Diseño y comportamiento de un lumiducto vertical para aulas

El presente trabajo muestra los resultados del estudio de un lumiducto vertical que permite el ingreso de iluminación solar en aulas de un edificio escolar en la Provincia de Mendoza. El concepto constructivo del lumiducto se basa en un colector que capta la mayor cantidad de luz solar posible, un elemento conductor que transporte la luz con la mínima cantidad de reflexiones y con una boca de salida para direccionar el haz de luz solar hacia el cieloiraso que aportará luz difusa evitando el deslumbramiento de las personas. La longitud total del lumiducto está condicionada por la arquitectura. Los resultados obtenidos tanto en los cálculos analíticos como en las mediciones en modelo a escala, nos hacen suponer un funcionamiento eficiente del lumiducto diseñado, asegurando condiciones lumínicas interiores dentro de rangos esperables de confort, ingresando al espacio interior luz solar controlada.Facultad de Arquitectura y Urbanism

Importance of Chiral Recognition in Designing Metal-Free Ligands for G-Quadruplex DNA

Four pairs of amino acid-functionalized naphthalenediimide enantiomers (d- and l-lysine derived NDIs) were screened toward G-quadruplex forming sequences in telomeres (h-TELO) and oncogene promoters: c-KIT1, c-KIT2, k-RAS and BCL-2. This is the first study to address the effect of point chirality toward G-quadruplex DNA stabilization using purely small organic molecules. Enantioselective behavior toward the majority of ligands was observed, particularly in the case of parallel conformations of c-KIT2 and k-RAS. Additionally, Nε-Boc-l-Lys-NDI and Nε-Boc-d-Lys-NDI discriminate between quadruplexes with parallel and hybrid topologies, which has not previously been observed with enantiomeric ligands

Tropheryma whipplei associated with diarrhoea in young children

International audienceTropheryma whipplei was detected in preliminary studies in faeces of young children with diarrhoea and also in faeces of asymptomatic persons, not only in Europe but also in Africa. In this study, the link between this bacterium and the presence of acute diarrhoea was evaluated in a large group of children. From December 2009 to January 2013, rectal swabs collected from 3796 children in the emergency departments of university hospitals in Marseille, France, were analysed: 555 children (245 female and 310 male, from 6 days to 6 years old) with acute diarrhoea defined as at least three loose stools per day for <1 week and 3241 children (1444 female and 1797 male, from 22 days to 6 years old) without diarrhoea. Specific quantitative real-time PCR was performed to detect the presence of T. whipplei and of two enteric pathogens Clostridium difficile and Giardia duodenalis. Tropheryma whipplei was significantly more common in children with diarrhoea (22/555, 4%) than without (56/3241, 1.7%; p 0.001). Neither C. difficile nor G. duodenalis showed this association. For C. difficile, 39 of 531 (7.3%) children with diarrhoea were positive versus 184 of 3119 (5.9%) of children without diarrhoea (p 0.25). For G. duodenalis, 2 of 529 (0.37%) children with diarrhoea were positive versus 5 of 3119 (0.16%) children without diarrhoea (p 0.26). Tropheryma whipplei was found more commonly in autumn. Tropheryma whipplei is significantly associated with diarrhoea in children, suggesting that the bacterium may be a cause of acute diarrhoea. (C) 2016 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved

The Evolution of the Seine Basin Water Bodies Through Historical Maps

International audienc