Circulating Pro- and Anti-Inflammatory Metabolites and Its Potential Role in Rheumatoid Arthritis Pathogenesis.

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that affects synovial joints, leading to inflammation, joint destruction, loss of function, and disability. Although recent pharmaceutical advances have improved the treatment of RA, patients often inquire about dietary interventions to improve RA symptoms, as they perceive pain and/or swelling after the consumption or avoidance of certain foods. There is evidence that some foods have pro- or anti-inflammatory effects mediated by diet-related metabolites. In addition, recent literature has shown a link between diet-related metabolites and microbiome changes, since the gut microbiome is involved in the metabolism of some dietary ingredients. But diet and the gut microbiome are not the only factors linked to circulating pro- and anti-inflammatory metabolites. Other factors including smoking, associated comorbidities, and therapeutic drugs might also modify the circulating metabolomic profile and play a role in RA pathogenesis. This article summarizes what is known about circulating pro- and anti-inflammatory metabolites in RA. It also emphasizes factors that might be involved in their circulating concentrations and diet-related metabolites with a beneficial effect in RA

Spectroscopy of Stardust from 200nm to 16µM (with a gap in the middle)

UV/Vis and IR spectroscopy are complementary, non-destructive techniques that can be used to identify the presence of a range of organic and inorganic, hydrated and anhydrous minerals within micron-sized grains. We look forward to applying these techniques to the Stardust materials

Dissecting the Oligomeric Behavior of Caveolin-1 using the Analytical Ultracentrifuge

https://nsuworks.nova.edu/nsudigital_harrison/3450/thumbnail.jp

Lithospheric deformation beneath the San Gabriel Mountains in the Southern California Transverse Ranges

High-resolution tomographic images from Los Angeles Region Seismic Experiment (LARSE) array and southern California Seismic Network (SCSN) teleseismic data suggest that the entire lithosphere below the San Gabriel Mountains and San Andreas fault in the Transverse Ranges has thickened in a narrow, vertical sheet. P wave travel time inversions of the combined data support the presence of the well-documented upper mantle high-velocity anomaly that extends ∼200 km into the mantle under the northernmost Los Angeles basin and Transverse Ranges, and is associated with mantle downwelling due to oblique convergence. We find that the high-velocity, high-density upper mantle anomaly comprises a 60–80 km wide sheet of mantle material that lies directly below a substantial crustal root in the San Gabriel Mountains. The velocity perturbations are as large as 3% in the anomaly, corresponding to a ∼2% density increase. The tomographic images suggest that deformation in the ductile lower crust and mantle lithosphere may be partially coupled mechanically and thermally if the thickening is occurring together in response to convergence and that it may be a local compressional feature

Collapse of Flexible Polyelectrolytes in Multivalent Salt Solutions

The collapse of flexible polyelectrolytes in a solution of multivalent counterions is studied by means of a two state model. The states correspond to rod-like and spherically collapsed conformations respectively. We focus on the very dilute monomer concentration regime where the collapse transition is found to occur when the charge of the multivalent salt is comparable (but smaller) to that of the monomers. The main contribution to the free energy of the collapsed conformation is linear in the number of monomers $N$, since the internal state of the collapsed polymer approaches that of an amorphous ionic solid. The free energy of the rod-like state grows as $N\ln N$, due to the electrostatic energy associated with that shape. We show that practically all multivalent counterions added to the system are condensed into the polymer chain, even before the collapse.Comment: LaTeX-revtex, psfig file, 4 figure

Langston University, A History: Education and Programs from 1897-1994

Originally known as the Colored Agricultural and Normal University, Langston University is Oklahoma \u27 s only historically black college and the only institution of higher education in Oklahoma and perhaps in the United States which has both a land grant and urban mission. Founded in 1897 as a result of the Morrill Act of 1890 and Oklahoma Territorial House Bill 151, Langston University has been providing higher education in Oklahoma for almost a century. Originally the University\u27s purpose was to instruct both male and female colored persons in the art of teaching various branches which pertain to a common school education and in such higher education as may be deemed advisable, and in the fundamental laws of the United States in the rights and duties of citizens in the agricultural, mechanical and industrial arts. Now Langston University offers some thirty-six degree programs supportive * of both its original land grant mission and the urban mission assigned by the Oklahoma State Regents for Higher Education in 1978. As the University approaches its centennial it continues to strive toward excellence from Langston to the World. The topic LANGSTON UNIVERSITY, A HISTORY: EDUCATION AND PROGRESS FROM 1897-1994 was selected for this study because of the need of a current working history of the University and its progress. The purpose of this study is to compile a comprehensive up-to-date history of Langston University to serve as a tool of reference for students and interested scholars and readers alike and to assist in preserving the heritage of the historically black institution. The documentary production (videotape) that accompanies the research reflects current technology in the media. Because of poor record keeping, many historical facts relative to activities and accomplishments of Langston University during the early years have not appeared in previous studies. The few written materials are, in this study, supplemented with interviews of persons knowledgeable of the University in its earlier years and of its early history. The value of this thesis and documentary production will be its availability as a research tool produced in the decade preceding the centennial, a study which includes some data omitted from previous studies

OMG! ESD Codified!: The Overreaction to Codification of the Economic Substance Doctrine

Tanulmányi rendszerbe betöltv

Stress Experienced by Respite Care Workers and Family Caregivers When Caring for Alzheimer\u27s Patients

Changing demographics and cost containment in health care in caring for the Alzheimer\u27s Disease (AD) patient has given birth to a growing need for respite care workers. The purpose of the study was to determine whether the stress level of a respite care worker who works with an AD patient in a noninstitutionalized setting on a daily basis will be significantly less than that of a family caregiver when caring for an AD patient. The Revised Memory and Behavior Problem Checklist (RMBPC) was the instrument used to measure stress. This is a questionnaire consisting of 24 questions and allows 5 levels of responses for both the frequencies of behaviors of AD patients and the reactions of the caregivers. A total of 25 respite care workers and 25 family caregivers responded to the same questionnaire. The results of the study determined that overall, the stress levels of respite care workers was less than that of family caregivers. However, averaging of the responses to certain questions showed surprising results. The findings of this study conclude that since there is a dearth of research in this area, additional research will be needed to determine what interventions could be instituted to reduce respite care workers\u27 stress in certain areas of AD patient behaviors