Cancer immunotherapy as a new treatment option

Cancer can coaptate the immune control of the immune system (IS), evade immunity and its destruction. So, could we say openly that immunotherapy is a viable treatment option for patients with advanced cancer? Yes, immunotherapy would give us great advances in the war against cancer. Therefore, the development of a new generation of immune modulators (which have been analyzed in the following article) is necessary. In addition, these will be more effective if we use them in combination, taking advantage of their synergy.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Mètode alternatiu a la modelització gràfica en el càlcul de l'espai necessari per crear zones lineals d'aparcament en vies urbanes

Aquest mètode permet calcular numèricament l'espai necessari per crear zones lineals d'aparcament d' n places sense haver de recórrer a la modelització gràfica. Està dissenyat especialment per trobar amb facilitat les característiques òptimes de zones d'aparcament en vies amb limitacions d'espai. Aquest estudi és una anàlisi trigonomètrica d'una àrea d'aparcament tenint en compte el comportament d'un vehicle estàndard en la maniobra d'estacionament.Este método permite calcular numéricamente el espacio necesario para crear zonas lineales de aparcamiento de n plazas sin tener que recurrir a la modelización gráfica. Está diseñado especialmente para encontrar con facilidad las características óptimas de zonas de aparcamiento en vías urbanas con limitaciones de espacio. Este estudio es un análisis trigonométrico de un área de aparcamiento teniendo en cuenta el comportamiento de un vehículo estándar en la maniobra de estacionamiento.This method allows calculating numerically the space that is necessary to create lineal parking areas of n places without having to resort to graphic modelization. It is specially designed to easily find out the optimal characteristics for lineal parking areas in urban ways with limitations of space. This study is a trigonometrical analysis of a parking area taking into account the behaviour of a standard vehicle during the parking manoeuvre

Método alternativo a la modelización gráfica en el cálculo del espacio necesario para crear zonas lineales de aparcamiento en vías urbanas

Aquest mètode permet calcular numèricament l¿espai necessari per crear zones lineals d¿aparcament d¿ n places sense haver de recórrer a la modelització gràfica. Està dissenyat especialment per trobar amb facilitat les característiques òptimes de zones d¿aparcament en vies amb limitacions d¿espai. Aquest estudi és una anàlisi trigonomètrica d¿una àrea d¿aparcament tenint en compte el comportament d¿un vehicle estàndard en la maniobra d¿estacionament.Este método permite calcular numéricamente el espacio necesario para crear zonas lineales de aparcamiento de n plazas sin tener que recurrir a la modelización gráfica. Está diseñado especialmente para encontrar con facilidad las características óptimas de zonas de aparcamiento en vías urbanas con limitaciones de espacio. Este estudio es un análisis trigonométrico de un área de aparcamiento teniendo en cuenta el comportamiento de un vehículo estándar en la maniobra de estacionamiento.This method allows calculating numerically the space that is necessary to create lineal parking areas of n places without having to resort to graphic modelization. It is specially designed to easily find out the optimal characteristics for lineal parking areas in urban ways with limitations of space. This study is a trigonometrical analysis of a parking area taking into account the behaviour of a standard vehicle during the parking manoeuvre

Gamification and entrepreneurial intentions

Purpose – The purpose of this paper is to investigate how gamification can influence entrepreneurial intentions (EI) of a group of users of an online platform provided by a private company.Design/methodology/approach – A quantitative research strategy was used with a sample of 220 respondents. These respondents were tested before and after the gamification experience.Findings – Main findings support literature suggesting a clear effect of attitudes towards behaviour and perceived behavioural control on EI, in line with the theory of planned behaviour (TPB). Once the basic assumptions of TPB were confirmed, the authors tested the effects of gamification comparing before and after results. Main findings highlight an increase of these effects after the gamification experience, aligned with the self-determination theory.Practical implications – These findings suggest that gamification is able to influence entrepreneurial behaviours. This contributes to both companies and educators’ knowledge on training for EI with gamification and the use of online platforms to this effect. Recommendations are provided.Originality/value – This is the first study that investigates the impact of gamification on EI and howgamification can influence the different relationships between the antecedents of EI

Servitization strategies from customers’ perspective: the moderating role of co-creation

© 2018, Emerald Publishing Limited. Purpose: This paper aims to investigate the moderating role of co-creation in the implementation of servitization strategies in the pharmaceutical industry in a business-to-business (B-to-B) context. More specifically, this investigation explores the impact of different levels of services (base, intermediate and advanced) on servitization and on performance by using co-creation as a moderating factor. Design/methodology/approach: A research framework was developed and empirically tested in the pharmaceutical sector. Data collection was conducted through the online distribution of questionnaires. The final sample included 219 pharmacy stores, and the data were analysed using structural equation modelling. Findings: Main findings suggest that when the level of co-creation of the design of services is high, there are significant effects of servitization on firm performance. The moderating effect of co-creation is illustrated in regard to intermediate and advanced services, but results referring to the impact of intermediate services on servitization appear non-significant with a low degree of co-creation. No significant effects could be found for the impact of base services on performance and servitization for both high and low degrees of co-creation. Findings show an impact of advanced services on performance through the mediating effect of servitization when the degree of co-creation is high. Originality/value: Most research concerning servitization has been done from the perspective of manufacturers and service providers. This study adds value to the literature because it was designed from a customer’s perspective. Moreover, it contributes towards the conceptualization of the servitization research strategy and business models in a B2B context. This is accomplished through the investigation of the moderating effect of co-creation on the impact of the different levels of services on servitization and on performance

Museum visitors’ heterogeneity and experience processing

This research examines the relationships between affective and cognitive antecedents and consequences of satisfaction under a market heterogeneity approach. It includes co-creation of preparatory activities. The sample consisted of 276 museum visitors in London. Two analysis have been conducted: structural equation model and latent class path analysis. The paper contributes to the development of a theoretical framework for further understanding of service experience in which co-creation plays an important role. Two segments were identified: 1) emotional (with lower degree of co-creation, equally distributed by age and nationality); 2) rational (higher degree of co-creation, younger and domestic visitors). Our research shows significant differences between the two segments regarding variables such as satisfaction, loyalty, service experience, emotion, positive disconfirmation and willingness to pay more

Manual for the use of the equipment and materials into the interactive English Laboratory at the technical university of Cotopaxi during the academic cycle march– august 2012

The present researching work is focused on the design of a "Manual for the Use of the equipment and materials into the interactive English laboratory” at Technical University of Cotopaxi

Louis Kahn, 1901-1975: pensamiento y obra en torno a la luz en la arquitectura

[ES] Si hay un elemento que comparten todas las obras de arquitectura es la influencia de la luz natural. Ésta genera una diversidad de matices, tonalidades y contrastes de luces y sombras que dotan a los espacios de una vitalidad y dinamismo que no puede ser comparable con la luz artificial. Para Louis I. Kahn la luz natural se convierte en la génesis de la arquitectura, siendo la propia materia creación de la luz, ya que sin ella no podríamos ver el espacio. La luz natural, junto con la materia y la estructura, forman una entidad que es la base de toda obra arquitectónica. La luz natural permitirá que el usuario sea testigo del paso del tiempo y captará los reflejos del entorno. De esta manera se establece un paralelismo entre la naturaleza, que es creación del universo y, la arquitectura, que es creación del hombre, introduciendo la naturaleza en la arquitectura por medio de la luz solar. La obra arquitectónica de Kahn distinguirá cuatro tipo de iluminación en función de su cualidad y mecanismo empleado: luz directa, luz indirecta, luz difusa y doble piel.[EN] Natural light is probably the core component acting upon all architectonical masterpieces. Actually, it spawns a diversity of hues, tones and contrasts of lights and shadows that endows a dynamic atmosphere, never achieved by artificial light. According to Louis I. Kahn, natural light becomes the genesis of every architectural masterpiece, being the matter itself the creation of light without which, we would not be able to see the space. Natural light, together with matter and structure, constitute the core entity of the piece oeuvre. Natural light will favour users, not only, to be conscious of time passage, but also, to capture the echoes given by the environment. Thus, it emerges a parallelism between nature, being the universes' origin; and architecture, being the result of human creation. Consequently, this fusion gives rise to nature which, by means of the sun light, becomes part of architecture. Kahn's architectural masterpiece will distinguish four illumination types depending on their quality and applied mechanism: direct light, indirect light, diffuse light and double skin.Onetti Molina, A. (2017). Louis Kahn, 1901-1975: pensamiento y obra en torno a la luz en la arquitectura. http://hdl.handle.net/10251/131067TFG

The moderating role of gender on entrepreneurial intentions: a TPB perspective

Purpose: To disentangle the ways in which social norms shape entrepreneurial intentions of university students and to analyse the moderating effect of gender that may arise. Design/methodology/approach: We have used the entrepreneurial intention model based on Theory of Planned Behaviour (TPB) literature and moderated by students’ gender affecting this intention. We tested some hypotheses using data from undergraduate business students in Spain and their entrepreneurial intentions. Findings: Our results suggest that perceived behavioural control and attitudes affect the entrepreneurial intentions of university students towards entrepreneurship while subjective norms do not. Furthermore, our findings reveal that the moderating effect of gender has a positive influence for women in the relationship between those subjective norms and the perceived behavioural control. However, as to some research done so far, the moderating role of gender does not seem to have a particular effect on predicting entrepreneurial intentions when moderating TPB dimensions. Practical implications: Given the socio-economic benefits attributed to entrepreneurship, the results allow the design of more effective education initiatives and policies. Originality/value: This research provides support for the application of the TPB, allowing for a better understanding of gender differences in entrepreneurial intentions

The influence of digital capabilities on customer orientation of service employees (COSE) and its consequences on customer satisfaction and e-WOM within Family Businesses

Customer relations have become a key matter in services businesses daily activities. Due to the intangibility of services, the employee service performance is what customers perceive as the reflection of the service quality. Due to this fact, the customer orientation of front-line employees, primarily in services industry, plays a crucial role in getting positives/negatives results with regards to customer satisfaction. Customer orientation of service employees (COSE) is a key concept within marketing literature. It has been demonstrated by previous authors the positives effects that has in customer satisfaction and customer retention (Hennig-Thurau. 2004: Morales and Ruiz-Alba, 2018)