PRE-FORMULATION STUDY ON 5-FLUOROURACIL AND CERTAIN LIPIDS FOR SOLID LIPID NANOPARTICLES PREPARATION

Objective: The study's objective involved compatibility studies to investigate the possible interactions between 5-fluorouracil (5-FU) and four different lipids, and the most appropriate lipid was chosen.  Differential scanning calorimetry (DSC), X-ray diffraction (XRD), and Fourier Transform Infrared spectroscopy (FT-IR) are used for the compatibility study between 5-FU and several excipients as cholesterol, compritol®, stearic acid, and glycerol monostearate (GMS). Methods: The physical mixture between 5-FU and each lipid was made by mixing of a certain amount of drug with the same amount of lipid. Drug lipid blended mixtures were made by solvent evaporation casting method. 5-FU alone, physical mixture and blended mixture were measured using Differential scanning calorimetry (DSC) to investigate melting peak of drug and effect of each lipid on this melting point, X-ray diffraction (XRD) to observe the crystalline or amorphous state of drug and Fourier Transform Infrared (FT-IR) to determine any chemical interaction between drug and these lipids by observing any shift happened to characteristic peaks related to the drug. Results: 5-FU Tm (280.04 °C) peak appeared in drug-lipid physical mixtures with minor changes in position while this peak disappeared in 5-FU-compritol® and 5-FU-cholesterol blended mixture, indicating that the drug is molecular dispersed. XRD result showed that the crystalline structure of 5-FU was present in physical mixtures with four lipids, while in the 5-FU-compritol® blended mixture, the crystalline state of the drug was disappeared, confirming the DSC result. The FT-IR spectrum of the 5-FU-physical mixtures with four lipids showed that all characteristic peaks of the drug appeared with minor changes. In the case of 5-FU-blended mixtures with mentioned lipids, no chemical interaction occurred between the drug and mentioned lipids except in the drug-stearic acid blended mixture, the N-H peak at 3136.25 cm-1 was disappeared due to amide ester formation. Conclusion: The most appropriate lipids suitable for the preparation of 5-FU solid lipid nanoparticles were GMS and cholesterol

Monte Carlo Simulation of Electron Transport in Degenerate Semiconductors

A modified algorithm is proposed to include Pauli exclusion principle in Monte-Carlo simulations. This algorithm has significant advantages to implement in terms of simplicity, speed and memory storage. We show that even in moderately high applied fields, one can estimate electronic distribution with a shifted Fermi sphere without introducing significant errors. Furthermore, the free-flights must be coupled to state availability constraints; this leads to substantial decrease in carrier heating at high fields. We give the correct definition for electronic temperature and show that in high applied fields, the quasi Fermi level is valley dependent. The effect of including Pauli exclusion principle on the band profile; electronic temperature and quasi Fermi level for inhomogeneous case of a single barrier heterostructure is illustrated

Assessment of Body Composition, Endurance and Nutrient Intakes among Females Team Players in Sports Club

Aim: The aim of the study was to assess the body composition, endurance level and usual nutrient intakes in female players representing a Sports Club in Sharjah, United Arab Emirates. Materials and Methods: Twenty-six adult female players aged between 15-24 years were selected from three different teams (basketball=12, tennis=4, volleyball=10) using convenience sampling technique. All participants were assessed for body composition through bioelectrical impedance method, endurance level using step test and nutrient intakes using 24-hour recall method. Significant differences (P < 0.05) were determined among the three teams in relation to body composition, endurance levels and nutrient intakes. Results: Body composition of players in three sports was significantly different in terms of body mass index, body fat mass, and percentage body fat and fitness scores. Tennis players had significantly higher body fat mass (28.5 ± 8.2 kg) and percent body fat (41 ± 7%) in contrast to that in basketball players (body fat mass: 19.2 ± 10.5 kg; percent body fat: 30.6 + 7.9%) and tennis players (body fat mass: 13 ± 4.2 kg; percent body fat: 26.5 ± 6.5%), respectively. On the other hand, volleyball players had significantly higher fitness score (72.2 ± 3.5) as compared to basketball players (71 ± 6.7), and tennis players (63 ± 8.2). On an average, volleyball players scored “very good” endurance level in contrast to “good” scores in basketball and tennis team players. However, this difference was not statistically significant. The average intakes of all nutrients including energy, protein, vitamins and minerals were below the recommended intakes among players of all sports teams.   Conclusions: Body composition and endurance level differ with the type of sports. Volleyball team players had the lowest BMI, body fat mass as well as percent body fat and highest fitness score and endurance level. However, the overall nutrient intakes of the female players representing the three teams were less than the recommended allowances for highly active women and did not differ with the type of sports played

Performance Evaluation of Applying Fuzzy Multiple Regression Model to TLS in the Geodetic Coordinate Transformation

It is known that the classical technique for solving the linear regression problem of the geodetic transformation process is using least squares approach (LS). On the contrary, this research explores the application of total least squares (TLS) approach to solve linear regression with and without fuzzy multiple regression model in Bursa-Wolf similarity transformation process. In this research two groups of data sets are used; the first group is the solution points which are used to compute the values of the transformation parameters. The second is the check points that were used to assess the accuracy of the applied methods (in terms of mean and Root Mean Squares Errors RMSE). The applied four solutions show how the accuracy of TLS is relatively better than LS. The weight has a better effect on improving the accuracy of both cases, LS and TLS; however, its effects are greater on TLS. By using the fuzzy multiple regression models, the results improved further and the need for accurate weights/confidence is eliminated

Thermoelectric transport perpendicular to thin film heterostructures using Monte Carlo technique

The Monte Carlo technique is used to calculate electrical as well as thermoelectric transport properties across thin film heterostructures. We study a thin InGaAsP barrier layer sandwiched between two InGaAs contact layers, when the barrier thickness is in 50nm-2000nm range. We found that with decreasing size, the effective Seebeck coefficient is increased substantially. The transition between pure ballistic thermionic transport and fully diffusive thermoelectric transport is also described

Impact of Genital and Non-Genital Psoriasis on Genital Self-Image, Quality of Life, and Sexual Dysfunction in Female Patients

Introduction: Psoriasis is a chronic systemic inflammatory disease that affects millions of people worldwide. While its physical manifestations are well-documented, the psychosocial impact of psoriasis, particularly on female patients, is an area of growing concern. Feelings of shame, inferiority, and stigma are common among individuals with psoriasis, and these emotional burdens can be especially pronounced in females, particularly when the genital area is affected.  Objectives: We aimed to shed light on the significance of genital psoriasis on the  overall well-being of female patients. Methods: We conducted a cross-sectional assessment of quality of life using the Dermatology Life Quality Index (DLQI), sexual function using Female Sexual Function Index (FSFI), genital self-image using Female Genital Self-Image Assessment (FGSIS), among Egyptian females with and without genital psoriasis. By comparing these aspects across different groups, Results: We found that females with genital lesions, experience a notable decline in sexual health with higher levels of sexual distress compared to healthy individuals. In terms of the six FSFI domains, the psoriatic group scored lower than the control group in all areas, except for pain, which showed a significant increase. Psoriatic females also exhibited a significantly more negative FGSIS compared to the control group, and there was a highly significant difference in FGSIS between females with and without genital psoriasis. Conclusion: Understanding the impact of genital psoriasis on female sexual health and overall quality of life is essential for comprehensive patient care This research is instrumental in addressing the psychosocial aspects of psoriasis and enhancing patient well-being

3-(Adamantan-1-yl)-4-(prop-2-en-1-yl)-1H-1,2,4-triazole-5(4H)-thione

The title mol­ecule, C15H21N3S, exists as the thione tautomer in the solid state. The 1,2,4-triazole ring is almost planar (r.m.s. deviation = 0.004 Å) and the prop-2-en-1-yl chain is close to being perpendicular to this plane [C—N—C—C torsion angle = 77.1 (5)°]. In the crystal, centrosymmetric dimeric aggregates are formed by pairs of N—H⋯S hydrogen bonds as parts of eight-membered (⋯HNCS)2 synthons. These are connected into layers parallel to (101) via C—H⋯π inter­actions, where the π-system is the triazole ring. The investigated sample was a nonmerohedral twin; the refined domain ratio was 0.655 (4):0.345 (4)

The Influence of Nano-Materials in Presence of Vinyl Acetate Copolymer ( Beva 371) for Consolidation of an Egyptian Coptic Fresco Painting

Nano-lime dispersed in propanol was extensively used for consolidation of mural paintings. Current result pointed out the effect of using different nano-dispersed materials (nano silica, nano calcium hydroxide and carbonate) with Beva 37 soluble in toluene/ethanol to consolidate models of an Egyptian Coptic fresco. Scanning electron microscope (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR) and spectrophotometer were used to determine the visual properties, morphological and physical properties of the treated models. The influence of treatment on various mechanical characteristics of consolidated models were also, tested in detail by means of tests on specimens of the treated models. The treatment was carried out in presence of the nano-materials with or without the polymeric material. The mechanical characteristics of the treated models were improved. This can be attributed to nano-calcium hydroxide was turned into calcium carbonate and both of nano- silica and nano-calcium carbonate appeared as filler. The high impact of nano-materials remind even in presence of polymeric material (Beva 371)

Detection Some Trace Elements in Human Milk and Effect of Some Factors on its Concentrations

Study aim to determination some trace elements in lactating mothers human milk and study effect different factors on its concentration, Age , Body mass index, Home and Smoking habitat, atomic absorption flame less used to measured (Mn, Cd, Co and Zn) in 70 sample of lactating mothers milk which digested using tricolor acetic acid 24%. Result show that concentration of these elements increasing than normal value of these elements,Mn was 1801.40, Cd was 114.64, Co was 288.52 and Zn was 212.10.Also factors were studied effect on minerals concentration,  increasing age was  non effected on minerals concentration, over weight causes increasing it, urban resident causesincreasing in Mn concentration while rural residence causes increasing in others minerals, negative smoking habitat causes increasing in Cd and Co concentrations. Key words: trace element, lactating mother’s human milk, atomic absorptio

Role of calcium and magnesium on dramatic physiological and anatomical responses in tomato plants

Minerals are the fundamental source of nutrients for plant functions such as photosynthesis, ATP currency, cellular respiration, metabolic activities, defense mechanisms, and tolerance to biotic and abiotic stressors. Minerals are the most significant component of plant nutrition and applying these minerals supplements can increase fruit output. The study’s main aim was to make agricultural farming easier by foliar applying newly created nutrients like Lebosol-calcium and Magnesium. The four treatments: To (Control), T1 (Lebosol-Mg-Plus, 3 ml/L), T2 (Lebosol-Ca-Forte, 3 ml/L), and T3 (Lebosol-Mg-Plus and Lebosol-Ca-Forte, 3 ml/L) was applied as foliar spray to the seedlings of tomato. It was found that T3 substantially enhanced tomato’s morphological features and yield. The treatment T3 significantly increased total soluble protein, chlorophyll content, and antioxidant enzyme activity. Furthermore, the foliar application of T3 considerably improved phenolic and ascorbic acid contents. The general anatomical features of the leaf, stem, and roots of tomato were qualitatively affected by the treatments. Application of Lebosol-Ca provided the highest total thickness of lamina, number of vessel elements, total phloem area, chlorenchyma layer, total area of vessel elements, xylem ratio, and increased palisade layer thickness, vessel diameter. Furthermore, T3 treatment showed a diverse impact on the internal structure of tomato organs, with palisade and spongy parenchyma growing to maximum values and vessel diameters expanding. T3 had also posed remarkable alterations in morpho-physiological, biochemical, and anatomical aspects in tested plants