Disrupting Evasion Pedagogies

As we have researched in schools and reflected on our own teaching, we have come to recognize the lie and our untruthfulness that permeates many of our cultural scripts (Gutierrez et al., 1995) and practices as teachers. It is within these cultural scripts and practices that inequity is perpetuated and humanizing learning evaded. Thus, what we term evasion pedagogies, serve to sustain the status quo and are powerful tools to maintain oppressive projects like white supremacy, heteronormativity, gender binaries, patriarchy, ableism, classism, and linguicism. In this piece, we examine the notion of evasion pedagogies as a powerful lie in practice that needs to be disrupted in teaching and learning across grade levels and contexts. Then, we draw on decades of research to illustrate how existing scholarship offers meaningful opportunities to disrupt evasion pedagogies by focusing on humanization

Kinder – 1st grade: Summer Packet #3 • Theme: Community

These packets are self-contained. Everything a child will need to be successful with the activities is provided in the packet. Students will only need a writing utensil. Additional tools like crayons or scissors can be used, but do not have to be. Day 1 • My Buddy • Check the Weather • What will you wear? • The United States of America • Read the story: What is the United States of • America? • Dictionary • Color the Flag of the U.S.A. • U.S.A. Math Day 2 • Check the Weather • What will you wear? • U.S.A. Math #2: Count the symbols. Add or subtract! • Journal: All people are equal, all people have the right to life, liberty, and the pursuit of happiness. • Read the story: All People are Equal • Journal Review Day 3 • Check the Weather • What will you wear? • Read the story: Celebrating the United States of America • Dictionary • Skip Counting Day 4 • Check the Weather • What will you wear? • Math Patterns • Read the story: Celebrating with Fireworks • Fireworks! Create your own fireworks show. Day 5 • Check the Weather • What will you wear? • Read to Your Buddy • Connect the Dots • Move Like a Firewor

K–1st Grade: English Level 3, Learning Packet #1 • Theme: Space

These packets are self-contained. Everything a child will need to be successful with the activities is provided in the packet. Students will only need a writing utensil. Additional tools like crayons or scissors can be used, but do not have to be. Day 1 • Vocabulary trace, Label My Buddy, Space shapes, Let\u27s move Day 2 • Reading passage, Mix it fix it, Space dot-to-dot, Window or walk Day 3 • Vocabulary matching, Let\u27s compare, Astronaut writing, Move with your Buddy Day 4 • Space graphing, Space addition, If I lived in space, Let\u27s draw Day 5 • My journal, Would your rather writing, Let\u27s create, Space patterns My Packet Journal Reference Shee

K–1st Grade: English Level 2, Learning Packet #1 • Theme: Shapes

Day 1 • Choose a Buddy, Writing new words, Shapes memory, Make a pattern, Building sentences Day 2 • Writing new words, Matching, Today\u27s number (63) Day 3 • Showing location, Exercise addition, Sorting shapes Day 4 • Shapes walk, Journal writing, Today\u27s number (23) Day 5 • Searching for shapes, Making pictures from shapes, Write about a picture, Dictionary My Packet Journal Answer Key

4th–5th Grade: English Level 2, Learning Packet #2 • Theme: Habitats

Packet #2 outline: habitats Choose a Buddy Reading daily practice Roll your sight words #2 Vocabulary cards: habitats Habitats Write and draw Facts and opinions about habitats Compound words Vocabulary cut and paste Writing a poem: acrostic Math daily practice Coordinate habitat Goods from habitats Lunchtime goods and services Let\u27s take a break! My Packet Journal Reference Sheet Answer Key

Transcript availability dictates the balance between strand-asynchronous and strand-coupled mitochondrial DNA replication.

Mammalian mitochondria operate multiple mechanisms of DNA replication. In many cells and tissues a strand-asynchronous mechanism predominates over coupled leading and lagging-strand DNA synthesis. However, little is known of the factors that control or influence the different mechanisms of replication, and the idea that strand-asynchronous replication entails transient incorporation of transcripts (aka bootlaces) is controversial. A firm prediction of the bootlace model is that it depends on mitochondrial transcripts. Here, we show that elevated expression of Twinkle DNA helicase in human mitochondria induces bidirectional, coupled leading and lagging-strand DNA synthesis, at the expense of strand-asynchronous replication; and this switch is accompanied by decreases in the steady-state level of some mitochondrial transcripts. However, in the so-called minor arc of mitochondrial DNA where transcript levels remain high, the strand-asynchronous replication mechanism is instated. Hence, replication switches to a strand-coupled mechanism only where transcripts are scarce, thereby establishing a direct correlation between transcript availability and the mechanism of replication. Thus, these findings support a critical role of mitochondrial transcripts in the strand-asynchronous mechanism of mitochondrial DNA replication; and, as a corollary, mitochondrial RNA availability and RNA/DNA hybrid formation offer means of regulating the mechanisms of DNA replication in the organelle

Cladophialophora Bantiana Brain Abscess and Concurrent Pulmonary Cryptococcus Neoformans Infection in a Patient Twenty Years After Renal Transplantation

Recipients of solid organ transplants are at risk for a variety of infections due to their immunocompromised status. The types of infections are often correlated to the timing from their transplant. After about six to twelve months, transplant recipients remain at risk for typical community acquired pathogens, late viral infections, and fungal infections including atypical molds such as Cladophialophora bantiana. C. bantiana is a dematiaceous fungus that has a predilection for infecting the brain and is the most common cause of cerebral phaeohyphomycosis - a term used to describe infections caused by molds that produce dark cell walls. Patients with cerebral abscesses due to C. bantiana infections have an estimated mortality of about 70%. Improved outcomes have been seen in patients who receive both surgical and antifungal therapy. While there are no clear guidelines on antifungal therapy, most cases have been treated with combination amphotericin B, a triazole (itraconazole, voriconazole, or posaconazole) with flucytosine sometimes in conjunction as well. This case describes a patient with C. bantiana brain abscess and concurrent Cryptococcus neoformans pulmonary infection that occurred twenty years after his kidney transplantation. He was treated successfully with two craniotomies for cerebral abscess debridement and liposomal amphotericin B followed by planned lifelong voriconazole

Determining the role of novel metabolic pathways in driving intracranial pressure reduction after weight loss

Idiopathic intracranial hypertension, a disease classically occurring in women with obesity, is characterised by raised intracranial pressure. Weight loss leads to reduction in intracranial pressure. Additionally, pharmacological glucagon-like peptide-1 agonism reduces cerebrospinal fluid secretion and intracranial pressure. The potential mechanisms by which weight loss reduces intracranial pressure are unknown and was the focus for this study.Meal stimulation tests (fasted plasma sample, then samples at 15, 30, 60, 90 and 120 minutes following a standardised meal) were conducted pre- and post-bariatric surgery (early (2 weeks) and late (12 months)) in patients with active idiopathic intracranial hypertension. Dynamic changes in gut neuropeptides (glucagon-like peptide-1, gastric inhibitory polypeptide, and ghrelin) and metabolites (untargeted ultra-high performance liquid chromatography-mass spectrometry) were evaluated. We determined the relationship between gut neuropeptides, metabolites, and intracranial pressure.18 idiopathic intracranial hypertension patients were included (Roux-En-Y gastric bypass n=7, gastric banding n=6, or sleeve gastrectomy n=5). At 2 weeks post-bariatric surgery, despite similar weight loss, Roux-En-Y gastric bypass had a two-fold (50%) greater reduction in intracranial pressure compared to sleeve. Increased meal stimulated glucagon-like peptide-1 secretion was observed after Roux-En-Y gastric bypass (+600 %) compared to sleeve (+319 %). There was no change in gastric inhibitory polypeptide and ghrelin. Dynamic changes in meal stimulated metabolites after bariatric surgery consistently identified changes in lipid metabolites, predominantly ceramides, glycerophospholipids and lysoglycerophospholipids, which correlated with intracranial pressure. A greater number of differential lipid metabolites were observed in the Roux-En-Y gastric bypass cohort at 2 weeks, and these also correlated with intracranial pressure.In idiopathic intracranial hypertension, we identified novel changes in lipid metabolites and meal stimulated glucagon-like peptide-1 levels following bariatric surgery which were associated with changes in intracranial pressure. Roux-En-Y gastric bypass was most effective at reducing intracranial pressure despite analogous weight loss to gastric sleeve at 2 weeks post-surgery and was associated with more pronounced changes in these metabolite pathways. We suggest that these novel perturbations in lipid metabolism and glucagon-like peptide-1 secretion are mechanistically important in driving reduction in intracranial pressure following weight loss in patients with idiopathic intracranial hypertension. Therapeutic targeting of these pathways, for example with glucagon-like peptide-1 agonist infusion, could represent a therapeutic strategy

The Heritage Landscape of Plymouth, MA Greenway Planning and Cultural Design

In anticipation of the 400th anniversary of the Pilgrim’s landing in 1620, this studio combined greenway planning and cultural landscape design and interpretation to revitalize the public landscape of Plymouth, Massachusetts and convey the significance of these historic places to visitors and residents. Through the use of landscape research combining GIS data and analysis with historical narratives and maps, this fourteen-week senior BSLA capstone studio developed a regional and town-scale greenway plan along with detailed designs of individual public landscapes in historic downtown Plymouth