21 research outputs found
Fabrication and vibration characterization of curcumin extracted from turmeric (Curcuma longa) rhizomes of the northern Vietnam
Curcumin-loaded redox-responsive mesoporous silica nanoparticles for targeted breast cancer therapy
Disparity in rates of HPV infection and cervical cancer in underserved US populations
There is a higher rate of HPV infection and cervical cancer incidence and mortality in underserved US population who reside in Appalachian mountain region compared to Northern Plains. Social and behavioral factors such as smoking and alcohol consumption are for such a high incidence. However, by and large, the reasons for these discrepancies lie in the reluctance of the underserved population to adopt preventive measures such as prophylactic Human papilloma virus (HPV) vaccines and Pap smear screening that have significantly reduced the incidence and mortality rate of cervical cancer in Caucasian women. Thus, it is clear that drastic change in social behavior and implementation of preventive measures is required to effectively reduce the incidence and mortality from cervical cancer in this underserved population
A Magnetically Drivable Nanovehicle for Curcumin with Antioxidant Capacity and MRI Relaxation Properties
Ormeloxifene Suppresses Desmoplasia and Enhances Sensitivity of Gemcitabine in Pancreatic Cancer
Synthesis and Antitumor Activity of Brominated-Ormeloxifene (Br-ORM) against Cervical Cancer
Aberrant regulation
of β-catenin signaling is strongly linked
with cancer proliferation, invasion, migration, and metastasis, thus,
small molecules that can inhibit this pathway might have great clinical
significance. Our molecular modeling studies suggest that ormeloxifene
(ORM), a triphenylethylene molecule that docks with β-catenin,
and its brominated analogue (Br-ORM) bind more effectively with relatively
less energy (â7.6 kcal/mol) to the active site of β-catenin
as compared to parent ORM. Herein, we report the synthesis and characterization
of a Br-ORM by NMR and FTIR, as well as its anticancer activity in
cervical cancer models. Br-ORM treatment effectively inhibited tumorigenic
features (cell proliferation and colony-forming ability, etc.) and induced apoptotic death, as evident by pronounced PARP cleavage.
Furthermore, Br-ORM treatment caused cell cycle arrest at the G1-S
phase. Mechanistic investigation revealed that Br-ORM targets the
key proteins involved in promoting epithelialâmesenchymal transition
(EMT), as demonstrated by upregulation of E-cadherin and repression
of N-cadherin, Vimentin, Snail, MMP-2, and MMP-9 expression. Br-ORM
also represses the expression and nuclear subcellular localization
of β-catenin. Consequently, Br-ORM treatment effectively inhibited
tumor growth in an orthotopic cervical cancer xenograft mouse model
along with EMT associated changes as compared to vehicle control-treated
mice. Altogether, experimental findings suggest that Br-ORM is a novel,
promising β-catenin inhibitor and therefore can be harnessed
as a potent anticancer small molecule for cervical cancer treatment