2 research outputs found
Use of Collagen Scaffolds in Conjunction with NPWT for the Care of Complex Wounds: Clinical Report
Open wounds treatment is very often a challenge for both the physician and patient. They
require long term complex treatment with surgical debridement, dressing changing, additional
therapies including expensive medication, with a high risk of failure. The most difficult to treat are
the diabetic wounds and those that are associated with advanced arterial disease. In these special
cases, the peripheral vascularization is severely impaired and the complications are imminent.
Sixteen patients were selected from those appearing to our hospital departments of orthopedic and
plastic surgery. Inclusion criteria included patients with a recurrent mixed fibrotic and granular
wound base following trauma or diabetes, in which NPWT was indicated, without exclusion
criteria. Patients enrolled were treated with regularly scheduled NPWT dressing change and using
of a collagen scaffold. Patients were followed until healing, with visual representations of wound
progression and time to full healing recorded. Both applications of these therapies appeared to
accelerate the wound healing by clearing degenerative fibrous tissue and expediting wound
granulation without additional complication. Some of the patients were healed partially and plastic
surgery techniques were applied. Use of collagen scaffolds in conjunction with negative pressure
wound therapy in the care of complex wounds is a reliable and effective method combining both the
new granular tissue formation capacity of the scaffold to hold osteoblasts. In our experience, we
have noticed that the patients benefit greatly when collagen scaffolds is combined with NPWT. It is
our belief that this combination therapy combines the molecular clearing of non-viable collagen
with the wound granulation necessary to advance complex wounds in healing