Sensory Evaluation of Antioxidant Enriched and Iron Based Prebiotic Milk Cake

The main objective of this research study was to develop antioxidant enriched and iron based prebiotic milk cake and to evaluate sensory analysis of newly prepared milk cake. In this research study, control milk cake was developed without prebiotics and experimental milk cake was prepared by different percentage of prebiotics. As a prebiotics kiwi fruits powder was used. The nutritional value of bakery goods and their potential for use in feeding programmes and emergencies captured the attention of customers. After sensory analysis, it was found that T3 treatment combination was showed higher overall acceptability

Fast response and low temperature sensing of acetone and ethanol using Al-doped ZnO microrods

We report low temperature acetone and ethanol sensing properties of Al-doped ZnO microrods synthesized using hydrothermal technique. We observe the acetone detection at room temperature as well as ethanol and acetone detection at low temperature of 150 °C using Al-doped ZnO microrods. 3 wt% Al-doped ZnO microrods sensor exhibits the highest response of 231 toward 8100 parts per million (ppm) of ethanol at 150 °C. The response & recovery time are found to be ultrafast of 60 ms & 870 ms for ethanol and 110 ms & 330 ms for acetone of the Al-doped ZnO microrods at an operating temperature of 150 °C, respectively. In addition, sensing mechanism has explained to illuminate the improved sensing performances of Al-doped ZnO microrods. Thus it is revealed that Al-doped ZnO microrods are promising as an ultrafast gas sensor

Histopathological and Immunohistochemical Analysis of Rare Parotid Tumours: A Case Series

Malignant salivary gland tumours are rare representing only 2% of all head and neck malignancies. The most common malignant salivary gland tumour is mucoepidermoid carcinoma followed by adenoid cystic carcinoma while parotid is the most common site. But there are presence of other rare variants with diverse biological feature of maliganacy including Salivary Duct Carcinoma (SDC), basal cell adenocarcinoma, Carcinoma ex Pleomorphic Adenoma (CXPA), polymorphous adenocarcinoma which represent 1-5% of all salivary gland neoplasm. They typically are high-grade carcinomas with presence lymph nodal metastases. Hereby, author report 5 rare cases of parotid gland malignancy detected by histopathological examination along with confirmation by immunohistochemical examination. A 60-year-old and 65-year-old male diagnosed with salivary duct carcinoma of left parotid and right parotid respectively with ipsilateral cervical lymph node involvement but peripheral resection margins were free from tumour invasion. A 50-year-old female diagnosed with basal cell adenocarcinoma of left parotid with lymph node metastasis and resection margin was involved by the tumour. A 60-year-old male presented with recurrent swelling in left parotid region, diagnosed as carcinoma ex pleomorphic adenoma with lymph node involvement in a case of pleomorphic adenoma of parotid, reported previously. A 52-year-old male presented with right-sided parotid region swelling for last six months having Fine Needle Aspiration Cytology (FNAC) report of pleomorphic adenoma. Parotidectomy revealed diagnosis of polymorphous adenocarcinoma while surgical resection margins were free. Surgery is the main mode of treatment in these tumours. Involvement of resection margins, extraparotid extension, lymphovascular and perineural invasion along with lymph node metastasis are the common indicator for postoperative radiation therapy

Non small cell Carcinoma- Lung: Distribution and spectrum of mutations among patients in Eastern India

Background: Lung cancer is one of the most common malignancies in the world. About 80–85% of lung cancers are non-small cell lung cancer (NSCLC). The development of therapeutic agents targeting products of epidermal growth factor receptor (EGFR) gene mutation and anaplastic lymphoma kinase (ALK) rearrangements has significantly improved survival in patients with NSCLC. Thus, the patients eligible for the treatment should be selected through appropriate molecular tests. Objective: The main objective was to study the distribution of NSCLC and its genetic mutations, in the patients of Eastern India. Methodology: A prospective study was carried out among 228 patients, in a tertiary care hospital of Eastern India during a period of 2 years from January 2016 to January 2018. We have included all the patients who were screened and found to have lug carcinoma. The detailed clinical history of the patients was recorded. We have used techniques such as radiology, histopathology, immunohistochemistry (IHC) and molecular study by FISH technique. Results: Out of 138 cases of NSCLC on histopathology 78 cases (56.7%) were reported as squamous cell carcinoma, 46 cases (33.3%) as adenocarcinoma and 14 cases (10.1%) as NSCLC. IHC was used for categorization of NSCLC cases which showed adenocarcinoma in 4 patients and squamous cell carcinoma in 10 patients. EGFR exon 19 deletion mutation was the predominant mutation in adenocarcinoma. Conclusion: Molecular study for genetic analysis has improved the scope for targeted therapy in Nonsmall cell carcinoma patients, thereby reducing mortality and morbidity in cases of lung carcinoma

Seasonal variation of soil enzymes in areas of fluoride stress in Birbhum District, West Bengal, India

AbstractSoil enzyme activities provide a unique biochemical means for assessing soil function as an indicator of soil fertility, which can be altered by a profusion of fluoride in the soil and seasonal changes. Seven sites were chosen in the fluoride-affected area of Nasipur, Birbhum District, West Bengal, India, to compare seasonal changes in enzymes (urease, amylase, cellulase and invertase), fluoride content, physicochemical characteristics and the availability of microbes in the soil with a control. The activity of all the enzymes varied with season. Urease had greater activity in the summer, followed by winter; it showed marginal differences from the control area during the winter (p<0.002) and summer (p<0.110) but a significant (p<0.000) difference during the rainy season. Soil pH had a negative impact on urease activity during both winter and summer. Cellulase activity was accelerated by the organic matter and organic carbon content of the soil. Fluoride therefore had the greatest activity against urease activity during the rainy, summer and winter seasons. The microbial population of the soil also showed a negative impact of fluoride, which may in turn affect the soil enzymes and characteristics

Fever of unknown origin as a presenting manifestation of craniopharyngioma in a child

An unusual case of cranio-pharyngioma which presented with prolonged fever described here. Investigation revealed that the child was suffering from leaking craniopharyngioma with hypo-pituitarism Fever was due to chemical meningitis following cranio-pharyngioma as evident from the CSF findings. Craniopharyngioma can cause prolonged or recurrent fever due to various reasons. Prolonged fever as the sole manifestation of cranio-pharyngioma has been rarely reported in literature and this is probably first such report in Indian children

Ecthyma gangrenosum in the periorbital region in a previously healthy immunocompetent woman without bacteremia

Ecthyma gangrenosum (EG) is a cutaneous lesion classically associated with potentially fatal Pseudomonas septicemia in immunocompromised patients. Other bacterial and fungal pathogens have also been implicated. Although EG typically occurs in immunocompromised or neutropenic patients, it may occasionally affect a previously healthy person. The cutaneous findings are characteristic with small indurated papulovesicles progressing rapidly to necrotic ulcers with surrounding erythema and a central black Eschar. While lesions can occur at any site, most are commonly found over the buttocks, perineum, limbs, and axillae. We describe a case of EG in periorbital region in a previously healthy woman who responded to appropriate antibiotic treatment for Pseudomonas. It is very important to establish the diagnosis early so that appropriate systemic antibiotic therapy can be initiated to reduce morbidity and potential mortality

Vulnerability of bus and truck drivers affected from vehicle engine noise

The purpose of this study was to find out the vulnerability of bus and truck drivers due to constant exposure of vehicle-engine noise inside the vehicle cabin. Comparative results revealed that noise levels inside the cabin of buses and trucks were in the range of 88.6–102.4 dB and 87.95–103.4 dB, respectively. The health status of bus and truck drivers was assessed by measuring their systolic and diastolic pressure, pulse rate, BMI, digestion problem, hearing loss, vision problem, back pain and irritation. Paired t-test of the results revealed non-significant (p < 0.05) relation between systolic and diastolic pressure of both bus and truck drivers. The pulse rate of truck driver was significantly (p < 0.01) related with noise level inside the cabin of truck. The humidity level inside the cabin showed a positive relation with vehicle age (p < 0.01) and driving period (p < 0.01). This study clearly suggests that vehicle engine noise adversely affects the cardiovascular health of both bus and truck drivers

A misplaced intramuscular injection and limb-threatening ischemia

Femoral artery thrombosis is a rare complication of intramuscular (IM) injection in children. A 12-month-old boy presented with right lower limb ischemia and digital gangrene 3 days after an injection of ceftriaxone administered to his medial aspect of the right thigh. Successful thrombolysis and partial limb salvage was possible with enoxaparin despite a late presentation. Unnecessary and unsafe IM injection in community practice might lead to such devastating outcome which should be avoided