Constituyentes del aceite esencial de Ocimum micranthum W. y estudio antimicrobiano

The study of the chemistry composition of the volatil oil of Ocimum micranthum Wild was determinatged by chromatographies and spectronics methods, metil-eugenol (52.20%) was gottern like the principal component, in addition to cariofileno (15.67%), β-elemento (5,15%). The essential oil of Ocimum micranthum Wild were screened for antimicrobial activities (more sensibility over fungus), the agar overlay technique was applied over differents bacterials and fungus like this; Kleibsiella pneumonae, Staphylococcus aureus, Escherichia coli, Bacillus cereus, Shiguella sp., Aspergillus niger, aspergillus flavus, Aspergillus fumigatus and Penicllium sp.El estudio de la composición química del aceite volátil de Ocimun micranthum Wild, se determinó por medios cromatograficos y espectroscópicos obteniendo como componente principal al metil-eugenol (52.20%) además del cariofileno (15,67%) y β-elemento (5,15%). El aceite esencial de Ocimum micranthum Wild mostró actividad bacterial frente a microorganismos (mayor sensibilidad frente' a hongos), la determinación de esta actividad se realizó por el método de excavación placa-cultivo, frente a diferentes bacterias y hongos tales como: Kleibsiella pneumonae, Staphylococus aureus. Escherichia coli, Bacillus cereus. Shiguella sp., Aspergillus niger, Aspergillus flavus. Aspergillus fumigatus y Penicillum sp

Course of serological tests in treated subjects with chronic Trypanosoma cruzi infection: A systematic review and meta-analysis of individual participant data

Objective: To determine the course of serological tests in subjects with chronic Trypanosoma cruzi infection treated with anti-trypanosomal drugs. Methods: A systematic review and meta-analysis was conducted using individual participant data. Survival analysis and the Cox proportional hazards regression model with random effects to adjust for covariates were applied. The protocol was registered in the PROSPERO database (http://www.crd.york.ac.uk/PROSPERO; CRD42012002162). Results: A total of 27 studies (1296 subjects) conducted in eight countries were included. The risk of bias was low for all domains in 17 studies (63.0%). Nine hundred and thirteen subjects were assessed (149 seroreversion events, 83.7% censored data) for enzyme-linked immunosorbent assay (ELISA), 670 subjects (134 events, 80.0% censored) for indirect immunofluorescence assay (IIF), and 548 subjects (99 events, 82.0% censored) for indirect hemagglutination assay (IHA). A higher probability of seroreversion was observed within a shorter time span in subjects aged 1-19 years compared to adults. The chance of seroreversion also varied according to the country where the infection might have been acquired. For instance, the pooled adjusted hazard ratio between children/adolescents and adults for the IIF test was 1.54 (95% confidence interval 0.64-3.71) for certain countries of South America (Argentina, Bolivia, Chile, and Paraguay) and 9.37 (95% confidence interval 3.44-25.50) for Brazil. Conclusions: The disappearance of anti-T. cruzi antibodies was demonstrated along the course of follow-up. An interaction between age at treatment and country setting was found.UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme for Research and Training in Tropical Diseases (TDR), World Health Organization, Geneva, Switzerland B20393 European project BERENICE - European Community's 7th Framework Programme HEALTH-3059