel Claire
- Beckish Michael L.
- Bedard Julia C.
- Belaye Tigist
- Berenguer Alexandre
- Berhaneselase Eleni
- Bhandari Mohit
- Bhandari Mohit
- Blasman Jenna
- Bosse Michael
- Boulton Christina
- Boulton Christina
- Boyce Robert
- Boyer Dory S.
- Bray Christopher C.
- Breslin Mary A.
- Brown Timothy R.
- Brownrigg Maggie
- Bueno-Ruiz Mercedes
- Burnikel Alex
- Camara Megan
- Caparros-GarcĂa Ariadna
- Carballo Alejandro
- Carlisle Robert M.
- Choo Andrew M.
- Churchill Christine
- Clark Linda
- Cole Austin A.
- Colello Michael
- Cross Andrew W.
- Cruz Alejandro
- Culbert Hunter
- CĂĄmara-Cabrera Jaume
- Davies Jonah
- Degani Yasmin
- Dehghan Niloofar
- Del Fabbro Gina
- Della Rocca Gregory J.
- Demyanovich Haley
- Demyanovich Haley K.
- Denkers Matthew
- Devereaux P. J.
- Dew Timothy
- Ding Anthony
- Dodds Shannon
- Dodds Shannon
- DomĂšnech MĂČnica SalomĂł
- Donohue Erin
- Dykes Tayler
- DâAlleyrand Jean-Claude
- Eglseder Andrew
- Fan Chen âBrendaâ
- Faucher Gregory K.
- Fillat-GomĂ Ferran
- Fowler Justin
- Fraifogl Joanne
- Friedrich Jeff
- Fuentes-LĂłpez Ruben
- Gajari Vamshi
- Gallant Jodi
- Garcia-Rodriguez Ramona
- GarcĂa Yaiza
- Gardner Michael J.
- Garg Kartik
- Garibaldi Alisha
- Garitty Michael J.
- Gary Joshua L.
- Gaski Greg
- Gaski Greg E.
- George Annie
- Gimeno-Calavia Nuria
- Girardi Cara
- Gitajn I. Leah
- Gjorgjievski Marko
- Graells-Alonso Guillem
- Grissom Frances
- Guerra-FarfĂĄn Ernesto
- Guerra-FarfĂĄn Ernesto
- Gurich Richard W.
- Guyatt Gordon H.
- Hagen Jennifer E.
- Hale Diamond
- Halliday Paul G.
- Harris Anthony D.
- Harris Anthony D.
- Hebden Joan
- Hebden Joan
- Heels-Ansdell Diane
- Hill Lauren C.
- Hofer Erin Adams
- Holzman Michael A.
- Horne Brandon
- Howe Andrea
- Hsu Joseph
- Hudgins Andrea
- Huggins Brandon S.
- Hunter Michael D.
- Hurkett Colin
- Hymes Robert A.
- Jahangir Amir Alex
- Jeray Kyle J.
- Jerele Jennifer
- Johal Herman
- Johnson Aaron
- Jones Clifford B.
- Jornet-Gibert Montsant
- Joseph Katherine
- Joshi Manjari G.
- Kandemir Utku
- Karim Ammar
- Karunakar Madhav
- Kempton Laurence
- Kettering Eric
- Kimmel Joseph
- Knapp Thomas
- Koenig Chris
- Krupko Thomas
- Langhammer Christopher
- Lazarus David E.
- Lebrun Christopher
- Lemke H. Michael
- Leonard Jordan
- Li Silvia
- Liang Stephen
- Little Kelly
- Loeffler Markus F.
- Lowe Jason
- Lowney Maya
- Malekzadeh A. Stephen
- Maltz Ethan J.
- Manson Theodore
- Marcano-FernĂĄndez Francesc
- Marcano-FernĂĄndez Francesc
- Marcano-FernĂĄndez Francesc A.
- Marchand Lucas
- Marmor Meir
- Marshall William A.
- Martin Abigail
- Martinez Eric
- MartĂ-GarĂn David
- MartĂnez-Carreres Laia
- MartĂnez-Grau Patricia
- MartĂnez-Ălvarez Marta
- Marvel Debra
- Matityahu Amir
- Mayberry Robert Miles
- Mayfield Ada
- McClellan R. Trigg
- McKay Paula
- McKay Paula
- McKee Michael
- McKinley Todd O.
- Medeiros Michelle
- Mehta Samir
- Meinberg Eric
- Miclau Theodore
- Miller Adam
- Millon S. John
- Mitchell Phillip
- Moody M. Christian
- Moola Farhad O.
- Morshed Saam
- Mossuto Franca
- Mullins C. Daniel
- Mullins Daniel C.
- Mullis Brian H.
- Munz John W.
- Nascone Jason
- Natoli Roman M.
- Nguyen Uyen
- Obremskey William T.
- on behalf of the PREP-IT Investigators
- Osborn Patrick
- OâHara Lyndsay M.
- OâHara Lyndsay M.
- OâHara Nathan N.
- OâToole Robert V.
- Palmer Jana
- Palmer M. Jason
- Parker Wesley
- Paryavi Ebrahim
- Patrick Matthew
- Paul Alexandra
- Payne Kyrsten
- Pechero Guillermo
- Pelfort Xavier
- Pellejero-GarcĂa RaĂșl
- Pensy Raymond
- Perey Bertrand H.
- Persico Federico
- Petrisor Brad A.
- Petrisor Bradley A.
- Peñalver Juan Manuel
- Pham Kayla H.
- Phelps Kevin
- Pichiotino Erin R.
- Pierrie Sarah
- Pogorzelski David
- Pogorzelski David
- Pollak Andrew
- Poole Andrew S.
- Porter Scott E.
- Prayson Michael
- Pritchett Charles
- Rajaratnam Krishan
- Ramsey Lolita
- Ramsey T. Bennett
- Rao Mayank
- Ray Shea Bielby
- Ristevski Bill
- Rivera Jessica
- Robertson Emily
- Rodriguez Andres
- Rodriguez Elsa
- Rojas Alejandra
- Romeo Nicholas M.
- Routt Milton L. â Chipâ
- Rudisill L. Edwin
- Rudnicki Joshua
- Ruth John T.
- RĂ fols-Perramon Ona
- Sadasivan Kalia
- Saeed Sabina
- Sanders John L.
- Sanz-Molero Matsuyama
- Schaller Thomas M.
- Schulman Jeff E.
- Schwartz Justin
- Schwartzbach Cary C.
- Sciadini Marcus
- Scott Taryn
- Scott Taryn
- Seach Andrea
- Serrano-Sanz Jorge
- Sethi Manish
- Seymour Rachel
- Shearer David
- Sietsema Debra L.
- Sims Michael L.
- Sims Stephen
- Slobogean Gerard P.
- Slobogean Gerard P.
- Smith Cory D.
- Snider Rebecca G.
- Soler-Cano Albert
- Sorkin Anthony T.
- Spicer Ella
- Sprague Sheila
- Sprague Sheila
- Sridhar Michael S.
- Stewart Russell
- Stinner Daniel J.
- Stone Trevor B.
- Szasz Olivia Paige
- Szatkowski Jan P.
- SĂĄnchez-FernĂĄndez Joel
- SĂĄnchez-Palomino Estrella
- Talbot Max
- Talerico Michael
- Taljaard Monica
- Tanner Stephanie L.
- Taylor Michel
- Thabane Lehana
- Thabane Lehana
- Toogood Paul
- Townsend Christine E.
- Trochez Karen
- Vallier Heather A.
- Van Chi
- Velasco-Barrera Aldo
- Venkatarayappa Indresh
- Virkus Walter W.
- Viskontas Darius G.
- Vlasak Richard
- Wadenpfuhl Leanne K.
- Walker Clark M.
- Warner Stephen J.
- Watson J. Tracy
- Wells Jeffrey
- Wentworth Daniel
- Wild Jason
- Williams Alyse
- Williams Dale
- Wilson Eleanor S.
- Wise Jeremy
- Wood Amber
- Wood Amber
- Yela-VerdĂș Christian
- Zomar Mauri
- Zura Robert
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 30/09/2020
- Field of study
An amendment to this paper has been published and can be accessed via the original article
- âŠ