Bioaccumulation of some heavy metals and histopathological alterations in liver of Euryglossa orientalis and Psettodes erumei along North Coast of the Persian Gulf

In order to make evaluation of some heavy metals bioaccumulation and explore their histopathological effects on hepatocytes of oriental sole (Euryglossa orientalis) and deep flounder (Psettodes erumei), fishes were caught from two areas of north coast of the Persian Gulf, Bandar Abbass and Bandar Lengeh. Concentrations of nickel (Ni) and vanadium (V) in liver of both species in two sampling regions were in the following order: Bandar abbass> Bandar lengeh. Between the two species, these quantities were higher in P. erumei than E. orientalis in both sampling regions. Histopathology of the liver shows some cellular alterations including degeneration, necrosis and tissue disruption, and histopathological effects were severe in P. erumei than E. orientalis. Results showed that Bandar Abbass region was more polluted than Bandar Lengeh and because Ni and V were oil pollution indicators and two flat fishes were benthic, they can receive considerable amount of oil pollution through their biological activities like feeding. Also, higher amounts of heavy metal concentrations and major histopathological effects in E. orientalis showed strong relationship between benthic habitat of the fish and amounts of received pollutants from water and sediments since E. orientalis is more related to the bottom than P. erumei.Key words: Vanadium, nickel flatfishes, Persian Gulf

Molybdatophosphoric acid as an efficient catalyst for the catalytic and chemoselective oxidation of sulfides to sulfoxides using urea hydrogen peroxide as a commercially available oxidant

An efficient procedure for the chemoselective oxidation of alkyl (aryl) sulfides to the corresponding sulfoxides using urea hydrogen peroxide (UHP) in the presence of a catalytic amount of molybdatophosphoric acid at room temperature is described. The advantages of described method are: generality, high yield and chemoselectivity, short reaction time, low cost and compliment with green chemistry protocols

Prediction of preeclampsia based on blood lead levels in early pregnancy

زمینه و هدف: پره اکلامپسی شایع ترین عارضه بالینی دوران بارداری است. با توجه به اهمیت پره اکلامپسی در بارداری و عدم وجود عوامل قطعی موثر بر آن، این پژوهش با هدف پیشگویی وقوع پره اکلامپسی بر اساس سطح سرب خون مادران باردار در نیمه اول بارداری انجام شد. روش بررسی: این مطالعه توصیفی - تحلیلی بر روی 1033 مادر باردار در درمانگاه های پره ناتال شهر تهران انجام شد. در بدو ورود به مطالعه نمونه خون جهت سنجش سرب اخذ و پرسشنامه دموگرافیک تکمیل گردید. مادران باردار از زمان ورود به مطالعه تا زمان زایمان تحت مراقبت و پیگیری قرار گرفتند. در صورت وجود فشار خون مساوی یا بیش از 140 بر 90 میلی‌متر جیوه و پروتئین‌اوری پس از هفته 20 بارداری تشخیص پره اکلامپسی برای مادر داده می شد. برای تجزیه و تحلیل داده ها از آزمون های آماری من ویتنی و رگرسیون لجستیک در نرم افزارSPSS استفاده شد. یافته ها: از 1033 مادر باردار 20 نفر (9/1) مبتلا به پره اکلامپسی بودند. میانگین سطح سرب خون مادران µg/dl9/4 ± 7/4 بود. ارتباط میان سرب خون مادر و پره اکلامپسی مستقیم و معنادار بود (001/0>(P. سطح موثر سرب خون (نقطه ی برش) در پره اکلامپسی دارای حساسیت 85، ویژگی 5/70، ارزش اخباری منفی 6/99 و ارزش اخباری مثبت 4/5، µg/dl 5 بدست آمد. نتیجه گیری: نتایج این مطالعه نشان داد که سطح سرب µg/dl 5 و بالاتر در نیمه اول بارداری می تواند با حساسیت نسبتاً بالا با وقوع پره اکلامپسی همراه باشد؛ لذا انجام این آزمایش به عنوان روشی در اوایل بارداری، برای پیشگویی وقوع پره اکلامپسی در مادران باردار فاقد عوامل خطرزای مهم پره اکلامپسی، پیشنهاد می گردد

Design and synthesis of irreversible inhibitors of foot-and-mouth disease virus 3C protease.

Foot-and-mouth disease virus (FMDV) causes a highly infectious and economically devastating disease of livestock. The FMDV genome is translated as a single polypeptide precursor that is cleaved into functional proteins predominantly by the highly conserved viral 3C protease, making this enzyme an attractive target for antiviral drugs. A peptide corresponding to an optimal substrate has been modified at the C-terminus, by the addition of a warhead, to produce irreversible inhibitors that react as Michael acceptors with the enzyme active site. Further investigation highlighted key structural determinants for inhibition, with a positively charged P2 being particularly important for potency. © 2013 Elsevier Ltd. All rights reserved

New 2-Methoxy Acetylenic Acids and Pyrazole Alkaloids from the Marine Sponge Cinachyrella sp.

K

Obesity and insulin sensitivity effects on cardiovascular risk factors: Comparisons of obese dysglycemic youth and adults

Background: Obesity and pubertal insulin resistance worsen cardiovascular (CV) risk factors in youth. It is unclear how the relationships of obesity and insulin resistance with CV risk compare to adults. Subjects and Methods: We evaluated 66 pubertal youth (mean ± SD: age 14.2 ± 2.0 years, body mass index [BMI] 36.6 ± 6.0 kg/m2, hemoglobin A1c [HbA1c] 38.5 ± 6.1 mmol/mol) and 355 adults with comparable BMI (age 52.7 ± 9.4 years, BMI 35.1 ± 5.1 kg/m2, HbA1c 39.8 ± 4.2 mmol/mol) participating in a multicenter study. Insulin sensitivity was quantified using hyperglycemic clamps. Assessment of CV risk factors was standardized across sites. Regression analyses compared the impact of insulin sensitivity and CV risk factors between youth and adults. Results: Obese pubertal youth were more insulin resistant than comparably obese adults (P \u3c.001), but with similar slopes for the inverse relationship between insulin sensitivity and obesity. The impact of obesity on CV risk factors was explained by insulin sensitivity (P = NS after adjustment for sensitivity). The two age groups did not differ in relationships between insulin sensitivity and diastolic blood pressure, total cholesterol, and low-density lipoprotein (LDL) cholesterol, after adjusting for obesity. However, while systolic blood pressure (SBP) and high-density lipoprotein (HDL) cholesterol exhibited the expected direct and inverse relationships, respectively with insulin sensitivity in adults, these slopes were flat in youth across the range of insulin sensitivity (P ≤.05 for group differences). Conclusions: Effects of obesity on CV risk factors were attributable to insulin sensitivity in both groups. The relationships between insulin sensitivity and CV risk factors were similar in obese youth and adult groups except for SBP and HDL cholesterol. Clinical Trial Registration: The RISE consortium studies are registered through Clinicaltrials.gov as NCT01779362 (Adult Medication Study); NCT01763346 (Adult Surgery Study); and NCT01779375 (Pediatric Medication Study). Clinical trial registration numbers: NCT01779362, NCT01779375 and NCT01763346 at clinicaltrials.gov

Frequency of Oral and Maxillofacial Tumors in the Samples Referred to the Pathology Department of Qazvin University of Medical Sciences

Introduction: The mouth, jaw, and face are prone to oral and maxillofacial tumors, constituting a significant proportion of pathological lesions in Iran. Therefore, the present study aimed to investigate the frequency of oral and maxillofacial tumors in the samples referred to the Pathology Department of Qazvin University of Medical Sciences.Materials and Methods: This cross-sectional descriptive study was performed on 110 patients referred to Qazvin Dental Clinic with pathological diagnosis of oral and maxillofacial tumors. After reviewing the medical files, information on tumor type, anatomical location, tissue origin, age range, gender, smoking and drug use, alcohol consumption, family history, and pathological diagnosis were extracted. The data were analyzed in SPSS software (version 25).Results: According to the findings of the study, 58.18% of women and 41.81% of men developed tumors of the mouth, jaw, and face. These pathological lesions were in the age range of 9-90 years (mean age of 41.04±20.29 years). They made up 42.72% of benign tumors and 57.27% of malignant ones. Among these, 84 cases were odontogenic tumors, and 26 cases were non-odontogenic tumors.Conclusion: As evidenced by the obtained results, oral squamous cell carcinoma was the most common among Oral and Maxillofacial tumors. This finding is consistent with the results of many epidemiological studies in the field of tumors of the mouth, jaw, and face

Sex Differences in the Impact of Obstructive Sleep Apnea on Glucose Metabolism

Objectives: Obstructive sleep apnea (OSA) is more prevalent in men and is an independent risk factor for type 2 diabetes. We aimed to determine if there are sex differences in the impact of OSA on glucose metabolism in nondiabetic overweight and obese adults.Methods: One hundred and forty-five men and women (age 33.4 ± 0.6, BMI 37.2 ± 0.7, 70.3% blacks) from the community underwent in-laboratory polysomnography. Severity of OSA was assessed by the apnea-hypopnea index (AHI). Glucose tolerance was assessed using fasting glucose, 1-h glucose, 2-h glucose and the area under the curve (AUC) during the 2-h oral glucose tolerance test (OGTT). Fasting insulin resistance was assessed by HOMA-IR, and insulin sensitivity during the OGTT was assessed by the Matsuda Index. Pancreatic beta-cell function was assessed by fasting HOMA-%B and by AUCinsulin/glucose, insulinogenic index, and oral disposition index (DIoral) during the OGTT. All comparisons were adjusted for age, BMI, race and severity of OSA.Results: There were no significant demographic differences between men and women without OSA. Men and women with OSA were similar in age, BMI, and severity of OSA, but there were more black women with OSA. Compared to women with OSA, men with OSA had significantly higher fasting glucose, 1-h glucose levels, AUCglucose, and AUC for insulin secretion rate (AUCISR) but similar 2-h glucose levels. These differences persisted in adjusted analyses. Men with OSA secreted significantly more insulin than women with OSA in order to achieve similar glucose levels. Men with OSA had significantly worse beta cell function as measured by the DIoral than women with OSA. In contrast, there were no significant sex differences in measures of glucose tolerance and beta-cell function in participants without OSA.Conclusion: Men with OSA secreted more insulin compared to women with OSA in order to maintain glucose homeostasis. The adverse impact of OSA on beta-cell responsiveness was larger in men, which may result in an overall greater risk of type 2 diabetes compared to women