Anomalies Observed in VLF and LF Radio Signals on the Occasion of the Western Turkey Earthquake (Mw = 5.7) on May 19, 2011

VLF radio signals lie in the 10 - 60 kHz frequency band. These radio signals are used for worldwide navigation support, time signals and for military purposes. They are propagated in the earth-ionosphere wave-guide mode along great circle propagation paths. So, their propaga-tion is strongly affected by the ionosphere conditions. LF signals lie in 150 - 300 kHz frequency band. They are used for long way broadcasting by the few (this type of broadcasting is going into disuse) transmitters located in the world. These radio signals are characterized by the ground wave and the sky wave propagation modes [1]. The first generates a stable signal that propagates in the channel Earth-troposphere and is affected by the surface ground and troposphere condition. The second instead gives rise to a signal which varies greatly between day and night, and between summer and winter, and which propagates using the lower ionosphere as a reflector; its propagation is mainly affected by the ionosphere condi-tion, particularly in the zone located in the middle of the transmitter-receiver path. The propagation of the VLF/LF radio signals is affected by different factors such as the meteorological condition, the solar bursts and the geo-magnetic activity. At the same time, variations of some parameters in the ground, in the atmosphere and in the ionosphere occurring during the preparatory phase of earthquakes can produce disturbances in the above men-tioned signals. As already reported by many previous studies [2-18] the disturbances are classified as anoma-lies and different methods of analysis as the residual dA/ dP [15], the terminator time TT [9], the Wavelet spectra and the Principal Component Analysis have been used [6,7]. Here the analysis carried out on LF and VLF radio signals using three different methods on the occasion of a strong earthquake occurred recently in Turkey is pre-sented

Wavelet analysis of the LF radio signals collected by the European VLF/LF network from July 2009 to April 2011

In 2008, a radio receiver that works in very low frequency (VLF; 20-60 kHz) and LF (150-300 kHz) bands was developed by an Italian factory. The receiver can monitor 10 frequencies distributed in these bands, with the measurement for each of them of the electric field intensity. Since 2009, to date, six of these radio receivers have been installed throughout Europe to establish a ‘European VLF/LF Network’. At present, two of these are into operation in Italy, and the remaining four are located in Greece, Turkey, Portugal and Romania. For the present study, the LF radio data collected over about two years were analysed. At first, the day-time data and the night-time data were separated for each radio signal. Taking into account that the LF signals are characterized by ground-wave and sky-wave propagation modes, the day-time data are related to the ground wave and the night-time data to the sky wave. In this framework, the effects of solar activity and storm activity were defined in the different trends. Then, the earthquakes with M ≥5.0 that occurred over the same period were selected, as those located in a 300-km radius around each receiver/transmitter and within the 5th Fresnel zone related to each transmitter-receiver path. Where possible, the wavelet analysis was applied on the time series of the radio signal intensity, and some anomalies related to previous earthquakes were revealed. Except for some doubt in one case, success appears to have been obtained in all of the cases related to the 300 km circles in for the ground waves and the sky waves. For the Fresnel cases, success in two cases and one failure were seen in analysing the sky waves. The failure occurred in August/September, and might be related to the disturbed conditions of the ionosphere in summer

The European VLF/LF radio network to search for earthquake precursors: setting up and natural/man-made disturbances

In the last years disturbances in VLF/LF radio signals related to seismic activity have been presented. The radio data were collected by receivers located on the ground or on satellites. The ground-based research implies systematic data collection by a network of receivers. Since 2000 the “Pacific VLF network”, conducted by Japanese researchers, has been in operation. During 2008 a radio receiver was developed by the Italian factory Elettronika (Palo del Colle, Bari). The receiver is equipment working in VLF and LF bands. It can monitor 10 frequencies distributed in these bands and, for each of them, it saves the power level. At the beginning of 2009, five receivers were made for the realization of the “European VLF/LF Network”; two were planned for Italy and one for Greece, Turkey and Romania, respectively. In 2010 the network was enlarged to include a new receiver installed in Portugal. In this work, first the receiver and its setting up in the different places are described. Then, several disturbances in the radio signals related to the transmitters, receivers, meteorological/geomagnetic conditions are presented and described

Medical data processing and analysis for remote health and activities monitoring

Recent developments in sensor technology, wearable computing, Internet of Things (IoT), and wireless communication have given rise to research in ubiquitous healthcare and remote monitoring of human\u2019s health and activities. Health monitoring systems involve processing and analysis of data retrieved from smartphones, smart watches, smart bracelets, as well as various sensors and wearable devices. Such systems enable continuous monitoring of patients psychological and health conditions by sensing and transmitting measurements such as heart rate, electrocardiogram, body temperature, respiratory rate, chest sounds, or blood pressure. Pervasive healthcare, as a relevant application domain in this context, aims at revolutionizing the delivery of medical services through a medical assistive environment and facilitates the independent living of patients. In this chapter, we discuss (1) data collection, fusion, ownership and privacy issues; (2) models, technologies and solutions for medical data processing and analysis; (3) big medical data analytics for remote health monitoring; (4) research challenges and opportunities in medical data analytics; (5) examples of case studies and practical solutions

The European Network for studying the radio precursors of earthquakes: the case of the May 19, 2011 Turkey earthquake (Mw=5.7)

Since 2009 a network of VLF (20-60 kHz) and LF (150-300 kHz) radio receivers was put into operation in Europe in order to study the disturbances produced by the earthquakes on the propagation of these signals. In 2011 the network was formed by nine receivers located three in Italy and one in Austria, Greece, Portugal, Romania, Russia and Turkey. On May 19, 2001 an earthquake with Mw=5.7 occurred in western Turkey, that is inside the “sensitive” area of the network. The radio data collected during April-May 2011 were studied using three different methods of analysis which are the wavelet spectra, the principal component technique and the standard deviation trends. Clear anomalies were revealed both in the signals broadcasted by the TRT transmitter (180 kHz) located near Ankara and in some VLF signals coming from transmitters located in western Europe and collected by the receiver TUR of the network located in eastern Turkey. Evident precursors phases were pointed out. Some difference in the efficiency of the methods of analysis were revealed

The European Network for studying the radio precursors of earthquakes: Principal Component Analysis of LF radio signals collected during July 2009 - April 2011

Since 2009 a network of VLF (20-60 kHz) and LF (150-300 kHz) radio receivers was put into operation in Europe in order to study the disturbances produced by the earthquakes on the propagation of these signals. In 2011 the network for LF signals was formed by six receivers located two in Italy and one in Greece, Portugal, Romania, and Turkey. The LF radio data collected during about two years have been analysed. Each radio signal has been split in day-time and night-time data; then, the earthquakes with M 5.0, occurred in the same period, located in a 300 km radius around each receiver/transmitter and within the 5th Fresnel zone related to each transmitter-receiver path, have been selected. In this study we adopt the Principal Component Analysis (PCA) to study the radio signal anomalies possibly related to earthquake activity. A detailed comparison with similar studies that use wavelet analysis is done and advantages or drawback of the two methods are pointed out

Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis

Fatty acid β-oxidation (FAO) is the main bioenergetic pathway in human prostate cancer (PCa) and a promising novel therapeutic vulnerability. Here we demonstrate therapeutic efficacy of targeting FAO in clinical prostate tumors cultured ex vivo, and identify DECR1, encoding the rate-limiting enzyme for oxidation of polyunsaturated fatty acids (PUFAs), as robustly overexpressed in PCa tissues and associated with shorter relapse-free survival. DECR1 is a negatively-regulated androgen receptor (AR) target gene and, therefore, may promote PCa cell survival and resistance to AR targeting therapeutics. DECR1 knockdown selectively inhibited β-oxidation of PUFAs, inhibited proliferation and migration of PCa cells, including treatment resistant lines, and suppressed tumor cell proliferation and metastasis in mouse xenograft models. Mechanistically, targeting of DECR1 caused cellular accumulation of PUFAs, enhanced mitochondrial oxidative stress and lipid peroxidation, and induced ferroptosis. These findings implicate PUFA oxidation via DECR1 as an unexplored facet of FAO that promotes survival of PCa cells.Zeyad D Nassar, Chui Yan Mah, Jonas Dehairs, Ingrid JG Burvenich ... Lisa M Butler ... Luke Selth ... et al

Epidemiology, practice of ventilation and outcome for patients at increased risk of postoperative pulmonary complications

BACKGROUND Limited information exists about the epidemiology and outcome of surgical patients at increased risk of postoperative pulmonary complications (PPCs), and how intraoperative ventilation was managed in these patients. OBJECTIVES To determine the incidence of surgical patients at increased risk of PPCs, and to compare the intraoperative ventilation management and postoperative outcomes with patients at low risk of PPCs. DESIGN This was a prospective international 1-week observational study using the ‘Assess Respiratory Risk in Surgical Patients in Catalonia risk score’ (ARISCAT score) for PPC for risk stratification. PATIENTS AND SETTING Adult patients requiring intraoperative ventilation during general anaesthesia for surgery in 146 hospitals across 29 countries. MAIN OUTCOME MEASURES The primary outcome was the incidence of patients at increased risk of PPCs based on the ARISCAT score. Secondary outcomes included intraoperative ventilatory management and clinical outcomes. RESULTS A total of 9864 patients fulfilled the inclusion criteria. The incidence of patients at increased risk was 28.4%. The most frequently chosen tidal volume (VT) size was 500 ml, or 7 to 9 ml kg1 predicted body weight, slightly lower in patients at increased risk of PPCs. Levels of positive end-expiratory pressure (PEEP) were slightly higher in patients at increased risk of PPCs, with 14.3% receiving more than 5 cmH2O PEEP compared with 7.6% in patients at low risk of PPCs (P < 0.001). Patients with a predicted preoperative increased risk of PPCs developed PPCs more frequently: 19 versus 7%, relative risk (RR) 3.16 (95% confidence interval 2.76 to 3.61), P < 0.001) and had longer hospital stays. The only ventilatory factor associated with the occurrence of PPCs was the peak pressure. CONCLUSION The incidence of patients with a predicted increased risk of PPCs is high. A large proportion of patients receive high VT and low PEEP levels. PPCs occur frequently in patients at increased risk, with worse clinical outcome

Epidemiology, practice of ventilation and outcome for patients at increased risk of postoperative pulmonary complications: LAS VEGAS - An observational study in 29 countries

BACKGROUND Limited information exists about the epidemiology and outcome of surgical patients at increased risk of postoperative pulmonary complications (PPCs), and how intraoperative ventilation was managed in these patients. OBJECTIVES To determine the incidence of surgical patients at increased risk of PPCs, and to compare the intraoperative ventilation management and postoperative outcomes with patients at low risk of PPCs. DESIGN This was a prospective international 1-week observational study using the ‘Assess Respiratory Risk in Surgical Patients in Catalonia risk score’ (ARISCAT score) for PPC for risk stratification. PATIENTS AND SETTING Adult patients requiring intraoperative ventilation during general anaesthesia for surgery in 146 hospitals across 29 countries. MAIN OUTCOME MEASURES The primary outcome was the incidence of patients at increased risk of PPCs based on the ARISCAT score. Secondary outcomes included intraoperative ventilatory management and clinical outcomes. RESULTS A total of 9864 patients fulfilled the inclusion criteria. The incidence of patients at increased risk was 28.4%. The most frequently chosen tidal volume (V T) size was 500 ml, or 7 to 9 ml kg−1 predicted body weight, slightly lower in patients at increased risk of PPCs. Levels of positive end-expiratory pressure (PEEP) were slightly higher in patients at increased risk of PPCs, with 14.3% receiving more than 5 cmH2O PEEP compared with 7.6% in patients at low risk of PPCs (P ˂ 0.001). Patients with a predicted preoperative increased risk of PPCs developed PPCs more frequently: 19 versus 7%, relative risk (RR) 3.16 (95% confidence interval 2.76 to 3.61), P ˂ 0.001) and had longer hospital stays. The only ventilatory factor associated with the occurrence of PPCs was the peak pressure. CONCLUSION The incidence of patients with a predicted increased risk of PPCs is high. A large proportion of patients receive high V T and low PEEP levels. PPCs occur frequently in patients at increased risk, with worse clinical outcome.</p

The development of the Romanian VLF/LF monitoring system as part of the international network for frontier research on earthquake precursors (INFREP)

The Romanian VLF / LF monitoring system consists in a radio receiver and the infrastructure that is necessary to record and transmit the collected data, and is part of the international initiative INFREP and was put into operation in December 2009 on the Black-Sea shore (Dobruja Seismologic Observatory - Dob-RO). Since then the system was developed by replacing the vertical antenna with a magnetic loop-type one, by installing a vertical electric field monitor and a weather station, and by designing special software for the transfer, storage and initial processing of data using the LabView software platform