Case report: inferior vena cava agenesia in a young male patient presenting with bilateral iliac veins thrombosis

IntroductionAnomalies in inferior vena cava represent an uncommon finding with a prevalence of 0. 3 to 0.5% among healthy patients. Specifically, the condition characterized by the agenesis of the inferior vena cava (IVC; AIVC) has been observed among the 0.0005 to 1% of the general population. AIVC is strongly related to deep vein thrombosis (DVT) of the lower limb and pelvic district, especially in young patients. The rarity of the presented condition could relate to an underestimation of its impact on a particular clinical setting leading to a delayed diagnosis and inaccurate early- and long-term management. ReportWe presented a case of this anomaly regarding a 31-year-old man presenting with bilateral symptomatic proximal DVT. Duplex vascular ultrasound and subsequent CT-angiography revealed the complete occlusion of the right external and common iliac vein, as well as partial occlusion of the contralateral external iliac vein, in the patient. The exam also revealed the interruption of IVC in its infrarenal part. At the level of renal veins coalescence, IVC appeared again in its usual position. A dilatated portal system, hepatic veins, and azygos and hemiazygos systems were also highlighted. Anticoagulation was promptly started with the administration of Fondaparinux (7.5 mg/die). In addition, compression stocking was initiated within 24 h from diagnosis. After 3 weeks, the anticoagulation regimen was shifted toward the administration of a direct oral anticoagulant (Apixaban; 5 mg two times a day). At 1-month follow-up, a vascular duplex ultrasound revealed a complete resolution of the iliac veins' thrombosis. ConclusionIt is important to consider the eventuality of IVC anomalies in a young adult presenting with unexplained, extensive, or bilateral DVT. Accurate diagnostic evaluation is necessary to fully identify this condition that could represent a real challenge

Selective precipitation of calcium ion from seawater desalination reverse osmosis brine

The near zero liquid discharge (NZLD) approach, by recovering water and dissolved valuable salts, is the most attractive clean solution for the valorisation of brines from seawater desalination reverse osmosis (SWD-RO) plants. In this perspective, a key aspect is calcium removal/recovery, to avoid scaling problems in the successive advanced separation units for recovering other valuable salts. In this work sodium citrate (Na3C6H5O7), carbonate (Na2CO3) and hydrogencarbonate (NaHCO3) were tested as calcium precipitation reagents. Different pH, temperature, ionic strength and reagent molar ratio were tested to maximize the Ca2+ precipitation and minimize the Mg2+ loss. Aqueous solutions containing Ca and Mg ions with/without all major seawater electrolytes were used. The chemical basis of the precipitation processes were discussed based on the effective ion surface density (e.g. Slater rule), ion hydration and Eigen association process of the precipitate formation in the complex multicomponent brine. PhreeqC and Medusa equilibrium numerical codes were applied on some experimental data of the precipitation processes providing a good agreement between calculated and experimental values. Ca2+ removal efficiency higher than 90% coupled with an Mg2+ loss below 7% was obtained at 60 °C and controlled pH, by using NaHCO3. These results are very promising in view of designing a process for brines valorisation, thus mitigating the environmental problems related to SWD-RO brines disposal.Peer ReviewedPostprint (published version

Adiposity Predicts Cognitive Decline in Older Persons with Diabetes: A 2-Year Follow-Up

BACKGROUND: The mechanisms related to cognitive impairment in older persons with Type 2 diabetes (DM) remains unclear. We tested if adiposity parameters and body fat distribution could predict cognitive decline in older persons with DM vs. normal glucose tolerance (NGT). METHODOLOGY: 693 older persons with no dementia were enrolled: 253 with DM in good metabolic control; 440 with NGT (age range:65-85 years). Longitudinal study comparing DM and NGT individuals according to the association of baseline adiposity parameters (body mass index (BMI), waist-hip-ratio (WHR), waist circumference (WC) and total body fat mass) to cognitive change (Mini Mental State Examination (MMSE), a composite score of executive and attention functioning (CCS) over time. FINDINGS: At baseline, in DM participants, MMSE correlated with WHR (beta = -0.240; p = 0.043), WC (beta = -0.264; p = 0.041) while CCS correlated with WHR (beta = -0.238; p = 0.041), WC (beta = -0.326; p = 0.013) after adjusting for confounders. In NGT subjects, no significant correlations were found among any adiposity parameters and MMSE, while CCS was associated with WHR (beta = -0.194; p = 0.036) and WC (beta = -0.210; p = 0.024). Participants with DM in the 3(rd) tertile of total fat mass showed the greatest decline in cognitive performance compared to those in 1(st) tertile (tests for trend: MMSE(p = 0.007), CCS(p = 0.003)). Logistic regression models showed that 3(rd) vs. 1(st) tertile of total fat mass, WHR, and WC predicted an almost two-fold decline in cognitive function in DM subjects at 2(nd) yr (OR 1.68, 95%IC 1.08-3.52). CONCLUSIONS: Total fat mass and central adiposity predict an increased risk for cognitive decline in older person with DM

An Investigation into the Stability of Graphitic C3N4 as a Photocatalyst for CO2 Reduction

The increasing CO 2 concentration in the atmosphere exerts a significant influence on global warming and climate change. The capture and utilization of CO 2 by conversion to useful products is an area of active research. In this work, the photodriven reduction of CO 2 was investigated using graphitic carbon nitride (g-C 3 N 4 ) as a potential photocatalyst. The photocatalytic reduction of CO 2 was investigated with g-C 3 N 4 powder immobilized on a glass support in a batch gas-phase photoreactor. The experiments were carried out under UV-vis irradiation at 70 \ub0C and an initial pressure of 2.5 bar. The only gas-phase product detected during the irradiation of the g-C 3 N 4 in the presence of CO 2 was CO, and the rate of production was observed to decrease over time. Oxygen-doped g-C 3 N 4 was also tested for CO 2 reduction but had efficiency lower than that of the parent g-C 3 N 4 . Repeated cycles of photocatalytic CO 2 reduction showed a decline in the activity of the g-C 3 N 4 . In the absence of CO 2 some CO generation was also observed. Characterization of used and unused materials, using FTIR and XPS, showed an increase in the oxygen functional groups following UV-vis irradiation or thermal treatment. While others report the use of g-C 3 N 4 as a photocatalyst, this work highlights the important need for replicates and control testing to determine material stability

Psychological treatments and psychotherapies in the neurorehabilitation of pain. Evidences and recommendations from the italian consensus conference on pain in neurorehabilitation

BACKGROUND: It is increasingly recognized that treating pain is crucial for effective care within neurological rehabilitation in the setting of the neurological rehabilitation. The Italian Consensus Conference on Pain in Neurorehabilitation was constituted with the purpose identifying best practices for us in this context. Along with drug therapies and physical interventions, psychological treatments have been proven to be some of the most valuable tools that can be used within a multidisciplinary approach for fostering a reduction in pain intensity. However, there is a need to elucidate what forms of psychotherapy could be effectively matched with the specific pathologies that are typically addressed by neurorehabilitation teams. OBJECTIVES: To extensively assess the available evidence which supports the use of psychological therapies for pain reduction in neurological diseases. METHODS: A systematic review of the studies evaluating the effect of psychotherapies on pain intensity in neurological disorders was performed through an electronic search using PUBMED, EMBASE, and the Cochrane Database of Systematic Reviews. Based on the level of evidence of the included studies, recommendations were outlined separately for the different conditions. RESULTS: The literature search yielded 2352 results and the final database included 400 articles. The overall strength of the recommendations was medium/low. The different forms of psychological interventions, including Cognitive-Behavioral Therapy, cognitive or behavioral techniques, Mindfulness, hypnosis, Acceptance and Commitment Therapy (ACT), Brief Interpersonal Therapy, virtual reality interventions, various forms of biofeedback and mirror therapy were found to be effective for pain reduction in pathologies such as musculoskeletal pain, fibromyalgia, Complex Regional Pain Syndrome, Central Post-Stroke pain, Phantom Limb Pain, pain secondary to Spinal Cord Injury, multiple sclerosis and other debilitating syndromes, diabetic neuropathy, Medically Unexplained Symptoms, migraine and headache. CONCLUSIONS: Psychological interventions and psychotherapies are safe and effective treatments that can be used within an integrated approach for patients undergoing neurological rehabilitation for pain. The different interventions can be specifically selected depending on the disease being treated. A table of evidence and recommendations from the Italian Consensus Conference on Pain in Neurorehabilitation is also provided in the final part of the pape

GIARPS: the unique VIS-NIR high precision radial velocity facility in this world

GIARPS (GIAno & haRPS) is a project devoted to have on the same focal station of the Telescopio Nazionale Galileo (TNG) both the high resolution spectrographs HARPS-N (VIS) and GIANO (NIR) working simultaneously. This could be considered the first and unique worldwide instrument providing cross-dispersed echelle spectroscopy at a high resolution (R=115,000 in the visual and R=50,000 in the IR) and over in a wide spectral range (0.383 - 2.45 micron) in a single exposure. The science case is very broad, given the versatility of such an instrument and the large wavelength range. A number of outstanding science cases encompassing mainly extra-solar planet science starting from rocky planet search and hot Jupiters, atmosphere characterization can be considered. Furthermore both instrument can measure high precision radial velocity by means the simultaneous thorium technique (HARPS - N) and absorbing cell technique (GIANO) in a single exposure. Other science cases are also possible. Young stars and proto-planetary disks, cool stars and stellar populations, moving minor bodies in the solar system, bursting young stellar objects, cataclysmic variables and X-ray binary transients in our Galaxy, supernovae up to gamma-ray bursts in the very distant and young Universe, can take advantage of the unicity of this facility both in terms of contemporaneous wide wavelength range and high resolution spectroscopy.Comment: 8 pages, 5 figures, SPIE Conference Proceeding

Global Architecture of Planetary Systems (GAPS), a project for the whole Italian Community

The GAPS project is running since 2012 with the goal to optimize the science return of the HARPS-N instrument mounted at Telescopio Nazionale Galileo. A large number of astronomers is working together to allow the Italian community to gain an international position adequate to the HARPS-N capabilities in the exoplanetary researches. Relevant scientific results are being obtained on both the main guidelines of the collaboration, i.e., the discovery surveys and the characterization studies. The planetary system discovered around the southern component of the binary XO-2 and its characterization together with that of the system orbiting the northern component are a good example of the completeness of the topics matched by the GAPS project. The dynamics of some planetary systems are investigated by studying the Rossiter-McLaughlin effect, while host stars are characterized by means of asteroseismology and star-planet interaction

The GAPS Project: First Results

The GAPS programme is an Italian project aiming to search and characterize extra-solar planetary systems around stars with different characteristics (mass, metallicity, environment). GAPS was born in 2012, when single research groups joined in order to propose a long-term multi-purpose observing program for the exploitation of the extraordinary performances of the HARPS-N spectrograph, mounted at the Telescopio Nazionale Galileo. Now this group is a concerted community in which wide range of expertise and capabilities are shared in order to reach a more important role in the wider international context. We present the results achieved up to now from the GAPS radial velocity survey: they were obtained in both the two main objectives of the project, the planet detection and the characterization of already known exoplanetary systems. With GAPS we detected, for instance, the first confirmed binary system in which both components host planets (Desidera et al. 2014), the first planetary system around a star in an open cluster (Malavolta et al. 2016), a system of Super-Earths orbiting an M-dwarf star (Affer et al. 2016)