Proteomic analysis in wild type and cisplatin resistant yeast strain of saccharomyces cerevisiae

Research carried out in oncology has allowed the identification and characterization of molecular markers of resistance to antineoplastic drugs. It supposes a great advance and allows the administration of customized chemotherapies to patients. The aim of this work is to carry out a proteomic analysis in the wild type strain and cisplatin resistant strain of Saccharomyces cerevisiae in order to look for possible markers of resistance, as well as the mechanisms involved.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

One hundred of cells generations connect the resistance to drugs and the replicative aging mechanisms

There are researchs that reveal a relationship between acquired resistance to antineoplastic drugs and aging. Therefore, the identification of genes involved in senescence could have a potential therapeutic utility for the prediction and/or prevention of resistance to antineoplastic drugs. The aim of this work is to study the relationship between replicative aging and acquired resistance to Cisplatin and Bleomycin in the yeast Saccharomyces cerevisiae.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Mechanisms of cross resistance between cisplatin and bleomycin in saccharomyces cerevisiae

Tumor cells can simultaneously acquire resistance against a diverse group of drugs. This phenomenon is called pleotropic resistance or multidrug resistance. This mechanism could explain the tumor resistance observed in chemotherapy treatments with multiple agents. The aim of this work is to study possible mechanisms of cross resistance between Cisplatin and Bleomycin in Saccharomyces cerevisiae.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

New markers of bleomycin resistance

Resistance to chemotherapy is one of the main problems of this type of therapy. Studies carried out determine the usefulness of predictive biomarkers to improve this treatment. The aim of this work is to carry out a proteomic analysis in the wild type strain and bleomycin resistant strain of Saccharomyces cerevisiae in order to look for possible markers of resistance, as well as the mechanisms involved.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Resistance to bleomycin increases the chronological life of cells

The identification of genes involved in chronological aging could have a potential utility as molecular markers in the chemotherapy treatment of cancer. The aim of this work is to study the relationship between the chronological aging and the resistance to Bleomycin for the purpose of establish the basic interactions between these phenomenons for further investigation of molecular markers.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Resistance acquisition after seven cycles of in vitro bleomycin exposure

Bleomycin is an antineoplastic drug that causes DNA damage by intra- and inter-strand crosslink and DNA strand breaks. This drug is used to treat several types of cancer. The aim of this work is to study the effect of Bleomycin on S. cerevisiae cells and select bleomycin-resistant cells to study the process of resistance acquisition to establish new protocols in in vitro drugs exposure.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Relationship between chronological aging and acquired resistance to cisplatin in the yeast saccharomyces cerevisiae

The Sir2 gene is associated with an increase in longevity in yeasts, worms, flies and rodents. The human homolog, Sirt1, is also involved in longevity, by inhibiting cellular senescence. Studies carry out in tumor cells of neuroblastoma, osteosarcoma, breast and ovary, resistant and sensitive to antineoplastic drugs, suggest that the increase of Sirt1 expression may represent a general phenomenon associated with resistance to chemotherapy, independent of cell type or drug used to induce resistance. Thus, after analyzing tumor biopsies after treating patients with chemotherapy, high amounts of Sirt1 have been observed. The aim of this work is to study the relationship between chronological aging and acquired resistance to Cisplatin in the yeast Saccharomyces cerevisiae.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Selection of resistance to cisplatin in saccharomyces cerevisiae as a model for antineoplastic drugs studies

The budding yeast (S. cerevisiae) is an excellent eukaryotic model to study the antineoplastic drugs effects, due to the well-characterized metabolic and genetic characteristics and the conserved similarity in molecular mechanisms with other species including human cells. The aim of this work is to study the effect of cisplatin on S. cerevisiae cells and select cisplatin-resistant cells of this organism as a model of study of resistance to antineoplastic drugs.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Merging plans with incomplete knowledge about actions and goals through an agent-based reputation system

Managing transition plans is one of the major problems of people with cognitive disabilities. Therefore, finding an automated way to generate such plans would be a helpful tool for this community. In this paper we have specifically proposed and compared different alternative ways to merge plans formed by sequences of actions of unknown similarities between goals and actions executed by several operator agents which cooperate between them applying such actions over some passive elements (node agents) that require additional executions of another plan after some time of use. Such ignorance of the similarities between plan actions and goals would justify the use of a distributed recommendation system that would provide an useful plan to be applied for a certain goal to a given operator agent, generated from the known results of previous executions of different plans by other operator agents. Here we provide the general framework of execution (agent system), and the different merging algorithms applied to this problem. The proposed agent system would act as an useful cognitive assistant for people with intelectual disabilities such as autism

Semantic Approach for Discovery and Visualization of Academic Information Structured with OAI-PMH

There are different channels to communicate the results of a scientific research; however, several research communities state that the Open Access (OA) is the future of acad emic publishing. These Open Ac cess Platforms have adopted OAI - PMH (Open Archives Initiative - the Protocol for Metadata Harvesting) as a standard for communication and interoperability. Nevertheless, it is significant to highlight that the open source know ledge discovery services based on an index of OA have not been developed. Therefore, it is necessary to address Knowledge Discovery (KD) within these platforms aiming at studen ts, teachers and/ or researchers , to recover both , the resources requested and th e resources that are not explicitly requested – which are also appropriate . This objective represents an important issue fo r structured resources under OAI - PMH. This fact is caused because interoperability with other developments carried out outside their implementation environment is generally not a priority (Level 1 "Shared term definitions"). It is here , where the Semantic Web (SW) beco mes a cornerstone of this work. Consequently, we propose OntoOAIV, a semantic approach for the selective knowledge disco very an d visu alization into structured information with OAI - PMH, focused on supporting the activities of scientific or academic research for a specific user. Because of the academic nature of the structured resources with OAI - PMH, the field of application chosen is the context information of a student. Finally, in order to validate the proposed approach, we use the RUDAR (Roskilde University Digital Archive) and REDALYC (Red de Revistas Científicas de América Latina y el Caribe, España y Portugal) repositor ies, which imple ment the OAI - PMH protocol , as well as one s tudent profile for carrying out KD