Performance of profiled single noise barriers covered with quadratic residue diffusers

The paper describes an investigation about the acoustic performance of noise barriers with quadratic residue diffuser (QRD) tops, and with T-, Arrow-, Cylindrical and Y-shape profiles. A 2D boundary element method (BEM) is used to calculate the barrier insertion loss. The results of rigid and with absorptive coverage are also calculated for comparisons. Using QRD on the top surface of almost all barrier models presented here is found to improve the efficiency of barriers compare with using absorptive coverage at the examined receiver positions. T-shape and Arrow-shape barriers are also found to provide better performance than other shapes of barriers. The best shape of barriers for utilising QRD among the tested models is the T-shape profile barrier. It is found that reducing the design frequency of QRD shifts the performance improvement towards lower frequency, and therefore the most efficient model for traffic noise is a barrier covered with a QRD tuned to around 400 Hz. © Elsevier Ltd. All rights reserved

Performance of T-shape barriers with top surface covered with absorptive quadratic residue diffusers

A previous paper [Applied Acoustics 66 (2005) 709–730] has shown that adding a quadratic residue diffuser (QRD) to the top of a T-shape barrier can provide better barrier performance than an equivalent purely absorptive barrier. In here, we extend the study to look at the performance when a QRD is made absorptive. This paper presents an investigation on the acoustic performance of a few welled-diffusers with different absorption ability on top of a T-shape noise barrier. The absorption properties of the diffusers are modified with different sequences, by filling the wells with fiberglass, by covering the well entrance with wire meshes, and by putting perforated sheet either on the top surface or inside the wells. A 2D Boundary Element Method (BEM) is used to calculate the barrier insertion loss. The numerical and experimental results on diffuser barriers with rigid and absorptive covers are compared. Among the tested models the best method of treating diffuser barriers with absorbent agents in the QRD is found to be a perorated sheet on top or inside the diffuser wells. It is found that increasing the absorption ability of QRD by fiberglass or high resistance wire meshes has negative effect on the efficiency of a QRD barrier. It is shown that, if the increase in absorption destroys the effect of resonance in wells, it will also have negative effect on the insertion loss performance of the QRD edge barrier. © Elsevier Ltd. All rights reserved

On the modeling of sound propagation over multi-impedance discontinuities using a semiempirical diffraction formulation

Several approximate extensions of the semi-empirical De Jong model [ De Jong et al., J. Sound and Vib. 86, 23–46 (1983) ] are considered for the prediction of sound propagation over multiple impedance discontinuities. A limitation in the original formulation of the De Jong model is highlighted and a modified form that overcomes this limitation is derived based on reciprocity. This leads to the development of a model for multiple impedance discontinuities that can be used for the investigation of sound-wave propagation above a mixed, striped soft ground that is created by either porous absorbent strips, embedded grooves, or wells with different depths. The accuracy of the model is validated against the boundary element method. It is then used to evaluate the importance of the imaginary part of the admittance of the ground strips on sound attenuation along welled surface. It is shown that the attenuation performance of a surface with multiple impedance discontinuities is high when the imaginary part of the average admittance is large and negative (with an −iωt convention), but the magnitudes of the attenuation peaks are also substantially affected by diffraction from the impedance discontinuities. © 2006 Acoustical Society of Americ

The Development of an Empirical Model for Estimation of the Sensitivity to Heat Stress in the Outdoor Workers at Risk

Background: Workers who work in hot environments may be at risk for heat stress. Exposure to heat can result in occupational illnesses, including heat stroke, heat cramps, and heat exhaustion. The risk of exposure to heat depends on individual, environmental, and occupational risk factors. Individual risk factors may decrease the individual’s tolerance to heat stress. Sensitivity as an intrinsic factor may predispose a person to heat stress. Aim: This study was aimed to determine the criteria for sensitivity parameter, specify their weights using the fuzzy Delphi-analytical hierarchy, and finally providing a model to estimate sensitivity. The significant of the study is presenting a model to estimate the sensitivity to heat stress. Materials and Methods: The expert’s opinions were used to extract the criteria in Delphi method. After determining the weight of each criterion, Fuzzy analytic hierarchy Process (FAHP), by mathematical principles matrix and triangular fuzzy numbers, was applied for the prioritization of criteria. Results: According to experts’ viewpoints and considering some exclusion, 10 of 36 criteria were selected. Among 10 selected criteria, age had the highest percentage of responses (90% (27/30)) and its relative weight was 0.063. After age, the highest percentages of response were assigned to the factors of preexisting disease (66.6% (20/30)), body mass index (56.6% (17/30)), work experience (53.3% (16/30)), and clothing (40% (16/30)), respectively. Other effective criteria on sensitivity were metabolic rate, daily water consumption, smoking habits, drugs that interfere with the thermoregulatory processes, and exposure to other harmful agents. Conclusions: Eventually, based on the criteria, a model for estimation of the workers’ sensitivity to heat stress was presented for the first time, by which the sensitivity is estimated in percent.Keywords: Heat stress, Sensitivity, Personal factors, Fuzzy AH

Environmental evaluation and employee's exposure of a thermal power plant with extremely low frequency magnetic fields

Background and aims: Extremely low frequency magnetic field (ELF) is a Spectrum of electromagnetic waves with the range of 30 to 300 Hz. The average magnetic field exposures in the workplace have been found to be higher in "electrical occupations" compared to the other occupations such as office work. The interaction between magnetic fields produced by power lines and substations with living organisms are not fully understood and still open to many researchers. Methods: The three axes TES-1394 was used for magnetic field measurement. Magnetic field measurement conducted based on the IEEE std 644-1994 standard. Firstly all magnetic field sources were detected, then the measuring stations were determined nearby and around the source. The occupational groups with exposure to magnetic field were identified to determine the maximum exposure level and then to compare with ISIRI 8567 national standard. Results: The minimum and maximum measured magnetic field were in near of 63 Kv lines (1.03 μT) and generators (17.6 μT), respectively. The mean of magnetic flux density nearby the generators building source was significantly different from the other sources. The environmental amount of magnetic flux density in 230 Kv (1.58 μT) post was higher than the other environments. Maximum exposure (17.6 μT) of occupational groups was related to engineer's of generators building. Conclusion: Our results of the magnetic flux density measurement close to sources matched with the other relevant studies except for control room. The maximum exposure level of the occupational groups was not higher than the occupational exposure standard value

Modeling signal-to-noise ratio of otoacoustic emissions in workers exposed to different industrial noise levels

Introduction: Noise is considered as the most common cause of harmful physical effects in the workplace. A sound that is generated from within the inner ear is known as an otoacoustic emission (OAE). Distortion-product otoacoustic emissions (DPOAEs) assess evoked emission and hearing capacity. The aim of this study was to assess the signal-to-noise ratio in different frequencies and at different times of the shift work in workers exposed to various levels of noise. It was also aimed to provide a statistical model for signal-to-noise ratio (SNR) of OAEs in different frequencies based on the two variables of sound pressure level (SPL) and exposure time. Materials and Methods: This case-control study was conducted on 45 workers during autumn 2014. The workers were divided into three groups based on the level of noise exposure. The SNR was measured in frequencies of 1000, 2000, 3000, 4000, and 6000 Hz in both ears, and in three different time intervals during the shift work. According to the inclusion criterion, SNR of 6 dB or greater was included in the study. The analysis was performed using repeated measurements of analysis of variance, spearman correlation coefficient, and paired samples t-test. Results: The results showed that there was no statistically significant difference between the three exposed groups in terms of the mean values of SNR (P > 0.05). Only in signal pressure levels of 88 dBA with an interval time of 10:30-11:00 AM, there was a statistically significant difference between the right and left ears with the mean SNR values of 3000 frequency (P = 0.038). The SPL had a significant effect on the SNR in both the right and left ears (P = 0.023, P = 0.041). The effect of the duration of measurement on the SNR was statistically significant in both the right and left ears (P = 0.027, P < 0.001). Conclusion: The findings of this study demonstrated that after noise exposure during the shift, SNR of OAEs reduced from the beginning to the end of the shift

Exposure to heat stress in the workplace: A systematic review

Background and aims: Working in hot environments is one of the common physical risks factor in the workplace, which can also cause heat-related illnesses and various health effects on workers, and also increasing the risk of injuries and occupational accidents. The purpose of this paper is review conducted studies about heat stress in different countries, investigation the indices of heat stress, the characteristics of the exposure in hot environments, high-risk occupations, and sutvey the status and importance of these studies. Methods: In this review study used Web of Science, Scopus, Pubmed, ScienceDirect, Iran Medex, Magiran, Google Scholar and SID databases. The keywordsincluded Heat stress, Heat strain, Heat exposure, Heat waves, Workplace, Knowledge and attitude of workers about heat stress, the period of 2000 to 2015 was investigated, and finally 103 original articles were identifed. Results: 90 of all study being cross-sectional studies, 41 being related to outdoor workplaces, and 42 being related to indoor environment. 19 studies were about perceptions and behavioural responses of exposure to heat stress.A range of heat indices were used with 60 (71) studies using Wet Bulb Globe Temperature Index (WBGT). Most of studied focused on manufacturing workers and farmers. Most of studies indicated that workers were suffering from heat stress and strain. Conclusion: The results of reviewed studies showed that stress in workplace is worrying due to the nature of the working processes both indoor and outdoor, and of climate change. Therefore it is necessary to considering preventive and control programs to reduce the heat stress by the management and staff's participation to eliminate or reduce its lethal effects. © 2018 JTehran University of Medical Sciences and Health Services. All rights reserved

Assessment of construction workers' hydration status using urine specific gravity

Objectives: The study objective was to assess hydration status by measuring USG among construction workers in Iran. Materials and Methods: The study design was comparative and experimental. Sixty participants were randomly selected from the construction workers from a construction campus with a similar type of work, climate and diet and formed 2 groups (individuals exposed to the sun and non-exposed individuals). TWL and USG were measured in both groups on 2 consequent days, at the beginning, mid and end of the work shift. Results: USG test showed that mean USG was 1.0213±0.0054 in the control group and in the exposed group, where it was significantly higher, it amounted to 1.026±0.005. In the exposed group, 38 of workers had a USG level between 1.026-1.030, representing a higher risk of heat illness and impaired performance and 12.72 had a USG level above 1.030 representing a clinically dehydrated status, while this proportion in the control group was 15.2 and 0.58, respectively. The mean TWL index measure was 215.8±5.2 W/m2 for the control group and 144±9.8 W/m2 for the exposed group, where, again, it was significantly higher. The Pearson correlation measure showed a significant correlation between USG and TWL. Conclusions: Strong correlation between TWL, as an indicator of thermal stress and USG shows that USG can be considered as a predictor of thermal stress. The difference between USG among the exposed and non-exposed workers and the increase in USG during midday work show the sensitivity of this measure in different thermal and climatic conditions, whereas, the high level of dehydration among workers despite acceptable TWL level, shows that heat stress management without considering the real hydration status of workers, is insufficient. © 2013 Versita Warsaw and Springer-Verlag Wien

Masked volume wise principal component analysis of small adrenocortical tumours in dynamic [11C]-metomidate positron emission tomography

<p>Abstract</p> <p>Background</p> <p>In previous clinical Positron Emission Tomography (PET) studies novel approaches for application of Principal Component Analysis (PCA) on dynamic PET images such as Masked Volume Wise PCA (MVW-PCA) have been introduced. MVW-PCA was shown to be a feasible multivariate analysis technique, which, without modeling assumptions, could extract and separate organs and tissues with different kinetic behaviors into different principal components (MVW-PCs) and improve the image quality.</p> <p>Methods</p> <p>In this study, MVW-PCA was applied to 14 dynamic 11C-metomidate-PET (MTO-PET) examinations of 7 patients with small adrenocortical tumours. MTO-PET was performed before and 3 days after starting per oral cortisone treatment. The whole dataset, reconstructed by filtered back projection (FBP) 0–45 minutes after the tracer injection, was used to study the tracer pharmacokinetics.</p> <p>Results</p> <p>Early, intermediate and late pharmacokinetic phases could be isolated in this manner. The MVW-PC1 images correlated well to the conventionally summed image data (15–45 minutes) but the image noise in the former was considerably lower. PET measurements performed by defining "hot spot" regions of interest (ROIs) comprising 4 contiguous pixels with the highest radioactivity concentration showed a trend towards higher SUVs when the ROIs were outlined in the MVW-PC1 component than in the summed images. Time activity curves derived from "50% cut-off" ROIs based on an isocontour function whereby the pixels with SUVs between 50 to 100% of the highest radioactivity concentration were delineated, showed a significant decrease of the SUVs in normal adrenal glands and in adrenocortical adenomas after cortisone treatment.</p> <p>Conclusion</p> <p>In addition to the clear decrease in image noise and the improved contrast between different structures with MVW-PCA, the results indicate that the definition of ROIs may be more accurate and precise in MVW-PC1 images than in conventional summed images. This might improve the precision of PET measurements, for instance in therapy monitoring as well as for delineation of the tumour in radiation therapy planning.</p

17-allyamino-17-demethoxygeldanamycin treatment results in a magnetic resonance spectroscopy-detectable elevation in choline-containing metabolites associated with increased expression of choline transporter SLC44A1 and phospholipase A2

Abstract Introduction 17-allyamino-17-demethoxygeldanamycin (17-AAG), a small molecule inhibitor of Hsp90, is currently in clinical trials in breast cancer. However, 17-AAG treatment often results in inhibition of tumor growth rather than shrinkage, making detection of response a challenge. Magnetic resonance spectroscopy (MRS) and spectroscopic imaging (MRSI) are noninvasive imaging methods than can be used to monitor metabolic biomarkers of drug-target modulation. This study set out to examine the MRS-detectable metabolic consequences of Hsp90 inhibition in a breast cancer model. Methods MCF-7 breast cancer cells were investigated, and MRS studies were performed both on live cells and on cell extracts. 31P and 1H MRS were used to determine total cellular metabolite concentrations and 13C MRS was used to probe the metabolism of [1,2-13C]-choline. To explain the MRS metabolic findings, microarray and RT-PCR were used to analyze gene expression, and in vitro activity assays were performed to determine changes in enzymatic activity following 17-AAG treatment. Results Treatment of MCF-7 cells with 17-AAG for 48 hours caused a significant increase in intracellular levels of choline (to 266 ± 18% of control, P = 0.05) and phosphocholine (PC; to 181 ± 10% of control, P = 0.001) associated with an increase in expression of choline transporter SLC44A1 and an elevation in the de novo synthesis of PC. We also detected an increase in intracellular levels of glycerophosphocholine (GPC; to 176 ± 38% of control, P = 0.03) associated with an increase in PLA2 expression and activity. Conclusions This study determined that in the MCF-7 breast cancer model inhibition of Hsp90 by 17-AAG results in a significant MRS-detectable increase in choline, PC and GPC, which is likely due to an increase in choline transport into the cell and phospholipase activation. 1H MRSI can be used in the clinical setting to detect levels of total choline-containing metabolite (t-Cho, composed of intracellular choline, PC and GPC). As Hsp90 inhibitors enter routine clinical use, t-Cho could thus provide an easily detectable, noninvasive metabolic biomarker of Hsp90 inhibition in breast cancer patients