NUEVAS CONSTRUCCIONES DE GÉNERO

El trabajo del semillero se ha enfocado en indagar desde la perspectiva de género, concepto entendido como una construcción social la cual se teje de manera histórica y que se va modificando según los cánones sociales, morales y estéticos de cada época y generación (Gambas, 2008)

Psychometric characteristics of the Spanish version of instruments to measure neck pain disability

Background: The NDI, COM and NPQ are evaluation instruments for disability due to NP. There was no Spanish version of NDI or COM for which psychometric characteristics were known. The objectives of this study were to translate and culturally adapt the Spanish version of the Neck Disability Index Questionnaire (NDI), and the Core Outcome Measure (COM), to validate its use in Spanish speaking patients with non-specific neck pain (NP), and to compare their psychometric characteristics with those of the Spanish version of the Northwick Pain Questionnaire (NPQ). Methods: Translation/re-translation of the English versions of the NDI and the COM was done blindly and independently by a multidisciplinary team. The study was done in 9 primary care Centers and 12 specialty services from 9 regions in Spain, with 221 acute, subacute and chronic patients who visited their physician for NP: 54 in the pilot phase and 167 in the validation phase. Neck pain (VAS), referred pain (VAS), disability (NDI, COM and NPQ), catastrophizing (CSQ) and quality of life (SF-12) were measured on their first visit and 14 days later. Patients' self-assessment was used as the external criterion for pain and disability. In the pilot phase, patients' understanding of each item in the NDI and COM was assessed, and on day 1 test-retest reliability was estimated by giving a second NDI and COM in which the name of the questionnaires and the order of the items had been changed. Results: Comprehensibility of NDI and COM were good. Minutes needed to fill out the questionnaires [median, (P25, P75)]: NDI. 4 (2.2, 10.0), COM: 2.1 (1.0, 4.9). Reliability: [ICC, (95%CI)]: NDI: 0.88 (0.80, 0.93). COM: 0.85 (0.75,0.91). Sensitivity to change: Effect size for patients having worsened, not changed and improved between days 1 and 15, according to the external criterion for disability: NDI: -0.24, 0.15, 0.66; NPQ: -0.14, 0.06, 0.67; COM: 0.05, 0.19, 0.92. Validity: Results of NDI, NPQ and COM were consistent with the external criterion for disability, whereas only those from NDI were consistent with the one for pain. Correlations with VAS, CSQ and SF-12 were similar for NDI and NPQ (absolute values between 0.36 and 0.50 on day 1, between 0.38 and 0.70 on day 15), and slightly lower for COM (between 0.36 and 0.48 on day 1, and between 0.33 and 0.61 on day 15). Correlation between NDI and NPQ: r = 0.84 on day 1, r = 0.91 on day 15. Correlation between COM and NPQ: r = 0.63 on day 1, r = 0.71 on day 15. Conclusion: Although most psychometric characteristics of NDI, NPQ and COM are similar, those from the latter one are worse and its use may lead to patients' evolution seeming more positive than it actually is. NDI seems to be the best instrument for measuring NP-related disability, since its results are the most consistent with patient's assessment of their own clinical status and evolution. It takes two more minutes to answer the NDI than to answer the COM, but it can be reliably filled out by the patient without assistance

Evaluating model outputs using integrated global speleothem records of climate change since the last glacial

Although quantitative isotopic data from speleothems has been used to evaluate isotope-enabled model simulations, currently no consensus exists regarding the most appropriate methodology through which to achieve this. A number of modelling groups will be running isotope-enabled palaeoclimate simulations in the framework of the Coupled Model Intercomparison Project Phase 6, so it is timely to evaluate different approaches to use the speleothem data for data-model comparisons. Here, we illustrate this using 456 globally-distributed speleothem δ18O records from an updated version of the Speleothem Isotopes Synthesis and Analysis (SISAL) database and palaeoclimate simulations generated using the ECHAM5-wiso isotope-enabled atmospheric circulation model. We show that the SISAL records reproduce the first-order spatial patterns of isotopic variability in the modern day, strongly supporting the application of this dataset for evaluating model-derived isotope variability into the past. However, the discontinuous nature of many speleothem records complicates procuring large numbers of records if data-model comparisons are made using the traditional approach of comparing anomalies between a control period and a given palaeoclimate experiment. To circumvent this issue, we illustrate techniques through which the absolute isotopic values during any time period could be used for model evaluation. Specifically, we show that speleothem isotope records allow an assessment of a model’s ability to simulate spatial isotopic trends. Our analyses provide a protocol for using speleothem isotopic data for model evaluation, including screening the observations to take into account the impact of speleothem mineralogy on 18O values, the optimum period for the modern observational baseline, and the selection of an appropriate time-window for creating means of the isotope data for palaeo time slices

High frequency of low-count monoclonal B-cell lymphocytosis in hospitalized COVID-19 patients

Low-count monoclonal B-cell lymphocytosis (MBLlo, <500 clonal B-cells/μL) is a highly prevalent condition in the general population (4% to 16% of otherwise healthy adults), which increases significantly with age.1-7 In most cases, clonal B-cells share phenotypic and cytogenetic features with chronic lymphocytic leukemia (CLL), but only a small fraction (≈1.8%) progresses to high-count MBL (MBLhi; ≥500 and <5000 clonal B-cells/μL)3 in the medium-term.8 However, previous reports showed that MBLlo subjects had an increased risk of severe infections in association with a (predominantly) secondary antibody deficiency,8-10 suggesting that MBLlo might be a risk marker for developing more severe infections.This work was supported by the Instituto de Salud Carlos III (Ministerio de Ciencia e Innovación, Madrid, Spain, and FONDOS FEDER (a way to build Europe) grants CB16/12/00400 (CIBERONC), COV20/00386, and PI17/00399; the Consejería de Educación and the Gerencia Regional de Salud, Consejería de Sanidad from Junta de Castilla y León (Valladolid, Spain) grants SA109P20 and GRS-COVID-33/A/20; the European Regional Development Fund (INTERREG POCTEP Spain-Portugal) grant 0639-IDIAL-NET-3-3; and the CRUK (United Kingdom), Fundación AECC (Spain), and Associazione Italiana per la Ricerca Sul Cancro (Italy) “Early Cancer Research Initiative Network on MBL (ECRINM3)” ACCELERATOR award. G.O.-A. is supported by a grant from the Consejería de Educación, Junta de Castilla y León (Valladolid, Spain); B.F.-H. was supported by grant 0639-IDIAL-NET-3-3.Peer reviewe

Immune cell kinetics and antibody response in COVID-19 patients with low-count monoclonal B-cell lymphocytosis

Low-count monoclonal B-cell lymphocytosis (MBLlo) has been associated with an underlying immunodeficiency and has recently emerged as a new risk factor for severe COVID-19. Here, we investigated the kinetics of immune cell and antibody responses in blood during COVID-19 of MBLlo versus non-MBL patients. For this study, we analyzed the kinetics of immune cells in blood of 336 COVID-19 patients (74 MBLlo and 262 non-MBL), who had not been vaccinated against SARS-CoV-2, over a period of 43 weeks since the onset of infection, using high-sensitivity flow cytometry. Plasma levels of anti-SARS-CoV-2 antibodies were measured in parallel by ELISA. Overall, early after the onset of symptoms, MBLlo COVID-19 patients showed increased neutrophil, monocyte, and particularly, plasma cell (PC) counts, whereas eosinophil, dendritic cell, basophil, and lymphocyte counts were markedly decreased in blood of a variable percentage of samples, and with a tendency toward normal levels from week +5 of infection onward. Compared with non-MBL patients, MBLlo COVID-19 patients presented higher neutrophil counts, together with decreased pre-GC B-cell, dendritic cell, and innate-like T-cell counts. Higher PC levels, together with a delayed PC peak and greater plasma levels of anti-SARS-CoV-2-specific antibodies (at week +2 to week +4) were also observed in MBLlo patients. In summary, MBLlo COVID-19 patients share immune profiles previously described for patients with severe SARS-CoV-2 infection, associated with a delayed but more pronounced PC and antibody humoral response once compared with non-MBL patients.This work was supported by “Early Cancer Research Initiative Network on MBL (ECRINM3)” ACCELERATOR award (CRUK-UK-, Fundación AECC-Spain-and Associazione Italiana per la Ricerca Sul Cancro _Italy-), by the CB16/12/00400 (CIBERONC), COV20/00386, PI17/00399, and PI22/00674, grants from the Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación, (Madrid, Spain) co-funded by FONDOS FEDER, and by the SA109P20 (Consejería de Educación) and GRS-COVID-33/A/20 (Gerencia Regional de Salud, Consejería de Sanidad) grants from Junta de Castilla y León (Valladolid, Spain), by 0639-IDIAL-NET-3-3 grant (INTERREG POCTEP Spain-Portugal) from Fondo Europeo de Desarrollo Regional. G. Oliva-Ariza is supported by a grant (PR-2019 487971) from the Consejería de Educación, Junta de Castilla y León (Valladolid, Spain), B. Fuentes-Herrero is supported by the 0639-IDIAL-NET-3-3, and ECRIN-M3 grants, and Ó. González-López is supported by a grant (FI20/00116) from Instituto de Salud Carlos III co-funded by Fondo Social Europeo Plus (FSE+).Peer reviewe

Delimitation, Characterization and Determination of the maximum flood level and protection area of ​​Wetlands in the jurisdiction of the CAR

La Corporación Autónoma Regional (CAR), es el ente encargado de velar por la protección y conservación de los Humedales de Cundinamarca, es por ello que se crea la necesidad de identificar el estado actual de algunos humedales ubicados dentro del Departamento de Cundinamarca. Para la evaluación de los humedales fue necesario explorar y reconocer los elementos Bióticos, Abióticos y el entorno social que conforma cada cuerpo de agua. Dentro de la evaluación de los humedales, se realizaron diversos procedimientos batimétricos que permitieron obtener el modelo de curvas de nivel para la superficie terrestre existente bajo la lámina de agua; con esta información se generó un modelamiento hidráulico que permitió determinar la cota máxima de inundación del cuerpo de agua. La finalidad del presente proyecto es mostrar como la combinación de varias técnicas de levantamientos topográficos y batimétricos, permitieron la creación de un modelo de curvas de nivel de un determinado terreno.The Corporación Autónoma Regional (CAR) is the entity in charge of protecting and conservation the wetlands of Cundinamarca, which is why it is necessary to identify the current state of some wetlands located within the Department of Cundinamarca. For the assessment of wetlands, it was necessary to explore and recognize the biotic, abiotic and social environment that make up each body of water. In the evaluation of the wetlands, several bathymetric procedures were carried out to obtain the model of contour lines for the terrestrial surface under the water sheet; With this information a hydraulic modeling was generated that allowed to determine the maximum level of flood of the body of water. The aim of the present project is to show how the combination of several topographic and bathymetric survey techniques allowed the creation of a model of level curves of a given terrain.SAR INGENIERIA LTD

Identificación de las prácticas socioculturales y uso de la lengua materna en el pueblo Achagua

PregradoTrabajador(a) Socia

Delimitation, Characterization and Determination of the maximum flood level and protection area of ​​Wetlands in the jurisdiction of the CAR

La Corporación Autónoma Regional (CAR), es el ente encargado de velar por la protección y conservación de los Humedales de Cundinamarca, es por ello que se crea la necesidad de identificar el estado actual de algunos humedales ubicados dentro del Departamento de Cundinamarca. Para la evaluación de los humedales fue necesario explorar y reconocer los elementos Bióticos, Abióticos y el entorno social que conforma cada cuerpo de agua. Dentro de la evaluación de los humedales, se realizaron diversos procedimientos batimétricos que permitieron obtener el modelo de curvas de nivel para la superficie terrestre existente bajo la lámina de agua; con esta información se generó un modelamiento hidráulico que permitió determinar la cota máxima de inundación del cuerpo de agua. La finalidad del presente proyecto es mostrar como la combinación de varias técnicas de levantamientos topográficos y batimétricos, permitieron la creación de un modelo de curvas de nivel de un determinado terreno.The Corporación Autónoma Regional (CAR) is the entity in charge of protecting and conservation the wetlands of Cundinamarca, which is why it is necessary to identify the current state of some wetlands located within the Department of Cundinamarca. For the assessment of wetlands, it was necessary to explore and recognize the biotic, abiotic and social environment that make up each body of water. In the evaluation of the wetlands, several bathymetric procedures were carried out to obtain the model of contour lines for the terrestrial surface under the water sheet; With this information a hydraulic modeling was generated that allowed to determine the maximum level of flood of the body of water. The aim of the present project is to show how the combination of several topographic and bathymetric survey techniques allowed the creation of a model of level curves of a given terrain.SAR INGENIERIA LTD