81 research outputs found

    Dynamical invariants for quantum control of four-level systems

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    We present a Lie-algebraic classification and detailed construction of the dynamical invariants, also known as Lewis-Riesenfeld invariants, of the four-level systems including two-qubit systems which are most relevant and sufficiently general for quantum control and computation. These invariants not only solve the time-dependent Schr\"odinger equation of four-level systems exactly but also enable the control, and hence quantum computation based on which, of four-level systems fast and beyond adiabatic regimes.Comment: 11 pages, 5 table

    The influence of cellulose pulp and cellulose microfibers on the flexural performance of green-engineered cementitious composites

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    The aim of this study was to investigate the flexural behavior of engineered cementitious composites (ECCs) reinforced by cellulose pulp (CP) and cellulose microfibers (CMF). The reinforcements were obtained from chemical-mechanical treatments of Kraft paper and used in ECC mix design. Results showed that cement reinforced by CP exhibited a strain-hardening behavior in the three-point bending test, while CMF led to a brittle behavior in cement composites. Moreover, different hybrid combinations of polyvinyl alcohol (PVA) and CMF  achieved quite a high strength while maintaining a high level of flexural toughness. A combination of 0.5 vol% CMF and 1.5 vol% PVA resulted in a significant increase in flexural toughness and a slight improvement in flexural strength. The properties of this hybrid composite were comparable with one containing 2 vol% of PVA fiber

    The Costs of Training Medical Parasitology and Mycology Students at Kerman University of Medical Sciences

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    Background: Training of expert human resources is one of the main and basic objectives of developed countries. One of the important challenges for attainment of this objective is shortage in funding and financial resources. This is while medical branches, due to being specialized and requiring vast practical courses, need spending considerable financial costs for training competent students. Objectives: The present study aimed to estimate the costs of training medical parasitology and mycology students at Kerman University of Medical Sciences. Methods: This was a descriptive research. The data collection tool was a form designed by researchers using various resources. Educational and non-educational costs of the academic year of 2017-2018, with a top-down approach, were analysed to estimate the costs of training and educating post-graduate students. Analyses were made using Microsoft Excel 2013 software. Results: The costs of educating master students in parasitology, Ph.D. students in parasitology, and master students in mycology in the academic year of 2017-2018 were 11,144, 18,365, and 7,821 USD, respectively. Forty-five percent of the total of educational costs was allocated to training Ph.D. students in parasitology alone, and a major share (81%) of these costs had been paid to human resources. Conclusion: Our findings indicated that the financial costs of training and educating students in the parasitology and mycology fields are high, needing the prompt attention of the policymakers of the national medical education system. Keywords: Cost, Parasitology, Mycology, Kerman University of Medical Sciences, Ph.D. program, MSc. progra

    A conventional PCR for differentiating common taeniid species of dogs based on in silico microsatellite analysis

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    Canine taeniids are among the major tapeworms with remarkable medical and economic significance. Reliable diagnosis and differentiation of dog taeniids using simple and sensitive tools are of paramount importance for establishing an efficient surveillance system. Microsatellites as abundant unique tandem repeats of short DNA motifs are useful genetic markers for molecular epidemiological studies. The purpose of the present study was to find a primer pair for rapid differentiation of major tapeworms of dogs, Taenia hydatigena, T. multiceps, T. ovis and Echinococcus granulosus, by screening existing nucleotide data. All the mitochondrial genome records as well as non-coding ITS1 sequences of Taeniidae species were downloaded from Nucleotide database from NCBI. For prediction and analysis of potential loci of STR/SSR in ITS1 as well as mitochondrial regions, we used ChloroMitoSSRDB 2.0 and GMATo v1.2. software. Different tapeworm species were categorized according to different motif sequences and type and size of each microsatellite locus. Three primer sets were designed and tested for differentiating taeniid species and evaluated in a conventional PCR system. Four taeniid species were successfully differentiated using a primer pair in a simple conventional PCR system. We predicted 2-19 and 1-4 microsatellite loci in ITS1 and mitochondrial genome, respectively. In ITS1, 41 Di and 21 Tri motifs were found in the taeniids while the majority of the motifs in the mitochondrial genome were Tetra (89) and Tri (70). It is documented that the number and diversity of microsatellite loci is higher in nuclear ITS1 region than mostly coding mitochondrial genome

    Genetic Identification of Echinococcus granulosus Isolates in Hamadan, Western Iran

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    Background: Cystic echinococcosis is a zoonotic infection and considered as a major economic and public health concern worldwide. This research was conducted to determine genotypic characteristics of livestock and human hydatid cyst isolates from Hamadan area, western Iran. Methods: Sampling was conducted in Hamadan industrial slaughterhouse and Beast Hospital of Hamadan City, western Iran, from 2015 to 2016. Overall, 74 livestock isolates including 69 sheep, 3 cattle and 2 goats and 9 human hydatid cysts were genotyped by PCR amplification of the rDNA ITS1 region and followed restriction fragment length polymorphism (RFLP) analysis with four restriction endonuclease enzymes, RsaI, HpaII, AluI, and TaqΙ, and sequencing. Results: The PCR amplicon size of each isolate was approximately 1 kb which was the same with that of sheep strain. According to the RFLP patterns, the isolates belonged to a single species, E. granulosus sensu stricto (G1–G3 complex). Furthermore, sequencing of representative amplicons confirmed that the RFLP-genotyped isolates corresponded to E. granulosus sensu stricto. Conclusion: E. granulosus sensu stricto is the prevailing species of E. granulosus sensu lato in the region and pointed out the importance of sheep/dog cycle in human transmission

    Emergence of a new focus of anthroponotic cutaneous leishmaniasis due to Leishmania tropica in rural communities of Bam district after the earthquake, Iran

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    objectives To describe a new emerging focus of anthroponotic cutaneous leishmaniasis (ACL) due to Leishmania tropica in rural areas of Dehbakry county, south-eastern Iran, after the earthquake of 2003. methods House-to-house survey of 3884 inhabitants for active leishmaniasis lesions or scars. The diagnosis was confirmed by smears, cultures and identification of the parasite by polymerase chain reaction (PCR). results All age groups were affected, although patients £10 years of age showed the highest rate of infection (P = 0.0001). The overall prevalence rate was 5.3%; 6.3% in females and 4.3% in males. Of 204 cases, 1.8% had active sores and 3.5% had scars, with a significant difference between the sexes (P = 0.005). 47% of the lesions were on the face and 77.9% had one lesion. The incidence rose gradually 2004–2005, but grew exponentially 2006–2008. Electrophoresis of PCR products indicated that L. tropica was the causative agent. conclusions The current emergence was unexpected in this rural locality, where no previous history of CL was recorded. According to our knowledge this is the first report of a gradually establishing new ACL focus in rural communities after the 2003 earthquake

    The effect of verapamil on in vitro susceptibility of promastigote and amastigote stages of Leishmania tropica to meglumine antimoniate

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    Pentavalent antimonials are the standard treatment for cutaneous leishmaniasis (CL) with low efficacy and resistance is emerging. CL is increased significantly in respect to incidence rate and expanding to new foci. In the present study, the effect of verapamil on in vitro susceptibility of promastigote and amastigote stages of Leishmania tropica to meglumine antimoniate (MA, Glucantime) was evaluated using colorimetric assay (MTT) and in a macrophage model, respectively. Verapamil, as a calcium channel blocker, affects drug uptake by preventing of drug efflux from the cells. In promastigote form, several concentrations of MA with or without verapamil showed significant decrease (P<0.05) in optical density. The overall mean IC50 value with combination of MA plus verapamil (IC50=116.03 μg/ml) was significantly less than MA (IC50=225.14 μg/ml) alone (P<0.05) for promastigote stage. Similarly, the amastigote stage was more susceptible to treatment with MA plus verapamil to that of MA alone (P<0.05). Analysis of overall effect of different concentrations of MA alone, compared with combination of MA plus verapamil by mean infection rate of amastigotes in each macrophage showed a significant difference (P<0.05).These findings indicated some degree of synergistic effects between MA and verapamil on in vitro susceptibility of L. tropica to MA. Further works are required to evaluate this synergistic effect on animal model or volunteer human subjects
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