Ethnobotanical Review and Dataset Compiling on Wild and Cultivated Plants Traditionally Used as Medicinal Remedies in Italy

Over the centuries, wild plants have constituted the main food ingredients and traditional medicine in rural communities. In the last decades, thousands of ethnobotanical studies have been conducted, with the aim of documenting the traditional knowledge on wild and cultivated plants both for food and therapeutic purposes. In the present work, 75 published papers related to Italian ethnobotanical knowledge on wild and cultivated plants traditionally used for medical purposes were analyzed and data on 1117 different species organized in the first dataset to target medicinal applications only. For each plant species, the Italian region of use, plant organs, mode of preparation, specific pathological group of application, citation index, and use index were listed. The different therapeutic applications were subdivided into nine main pathological groups according to the targeted human apparatus. Overall, the cited species with highest number of uses were related to the treatment of the digestive system and skin-ears-eyes-hair diseases, followed by diseases of the genito-urinary and respiratory systems. The 13 most relevant species were identified on the basis of their citation and use indexes. The present review on Italian medicinal flora aims to provide valuable information on wild and cultivated species, which are potential sources of plant-based therapeutic remedies, to preserve and reevaluate endangered traditional folk knowledge

Saccharomyces cerevisiae-Based Probiotics as Novel Antimicrobial Agents to Prevent and Treat Vaginal Infections

Vaginal infections affect 70% of women during their lifetimes and account for millions of annual doctors' visits. These infections are predominantly represented by vulvovaginal candidiasis (VVC) and bacterial vaginosis (BV). Although standard antimicrobial agents remain the major strategy for the prevention and treatment of vaginal infections, both VVC and BV are difficult to treat due to high rates of resistance and recurrence, high probability of complications, and negative effects on the vaginal microbiota. This review focuses on a new approach of yeast-based probiotics for the prevention and/or treatment of these common vaginal infections

Spiral and bar driven peculiar velocities in Milky Way sized galaxy simulations

We investigate the kinematic signatures induced by spiral and bar structure in a set of simulations of Milky Way-sized spiral disc galaxies. The set includes test particle simulations that follow a quasi-stationary density wave-like scenario with rigidly rotating spiral arms, and $N$-body simulations that host a bar and transient, co-rotating spiral arms. From a location similar to that of the Sun, we calculate the radial, tangential and line-of-sight peculiar velocity fields of a patch of the disc and quantify the fluctuations by computing the power spectrum from a two-dimensional Fourier transform. We find that the peculiar velocity power spectrum of the simulation with a bar and transient, co-rotating spiral arms fits very well to that of APOGEE red clump star data, while the quasi-stationary density wave spiral model without a bar does not. We determine that the power spectrum is sensitive to the number of spiral arms, spiral arm pitch angle and position with respect to the spiral arm. However, it is necessary to go beyond the line of sight velocity field in order to distinguish fully between the various spiral models with this method. We compute the power spectrum for different regions of the spiral discs, and discuss the application of this analysis technique to external galaxies.Comment: 14 pages, 11 figures. Improved and MNRAS Accepte

Gastropods from the Jurassic neptunian sills of Rocca Busambra (north-western Sicily, Italy): Patellogastropoda, Pleurotomarioidea, Scissurelloidea, Fissurelloidea and Eucycloidea

The gastropods from Jurassic neptunian sills of Rocca Busambra (Sicily, Italy) represent an extraordinary assemblage for richness and extremely high degree of novelty, consisting of about 250 species (two-thirds of which are new) of 20 superfamilies. A total of 38 species and 18 genera of Lottioidea, Pleurotomarioidea, Scissurelloidea, Fissurelloidea and Eucycloidea are described. Of these, 30 species and 9 genera are new, namely Ramusatomaria nuda gen. et sp. nov., Trapanimaria gattoi gen. et sp. nov., Trapanimaria nicolosiensis gen. et sp. nov., Trapanimaria? pallinii gen. et sp. nov., Trochotomaria conoidea sp. nov., Trochotomaria polymorpha sp. nov., Laevitomaria babalusciae sp. nov., Pyrgotrochus vorosi sp. nov., Auritoma lenticula gen. et sp. nov., Busambrella fasciata gen. et sp. nov., Emarginula (Emarginula) burgioi sp. nov., Emarginula (Tauschia) acutidens sp. nov., Propeucyclus sicanus gen. et sp. nov., Propeucyclus obesus gen. et sp. nov., Propeucyclus? semireticulatus gen. et sp. nov., Eucyclomphalus? marenostrum sp. nov., Toronyella lineata gen. et sp. nov., Toronyella margaritata gen. et sp. nov., Zarnglaffia polygonalis sp. nov., Zarnglaffia palermitana sp. nov., Ambercyclus cratisculptus sp. nov., Elymicyclus alternatus gen. et sp. nov., Elymicyclus ietumensis gen. et sp. nov., Elymicyclus martae gen. et sp. nov., Elymicyclus garibaldii gen. et sp. nov., Jurassiscala sturanii gen. et sp. nov., Jurassiscala? tenuiretis gen. et sp. nov., Fischeriella sicula sp. nov., Retimusina poseidoni gen. et sp. nov. and Retimusina? tritoni sp. nov. The new scissurelloidean family Auritomidae fam. nov. is erected. A palaeobiogeographical analysis indicates close relationships with coeval faunas from condensed pelagic carbonates of the central region of western Tethys

Full-Configuration-Interaction Study of the Metal-Insulator Transition in Model Systems: Li_N Linear Chains (N=2,4,6,8)

International audienceThe precursor of the metal-insulator transition is studied at ab initio level in linear chains of equally spaced lithium atoms. In particular, full configuration interaction calculations (up to 1×109 determinants) are performed, in order to take into account the different nature of the wave function at different internuclear distances. Several indicators of the Metal-Insulator transition (minimum of the energy gap, maximum of the localization tensor or of the polarizability) are considered and discussed. It is shown that the different indicators give concordant results, showing a rapid change in the nature of the wave function at an internuclear distance of about 7bohrs

Ruthenium-thymine acetate binding modes: Experimental and theoretical studies

Ruthenium complexes have proved to exhibit antineoplastic activity, related to the interaction of the metal ion with DNA. In this context, synthetic and theoretical studies on ruthenium binding modes of thymine acetate (THAc) have been focused to shed light on the structure-activity relationship. This report deals with the reaction between dihydride ruthenium mer-[Ru(H)2(CO)(PPh3)3], 1 and the thymine acetic acid (THAcOH) selected as model for nucleobase derivatives. The reaction in refluxing toluene between 1 and THAcOH excess, by H2 release affords the double coordinating species k1-(O)THAc-, k2-(O,O)THAc-[Ru(CO)(PPh3)2], 2. The X-ray crystal structure confirms a simultaneous monohapto, dihapto- THAc coordination in a reciprocal facial disposition. Stepwise additions of THAcOH allowed to intercept the monohapto mer-k1(O)THAc-Ru(CO)H(PPh3)3] 3 and dihapto trans(P,P)-k2(O,O)THAc-[Ru(CO)H(PPh3)2] 4 species. Nuclear magnetic resonance (NMR) studies, associated with DFT (Density Function Theory)-calculations energies and analogous reactions with acetic acid, supported the proposed reaction path. As evidenced by the crystal supramolecular hydrogen-binding packing and 1H NMR spectra, metal coordination seems to play a pivotal role in stabilizing the minor [(N=C(OH)] lactim tautomers, which may promote mismatching to DNA nucleobase pairs as a clue for its anticancer activity

Sequence randomness and polymer collapse transitions

Contrary to expectations based on Harris' criterion, chain disorder with frustration can modify the universality class of scaling at the theta transition of heteropolymers. This is shown for a model with random two-body potentials in 2D on the basis of exact enumeration and accurate Monte Carlo results. When frustration grows beyond a certain finite threshold, the temperature below which disorder becomes relevant coincides with the theta one and scaling exponents definitely start deviating from those valid for homopolymers.Comment: 4 pages, 4 eps figure

C-N coupling between µ-aminocarbyne and nitrile ligands promoted by tolylacetylide addition to [Fe2CN(Me)(Xyl)}(CO)(CO)(NCCMe3)(Cp)2][SO3CF3]: formation of a novel bridging allene-diaminocarbene ligand

The reaction of the mu-aminocarbyne complex [Fe-2{mu-CN(Me)(Xyl)}(mu-CO)(CO)(NCCMe3)(CP)(2)][SO3CF3] (2) (Xyl = 2,6-Me2C6H3) with tolylacetylide, followed by treatment with HSO3CF3 affords the complex [Fe-2{mu-eta(1):eta(3)C(Tol)double bondCdouble bondC(CMe3)N(H)CN(Me)(Xyl)}(mu-CO)(CO)(Cp-2)][SO3CF3] (3) (Tol = 4-MeC6H4). The X-ray molecular structure of 3 reveals the peculiar character of the bridging ligand, which exhibits both eta(1):eta(2) allene and aminocarbene nature. The formation of 3 proceeds through several intermediate species, which have been detected by IR spectroscopy. Addition of HSO3CF3 at an early stage of the reaction between 2 and LiCdropCTol leads to the formation of the imine complex [Fe-2{mu-CN(Me)Xyl}(mu-CO)(CO){NHC(CdropCTol)CMe3}(Cp)(2)][SO3CF3] (6) indicating that the first step of the reaction consists in the acetylide addition at the coordinated NCCMe3. The molecular structure of 6 has been elucidated by an X-ray diffraction study

Enzymatic digestion of calf fleshing meat by-products: Antioxidant and anti-tyrosinase activity of protein hydrolysates, and identification of fatty acids

open7noThis research was funded by Italian Ministry of Education, University and Research, National Project Cluster Agrifood SO.FI.A. (SOstenibilità della FIliera Agroalimentare) (2013–2017, Grant Number CTN01_00230_450760).The food waste reduction through an efficient recovery of its valuable building molecules has become an important topic with a positive effect on the economy and the environment. In this work, the revalorization of slaughterhouse calf fleshing meat through its enzymatic hydrolysis is proposed. The proteolytic activity of 11 enzymes was initially screened and the four most efficient enzymes (papain, trypsin, pancreatin, and bromelain) were selected. The molecular profiling of the different protein/peptide fractions by the Linear Trap Quadrupole-OrbiTrap technique showed compositional differences due to the specificity of the enzymes’ cleavage sites. In order to find a potential reuse of these hydrolysates, the analysis of antioxidant and, for the first time on fleshing meat hydrolysates, of anti-tyrosinase activities, was performed. Papain-digested samples were those showing the highest inhibition activity of tyrosinase enzyme (55.6%) as well as the highest antioxidant activity (3.52 g TEAC/L). In addition, the composition analysis of the lipid fraction was performed. The mono-unsaturated fatty acids resulted to be the most abundant lipid in all the samples with the exception of pancreatin-treated hydrolysates in which poly-unsaturated fatty acids were predominant. The present results seemed to support a possible valorization of isolated fractions from calf fleshing by-products, as food or feed ingredients, by the implementation of fraction isolation within the meat-processing pipeline.openTedeschi T.; Anzani C.; Ferri M.; Marzocchi S.; Caboni M.F.; Monari S.; Tassoni A.Tedeschi T.; Anzani C.; Ferri M.; Marzocchi S.; Caboni M.F.; Monari S.; Tassoni A